IMP

Process View

Homo sapiens

35 genes annotated in human

glycosaminoglycan metabolic process

The chemical reactions and pathways involving glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars. Formerly known as mucopolysaccharides, they include hyaluronic acid and chondroitin, which provide lubrication in joints and form part of the matrix of cartilage. The three-dimensional structure of these molecules enables them to trap water, which forms a gel and gives glycosaminoglycans their elastic properties.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "glycosaminoglycan metabolic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "glycosaminoglycan metabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.923
FGFR2	fibroblast growth factor receptor 2	0.777
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.761	Human
TEK	TEK tyrosine kinase, endothelial	0.634
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.579	Human
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.575
IL1R1	interleukin 1 receptor, type I	0.542
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.479	Human
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.396
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.365
BCL3	B-cell CLL/lymphoma 3	0.263
HIP1	huntingtin interacting protein 1	0.223
FGF1	fibroblast growth factor 1 (acidic)	0.215	Human
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.179
REL	v-rel reticuloendotheliosis viral oncogene homolog (avian)	0.162	Human
NUMB	numb homolog (Drosophila)	0.127
FGA	fibrinogen alpha chain	0.123
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.106
NRP1	neuropilin 1	0.095
PLAUR	plasminogen activator, urokinase receptor	0.085
APBB1	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	0.081
ENG	endoglin	0.073
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.066
THBS1	thrombospondin 1	0.065
MAP3K8	mitogen-activated protein kinase kinase kinase 8	0.061
COL6A1	collagen, type VI, alpha 1	0.061
FGF10	fibroblast growth factor 10	0.054	Human
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.047
MSN	moesin	0.044
APP	amyloid beta (A4) precursor protein	0.043
IL8	interleukin 8	0.040
TOM1L1	target of myb1 (chicken)-like 1	0.039
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.039
FGF7	fibroblast growth factor 7	0.038	Human
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.036
FGFR1	fibroblast growth factor receptor 1	0.036
EGFR	epidermal growth factor receptor	0.034
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.033
CAV1	caveolin 1, caveolae protein, 22kDa	0.031
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.030
COL6A2	collagen, type VI, alpha 2	0.027
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.026
HSPG2	heparan sulfate proteoglycan 2	0.026
DKK1	dickkopf homolog 1 (Xenopus laevis)	0.026
TGFBR1	transforming growth factor, beta receptor 1	0.025
FGF2	fibroblast growth factor 2 (basic)	0.022
DCN	decorin	0.022	Zebrafish Mouse
COL2A1	collagen, type II, alpha 1	0.022
INHBA	inhibin, beta A	0.022
MMP14	matrix metallopeptidase 14 (membrane-inserted)	0.022
OCRL	oculocerebrorenal syndrome of Lowe	0.021
STC1	stanniocalcin 1	0.021
TGFB1	transforming growth factor, beta 1	0.021
COL4A2	collagen, type IV, alpha 2	0.021
ELN	elastin	0.020
FCN2	ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)	0.020
DDR2	discoidin domain receptor tyrosine kinase 2	0.019
PLCG1	phospholipase C, gamma 1	0.019
FNDC3B	fibronectin type III domain containing 3B	0.019
PLAU	plasminogen activator, urokinase	0.019
IGFBP5	insulin-like growth factor binding protein 5	0.019
FSTL1	follistatin-like 1	0.019
CNTF	ciliary neurotrophic factor	0.019
COL5A1	collagen, type V, alpha 1	0.018
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.018
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.018
CAPRIN2	caprin family member 2	0.018
FRS2	fibroblast growth factor receptor substrate 2	0.018
BMP1	bone morphogenetic protein 1	0.017
TGFB3	transforming growth factor, beta 3	0.017
ACSL4	acyl-CoA synthetase long-chain family member 4	0.017
ICAM1	intercellular adhesion molecule 1	0.017
MRC2	mannose receptor, C type 2	0.017
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.017
FBN1	fibrillin 1	0.016
MBL2	mannose-binding lectin (protein C) 2, soluble	0.016
MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	0.016
TGFB2	transforming growth factor, beta 2	0.016	Human
B3GAT3	beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)	0.016
COL4A1	collagen, type IV, alpha 1	0.016
IL1R2	interleukin 1 receptor, type II	0.015
ZNF431	zinc finger protein 431	0.015
MAN1B1	mannosidase, alpha, class 1B, member 1	0.015
NFKBIB	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	0.015
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.015
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.015	Rat
VEGFC	vascular endothelial growth factor C	0.014	Human
VEGFA	vascular endothelial growth factor A	0.014	Human Rat
PCOLCE	procollagen C-endopeptidase enhancer	0.014
LAMA2	laminin, alpha 2	0.014
CHPF	chondroitin polymerizing factor	0.014	Human Mouse
TIMP3	TIMP metallopeptidase inhibitor 3	0.013
DOCK7	dedicator of cytokinesis 7	0.013
DPT	dermatopontin	0.013
PIP5K1C	phosphatidylinositol-4-phosphate 5-kinase, type I, gamma	0.013
BMP2	bone morphogenetic protein 2	0.013
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.013	Human
CTSB	cathepsin B	0.013
CD81	CD81 molecule	0.013
CSPG4	chondroitin sulfate proteoglycan 4	0.013
PRKCZ	protein kinase C, zeta	0.013
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.013
TFPI2	tissue factor pathway inhibitor 2	0.013
SERPINB2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	0.012
ARFGAP3	ADP-ribosylation factor GTPase activating protein 3	0.012
CCND2	cyclin D2	0.012
VCAN	versican	0.012
LRRK2	leucine-rich repeat kinase 2	0.012
LUM	lumican	0.012
PRELP	proline/arginine-rich end leucine-rich repeat protein	0.012
SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	0.012
SLC7A11	solute carrier family 7, (cationic amino acid transporter, y+ system) member 11	0.012
HGF	hepatocyte growth factor (hepapoietin A; scatter factor)	0.012	Rat
ZEB2	zinc finger E-box binding homeobox 2	0.012
AMMECR1	Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1	0.012
GPC1	glypican 1	0.012
ECM2	extracellular matrix protein 2, female organ and adipocyte specific	0.012
LYVE1	lymphatic vessel endothelial hyaluronan receptor 1	0.012	Human Mouse
B4GALT7	xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I)	0.011
FGG	fibrinogen gamma chain	0.011
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.011
ADH1B	alcohol dehydrogenase 1B (class I), beta polypeptide	0.011
FST	follistatin	0.011
EMILIN1	elastin microfibril interfacer 1	0.011
ACVR2B	activin A receptor, type IIB	0.011
PHLDA1	pleckstrin homology-like domain, family A, member 1	0.011
OLFML3	olfactomedin-like 3	0.011
PID1	phosphotyrosine interaction domain containing 1	0.011
CCL2	chemokine (C-C motif) ligand 2	0.011
AP2B1	adaptor-related protein complex 2, beta 1 subunit	0.011
CXCL12	chemokine (C-X-C motif) ligand 12	0.011
CTSK	cathepsin K	0.010
BMX	BMX non-receptor tyrosine kinase	0.010
TNIP1	TNFAIP3 interacting protein 1	0.010
BCL2A1	BCL2-related protein A1	0.010
C7	complement component 7	0.010
PTGIS	prostaglandin I2 (prostacyclin) synthase	0.010
CTSL1	cathepsin L1	0.010
LEPRE1	leucine proline-enriched proteoglycan (leprecan) 1	0.010
ANGPTL2	angiopoietin-like 2	0.010	Human
TIMP2	TIMP metallopeptidase inhibitor 2	0.010
CRYAB	crystallin, alpha B	0.010
WNT3A	wingless-type MMTV integration site family, member 3A	0.010
TLR2	toll-like receptor 2	0.010
SRPX	sushi-repeat containing protein, X-linked	0.010