IMP
Process View
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| CASP8 | caspase 8, apoptosis-related cysteine peptidase | 0.997 | ||
| BCL2L1 | BCL2-like 1 | 0.989 | Human | |
| BCL2 | B-cell CLL/lymphoma 2 | 0.987 | ||
| MCL1 | myeloid cell leukemia sequence 1 (BCL2-related) | 0.915 | Human | |
| FADD | Fas (TNFRSF6)-associated via death domain | 0.913 | ||
| SYVN1 | synovial apoptosis inhibitor 1, synoviolin | 0.907 | Mouse | |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | 0.611 | ||
| BAX | BCL2-associated X protein | 0.605 | ||
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.594 | ||
| BCL2L11 | BCL2-like 11 (apoptosis facilitator) | 0.564 | Zebrafish | |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.405 | ||
| ATF4 | activating transcription factor 4 (tax-responsive enhancer element B67) | 0.404 | Mouse | |
| BID | BH3 interacting domain death agonist | 0.369 | ||
| BAD | BCL2-associated agonist of cell death | 0.236 | ||
| TRIB3 | tribbles homolog 3 (Drosophila) | 0.224 | ||
| LASS2 | LAG1 homolog, ceramide synthase 2 | 0.215 | ||
| MAFA | v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) | 0.212 | ||
| BAK1 | BCL2-antagonist/killer 1 | 0.195 | Human | |
| TRADD | TNFRSF1A-associated via death domain | 0.190 | ||
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.183 | ||
| DERL1 | Der1-like domain family, member 1 | 0.162 | ||
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.157 | ||
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | 0.149 | ||
| CEBPG | CCAAT/enhancer binding protein (C/EBP), gamma | 0.146 | ||
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.127 | Mouse | |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.125 | ||
| CABLES1 | Cdk5 and Abl enzyme substrate 1 | 0.116 | ||
| RIPK1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.113 | ||
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 0.105 | ||
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.102 | ||
| DAXX | death-domain associated protein | 0.097 | ||
| CEBPB | CCAAT/enhancer binding protein (C/EBP), beta | 0.092 | ||
| VCP | valosin containing protein | 0.091 | ||
| FAM101B | family with sequence similarity 101, member B | 0.075 | ||
| TP53BP2 | tumor protein p53 binding protein, 2 | 0.072 | ||
| JUN | jun proto-oncogene | 0.072 | ||
| TRAF1 | TNF receptor-associated factor 1 | 0.070 | ||
| ZNF746 | zinc finger protein 746 | 0.069 | ||
| KRT5 | keratin 5 | 0.061 | ||
| FLNB | filamin B, beta | 0.054 | ||
| FASLG | Fas ligand (TNF superfamily, member 6) | 0.053 | ||
| BIK | BCL2-interacting killer (apoptosis-inducing) | 0.048 | ||
| ATF3 | activating transcription factor 3 | 0.040 | ||
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.036 | ||
| SQSTM1 | sequestosome 1 | 0.034 | ||
| RXRB | retinoid X receptor, beta | 0.033 | ||
| STX5 | syntaxin 5 | 0.032 | ||
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.030 | ||
| DDIT3 | DNA-damage-inducible transcript 3 | 0.030 | ||
| BECN1 | beclin 1, autophagy related | 0.028 | ||
| BBC3 | BCL2 binding component 3 | 0.026 | ||
| IKBKB | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 0.024 | ||
| ARHGDIA | Rho GDP dissociation inhibitor (GDI) alpha | 0.021 | ||
| VEGFA | vascular endothelial growth factor A | 0.021 | ||
| ATF5 | activating transcription factor 5 | 0.020 | ||
| INPP5D | inositol polyphosphate-5-phosphatase, 145kDa | 0.020 | ||
| CDK5R1 | cyclin-dependent kinase 5, regulatory subunit 1 (p35) | 0.020 | ||
| SESN2 | sestrin 2 | 0.020 | ||
| BCL2L2 | BCL2-like 2 | 0.018 | Human | |
| AMBRA1 | autophagy/beclin-1 regulator 1 | 0.018 | ||
| HUWE1 | HECT, UBA and WWE domain containing 1 | 0.018 | ||
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.018 | ||
| CUL3 | cullin 3 | 0.018 | ||
| CREBBP | CREB binding protein | 0.016 | ||
| DNAJB9 | DnaJ (Hsp40) homolog, subfamily B, member 9 | 0.016 | ||
| RNR2 | l-rRNA | 0.016 | ||
| WBP2 | WW domain binding protein 2 | 0.015 | ||
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.015 | ||
| RARA | retinoic acid receptor, alpha | 0.014 | ||
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 0.013 | ||
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.013 | ||
| BANP | BTG3 associated nuclear protein | 0.013 | ||
| DERL2 | Der1-like domain family, member 2 | 0.013 | ||
| TP53 | tumor protein p53 | 0.012 | ||
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | 0.012 | ||
| NCOA3 | nuclear receptor coactivator 3 | 0.012 | ||
| CANX | calnexin | 0.012 | ||
| USP7 | ubiquitin specific peptidase 7 (herpes virus-associated) | 0.012 | ||
| RNF144B | ring finger protein 144B | 0.011 | ||
| SH3BP2 | SH3-domain binding protein 2 | 0.011 | ||
| RASSF1 | Ras association (RalGDS/AF-6) domain family member 1 | 0.011 | ||
| POLR2C | polymerase (RNA) II (DNA directed) polypeptide C, 33kDa | 0.010 |