IMP

Process View

Mus musculus

1 genes annotated in mouse

negative regulation of lyase activity

Any process that stops or reduces the rate of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of lyase activity"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of lyase activity" (in gray)

Name	Description	Probability	Func Analog Organism
Drd2	dopamine receptor D2	0.582	Human Rat
Drd1a	dopamine receptor D1A	0.544
Slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.316
Grin1	glutamate receptor, ionotropic, NMDA1 (zeta 1)	0.282
Slc34a1	solute carrier family 34 (sodium phosphate), member 1	0.277
Cckbr	cholecystokinin B receptor	0.265
Dlg4	discs, large homolog 4 (Drosophila)	0.245
Lhx3	LIM homeobox protein 3	0.219
Gpr27	G protein-coupled receptor 27	0.191
Drd3	dopamine receptor D3	0.160	Human Rat
Gabbr2	gamma-aminobutyric acid (GABA) B receptor, 2	0.158
Oprm1	opioid receptor, mu 1	0.150	Rat
Rgs9	regulator of G-protein signaling 9	0.147
Cnr1	cannabinoid receptor 1 (brain)	0.133
Srcin1	SRC kinase signaling inhibitor 1	0.097
Gnao1	guanine nucleotide binding protein, alpha O	0.097
Thra	thyroid hormone receptor alpha	0.094
Ptms	parathymosin	0.089
Crhr1	corticotropin releasing hormone receptor 1	0.088
Acsm2	acyl-CoA synthetase medium-chain family member 2	0.079
Esr1	estrogen receptor 1 (alpha)	0.072
Grik5	glutamate receptor, ionotropic, kainate 5 (gamma 2)	0.071
Adora2a	adenosine A2a receptor	0.065
Prop1	paired like homeodomain factor 1	0.061
Thrb	thyroid hormone receptor beta	0.059
Hdac7	histone deacetylase 7	0.057
Emx1	empty spiracles homolog 1 (Drosophila)	0.056
Prlhr	prolactin releasing hormone receptor	0.049
Oprd1	opioid receptor, delta 1	0.047
Rnf112	ring finger protein 112	0.047
Slc18a2	solute carrier family 18 (vesicular monoamine), member 2	0.046
Cdk5r2	cyclin-dependent kinase 5, regulatory subunit 2 (p39)	0.045
Kcnd3	potassium voltage-gated channel, Shal-related family, member 3	0.044
Kctd17	potassium channel tetramerisation domain containing 17	0.043
Smpd3	sphingomyelin phosphodiesterase 3, neutral	0.043
Irs2	insulin receptor substrate 2	0.042
Pspn	persephin	0.039
Htr5a	5-hydroxytryptamine (serotonin) receptor 5A	0.037
Dctn1	dynactin 1	0.036
Apbb1	amyloid beta (A4) precursor protein-binding, family B, member 1	0.034
Cacna1b	calcium channel, voltage-dependent, N type, alpha 1B subunit	0.034
Pgr	progesterone receptor	0.034
Clock	circadian locomotor output cycles kaput	0.034
Slc9a3r2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.033
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.033
Npy2r	neuropeptide Y receptor Y2	0.033
Hmx1	H6 homeobox 1	0.032
Kl	klotho	0.032
Syn2	synapsin II	0.030
Icam5	intercellular adhesion molecule 5, telencephalin	0.028
Slc17a1	solute carrier family 17 (sodium phosphate), member 1	0.028
Neurod2	neurogenic differentiation 2	0.028
Kcnj6	potassium inwardly-rectifying channel, subfamily J, member 6	0.028
B3gat1	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	0.027
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.027
Pax8	paired box gene 8	0.027
Trim3	tripartite motif-containing 3	0.027
Ypel3	yippee-like 3 (Drosophila)	0.027
Fshr	follicle stimulating hormone receptor	0.026
App	amyloid beta (A4) precursor protein	0.026
Emid2	EMI domain containing 2	0.026
Mark4	MAP/microtubule affinity-regulating kinase 4	0.026
Kcna4	potassium voltage-gated channel, shaker-related subfamily, member 4	0.026
Nynrin	NYN domain and retroviral integrase containing	0.026
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.026
Grin2a	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	0.025
Gria1	glutamate receptor, ionotropic, AMPA1 (alpha 1)	0.024
Cacng4	calcium channel, voltage-dependent, gamma subunit 4	0.024
Pou1f1	POU domain, class 1, transcription factor 1	0.024
Pnma2	paraneoplastic antigen MA2	0.024
Chpf	chondroitin polymerizing factor	0.023
Cx3cl1	chemokine (C-X3-C motif) ligand 1	0.023
Tshr	thyroid stimulating hormone receptor	0.023
Htr1d	5-hydroxytryptamine (serotonin) receptor 1D	0.023
Sorcs3	sortilin-related VPS10 domain containing receptor 3	0.023
Shc3	src homology 2 domain-containing transforming protein C3	0.023
Grpr	gastrin releasing peptide receptor	0.022
Nkx1-2	NK1 transcription factor related, locus 2 (Drosophila)	0.021
Zfp651	zinc finger protein 651	0.021
Oprk1	opioid receptor, kappa 1	0.021
Grm1	glutamate receptor, metabotropic 1	0.021
Zfp385a	zinc finger protein 385A	0.021
Dnm1	dynamin 1	0.021
Git1	G protein-coupled receptor kinase-interactor 1	0.021
Btn1a1	butyrophilin, subfamily 1, member A1	0.021
Lphn1	latrophilin 1	0.021
Htr7	5-hydroxytryptamine (serotonin) receptor 7	0.020
Syt6	synaptotagmin VI	0.019
Psd	pleckstrin and Sec7 domain containing	0.019
Htr4	5 hydroxytryptamine (serotonin) receptor 4	0.019
Cntn4	contactin 4	0.019
Epn1	epsin 1	0.018
Kcnk3	potassium channel, subfamily K, member 3	0.018
Chrm1	cholinergic receptor, muscarinic 1, CNS	0.018
Jph3	junctophilin 3	0.018
Alppl2	alkaline phosphatase, placental-like 2	0.018
Adra2c	adrenergic receptor, alpha 2c	0.018
Spock1	sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1	0.018
Epha8	Eph receptor A8	0.017
Crygs	crystallin, gamma S	0.017
Slc12a5	solute carrier family 12, member 5	0.017
Olfr1264	olfactory receptor 1264	0.017
Dtx3	deltex 3 homolog (Drosophila)	0.017
Wwox	WW domain-containing oxidoreductase	0.017
Pde6b	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	0.017
Gria2	glutamate receptor, ionotropic, AMPA2 (alpha 2)	0.017
Pcsk2	proprotein convertase subtilisin/kexin type 2	0.017
Zfr2	zinc finger RNA binding protein 2	0.017
Hcrt	hypocretin	0.017
Krt12	keratin 12	0.017
Rgs4	regulator of G-protein signaling 4	0.017
Celsr2	cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)	0.017
Gjb5	gap junction protein, beta 5	0.017
Pde1b	phosphodiesterase 1B, Ca2+-calmodulin dependent	0.016
Kiss1r	KISS1 receptor	0.016
Cyp19a1	cytochrome P450, family 19, subfamily a, polypeptide 1	0.016
Sprr2d	small proline-rich protein 2D	0.016
Alk	anaplastic lymphoma kinase	0.016
Cplx3	complexin 3	0.016
Lhcgr	luteinizing hormone/choriogonadotropin receptor	0.016
Chrna4	cholinergic receptor, nicotinic, alpha polypeptide 4	0.016
Pitx2	paired-like homeodomain transcription factor 2	0.016
Acr	acrosin prepropeptide	0.016
Scrt1	scratch homolog 1, zinc finger protein (Drosophila)	0.015
Chrna6	cholinergic receptor, nicotinic, alpha polypeptide 6	0.015
Map4k2	mitogen-activated protein kinase kinase kinase kinase 2	0.015
Ap2a1	adaptor protein complex AP-2, alpha 1 subunit	0.015
Cga	glycoprotein hormones, alpha subunit	0.015
Rtbdn	retbindin	0.015
Pcbp4	poly(rC) binding protein 4	0.015
Numbl	numb-like	0.015
C1ql2	complement component 1, q subcomponent-like 2	0.015
Ache	acetylcholinesterase	0.014
Pde6a	phosphodiesterase 6A, cGMP-specific, rod, alpha	0.014
Bmp15	bone morphogenetic protein 15	0.014
Kcnc4	potassium voltage gated channel, Shaw-related subfamily, member 4	0.014
Oxt	oxytocin	0.014
Guca2b	guanylate cyclase activator 2b (retina)	0.014
Sstr2	somatostatin receptor 2	0.014
Gsg1	germ cell-specific gene 1	0.014
Nrgn	neurogranin	0.013
Rs1	retinoschisis (X-linked, juvenile) 1 (human)	0.013
Calb2	calbindin 2	0.013
Wnt7a	wingless-related MMTV integration site 7A	0.013
Spock2	sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2	0.013
Col4a4	collagen, type IV, alpha 4	0.013
Trpc4	transient receptor potential cation channel, subfamily C, member 4	0.013
Anks1b	ankyrin repeat and sterile alpha motif domain containing 1B	0.013
Tdrd1	tudor domain containing 1	0.013
Crtac1	cartilage acidic protein 1	0.013
Hrh1	histamine receptor H1	0.013
Ido2	indoleamine 2,3-dioxygenase 2	0.013
Invs	inversin	0.013
Ambn	ameloblastin	0.013
Sept5	septin 5	0.013
St3gal2	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	0.013
Htr1a	5-hydroxytryptamine (serotonin) receptor 1A	0.012
Irs3	insulin receptor substrate 3	0.012
Kcnj5	potassium inwardly-rectifying channel, subfamily J, member 5	0.012
Dlx4	distal-less homeobox 4	0.012
Necab3	N-terminal EF-hand calcium binding protein 3	0.012
Hdac5	histone deacetylase 5	0.012
Rasal1	RAS protein activator like 1 (GAP1 like)	0.012
Esr2	estrogen receptor 2 (beta)	0.012
Mll1	myeloid/lymphoid or mixed-lineage leukemia 1	0.012
Agap2	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	0.012
Lhx4	LIM homeobox protein 4	0.012
Phldb1	pleckstrin homology-like domain, family B, member 1	0.012
Rnf208	ring finger protein 208	0.012
Gad2	glutamic acid decarboxylase 2	0.012
Dpp10	dipeptidylpeptidase 10	0.012
Wnt2b	wingless related MMTV integration site 2b	0.012
Mmp24	matrix metallopeptidase 24	0.012
Fxyd7	FXYD domain-containing ion transport regulator 7	0.012
Cyp11b1	cytochrome P450, family 11, subfamily b, polypeptide 1	0.011
Vamp2	vesicle-associated membrane protein 2	0.011
Shank3	SH3/ankyrin domain gene 3	0.011
Zfp362	zinc finger protein 362	0.011
Sstr4	somatostatin receptor 4	0.011
Pex5l	peroxisomal biogenesis factor 5-like	0.011
Rho	rhodopsin	0.011
Zc3h3	zinc finger CCCH type containing 3	0.011
Hoxd13	homeobox D13	0.011
Gm1337	predicted gene 1337	0.011
Lmx1b	LIM homeobox transcription factor 1 beta	0.011
Ghrhr	growth hormone releasing hormone receptor	0.011
Slc12a3	solute carrier family 12, member 3	0.011
Thsd7b	thrombospondin, type I, domain containing 7B	0.011
Ppy	pancreatic polypeptide	0.011
Kcnj9	potassium inwardly-rectifying channel, subfamily J, member 9	0.011
Emx2	empty spiracles homolog 2 (Drosophila)	0.011
Aatk	apoptosis-associated tyrosine kinase	0.011
Gpr12	G-protein coupled receptor 12	0.011
Ephb2	Eph receptor B2	0.011
Prima1	proline rich membrane anchor 1	0.010
Tbxa2r	thromboxane A2 receptor	0.010
Ptprn	protein tyrosine phosphatase, receptor type, N	0.010
Kcnj4	potassium inwardly-rectifying channel, subfamily J, member 4	0.010
Enam	enamelin	0.010
Fam164c	family with sequence similarity 164, member C	0.010
Sstr1	somatostatin receptor 1	0.010
Fscn1	fascin homolog 1, actin bundling protein (Strongylocentrotus purpuratus)	0.010
Gja10	gap junction protein, alpha 10	0.010
Grin2d	glutamate receptor, ionotropic, NMDA2D (epsilon 4)	0.010
Nrg3	neuregulin 3	0.010
Kcnq2	potassium voltage-gated channel, subfamily Q, member 2	0.010
C1ql1	complement component 1, q subcomponent-like 1	0.010
Xkr4	X Kell blood group precursor related family member 4	0.010
Sorcs1	VPS10 domain receptor protein SORCS 1	0.010
Trpc5	transient receptor potential cation channel, subfamily C, member 5	0.010
Avp	arginine vasopressin	0.010
Vstm2l	V-set and transmembrane domain containing 2-like	0.010
Slc5a11	solute carrier family 5 (sodium/glucose cotransporter), member 11	0.010
Rfng	RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	0.010
Clps	colipase, pancreatic	0.010