IMP

Process View

Homo sapiens

16 genes annotated in human

muscle fiber development

The process whose specific outcome is the progression of the muscle fiber over time, from its formation to the mature structure. In skeletal muscle, fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "muscle fiber development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "muscle fiber development" (in gray)

Name	Description	Probability	Func Analog Organism
TRIM63	tripartite motif containing 63	0.998
TTN	titin	0.982
JAG1	jagged 1	0.822
NOTCH1	notch 1	0.804
MYOZ1	myozenin 1	0.620
FGF1	fibroblast growth factor 1 (acidic)	0.619
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.505
GMPPA	GDP-mannose pyrophosphorylase A	0.470
HDAC4	histone deacetylase 4	0.385	Mouse
NEB	nebulin	0.337	Zebrafish
SRF	serum response factor (c-fos serum response element-binding transcription factor)	0.328
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.302
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.278
STK4	serine/threonine kinase 4	0.253	Worm
JUN	jun proto-oncogene	0.253
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.208
TCAP	titin-cap (telethonin)	0.207
BMPR1A	bone morphogenetic protein receptor, type IA	0.193
CSRP3	cysteine and glycine-rich protein 3 (cardiac LIM protein)	0.177
NRP1	neuropilin 1	0.174
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.173
STK3	serine/threonine kinase 3	0.164	Worm
DTNA	dystrobrevin, alpha	0.150
UTRN	utrophin	0.139
FN1	fibronectin 1	0.139
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.130
BCL6	B-cell CLL/lymphoma 6	0.129
OBSCN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	0.127
LTA	lymphotoxin alpha (TNF superfamily, member 1)	0.124
IGF2	insulin-like growth factor 2 (somatomedin A)	0.113
NCAM1	neural cell adhesion molecule 1	0.112
HDAC9	histone deacetylase 9	0.111	Mouse
CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	0.105
FSTL1	follistatin-like 1	0.102
IQGAP1	IQ motif containing GTPase activating protein 1	0.102
SETD8	SET domain containing (lysine methyltransferase) 8	0.088
FLNA	filamin A, alpha	0.086
MEF2C	myocyte enhancer factor 2C	0.078
OBSL1	obscurin-like 1	0.076
APP	amyloid beta (A4) precursor protein	0.074
ACTN2	actinin, alpha 2	0.072	Zebrafish
PARVA	parvin, alpha	0.072
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.071
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.066
MYPN	myopalladin	0.062
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.059
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.057
ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	0.056
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.055
FLNC	filamin C, gamma	0.052	Mouse
NOTCH3	notch 3	0.052	Human
RASSF1	Ras association (RalGDS/AF-6) domain family member 1	0.050
NCOR2	nuclear receptor corepressor 2	0.050
ZFYVE9	zinc finger, FYVE domain containing 9	0.049
ATF3	activating transcription factor 3	0.049
CEBPG	CCAAT/enhancer binding protein (C/EBP), gamma	0.048
FBLN1	fibulin 1	0.046
BMP2	bone morphogenetic protein 2	0.045	Human
TNKS2	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2	0.043
TESK1	testis-specific kinase 1	0.040
BCL2L1	BCL2-like 1	0.038
MTMR12	myotubularin related protein 12	0.038
TAL1	T-cell acute lymphocytic leukemia 1	0.034
MEF2A	myocyte enhancer factor 2A	0.032	Human Fly
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.032
CXCL11	chemokine (C-X-C motif) ligand 11	0.032
CAV1	caveolin 1, caveolae protein, 22kDa	0.032
SPRY2	sprouty homolog 2 (Drosophila)	0.031	Fly
NCOR1	nuclear receptor corepressor 1	0.031
RASSF3	Ras association (RalGDS/AF-6) domain family member 3	0.030
SPTBN1	spectrin, beta, non-erythrocytic 1	0.029
TNNI2	troponin I type 2 (skeletal, fast)	0.029
RASSF5	Ras association (RalGDS/AF-6) domain family member 5	0.029
NFIL3	nuclear factor, interleukin 3 regulated	0.029
VIM	vimentin	0.029
TNNI1	troponin I type 1 (skeletal, slow)	0.029
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.029
MYL9	myosin, light chain 9, regulatory	0.029
E2F1	E2F transcription factor 1	0.026
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.026
DLL1	delta-like 1 (Drosophila)	0.026
CTGF	connective tissue growth factor	0.025
ANXA2	annexin A2	0.024
EPAS1	endothelial PAS domain protein 1	0.024
CNOT8	CCR4-NOT transcription complex, subunit 8	0.024
SGCD	sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)	0.024
DMD	dystrophin	0.024	Mouse
DES	desmin	0.023
ACTA1	actin, alpha 1, skeletal muscle	0.023	Mouse
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.023
PGF	placental growth factor	0.023
DAXX	death-domain associated protein	0.022
FYN	FYN oncogene related to SRC, FGR, YES	0.022
ADAM12	ADAM metallopeptidase domain 12	0.022
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.022	Mouse
CHRNA1	cholinergic receptor, nicotinic, alpha 1 (muscle)	0.021	Human Zebrafish
ATP2A1	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	0.020
TNNT3	troponin T type 3 (skeletal, fast)	0.020
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.020
MRPL41	mitochondrial ribosomal protein L41	0.019
TWIST2	twist homolog 2 (Drosophila)	0.019
HSPG2	heparan sulfate proteoglycan 2	0.019
EIF3E	eukaryotic translation initiation factor 3, subunit E	0.019
SGCG	sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)	0.018
PTEN	phosphatase and tensin homolog	0.018
CAPN3	calpain 3, (p94)	0.017	Mouse
UBASH3B	ubiquitin associated and SH3 domain containing B	0.017
ATF4	activating transcription factor 4 (tax-responsive enhancer element B67)	0.016
SAV1	salvador homolog 1 (Drosophila)	0.016
TGFBR1	transforming growth factor, beta receptor 1	0.016
MYLPF	myosin light chain, phosphorylatable, fast skeletal muscle	0.016
DUSP1	dual specificity phosphatase 1	0.015
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.015
MYBPH	myosin binding protein H	0.015
DTNB	dystrobrevin, beta	0.015
XIRP1	xin actin-binding repeat containing 1	0.015
EGLN3	egl nine homolog 3 (C. elegans)	0.015
MYOG	myogenin (myogenic factor 4)	0.015	Mouse
PPP3R1	protein phosphatase 3, regulatory subunit B, alpha	0.015
GSN	gelsolin	0.014
FGF2	fibroblast growth factor 2 (basic)	0.014
ITGB1BP3	integrin beta 1 binding protein 3	0.014
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.013
SMAD3	SMAD family member 3	0.013
IGF2R	insulin-like growth factor 2 receptor	0.013
TMSB10	thymosin beta 10	0.013
ACTN3	actinin, alpha 3	0.013
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.013
SOS2	son of sevenless homolog 2 (Drosophila)	0.013
KCNJ5	potassium inwardly-rectifying channel, subfamily J, member 5	0.013
PNRC1	proline-rich nuclear receptor coactivator 1	0.013
DNAJB4	DnaJ (Hsp40) homolog, subfamily B, member 4	0.013
MOBKL1A	MOB1, Mps One Binder kinase activator-like 1A (yeast)	0.012
CKM	creatine kinase, muscle	0.012
CNN1	calponin 1, basic, smooth muscle	0.012
APC	adenomatous polyposis coli	0.012
GATA4	GATA binding protein 4	0.012
H3F3C	H3 histone, family 3C	0.011
TGFB2	transforming growth factor, beta 2	0.011	Human
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.011
THBS1	thrombospondin 1	0.011
MSN	moesin	0.011
DPP4	dipeptidyl-peptidase 4	0.011
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.011
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.011
NCF2	neutrophil cytosolic factor 2	0.011
TCF4	transcription factor 4	0.011
NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	0.011
FGF10	fibroblast growth factor 10	0.011
PBX1	pre-B-cell leukemia homeobox 1	0.011
GFI1B	growth factor independent 1B transcription repressor	0.011
JAG2	jagged 2	0.010
ZFP36L1	zinc finger protein 36, C3H type-like 1	0.010
KRT8	keratin 8	0.010
TGFB3	transforming growth factor, beta 3	0.010
WFIKKN1	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1	0.010
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.010
ESR1	estrogen receptor 1	0.010
MYOD1	myogenic differentiation 1	0.010	Zebrafish Mouse
BMP3	bone morphogenetic protein 3	0.010