IMP

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Mus musculus

11 genes annotated in mouse

hippo signaling

The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "hippo signaling"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "hippo signaling" (in gray)

Name	Description	Probability	Func Analog Organism
Yap1	yes-associated protein 1	1.000
Wwtr1	WW domain containing transcription regulator 1	0.975	Human Mouse Fly
Tead1	TEA domain family member 1	0.923
Stk4	serine/threonine kinase 4	0.825
Trp53	transformation related protein 53	0.770
Mdm2	transformed mouse 3T3 cell double minute 2	0.553
Apc	adenomatosis polyposis coli	0.481
She	src homology 2 domain-containing transforming protein E	0.412
Invs	inversin	0.405
Nf1	neurofibromatosis 1	0.284
Wwc2	WW, C2 and coiled-coil domain containing 2	0.247	Human
Smad6	MAD homolog 6 (Drosophila)	0.244
Gli3	GLI-Kruppel family member GLI3	0.240
Nanog	Nanog homeobox	0.239
Lats2	large tumor suppressor 2	0.195
Efnb1	ephrin B1	0.172
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.172
Fgfr3	fibroblast growth factor receptor 3	0.150
Notch3	Notch gene homolog 3 (Drosophila)	0.147
Epas1	endothelial PAS domain protein 1	0.146
Tead2	TEA domain family member 2	0.145	Mouse Fly
Acvr1	activin A receptor, type 1	0.140
Gata3	GATA binding protein 3	0.132
Fgfr2	fibroblast growth factor receptor 2	0.125
Tsc1	tuberous sclerosis 1	0.125
Rassf5	Ras association (RalGDS/AF-6) domain family member 5	0.119
Sav1	salvador homolog 1 (Drosophila)	0.119
Sox4	SRY-box containing gene 4	0.094	Mouse
Sox11	SRY-box containing gene 11	0.092
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.088	Fly
Tbx2	T-box 2	0.087
Kitl	kit ligand	0.075
Sox2	SRY-box containing gene 2	0.069	Mouse
Tead4	TEA domain family member 4	0.068	Mouse Fly
Cpd	carboxypeptidase D	0.058
Ptk7	PTK7 protein tyrosine kinase 7	0.056
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.054
Zfhx3	zinc finger homeobox 3	0.054
Irs1	insulin receptor substrate 1	0.047
Tie1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.045
Grb10	growth factor receptor bound protein 10	0.045
Rybp	RING1 and YY1 binding protein	0.040
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.040
Meox2	mesenchyme homeobox 2	0.040
Hhex	hematopoietically expressed homeobox	0.039
Rock2	Rho-associated coiled-coil containing protein kinase 2	0.039
Bmpr2	bone morphogenic protein receptor, type II (serine/threonine kinase)	0.039
Nfib	nuclear factor I/B	0.036
Cyr61	cysteine rich protein 61	0.035
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.035
Ush1g	Usher syndrome 1G homolog (human)	0.033
Flt1	FMS-like tyrosine kinase 1	0.033
Sema3f	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	0.032
Tcf7l1	transcription factor 7-like 1 (T-cell specific, HMG box)	0.032
Vegfa	vascular endothelial growth factor A	0.031
Bmp4	bone morphogenetic protein 4	0.028
Kcnq1	potassium voltage-gated channel, subfamily Q, member 1	0.027
Tead3	TEA domain family member 3	0.027	Human
Myo10	myosin X	0.027
Hes1	hairy and enhancer of split 1 (Drosophila)	0.027
Adam17	a disintegrin and metallopeptidase domain 17	0.027
Braf	Braf transforming gene	0.026
Ptprg	protein tyrosine phosphatase, receptor type, G	0.026
Tsc2	tuberous sclerosis 2	0.026
Cdc42ep1	CDC42 effector protein (Rho GTPase binding) 1	0.024
Cux1	cut-like homeobox 1	0.023
Jub	ajuba	0.023	Human Fly
Ptpn21	protein tyrosine phosphatase, non-receptor type 21	0.023	Fly
Isl1	ISL1 transcription factor, LIM/homeodomain	0.021
Tbx3	T-box 3	0.021
Tgfbr1	transforming growth factor, beta receptor I	0.020
Npr3	natriuretic peptide receptor 3	0.020
Sema6a	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	0.020
Pax3	paired box gene 3	0.020
Pik3c2a	phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide	0.019
Arhgap29	Rho GTPase activating protein 29	0.019
Lrp5	low density lipoprotein receptor-related protein 5	0.019
Ephb4	Eph receptor B4	0.019
Espn	espin	0.019
Pard3	par-3 (partitioning defective 3) homolog (C. elegans)	0.019
Tgif2	TGFB-induced factor homeobox 2	0.018
Smad3	MAD homolog 3 (Drosophila)	0.018
Efs	embryonal Fyn-associated substrate	0.018
Fgfr1	fibroblast growth factor receptor 1	0.018
Shroom3	shroom family member 3	0.018
Ikbkap	inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein	0.018
Sox7	SRY-box containing gene 7	0.018	Mouse
Ptprb	protein tyrosine phosphatase, receptor type, B	0.017
Amotl2	angiomotin-like 2	0.017	Mouse
Pkn2	protein kinase N2	0.017
Igf2bp1	insulin-like growth factor 2 mRNA binding protein 1	0.017
Bcl6b	B-cell CLL/lymphoma 6, member B	0.017
Pxdn	peroxidasin homolog (Drosophila)	0.017
Xiap	X-linked inhibitor of apoptosis	0.016
Syde1	synapse defective 1, Rho GTPase, homolog 1 (C. elegans)	0.016
Nuak1	NUAK family, SNF1-like kinase, 1	0.016
Pax6	paired box gene 6	0.016
Celsr1	cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)	0.016
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.016
Csnk2a1	casein kinase 2, alpha 1 polypeptide	0.015
Samd4	sterile alpha motif domain containing 4	0.015
Rnf2	ring finger protein 2	0.015
Lama5	laminin, alpha 5	0.015
Fam171a1	family with sequence similarity 171, member A1	0.015
Fzd4	frizzled homolog 4 (Drosophila)	0.015
Rb1	retinoblastoma 1	0.014
Smo	smoothened homolog (Drosophila)	0.014
Gata2	GATA binding protein 2	0.014
Bcam	basal cell adhesion molecule	0.014
Tert	telomerase reverse transcriptase	0.014
Lzts2	leucine zipper, putative tumor suppressor 2	0.014
Dmtf1	cyclin D binding myb-like transcription factor 1	0.014
Itga3	integrin alpha 3	0.013
Stk3	serine/threonine kinase 3 (Ste20, yeast homolog)	0.013
Aff1	AF4/FMR2 family, member 1	0.013
Gsk3b	glycogen synthase kinase 3 beta	0.013
Pnpla6	patatin-like phospholipase domain containing 6	0.012
Ctnnd1	catenin (cadherin associated protein), delta 1	0.012
Bmp6	bone morphogenetic protein 6	0.012
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.012
Adam10	a disintegrin and metallopeptidase domain 10	0.012
Fzd6	frizzled homolog 6 (Drosophila)	0.012
Irx3	Iroquois related homeobox 3 (Drosophila)	0.012
Otud7b	OTU domain containing 7B	0.012
Rp2h	retinitis pigmentosa 2 homolog (human)	0.011
Plxna1	plexin A1	0.011
Ppl	periplakin	0.011
Igf2bp2	insulin-like growth factor 2 mRNA binding protein 2	0.011
Shh	sonic hedgehog	0.011
Runx1	runt related transcription factor 1	0.011
Lrp2	low density lipoprotein receptor-related protein 2	0.011
Hesx1	homeobox gene expressed in ES cells	0.011
Smtn	smoothelin	0.011
Bicd2	bicaudal D homolog 2 (Drosophila)	0.011
Pitx1	paired-like homeodomain transcription factor 1	0.010
Podxl	podocalyxin-like	0.010
Zfp503	zinc finger protein 503	0.010
Dag1	dystroglycan 1	0.010