IMP
Process View
cerebellar purkinje cell layer morphogenesis
The process in which the anatomical structure of the cerebellar Purkinje cell layer is generated and organized. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells.
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Click on a gene's description to view its network relationships with genes known to be involved in "cerebellar purkinje cell layer morphogenesis"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Otx2 | orthodenticle homolog 2 (Drosophila) | 0.999 | ||
| Pax2 | paired box gene 2 | 0.993 | ||
| Emx2 | empty spiracles homolog 2 (Drosophila) | 0.993 | ||
| Pax6 | paired box gene 6 | 0.977 | ||
| Pitx2 | paired-like homeodomain transcription factor 2 | 0.931 | ||
| Nr5a1 | nuclear receptor subfamily 5, group A, member 1 | 0.804 | ||
| Shh | sonic hedgehog | 0.786 | ||
| Gbx2 | gastrulation brain homeobox 2 | 0.776 | ||
| Lhx1 | LIM homeobox protein 1 | 0.766 | ||
| Lhx9 | LIM homeobox protein 9 | 0.693 | Mouse | |
| Emx1 | empty spiracles homolog 1 (Drosophila) | 0.688 | ||
| Lmx1b | LIM homeobox transcription factor 1 beta | 0.540 | Mouse | |
| Isl1 | ISL1 transcription factor, LIM/homeodomain | 0.493 | Mouse | |
| Thrb | thyroid hormone receptor beta | 0.488 | ||
| Fgf8 | fibroblast growth factor 8 | 0.462 | ||
| Lhx3 | LIM homeobox protein 3 | 0.395 | Mouse | |
| Ntrk2 | neurotrophic tyrosine kinase, receptor, type 2 | 0.376 | ||
| Neurod1 | neurogenic differentiation 1 | 0.372 | ||
| Otx1 | orthodenticle homolog 1 (Drosophila) | 0.358 | ||
| En1 | engrailed 1 | 0.333 | ||
| Phox2b | paired-like homeobox 2b | 0.321 | ||
| Kcnj6 | potassium inwardly-rectifying channel, subfamily J, member 6 | 0.318 | ||
| Eya1 | eyes absent 1 homolog (Drosophila) | 0.256 | ||
| Gabrb3 | gamma-aminobutyric acid (GABA) A receptor, subunit beta 3 | 0.244 | ||
| Ank1 | ankyrin 1, erythroid | 0.232 | ||
| Pax3 | paired box gene 3 | 0.228 | ||
| Six1 | sine oculis-related homeobox 1 homolog (Drosophila) | 0.225 | ||
| Atp2b2 | ATPase, Ca++ transporting, plasma membrane 2 | 0.222 | ||
| Wt1 | Wilms tumor 1 homolog | 0.204 | ||
| Hes3 | hairy and enhancer of split 3 (Drosophila) | 0.188 | ||
| Hes5 | hairy and enhancer of split 5 (Drosophila) | 0.182 | ||
| Neurog2 | neurogenin 2 | 0.181 | ||
| Ryr1 | ryanodine receptor 1, skeletal muscle | 0.181 | ||
| Nr2e1 | nuclear receptor subfamily 2, group E, member 1 | 0.175 | ||
| Chd7 | chromodomain helicase DNA binding protein 7 | 0.174 | ||
| Kiss1 | KiSS-1 metastasis-suppressor | 0.167 | ||
| Nodal | nodal | 0.165 | ||
| Lhx4 | LIM homeobox protein 4 | 0.148 | Mouse | |
| Pou4f2 | POU domain, class 4, transcription factor 2 | 0.144 | ||
| Ssbp2 | single-stranded DNA binding protein 2 | 0.139 | ||
| Gli3 | GLI-Kruppel family member GLI3 | 0.131 | ||
| Gfra1 | glial cell line derived neurotrophic factor family receptor alpha 1 | 0.131 | ||
| Kiss1r | KISS1 receptor | 0.128 | ||
| Add2 | adducin 2 (beta) | 0.124 | ||
| Ret | ret proto-oncogene | 0.117 | ||
| Sox2 | SRY-box containing gene 2 | 0.115 | ||
| Tulp1 | tubby like protein 1 | 0.112 | ||
| Sox11 | SRY-box containing gene 11 | 0.110 | ||
| Mll5 | myeloid/lymphoid or mixed-lineage leukemia 5 | 0.108 | ||
| Ptf1a | pancreas specific transcription factor, 1a | 0.106 | ||
| Drd2 | dopamine receptor D2 | 0.103 | ||
| Kcnma1 | potassium large conductance calcium-activated channel, subfamily M, alpha member 1 | 0.101 | ||
| AI118078 | expressed sequence AI118078 | 0.094 | ||
| Hcn3 | hyperpolarization-activated, cyclic nucleotide-gated K+ 3 | 0.094 | ||
| Ssbp3 | single-stranded DNA binding protein 3 | 0.092 | ||
| Ldb2 | LIM domain binding 2 | 0.092 | Mouse | |
| Atoh7 | atonal homolog 7 (Drosophila) | 0.091 | ||
| Atxn1 | ataxin 1 | 0.083 | ||
| Pax8 | paired box gene 8 | 0.080 | ||
| Sh3gl2 | SH3-domain GRB2-like 2 | 0.078 | ||
| Mycn | v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) | 0.078 | ||
| Grid2 | glutamate receptor, ionotropic, delta 2 | 0.076 | ||
| Foxg1 | forkhead box G1 | 0.072 | ||
| Dlx5 | distal-less homeobox 5 | 0.071 | ||
| Foxh1 | forkhead box H1 | 0.070 | ||
| Tcfap2a | transcription factor AP-2, alpha | 0.069 | ||
| Kcnj11 | potassium inwardly rectifying channel, subfamily J, member 11 | 0.065 | ||
| Cdh23 | cadherin 23 (otocadherin) | 0.060 | ||
| Mll3 | myeloid/lymphoid or mixed-lineage leukemia 3 | 0.059 | ||
| Sox10 | SRY-box containing gene 10 | 0.058 | ||
| Osr1 | odd-skipped related 1 (Drosophila) | 0.058 | ||
| Hand2 | heart and neural crest derivatives expressed transcript 2 | 0.056 | ||
| Ywhab | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide | 0.056 | ||
| Spna2 | spectrin alpha 2 | 0.055 | ||
| Ash1l | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.055 | ||
| Hoxd13 | homeobox D13 | 0.054 | ||
| Ywhaz | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | 0.053 | ||
| Mll1 | myeloid/lymphoid or mixed-lineage leukemia 1 | 0.051 | ||
| Ascl1 | achaete-scute complex homolog 1 (Drosophila) | 0.051 | ||
| Lgr4 | leucine-rich repeat-containing G protein-coupled receptor 4 | 0.048 | ||
| Macf1 | microtubule-actin crosslinking factor 1 | 0.047 | ||
| Srrm4 | serine/arginine repetitive matrix 4 | 0.047 | ||
| Tbx1 | T-box 1 | 0.046 | ||
| Dlx6 | distal-less homeobox 6 | 0.045 | ||
| En2 | engrailed 2 | 0.042 | ||
| Cga | glycoprotein hormones, alpha subunit | 0.041 | ||
| Cacnb4 | calcium channel, voltage-dependent, beta 4 subunit | 0.040 | ||
| Mycbp2 | MYC binding protein 2 | 0.040 | ||
| Dync1h1 | dynein cytoplasmic 1 heavy chain 1 | 0.039 | ||
| Zbtb20 | zinc finger and BTB domain containing 20 | 0.039 | ||
| Lhx5 | LIM homeobox protein 5 | 0.038 | ||
| Foxc1 | forkhead box C1 | 0.038 | ||
| Pax7 | paired box gene 7 | 0.037 | ||
| Pdpk1 | 3-phosphoinositide dependent protein kinase 1 | 0.036 | ||
| Dcc | deleted in colorectal carcinoma | 0.035 | ||
| Zic3 | zinc finger protein of the cerebellum 3 | 0.035 | ||
| Fbn1 | fibrillin 1 | 0.035 | ||
| Klf7 | Kruppel-like factor 7 (ubiquitous) | 0.035 | ||
| Reln | reelin | 0.034 | ||
| Gad2 | glutamic acid decarboxylase 2 | 0.034 | ||
| Syn2 | synapsin II | 0.033 | ||
| Hand1 | heart and neural crest derivatives expressed transcript 1 | 0.033 | ||
| Kif5a | kinesin family member 5A | 0.032 | ||
| Gsc | goosecoid homeobox | 0.032 | ||
| Brd4 | bromodomain containing 4 | 0.032 | ||
| Tal1 | T-cell acute lymphocytic leukemia 1 | 0.032 | ||
| Mast1 | microtubule associated serine/threonine kinase 1 | 0.032 | ||
| Six3 | sine oculis-related homeobox 3 homolog (Drosophila) | 0.031 | ||
| Chrd | chordin | 0.031 | ||
| Mab21l2 | mab-21-like 2 (C. elegans) | 0.031 | ||
| Slc17a8 | solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8 | 0.031 | ||
| Lmx1a | LIM homeobox transcription factor 1 alpha | 0.030 | Mouse | |
| Celf4 | CUGBP, Elav-like family member 4 | 0.030 | ||
| Grm1 | glutamate receptor, metabotropic 1 | 0.029 | ||
| Gdnf | glial cell line derived neurotrophic factor | 0.028 | ||
| Bsn | bassoon | 0.028 | ||
| Uncx | UNC homeobox | 0.028 | ||
| Rarb | retinoic acid receptor, beta | 0.028 | ||
| Gsk3b | glycogen synthase kinase 3 beta | 0.028 | ||
| Vgf | VGF nerve growth factor inducible | 0.028 | ||
| Bptf | bromodomain PHD finger transcription factor | 0.028 | ||
| Vegfa | vascular endothelial growth factor A | 0.028 | ||
| Insm1 | insulinoma-associated 1 | 0.027 | ||
| Grin1 | glutamate receptor, ionotropic, NMDA1 (zeta 1) | 0.027 | ||
| Erbb3 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) | 0.026 | ||
| Pygo1 | pygopus 1 | 0.026 | ||
| Cacng2 | calcium channel, voltage-dependent, gamma subunit 2 | 0.026 | ||
| Med13l | mediator complex subunit 13-like | 0.025 | ||
| Cdk5r1 | cyclin-dependent kinase 5, regulatory subunit 1 (p35) | 0.024 | ||
| Epb4.1 | erythrocyte protein band 4.1 | 0.023 | ||
| Pou4f3 | POU domain, class 4, transcription factor 3 | 0.022 | ||
| Scn8a | sodium channel, voltage-gated, type VIII, alpha | 0.022 | ||
| Onecut1 | one cut domain, family member 1 | 0.022 | ||
| Pitx1 | paired-like homeodomain transcription factor 1 | 0.022 | ||
| Nrg1 | neuregulin 1 | 0.022 | ||
| Psap | prosaposin | 0.022 | ||
| Neurod4 | neurogenic differentiation 4 | 0.021 | ||
| Syt7 | synaptotagmin VII | 0.021 | ||
| Abcc8 | ATP-binding cassette, sub-family C (CFTR/MRP), member 8 | 0.021 | ||
| Slc31a1 | solute carrier family 31, member 1 | 0.021 | ||
| Tcf4 | transcription factor 4 | 0.021 | ||
| Fshr | follicle stimulating hormone receptor | 0.021 | ||
| Kcnj3 | potassium inwardly-rectifying channel, subfamily J, member 3 | 0.021 | ||
| Fgf3 | fibroblast growth factor 3 | 0.020 | ||
| Nisch | nischarin | 0.020 | ||
| Bdnf | brain derived neurotrophic factor | 0.020 | ||
| Sema5b | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B | 0.020 | ||
| Isl2 | insulin related protein 2 (islet 2) | 0.020 | Mouse | |
| Nr2f1 | nuclear receptor subfamily 2, group F, member 1 | 0.020 | ||
| Nog | noggin | 0.020 | ||
| Hbb-b1 | hemoglobin, beta adult major chain | 0.020 | ||
| Gata4 | GATA binding protein 4 | 0.019 | ||
| Dkk1 | dickkopf homolog 1 (Xenopus laevis) | 0.019 | ||
| Msx2 | homeobox, msh-like 2 | 0.019 | ||
| Cacnb2 | calcium channel, voltage-dependent, beta 2 subunit | 0.019 | ||
| Hpca | hippocalcin | 0.019 | ||
| Grid1 | glutamate receptor, ionotropic, delta 1 | 0.019 | ||
| Foxe3 | forkhead box E3 | 0.018 | ||
| Zswim6 | zinc finger, SWIM domain containing 6 | 0.018 | ||
| Ar | androgen receptor | 0.018 | ||
| Fgf10 | fibroblast growth factor 10 | 0.018 | ||
| Glg1 | golgi apparatus protein 1 | 0.018 | ||
| Wnt1 | wingless-related MMTV integration site 1 | 0.018 | ||
| Cacng1 | calcium channel, voltage-dependent, gamma subunit 1 | 0.018 | ||
| Epha8 | Eph receptor A8 | 0.018 | ||
| Kif1b | kinesin family member 1B | 0.017 | ||
| Tcfap2b | transcription factor AP-2 beta | 0.017 | ||
| Prkacb | protein kinase, cAMP dependent, catalytic, beta | 0.017 | ||
| Ncor1 | nuclear receptor co-repressor 1 | 0.017 | ||
| Cd151 | CD151 antigen | 0.017 | ||
| Cux2 | cut-like homeobox 2 | 0.017 | ||
| Msx3 | homeobox, msh-like 3 | 0.017 | ||
| Crebbp | CREB binding protein | 0.017 | ||
| Pklr | pyruvate kinase liver and red blood cell | 0.016 | ||
| Pou3f2 | POU domain, class 3, transcription factor 2 | 0.016 | ||
| Mycl1 | v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) | 0.016 | ||
| Npepps | aminopeptidase puromycin sensitive | 0.016 | ||
| Atp2a2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | 0.016 | ||
| Prop1 | paired like homeodomain factor 1 | 0.016 | ||
| Neto1 | neuropilin (NRP) and tolloid (TLL)-like 1 | 0.016 | ||
| Tlr4 | toll-like receptor 4 | 0.016 | ||
| Odz2 | odd Oz/ten-m homolog 2 (Drosophila) | 0.016 | ||
| Spna1 | spectrin alpha 1 | 0.016 | ||
| Fut8 | fucosyltransferase 8 | 0.016 | ||
| Myf6 | myogenic factor 6 | 0.015 | ||
| Ldb1 | LIM domain binding 1 | 0.015 | ||
| Lbx1 | ladybird homeobox homolog 1 (Drosophila) | 0.015 | ||
| Bmp4 | bone morphogenetic protein 4 | 0.015 | ||
| Actl6b | actin-like 6B | 0.015 | ||
| Nipbl | Nipped-B homolog (Drosophila) | 0.015 | ||
| Kifc2 | kinesin family member C2 | 0.015 | ||
| Hrc | histidine rich calcium binding protein | 0.015 | ||
| Zfhx4 | zinc finger homeodomain 4 | 0.015 | ||
| Evx2 | even skipped homeotic gene 2 homolog | 0.015 | ||
| Edar | ectodysplasin-A receptor | 0.015 | ||
| Cnnm1 | cyclin M1 | 0.014 | ||
| Gdap1l1 | ganglioside-induced differentiation-associated protein 1-like 1 | 0.014 | ||
| Ncoa1 | nuclear receptor coactivator 1 | 0.014 | ||
| Snrk | SNF related kinase | 0.014 | ||
| Chst10 | carbohydrate sulfotransferase 10 | 0.014 | ||
| Mef2a | myocyte enhancer factor 2A | 0.014 | ||
| Pitpnm1 | phosphatidylinositol transfer protein, membrane-associated 1 | 0.014 | ||
| Mecp2 | methyl CpG binding protein 2 | 0.014 | ||
| Nkx2-5 | NK2 transcription factor related, locus 5 (Drosophila) | 0.014 | ||
| Foxa2 | forkhead box A2 | 0.014 | ||
| Prkag1 | protein kinase, AMP-activated, gamma 1 non-catalytic subunit | 0.014 | ||
| Crim1 | cysteine rich transmembrane BMP regulator 1 (chordin like) | 0.014 | ||
| Gh | growth hormone | 0.014 | ||
| Scrt1 | scratch homolog 1, zinc finger protein (Drosophila) | 0.014 | ||
| Gpr98 | G protein-coupled receptor 98 | 0.013 | ||
| Gck | glucokinase | 0.013 | ||
| Arx | aristaless related homeobox | 0.013 | ||
| Syngr1 | synaptogyrin 1 | 0.013 | ||
| Slc29a4 | solute carrier family 29 (nucleoside transporters), member 4 | 0.013 | ||
| Ddx6 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 | 0.013 | ||
| Diras1 | DIRAS family, GTP-binding RAS-like 1 | 0.013 | ||
| Nhlh2 | nescient helix loop helix 2 | 0.013 | ||
| Kif1a | kinesin family member 1A | 0.013 | ||
| Kitl | kit ligand | 0.013 | ||
| Dynlt1b | dynein light chain Tctex-type 1D | 0.013 | ||
| Ptpn5 | protein tyrosine phosphatase, non-receptor type 5 | 0.013 | ||
| Dlx1 | distal-less homeobox 1 | 0.013 | ||
| Grxcr1 | glutaredoxin, cysteine rich 1 | 0.013 | ||
| Doc2b | double C2, beta | 0.013 | ||
| Slc26a5 | solute carrier family 26, member 5 | 0.012 | ||
| Rho | rhodopsin | 0.012 | ||
| Chd4 | chromodomain helicase DNA binding protein 4 | 0.012 | ||
| Efnb3 | ephrin B3 | 0.012 | ||
| Nhlh1 | nescient helix loop helix 1 | 0.012 | ||
| Emid2 | EMI domain containing 2 | 0.012 | ||
| Arid1a | AT rich interactive domain 1A (SWI-like) | 0.012 | ||
| Prokr2 | prokineticin receptor 2 | 0.012 | ||
| Hif3a | hypoxia inducible factor 3, alpha subunit | 0.012 | ||
| Magel2 | melanoma antigen, family L, 2 | 0.012 | ||
| Bmpr2 | bone morphogenic protein receptor, type II (serine/threonine kinase) | 0.012 | ||
| Kcne1 | potassium voltage-gated channel, Isk-related subfamily, member 1 | 0.012 | ||
| Adra2a | adrenergic receptor, alpha 2a | 0.012 | ||
| Spnb2 | spectrin beta 2 | 0.012 | Mouse | |
| Runx1t1 | runt-related transcription factor 1; translocated to, 1 (cyclin D-related) | 0.012 | ||
| Rspo2 | R-spondin 2 homolog (Xenopus laevis) | 0.012 | ||
| Cnr1 | cannabinoid receptor 1 (brain) | 0.012 | ||
| Sebox | SEBOX homeobox | 0.012 | ||
| Zmynd8 | zinc finger, MYND-type containing 8 | 0.012 | ||
| Pik3ca | phosphatidylinositol 3-kinase, catalytic, alpha polypeptide | 0.012 | ||
| Synj1 | synaptojanin 1 | 0.012 | ||
| Kcna6 | potassium voltage-gated channel, shaker-related, subfamily, member 6 | 0.012 | ||
| Gata3 | GATA binding protein 3 | 0.012 | ||
| Ankrd12 | ankyrin repeat domain 12 | 0.012 | ||
| Cbln1 | cerebellin 1 precursor protein | 0.012 | ||
| Otp | orthopedia homolog (Drosophila) | 0.011 | ||
| Birc6 | baculoviral IAP repeat-containing 6 | 0.011 | ||
| Wnt9b | wingless-type MMTV integration site 9B | 0.011 | ||
| Kdr | kinase insert domain protein receptor | 0.011 | ||
| Cntn4 | contactin 4 | 0.011 | ||
| Etv4 | ets variant gene 4 (E1A enhancer binding protein, E1AF) | 0.011 | ||
| Rbp3 | retinol binding protein 3, interstitial | 0.011 | ||
| Gnaq | guanine nucleotide binding protein, alpha q polypeptide | 0.011 | ||
| Dmbx1 | diencephalon/mesencephalon homeobox 1 | 0.011 | ||
| Ncan | neurocan | 0.011 | ||
| Kcnmb1 | potassium large conductance calcium-activated channel, subfamily M, beta member 1 | 0.011 | ||
| Ssbp4 | single stranded DNA binding protein 4 | 0.011 | ||
| Pnpla3 | patatin-like phospholipase domain containing 3 | 0.011 | ||
| Kcnj4 | potassium inwardly-rectifying channel, subfamily J, member 4 | 0.011 | ||
| Foxc2 | forkhead box C2 | 0.011 | ||
| Wnk1 | WNK lysine deficient protein kinase 1 | 0.011 | ||
| Slc12a5 | solute carrier family 12, member 5 | 0.011 | ||
| Phox2a | paired-like homeobox 2a | 0.011 | ||
| Caln1 | calneuron 1 | 0.011 | ||
| Kcnc3 | potassium voltage gated channel, Shaw-related subfamily, member 3 | 0.011 | ||
| Tg | thyroglobulin | 0.011 | ||
| Syt2 | synaptotagmin II | 0.011 | ||
| Tlx3 | T-cell leukemia, homeobox 3 | 0.011 | ||
| Neurod2 | neurogenic differentiation 2 | 0.011 | ||
| Dpysl4 | dihydropyrimidinase-like 4 | 0.011 | ||
| Olfr70 | olfactory receptor 70 | 0.011 | ||
| Vsx2 | visual system homeobox 2 | 0.011 | ||
| Zeb1 | zinc finger E-box binding homeobox 1 | 0.010 | ||
| Sbno1 | sno, strawberry notch homolog 1 (Drosophila) | 0.010 | ||
| Msx1 | homeobox, msh-like 1 | 0.010 | ||
| Barhl2 | BarH-like 2 (Drosophila) | 0.010 | ||
| Myh10 | myosin, heavy polypeptide 10, non-muscle | 0.010 | ||
| Tsc1 | tuberous sclerosis 1 | 0.010 | ||
| Pum1 | pumilio 1 (Drosophila) | 0.010 | ||
| Fev | FEV (ETS oncogene family) | 0.010 | ||
| Sox1 | SRY-box containing gene 1 | 0.010 | ||
| Trove2 | TROVE domain family, member 2 | 0.010 | ||
| Wbp2 | WW domain binding protein 2 | 0.010 | ||
| BC024139 | cDNA sequence BC024139 | 0.010 | ||
| Fam134a | family with sequence similarity 134, member A | 0.010 | ||
| Irs2 | insulin receptor substrate 2 | 0.010 | ||
| Cacna1d | calcium channel, voltage-dependent, L type, alpha 1D subunit | 0.010 | Mouse | |
| Mybpc3 | myosin binding protein C, cardiac | 0.010 | ||
| Kcnk3 | potassium channel, subfamily K, member 3 | 0.010 |