IMP

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Mus musculus

14 genes annotated in mouse

Multi-species View

positive regulation of heart contraction

GO:0045823

Any process that activates or increases the frequency, rate or extent of heart contraction.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of heart contraction"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of heart contraction" (in gray)

Name	Description	Probability	Func Analog Organism
Tbx5	T-box 5	0.828
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.776
Hand1	heart and neural crest derivatives expressed transcript 1	0.763
Cckbr	cholecystokinin B receptor	0.599
Fos	FBJ osteosarcoma oncogene	0.487
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.474
Gja5	gap junction protein, alpha 5	0.459
Chrnb4	cholinergic receptor, nicotinic, beta polypeptide 4	0.441	Mouse
Kcnma1	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	0.399
Cacna1s	calcium channel, voltage-dependent, L type, alpha 1S subunit	0.266
Pnpla2	patatin-like phospholipase domain containing 2	0.262
Scn5a	sodium channel, voltage-gated, type V, alpha	0.233	Rat
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.224
Gata4	GATA binding protein 4	0.223
Hand2	heart and neural crest derivatives expressed transcript 2	0.193
Kcna1	potassium voltage-gated channel, shaker-related subfamily, member 1	0.189
Hcn4	hyperpolarization-activated, cyclic nucleotide-gated K+ 4	0.188
Slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.180
Smyd1	SET and MYND domain containing 1	0.163
Ryr2	ryanodine receptor 2, cardiac	0.159
Efnb2	ephrin B2	0.158
Grm2	glutamate receptor, metabotropic 2	0.138
Tbx3	T-box 3	0.135
Ldb3	LIM domain binding 3	0.130
Zfpm2	zinc finger protein, multitype 2	0.123
Kcnk3	potassium channel, subfamily K, member 3	0.111
Chrna3	cholinergic receptor, nicotinic, alpha polypeptide 3	0.095	Mouse
Lhx6	LIM homeobox protein 6	0.093
Actn2	actinin alpha 2	0.093
Pthlh	parathyroid hormone-like peptide	0.091
Drd2	dopamine receptor D2	0.090
Ache	acetylcholinesterase	0.084
Kl	klotho	0.081
Htr1d	5-hydroxytryptamine (serotonin) receptor 1D	0.076	Mouse
Kcnj11	potassium inwardly rectifying channel, subfamily J, member 11	0.073
Chrna6	cholinergic receptor, nicotinic, alpha polypeptide 6	0.073	Mouse
Hbegf	heparin-binding EGF-like growth factor	0.072
Kcna2	potassium voltage-gated channel, shaker-related subfamily, member 2	0.064
Galr1	galanin receptor 1	0.062
Kcnq2	potassium voltage-gated channel, subfamily Q, member 2	0.060
Crhr2	corticotropin releasing hormone receptor 2	0.057	Rat
Sstr1	somatostatin receptor 1	0.053
Gh	growth hormone	0.053
Kcna4	potassium voltage-gated channel, shaker-related subfamily, member 4	0.052
Drd4	dopamine receptor D4	0.051
Slc16a8	solute carrier family 16 (monocarboxylic acid transporters), member 8	0.051
Sstr4	somatostatin receptor 4	0.051
Ighmbp2	immunoglobulin mu binding protein 2	0.049
Fndc7	fibronectin type III domain containing 7	0.043
Myl3	myosin, light polypeptide 3	0.041
Xirp1	xin actin-binding repeat containing 1	0.041
Ntf3	neurotrophin 3	0.040
ND6	NADH dehydrogenase subunit 6	0.040
Casq2	calsequestrin 2	0.036
Gpr27	G protein-coupled receptor 27	0.035
Myoz1	myozenin 1	0.034
Ckm	creatine kinase, muscle	0.034
Prox1	prospero-related homeobox 1	0.033
Sfrp5	secreted frizzled-related sequence protein 5	0.033
Adrb2	adrenergic receptor, beta 2	0.033	Mouse Rat
Shc3	src homology 2 domain-containing transforming protein C3	0.033
Lag3	lymphocyte-activation gene 3	0.033
Clcn1	chloride channel 1	0.032
Fgf8	fibroblast growth factor 8	0.032
Adra1b	adrenergic receptor, alpha 1b	0.032
Ckmt2	creatine kinase, mitochondrial 2	0.032
P2rx6	purinergic receptor P2X, ligand-gated ion channel, 6	0.032
Nppb	natriuretic peptide type B	0.032
Ednrb	endothelin receptor type B	0.032
Kcnj3	potassium inwardly-rectifying channel, subfamily J, member 3	0.031
Krtap5-1	keratin associated protein 5-1	0.031
Tff1	trefoil factor 1	0.031
Colq	collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase	0.031
Has1	hyaluronan synthase1	0.031
Htr5a	5-hydroxytryptamine (serotonin) receptor 5A	0.030	Mouse
Cox8b	cytochrome c oxidase, subunit VIIIb	0.030
Mobp	myelin-associated oligodendrocytic basic protein	0.030
Chrna10	cholinergic receptor, nicotinic, alpha polypeptide 10	0.029	Mouse
Six6	sine oculis-related homeobox 6 homolog (Drosophila)	0.029
Oprd1	opioid receptor, delta 1	0.029
Sox10	SRY-box containing gene 10	0.028
Chrna9	cholinergic receptor, nicotinic, alpha polypeptide 9	0.028	Mouse
Mybpc3	myosin binding protein C, cardiac	0.028
Foxe1	forkhead box E1	0.028
Hrh1	histamine receptor H1	0.026
Slc2a4	solute carrier family 2 (facilitated glucose transporter), member 4	0.025
Chrnb2	cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)	0.025	Mouse
Erbb4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.024
Atf3	activating transcription factor 3	0.024
Lalba	lactalbumin, alpha	0.024
Phkg1	phosphorylase kinase gamma 1	0.024
Otog	otogelin	0.024
Ntsr2	neurotensin receptor 2	0.023
Nrap	nebulin-related anchoring protein	0.023
Lrrk2	leucine-rich repeat kinase 2	0.023
Rgs4	regulator of G-protein signaling 4	0.023	Mouse
Nkx3-1	NK-3 transcription factor, locus 1 (Drosophila)	0.023
Sstr5	somatostatin receptor 5	0.023
Actc1	actin, alpha, cardiac muscle 1	0.022
Gjc2	gap junction protein, gamma 2	0.022
Krt36	keratin 36	0.022
Barx2	BarH-like homeobox 2	0.022
Foxc2	forkhead box C2	0.021
Nog	noggin	0.021
Sertad1	SERTA domain containing 1	0.021
Alx3	aristaless-like homeobox 3	0.021
Actg1	actin, gamma, cytoplasmic 1	0.021
Hcn1	hyperpolarization-activated, cyclic nucleotide-gated K+ 1	0.021
Htr1a	5-hydroxytryptamine (serotonin) receptor 1A	0.021	Mouse
Oprm1	opioid receptor, mu 1	0.021
Bsn	bassoon	0.021
Adora2a	adenosine A2a receptor	0.021
Kcnk4	potassium channel, subfamily K, member 4	0.021
Gata6	GATA binding protein 6	0.020
Kcna7	potassium voltage-gated channel, shaker-related subfamily, member 7	0.020
Glra1	glycine receptor, alpha 1 subunit	0.020
Cxcr7	chemokine (C-X-C motif) receptor 7	0.020
Gzmm	granzyme M (lymphocyte met-ase 1)	0.020
Trpc5	transient receptor potential cation channel, subfamily C, member 5	0.020
Acta1	actin, alpha 1, skeletal muscle	0.019
Adcyap1r1	adenylate cyclase activating polypeptide 1 receptor 1	0.019
Sult4a1	sulfotransferase family 4A, member 1	0.019
Cntn2	contactin 2	0.019
Ppp1r9b	protein phosphatase 1, regulatory subunit 9B	0.019
Hpca	hippocalcin	0.019
Ptprn	protein tyrosine phosphatase, receptor type, N	0.019
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.018
Dusp1	dual specificity phosphatase 1	0.018
Kcnq1	potassium voltage-gated channel, subfamily Q, member 1	0.018
Ppfia4	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	0.018
Sgca	sarcoglycan, alpha (dystrophin-associated glycoprotein)	0.018
Fosb	FBJ osteosarcoma oncogene B	0.018
Cdh13	cadherin 13	0.018
Chst5	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5	0.018
Grin1	glutamate receptor, ionotropic, NMDA1 (zeta 1)	0.018
Kcnc3	potassium voltage gated channel, Shaw-related subfamily, member 3	0.018
Rapsn	receptor-associated protein of the synapse	0.018
Popdc3	popeye domain containing 3	0.018
Snta1	syntrophin, acidic 1	0.017
Nppa	natriuretic peptide type A	0.017
Cldn26	claudin 26	0.017
Grm1	glutamate receptor, metabotropic 1	0.017
Gfra2	glial cell line derived neurotrophic factor family receptor alpha 2	0.017
Thbs1	thrombospondin 1	0.017
Stk32b	serine/threonine kinase 32B	0.016
Vamp2	vesicle-associated membrane protein 2	0.016
Ptgfr	prostaglandin F receptor	0.016
Insm1	insulinoma-associated 1	0.016
Fgf18	fibroblast growth factor 18	0.016
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.016
Art5	ADP-ribosyltransferase 5	0.016
Nodal	nodal	0.016
Myod1	myogenic differentiation 1	0.016
Kcnh1	potassium voltage-gated channel, subfamily H (eag-related), member 1	0.016
Mesp1	mesoderm posterior 1	0.016
Mpz	myelin protein zero	0.016
Epha6	Eph receptor A6	0.015
Ywhaz	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.015
Npy2r	neuropeptide Y receptor Y2	0.015
Axin1	axin 1	0.015
Npy5r	neuropeptide Y receptor Y5	0.015
Eras	ES cell-expressed Ras	0.015
Myog	myogenin	0.015
Gria1	glutamate receptor, ionotropic, AMPA1 (alpha 1)	0.015
Nkx6-1	NK6 homeobox 1	0.015
Cga	glycoprotein hormones, alpha subunit	0.015
Chrna7	cholinergic receptor, nicotinic, alpha polypeptide 7	0.014
Trh	thyrotropin releasing hormone	0.014
Pramel7	preferentially expressed antigen in melanoma like 7	0.014
Gpr12	G-protein coupled receptor 12	0.014
Cyr61	cysteine rich protein 61	0.014
Wwtr1	WW domain containing transcription regulator 1	0.014
Gfra3	glial cell line derived neurotrophic factor family receptor alpha 3	0.014
Gja1	gap junction protein, alpha 1	0.014
Tnni1	troponin I, skeletal, slow 1	0.014
Bhlhe23	basic helix-loop-helix family, member e23	0.014
Anxa3	annexin A3	0.014
Ankrd2	ankyrin repeat domain 2 (stretch responsive muscle)	0.014
Meox1	mesenchyme homeobox 1	0.014
Myom1	myomesin 1	0.014
Chrng	cholinergic receptor, nicotinic, gamma polypeptide	0.014	Mouse
Art1	ADP-ribosyltransferase 1	0.014
Itgb1bp2	integrin beta 1 binding protein 2	0.014
Hsp90ab1	heat shock protein 90 alpha (cytosolic), class B member 1	0.014
Scn10a	sodium channel, voltage-gated, type X, alpha	0.014
Ptgir	prostaglandin I receptor (IP)	0.013
Myh6	myosin, heavy polypeptide 6, cardiac muscle, alpha	0.013
Adrb1	adrenergic receptor, beta 1	0.013
Tcap	titin-cap	0.013
Tnnt3	troponin T3, skeletal, fast	0.013
Serpine1	serine (or cysteine) peptidase inhibitor, clade E, member 1	0.013
Casq1	calsequestrin 1	0.013
Rho	rhodopsin	0.013
Lpar1	lysophosphatidic acid receptor 1	0.013
Pvalb	parvalbumin	0.013
Des	desmin	0.013
Nos1	nitric oxide synthase 1, neuronal	0.013
Gnao1	guanine nucleotide binding protein, alpha O	0.013
Chrm1	cholinergic receptor, muscarinic 1, CNS	0.013
Pgr	progesterone receptor	0.013
Prkcc	protein kinase C, gamma	0.013
Hrh2	histamine receptor H2	0.013	Mouse
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.013
Camk2a	calcium/calmodulin-dependent protein kinase II alpha	0.013
Smad9	MAD homolog 9 (Drosophila)	0.013
Ank1	ankyrin 1, erythroid	0.013
Atp4a	ATPase, H+/K+ exchanging, gastric, alpha polypeptide	0.013	Mouse
Fgfrl1	fibroblast growth factor receptor-like 1	0.013
Ucp3	uncoupling protein 3 (mitochondrial, proton carrier)	0.013
Oprk1	opioid receptor, kappa 1	0.013
Nfatc2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	0.012
Neto1	neuropilin (NRP) and tolloid (TLL)-like 1	0.012
Kcnj5	potassium inwardly-rectifying channel, subfamily J, member 5	0.012
Cacna1d	calcium channel, voltage-dependent, L type, alpha 1D subunit	0.012
Cul9	cullin 9	0.012
Il12rb1	interleukin 12 receptor, beta 1	0.012
Ptprn2	protein tyrosine phosphatase, receptor type, N polypeptide 2	0.012
Nkx1-2	NK1 transcription factor related, locus 2 (Drosophila)	0.012
Rgs6	regulator of G-protein signaling 6	0.012
Foxb2	forkhead box B2	0.012
Kcns2	K+ voltage-gated channel, subfamily S, 2	0.012
Mog	myelin oligodendrocyte glycoprotein	0.012
Ncam2	neural cell adhesion molecule 2	0.012
Msx3	homeobox, msh-like 3	0.012
Adam19	a disintegrin and metallopeptidase domain 19 (meltrin beta)	0.012
Cacna2d1	calcium channel, voltage-dependent, alpha2/delta subunit 1	0.011
Amh	anti-Mullerian hormone	0.011
Rps6kl1	ribosomal protein S6 kinase-like 1	0.011
Cacng5	calcium channel, voltage-dependent, gamma subunit 5	0.011
Pcsk4	proprotein convertase subtilisin/kexin type 4	0.011
Crhr1	corticotropin releasing hormone receptor 1	0.011
Cox8c	cytochrome c oxidase, subunit VIIIc	0.011
Speg	SPEG complex locus	0.011
Tead4	TEA domain family member 4	0.011
Pou3f4	POU domain, class 3, transcription factor 4	0.011
Ecel1	endothelin converting enzyme-like 1	0.011
Wnt6	wingless-related MMTV integration site 6	0.011
Adra1a	adrenergic receptor, alpha 1a	0.011
Stx1b	syntaxin 1B	0.011
Tectb	tectorin beta	0.011
Klf6	Kruppel-like factor 6	0.011
Egr2	early growth response 2	0.011
Nobox	NOBOX oogenesis homeobox	0.011
Gjd3	gap junction protein, delta 3	0.011
Myh7	myosin, heavy polypeptide 7, cardiac muscle, beta	0.011
Msn	moesin	0.011
Gpr3	G-protein coupled receptor 3	0.011
Frmd5	FERM domain containing 5	0.011
Htra3	HtrA serine peptidase 3	0.011
Avp	arginine vasopressin	0.011
Plxnb3	plexin B3	0.011
Otp	orthopedia homolog (Drosophila)	0.011
Pkib	protein kinase inhibitor beta, cAMP dependent, testis specific	0.011
Rhob	ras homolog gene family, member B	0.010
Npy1r	neuropeptide Y receptor Y1	0.010
Actr3	ARP3 actin-related protein 3 homolog (yeast)	0.010
Syn2	synapsin II	0.010
Sst	somatostatin	0.010
Gabrg3	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 3	0.010
Pcdh12	protocadherin 12	0.010
Onecut1	one cut domain, family member 1	0.010
Usp13	ubiquitin specific peptidase 13 (isopeptidase T-3)	0.010
Tlx3	T-cell leukemia, homeobox 3	0.010
Scx	scleraxis	0.010
Tnnt2	troponin T2, cardiac	0.010