IMP

Process View

Mus musculus

7 genes annotated in mouse

neuroendocrine cell differentiation

The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a neuroendocrine cell. A neuroendocrine cell is a cell that receives input form a neuron which controls the secretion of an endocrine substance.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in mouse Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "neuroendocrine cell differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "neuroendocrine cell differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
Shh	sonic hedgehog	1.000
Otx2	orthodenticle homolog 2 (Drosophila)	0.996
Gli3	GLI-Kruppel family member GLI3	0.995
Pax2	paired box gene 2	0.995
Fgfr2	fibroblast growth factor receptor 2	0.964
Nodal	nodal	0.955
Nog	noggin	0.954
Lhx1	LIM homeobox protein 1	0.914
Hoxd11	homeobox D11	0.834
Fgf8	fibroblast growth factor 8	0.823
Alx4	aristaless-like homeobox 4	0.722
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.708
Chrd	chordin	0.704
Gli2	GLI-Kruppel family member GLI2	0.691
Wnt3a	wingless-related MMTV integration site 3A	0.679	Mouse
Foxa2	forkhead box A2	0.661	Fly
Hand2	heart and neural crest derivatives expressed transcript 2	0.616
Hoxa13	homeobox A13	0.586
Nkx2-1	NK2 homeobox 1	0.564
Hoxd13	homeobox D13	0.528
En1	engrailed 1	0.528
Fgf10	fibroblast growth factor 10	0.483	Mouse
Otx1	orthodenticle homolog 1 (Drosophila)	0.452
Emx2	empty spiracles homolog 2 (Drosophila)	0.431
Sox9	SRY-box containing gene 9	0.426
Fgf3	fibroblast growth factor 3	0.424	Mouse
Gbx2	gastrulation brain homeobox 2	0.392
Fgf15	fibroblast growth factor 15	0.373
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.372
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.333
Foxc1	forkhead box C1	0.323
Pax3	paired box gene 3	0.322
Emx1	empty spiracles homolog 1 (Drosophila)	0.322
Lmx1a	LIM homeobox transcription factor 1 alpha	0.310
Twist2	twist homolog 2 (Drosophila)	0.271
Dlx5	distal-less homeobox 5	0.266
Sox2	SRY-box containing gene 2	0.266
Fgfr3	fibroblast growth factor receptor 3	0.264
Nkx2-2	NK2 transcription factor related, locus 2 (Drosophila)	0.263
Pdx1	pancreatic and duodenal homeobox 1	0.248
Hand1	heart and neural crest derivatives expressed transcript 1	0.230
T	brachyury	0.223
Pou3f3	POU domain, class 3, transcription factor 3	0.210
Onecut1	one cut domain, family member 1	0.208
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.190
Wnt3	wingless-related MMTV integration site 3	0.175	Mouse
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.175
Nkx6-1	NK6 homeobox 1	0.173
Pax6	paired box gene 6	0.173
Lmx1b	LIM homeobox transcription factor 1 beta	0.160
Tcf21	transcription factor 21	0.151
Hmx3	H6 homeobox 3	0.148
Ctnnb1	catenin (cadherin associated protein), beta 1	0.144
Acan	aggrecan	0.140
Lhx5	LIM homeobox protein 5	0.134
Neurog3	neurogenin 3	0.132
Prrx1	paired related homeobox 1	0.128
Pax8	paired box gene 8	0.126
Zic3	zinc finger protein of the cerebellum 3	0.123
Hoxa2	homeobox A2	0.113
Rarg	retinoic acid receptor, gamma	0.110
Wnt2b	wingless related MMTV integration site 2b	0.108	Mouse
Ret	ret proto-oncogene	0.103
Tbx3	T-box 3	0.103
Tcf4	transcription factor 4	0.102	Fly
Bmp7	bone morphogenetic protein 7	0.097
Pthlh	parathyroid hormone-like peptide	0.095
Wnt4	wingless-related MMTV integration site 4	0.094
Tcfap2a	transcription factor AP-2, alpha	0.093
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.088
Foxa1	forkhead box A1	0.084	Fly
Gsc	goosecoid homeobox	0.083
Hoxa11	homeobox A11	0.083
Fgf18	fibroblast growth factor 18	0.080	Mouse
Pitx2	paired-like homeodomain transcription factor 2	0.078
Fgfr1	fibroblast growth factor receptor 1	0.077
Vax1	ventral anterior homeobox containing gene 1	0.077
Gdnf	glial cell line derived neurotrophic factor	0.075
Foxb1	forkhead box B1	0.074
Fgf9	fibroblast growth factor 9	0.074	Mouse
Meox2	mesenchyme homeobox 2	0.073
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.070
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.068
Gata6	GATA binding protein 6	0.068
Sox3	SRY-box containing gene 3	0.068
Fzd8	frizzled homolog 8 (Drosophila)	0.067
Gdf1	growth differentiation factor 1	0.066	Mouse
Lhx3	LIM homeobox protein 3	0.065
Alx3	aristaless-like homeobox 3	0.062
Pitx1	paired-like homeodomain transcription factor 1	0.061
Prrx2	paired related homeobox 2	0.061
Neurod1	neurogenic differentiation 1	0.060
Cdx1	caudal type homeobox 1	0.060
Foxd3	forkhead box D3	0.059
Isl1	ISL1 transcription factor, LIM/homeodomain	0.056
Sox1	SRY-box containing gene 1	0.055
Gli1	GLI-Kruppel family member GLI1	0.055
Hes1	hairy and enhancer of split 1 (Drosophila)	0.055
Btbd17	BTB (POZ) domain containing 17	0.055
Eya1	eyes absent 1 homolog (Drosophila)	0.054
Six6	sine oculis-related homeobox 6 homolog (Drosophila)	0.054
Pou3f4	POU domain, class 3, transcription factor 4	0.053
Hmx1	H6 homeobox 1	0.050
Rarb	retinoic acid receptor, beta	0.050
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.049
Rara	retinoic acid receptor, alpha	0.046
Msx2	homeobox, msh-like 2	0.046
Wnt5a	wingless-related MMTV integration site 5A	0.045	Mouse
Foxf1a	forkhead box F1a	0.044
Gata4	GATA binding protein 4	0.044
Wnt1	wingless-related MMTV integration site 1	0.042	Mouse
Nkx3-2	NK3 homeobox 2	0.042
Wnt7a	wingless-related MMTV integration site 7A	0.041	Mouse
Cyp26a1	cytochrome P450, family 26, subfamily a, polypeptide 1	0.041
Wt1	Wilms tumor 1 homolog	0.041
Tcf15	transcription factor 15	0.041
Fgf17	fibroblast growth factor 17	0.041	Mouse
Msx1	homeobox, msh-like 1	0.039
Wnt10b	wingless related MMTV integration site 10b	0.038	Mouse
Zfp771	zinc finger protein 771	0.038
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.037
Ihh	Indian hedgehog	0.037
Foxc2	forkhead box C2	0.036
Foxi1	forkhead box I1	0.035
Tbx1	T-box 1	0.035
Nrtn	neurturin	0.035
Wnt6	wingless-related MMTV integration site 6	0.035	Mouse
Wnt9a	wingless-type MMTV integration site 9A	0.035	Mouse
Sox14	SRY-box containing gene 14	0.034
Tlx2	T-cell leukemia, homeobox 2	0.034
Foxb2	forkhead box B2	0.032
Pou3f1	POU domain, class 3, transcription factor 1	0.032
Smo	smoothened homolog (Drosophila)	0.032
Ror1	receptor tyrosine kinase-like orphan receptor 1	0.032
Barx2	BarH-like homeobox 2	0.032
En2	engrailed 2	0.030
Htr1f	5-hydroxytryptamine (serotonin) receptor 1F	0.027
Tbx2	T-box 2	0.026
Otp	orthopedia homolog (Drosophila)	0.026
Rbpjl	recombination signal binding protein for immunoglobulin kappa J region-like	0.025
Fgfbp1	fibroblast growth factor binding protein 1	0.025
Uncx	UNC homeobox	0.024
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.024
Kcnk3	potassium channel, subfamily K, member 3	0.024
Ascl2	achaete-scute complex homolog 2 (Drosophila)	0.024	Mouse
Tal1	T-cell acute lymphocytic leukemia 1	0.023
Tnfrsf8	tumor necrosis factor receptor superfamily, member 8	0.023
Pou4f3	POU domain, class 4, transcription factor 3	0.023
Etv4	ets variant gene 4 (E1A enhancer binding protein, E1AF)	0.022
Pbx1	pre B-cell leukemia transcription factor 1	0.022
Sall3	sal-like 3 (Drosophila)	0.022
Adra2a	adrenergic receptor, alpha 2a	0.022
Neurog1	neurogenin 1	0.022
Foxh1	forkhead box H1	0.022
Arx	aristaless related homeobox	0.021
Neurog2	neurogenin 2	0.021
Id3	inhibitor of DNA binding 3	0.021
Glra1	glycine receptor, alpha 1 subunit	0.021
Lef1	lymphoid enhancer binding factor 1	0.021
Axin2	axin2	0.020
Fgf5	fibroblast growth factor 5	0.020	Mouse
Acvr1	activin A receptor, type 1	0.020
Insm1	insulinoma-associated 1	0.020
Hoxc9	homeobox C9	0.019
Ptch1	patched homolog 1	0.019
Sh3pxd2a	SH3 and PX domains 2A	0.019
Foxd2	forkhead box D2	0.018
Sox7	SRY-box containing gene 7	0.018
Npas1	neuronal PAS domain protein 1	0.018
Tlx3	T-cell leukemia, homeobox 3	0.018
Nkx1-2	NK1 transcription factor related, locus 2 (Drosophila)	0.018
Foxn1	forkhead box N1	0.018
Ptch2	patched homolog 2	0.018
Pitx3	paired-like homeodomain transcription factor 3	0.017
Tgfbr3	transforming growth factor, beta receptor III	0.017
BC024139	cDNA sequence BC024139	0.017
Ern2	endoplasmic reticulum (ER) to nucleus signalling 2	0.017
Matn3	matrilin 3	0.016
Smad6	MAD homolog 6 (Drosophila)	0.016
Pvrl1	poliovirus receptor-related 1	0.016
Rspo1	R-spondin homolog (Xenopus laevis)	0.016
Pyy	peptide YY	0.016
Shc3	src homology 2 domain-containing transforming protein C3	0.015
Cer1	cerberus 1 homolog (Xenopus laevis)	0.015
Barhl1	BarH-like 1 (Drosophila)	0.015
Ptf1a	pancreas specific transcription factor, 1a	0.015
Lrp6	low density lipoprotein receptor-related protein 6	0.015
Id1	inhibitor of DNA binding 1	0.015
Gja3	gap junction protein, alpha 3	0.015
Tdgf1	teratocarcinoma-derived growth factor 1	0.015
Efna4	ephrin A4	0.015
Amh	anti-Mullerian hormone	0.015
Gjb4	gap junction protein, beta 4	0.015
Zfpm2	zinc finger protein, multitype 2	0.015
Tgfb2	transforming growth factor, beta 2	0.014
Bmp4	bone morphogenetic protein 4	0.014	Mouse
Syt9	synaptotagmin IX	0.014
Adra2b	adrenergic receptor, alpha 2b	0.014
Tecta	tectorin alpha	0.014
Hoxd3	homeobox D3	0.013
Nobox	NOBOX oogenesis homeobox	0.013
Hnf4a	hepatic nuclear factor 4, alpha	0.013
Mnx1	motor neuron and pancreas homeobox 1	0.013	Fly
Bmp2	bone morphogenetic protein 2	0.013
Epha1	Eph receptor A1	0.013
Id2	inhibitor of DNA binding 2	0.013
Msi1	Musashi homolog 1(Drosophila)	0.013
Trp63	transformation related protein 63	0.013
Cacna2d1	calcium channel, voltage-dependent, alpha2/delta subunit 1	0.013
Hoxb6	homeobox B6	0.013
Ptk7	PTK7 protein tyrosine kinase 7	0.013
Sall4	sal-like 4 (Drosophila)	0.013
Fzd1	frizzled homolog 1 (Drosophila)	0.012
Gas1	growth arrest specific 1	0.012
Pou3f2	POU domain, class 3, transcription factor 2	0.012
Hoxb13	homeobox B13	0.012
Cabp7	calcium binding protein 7	0.012
Cbfa2t3	core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)	0.012
Adrb1	adrenergic receptor, beta 1	0.012
Efna2	ephrin A2	0.012
3110079O15Rik	RIKEN cDNA 3110079O15 gene	0.012
Tcf3	transcription factor 3	0.011	Fly
Hsd11b2	hydroxysteroid 11-beta dehydrogenase 2	0.011
Cux2	cut-like homeobox 2	0.011
Hoxb7	homeobox B7	0.011
Pax1	paired box gene 1	0.011
Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.011
Pax7	paired box gene 7	0.011
Tbx15	T-box 15	0.011
Foxd1	forkhead box D1	0.011
Pcdh12	protocadherin 12	0.011
Wnt11	wingless-related MMTV integration site 11	0.011	Mouse
Chd7	chromodomain helicase DNA binding protein 7	0.011
Adra1a	adrenergic receptor, alpha 1a	0.011
Sox11	SRY-box containing gene 11	0.011
Gdf11	growth differentiation factor 11	0.010
Sim2	single-minded homolog 2 (Drosophila)	0.010
Runx2	runt related transcription factor 2	0.010
Epha4	Eph receptor A4	0.010
Tcfap2c	transcription factor AP-2, gamma	0.010
Fndc7	fibronectin type III domain containing 7	0.010