IMP

Process View

Homo sapiens

20 genes annotated in human

positive regulation of type i interferon production

Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of type i interferon production"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of type i interferon production" (in gray)

Name	Description	Probability	Func Analog Organism
DDX58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	0.956
STAT1	signal transducer and activator of transcription 1, 91kDa	0.939
STAT2	signal transducer and activator of transcription 2, 113kDa	0.835
IKBKE	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	0.790	Human
EIF2AK2	eukaryotic translation initiation factor 2-alpha kinase 2	0.753
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.742
MYD88	myeloid differentiation primary response gene (88)	0.733
SP110	SP110 nuclear body protein	0.586
CYLD	cylindromatosis (turban tumor syndrome)	0.568
IRF9	interferon regulatory factor 9	0.531	Human
TRIM21	tripartite motif containing 21	0.524	Human
IRF7	interferon regulatory factor 7	0.509
PIAS4	protein inhibitor of activated STAT, 4	0.470
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.431
MED15	mediator complex subunit 15	0.408
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.223	Human
UBE2D4	ubiquitin-conjugating enzyme E2D 4 (putative)	0.222
OAS2	2'-5'-oligoadenylate synthetase 2, 69/71kDa	0.183
TICAM2	toll-like receptor adaptor molecule 2	0.175
IRF1	interferon regulatory factor 1	0.165
SAMD9	sterile alpha motif domain containing 9	0.153
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.152
DDX60	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	0.148
TRIM5	tripartite motif containing 5	0.128	Human
IFIH1	interferon induced with helicase C domain 1	0.124
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.104
OAS1	2',5'-oligoadenylate synthetase 1, 40/46kDa	0.091
ZNF263	zinc finger protein 263	0.091
MAVS	mitochondrial antiviral signaling protein	0.087
IFI44	interferon-induced protein 44	0.074
TRIM26	tripartite motif containing 26	0.074
TRIM25	tripartite motif containing 25	0.073
ZNF473	zinc finger protein 473	0.068
SP100	SP100 nuclear antigen	0.067
NMI	N-myc (and STAT) interactor	0.062
TBK1	TANK-binding kinase 1	0.061
IRF2	interferon regulatory factor 2	0.061	Human
OAS3	2'-5'-oligoadenylate synthetase 3, 100kDa	0.059
KAT2B	K(lysine) acetyltransferase 2B	0.055
IL15	interleukin 15	0.053
BIRC3	baculoviral IAP repeat containing 3	0.053
XAF1	XIAP associated factor 1	0.051
IRF3	interferon regulatory factor 3	0.050	Human Mouse
TRIM39	tripartite motif containing 39	0.048	Human
TNFSF10	tumor necrosis factor (ligand) superfamily, member 10	0.048
OASL	2'-5'-oligoadenylate synthetase-like	0.047
IFIT3	interferon-induced protein with tetratricopeptide repeats 3	0.045
RTP4	receptor (chemosensory) transporter protein 4	0.044
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.041
STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	0.040
TRAF3	TNF receptor-associated factor 3	0.039
IFI35	interferon-induced protein 35	0.038
IFNAR2	interferon (alpha, beta and omega) receptor 2	0.037
PARP12	poly (ADP-ribose) polymerase family, member 12	0.036	Human
TRANK1	tetratricopeptide repeat and ankyrin repeat containing 1	0.035
TRIM32	tripartite motif containing 32	0.034
IFNGR1	interferon gamma receptor 1	0.032
APOL6	apolipoprotein L, 6	0.028
MX1	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	0.028
MR1	major histocompatibility complex, class I-related	0.027
CREBBP	CREB binding protein	0.027
ZC3HAV1	zinc finger CCCH-type, antiviral 1	0.027
AZI2	5-azacytidine induced 2	0.027
POLR3E	polymerase (RNA) III (DNA directed) polypeptide E (80kD)	0.027
MX2	myxovirus (influenza virus) resistance 2 (mouse)	0.027
BTN3A3	butyrophilin, subfamily 3, member A3	0.026
NLRC5	NLR family, CARD domain containing 5	0.026
TRIM52	tripartite motif containing 52	0.024
IRAK1	interleukin-1 receptor-associated kinase 1	0.024
ADAR	adenosine deaminase, RNA-specific	0.024
TLR1	toll-like receptor 1	0.023	Human
TLR2	toll-like receptor 2	0.022
IFNAR1	interferon (alpha, beta and omega) receptor 1	0.022
HERC5	hect domain and RLD 5	0.021
PHF11	PHD finger protein 11	0.021
TRAF2	TNF receptor-associated factor 2	0.020
TRIM22	tripartite motif containing 22	0.020	Human
SPOP	speckle-type POZ protein	0.020
CXCL10	chemokine (C-X-C motif) ligand 10	0.019
USP18	ubiquitin specific peptidase 18	0.019
TMEM173	transmembrane protein 173	0.018
TRIM17	tripartite motif containing 17	0.018	Human
TLR4	toll-like receptor 4	0.018	Human Mouse
HSPA9	heat shock 70kDa protein 9 (mortalin)	0.018
PML	promyelocytic leukemia	0.018
FKBP5	FK506 binding protein 5	0.018
TDRD7	tudor domain containing 7	0.018
MAP3K14	mitogen-activated protein kinase kinase kinase 14	0.018
C19orf66	chromosome 19 open reading frame 66	0.017
EPSTI1	epithelial stromal interaction 1 (breast)	0.017
IFIT5	interferon-induced protein with tetratricopeptide repeats 5	0.017
POLR3H	polymerase (RNA) III (DNA directed) polypeptide H (22.9kD)	0.017
PRKRA	protein kinase, interferon-inducible double stranded RNA dependent activator	0.017
LY96	lymphocyte antigen 96	0.016
TMEM140	transmembrane protein 140	0.016
TRAFD1	TRAF-type zinc finger domain containing 1	0.016
SPI1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	0.016
IRF8	interferon regulatory factor 8	0.015	Human
IFI16	interferon, gamma-inducible protein 16	0.015
PPP2R2B	protein phosphatase 2, regulatory subunit B, beta	0.015
HTT	huntingtin	0.015
GIMAP2	GTPase, IMAP family member 2	0.015
XIAP	X-linked inhibitor of apoptosis	0.015
CCT8	chaperonin containing TCP1, subunit 8 (theta)	0.014
TFEC	transcription factor EC	0.014
ISG20	interferon stimulated exonuclease gene 20kDa	0.014
BRAP	BRCA1 associated protein	0.014
POLR3D	polymerase (RNA) III (DNA directed) polypeptide D, 44kDa	0.014
CTSO	cathepsin O	0.014
TLR7	toll-like receptor 7	0.013
PRPF4B	PRP4 pre-mRNA processing factor 4 homolog B (yeast)	0.013
RBCK1	RanBP-type and C3HC4-type zinc finger containing 1	0.013
TRIM35	tripartite motif containing 35	0.013
UBE2U	ubiquitin-conjugating enzyme E2U (putative)	0.013
KIAA1274	KIAA1274	0.013
BLNK	B-cell linker	0.012
GBP2	guanylate binding protein 2, interferon-inducible	0.012
TARBP2	TAR (HIV-1) RNA binding protein 2	0.012
IRF2BP2	interferon regulatory factor 2 binding protein 2	0.012
NCOA3	nuclear receptor coactivator 3	0.011
UBD	ubiquitin D	0.011
STAP2	signal transducing adaptor family member 2	0.011
RSAD2	radical S-adenosyl methionine domain containing 2	0.011
MAFB	v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)	0.011
APOL3	apolipoprotein L, 3	0.011
DTX3L	deltex 3-like (Drosophila)	0.011
TRIM34	tripartite motif containing 34	0.011
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.011
MCOLN1	mucolipin 1	0.011
TRIM41	tripartite motif containing 41	0.011	Human
CALCOCO2	calcium binding and coiled-coil domain 2	0.011
TLR3	toll-like receptor 3	0.011
KIAA0020	KIAA0020	0.010
TRIM8	tripartite motif containing 8	0.010
CTSS	cathepsin S	0.010
IL15RA	interleukin 15 receptor, alpha	0.010
GBP3	guanylate binding protein 3	0.010
MYL12A	myosin, light chain 12A, regulatory, non-sarcomeric	0.010