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Process View

Mus musculus

19 genes annotated in mouse

synaptic vesicle endocytosis

An endocytosis process that results in the invagination of the axonal plasma membrane to create a membrane-bounded vesicle. This process takes up excess membrane that would otherwise accumulate at the presynaptic terminal due to fusion of vesicle membranes during neurotransmitter release. The vesicles created may subsequently be used for neurotransmitter storage and release.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "synaptic vesicle endocytosis"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "synaptic vesicle endocytosis" (in gray)

Name	Description	Probability	Func Analog Organism
Grin1	glutamate receptor, ionotropic, NMDA1 (zeta 1)	0.999
Dlg4	discs, large homolog 4 (Drosophila)	0.993
Dnm1	dynamin 1	0.950	Fly
Ap2a2	adaptor protein complex AP-2, alpha 2 subunit	0.606	Fly
Ywhab	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.574
Itsn1	intersectin 1 (SH3 domain protein 1A)	0.463	Fly
Pip5k1c	phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma	0.327
Ywhaz	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.299
Dlgap1	discs, large (Drosophila) homolog-associated protein 1	0.296
Nrxn1	neurexin I	0.295	Fly
Stx1a	syntaxin 1A (brain)	0.267
Cltc	clathrin, heavy polypeptide (Hc)	0.220
Nrxn2	neurexin II	0.214	Fly
Sh3gl2	SH3-domain GRB2-like 2	0.192
Nrcam	neuron-glia-CAM-related cell adhesion molecule	0.185
Eps15	epidermal growth factor receptor pathway substrate 15	0.163	Worm
Nrxn3	neurexin III	0.159	Fly
Snap25	synaptosomal-associated protein 25	0.144
Grb2	growth factor receptor bound protein 2	0.137
Dlg2	discs, large homolog 2 (Drosophila)	0.126	Mouse
Nsf	N-ethylmaleimide sensitive fusion protein	0.112
Vamp2	vesicle-associated membrane protein 2	0.108
Arhgap31	Rho GTPase activating protein 31	0.097
Shc1	src homology 2 domain-containing transforming protein C1	0.093
Syn1	synapsin I	0.093
Pacsin1	protein kinase C and casein kinase substrate in neurons 1	0.089
Grin2b	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	0.084
Pdcd6ip	programmed cell death 6 interacting protein	0.083
Sh3kbp1	SH3-domain kinase binding protein 1	0.078
Syp	synaptophysin	0.066
App	amyloid beta (A4) precursor protein	0.056
Dlg1	discs, large homolog 1 (Drosophila)	0.051	Mouse
Arc	activity regulated cytoskeletal-associated protein	0.051
Ptpn12	protein tyrosine phosphatase, non-receptor type 12	0.045
Atp6v0a1	ATPase, H+ transporting, lysosomal V0 subunit A1	0.044
Cacnb1	calcium channel, voltage-dependent, beta 1 subunit	0.043
Mta1	metastasis associated 1	0.039
Klc2	kinesin light chain 2	0.039
Syt1	synaptotagmin I	0.037	Fly
Lrrk2	leucine-rich repeat kinase 2	0.035	Fly
Ptpn18	protein tyrosine phosphatase, non-receptor type 18	0.033
Cit	citron	0.033
Ap2b1	adaptor-related protein complex 2, beta 1 subunit	0.032	Rat
Gria2	glutamate receptor, ionotropic, AMPA2 (alpha 2)	0.031
Mtap2	microtubule-associated protein 2	0.030
Gria4	glutamate receptor, ionotropic, AMPA4 (alpha 4)	0.029
Gnao1	guanine nucleotide binding protein, alpha O	0.028
Hsp90b1	heat shock protein 90, beta (Grp94), member 1	0.028
Kcnab2	potassium voltage-gated channel, shaker-related subfamily, beta member 2	0.028
Camk2a	calcium/calmodulin-dependent protein kinase II alpha	0.028
Sgip1	SH3-domain GRB2-like (endophilin) interacting protein 1	0.027
Tubb4	tubulin, beta 4	0.027
Crk	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.027
Grik2	glutamate receptor, ionotropic, kainate 2 (beta 2)	0.025
Cdk5r1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0.025
Cacna1b	calcium channel, voltage-dependent, N type, alpha 1B subunit	0.025
Atp6v1a	ATPase, H+ transporting, lysosomal V1 subunit A	0.025
Rph3a	rabphilin 3A	0.024
Mapt	microtubule-associated protein tau	0.024
Cbl	Casitas B-lineage lymphoma	0.023
Jmjd1c	jumonji domain containing 1C	0.023
Kcna4	potassium voltage-gated channel, shaker-related subfamily, member 4	0.023
Arhgef7	Rho guanine nucleotide exchange factor (GEF7)	0.023
Bsn	bassoon	0.023
Vsnl1	visinin-like 1	0.022
Syn2	synapsin II	0.022
Lin7b	lin-7 homolog B (C. elegans)	0.022
Pik3r2	phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta)	0.022
Gng3	guanine nucleotide binding protein (G protein), gamma 3	0.021
Smad1	MAD homolog 1 (Drosophila)	0.021
Ptpn22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.021
Dsg1a	desmoglein 1 alpha	0.021
Eml6	echinoderm microtubule associated protein like 6	0.021
Kcna2	potassium voltage-gated channel, shaker-related subfamily, member 2	0.021
Nptn	neuroplastin	0.020
Adam9	a disintegrin and metallopeptidase domain 9 (meltrin gamma)	0.020
Nostrin	nitric oxide synthase trafficker	0.020
Abcb9	ATP-binding cassette, sub-family B (MDR/TAP), member 9	0.020
Mgat3	mannoside acetylglucosaminyltransferase 3	0.020
Lrp8	low density lipoprotein receptor-related protein 8, apolipoprotein e receptor	0.020
Ptprn	protein tyrosine phosphatase, receptor type, N	0.020
Ret	ret proto-oncogene	0.019
Cbln1	cerebellin 1 precursor protein	0.019
Stxbp1	syntaxin binding protein 1	0.019
Dctn1	dynactin 1	0.019
Slc1a2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	0.018
Sult4a1	sulfotransferase family 4A, member 1	0.018
Rasgrp1	RAS guanyl releasing protein 1	0.018
Kif3b	kinesin family member 3B	0.018
Camk2b	calcium/calmodulin-dependent protein kinase II, beta	0.018
Hspa12a	heat shock protein 12A	0.018
Ykt6	YKT6 homolog (S. Cerevisiae)	0.017
Drd2	dopamine receptor D2	0.017
Ina	internexin neuronal intermediate filament protein, alpha	0.017
Dvl3	dishevelled 3, dsh homolog (Drosophila)	0.017
Scn8a	sodium channel, voltage-gated, type VIII, alpha	0.017
Twsg1	twisted gastrulation homolog 1 (Drosophila)	0.017
Ids	iduronate 2-sulfatase	0.017
Gfap	glial fibrillary acidic protein	0.016
Ap2a1	adaptor protein complex AP-2, alpha 1 subunit	0.016	Fly
Mark4	MAP/microtubule affinity-regulating kinase 4	0.016
Nek7	NIMA (never in mitosis gene a)-related expressed kinase 7	0.015
Nedd4l	neural precursor cell expressed, developmentally down-regulated gene 4-like	0.015
Inpp5d	inositol polyphosphate-5-phosphatase D	0.015
Fmn2	formin 2	0.015
Grin2a	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	0.015
Baiap2	brain-specific angiogenesis inhibitor 1-associated protein 2	0.015
Pcdh10	protocadherin 10	0.015
Sos2	son of sevenless homolog 2 (Drosophila)	0.015
Pfn2	profilin 2	0.015
Vapa	vesicle-associated membrane protein, associated protein A	0.014
Ctnnd1	catenin (cadherin associated protein), delta 1	0.014
Hspa5	heat shock protein 5	0.014
Myo6	myosin VI	0.014
Shank2	SH3/ankyrin domain gene 2	0.014
Eno2	enolase 2, gamma neuronal	0.014
Dennd1a	DENN/MADD domain containing 1A	0.013
Spnb2	spectrin beta 2	0.013
Npcd	neuronal pentraxin chromo domain	0.013
Sacm1l	SAC1 (suppressor of actin mutations 1, homolog)-like (S. cerevisiae)	0.013
Rab1	RAB1, member RAS oncogene family	0.013
Homer1	homer homolog 1 (Drosophila)	0.013
Atp2b1	ATPase, Ca++ transporting, plasma membrane 1	0.013
Clip2	CAP-GLY domain containing linker protein 2	0.013
Snap91	synaptosomal-associated protein 91	0.013
Gsk3b	glycogen synthase kinase 3 beta	0.013
Park2	Parkinson disease (autosomal recessive, juvenile) 2, parkin	0.013
St8sia5	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5	0.013
Reep2	receptor accessory protein 2	0.013
Ywhag	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.012
Atp1a1	ATPase, Na+/K+ transporting, alpha 1 polypeptide	0.012
Crkl	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.012
Ckmt1	creatine kinase, mitochondrial 1, ubiquitous	0.012
Mapk8ip1	mitogen-activated protein kinase 8 interacting protein 1	0.012
Prnp	prion protein	0.012
Cttn	cortactin	0.012
Cntnap1	contactin associated protein-like 1	0.012
Grm1	glutamate receptor, metabotropic 1	0.012
Capza2	capping protein (actin filament) muscle Z-line, alpha 2	0.012
Nefl	neurofilament, light polypeptide	0.012
Lin7c	lin-7 homolog C (C. elegans)	0.012
Cend1	cell cycle exit and neuronal differentiation 1	0.012
Anks1b	ankyrin repeat and sterile alpha motif domain containing 1B	0.012
Ache	acetylcholinesterase	0.012
Calb2	calbindin 2	0.012
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.012
Sv2b	synaptic vesicle glycoprotein 2 b	0.012
Atp2b2	ATPase, Ca++ transporting, plasma membrane 2	0.012
Cntn1	contactin 1	0.012
Mapk8ip2	mitogen-activated protein kinase 8 interacting protein 2	0.012
Dlg3	discs, large homolog 3 (Drosophila)	0.012	Mouse
Nrip3	nuclear receptor interacting protein 3	0.012
Mknk1	MAP kinase-interacting serine/threonine kinase 1	0.012
Ywhah	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.012
Kif1a	kinesin family member 1A	0.011	Fly
Tbk1	TANK-binding kinase 1	0.011
Cask	calcium/calmodulin-dependent serine protein kinase (MAGUK family)	0.011	Fly
Ppp2r1a	protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform	0.011
Actl6b	actin-like 6B	0.011
Amph	amphiphysin	0.011
Ntrk3	neurotrophic tyrosine kinase, receptor, type 3	0.011
Abi1	abl-interactor 1	0.011
Mid2	midline 2	0.011
Kif5c	kinesin family member 5C	0.011
Fzd1	frizzled homolog 1 (Drosophila)	0.011
Atcay	ataxia, cerebellar, Cayman type homolog (human)	0.011
Mtap1b	microtubule-associated protein 1B	0.011
Ppp6r2	protein phosphatase 6, regulatory subunit 2	0.011
Cplx1	complexin 1	0.011
Gabbr1	gamma-aminobutyric acid (GABA) B receptor, 1	0.011
Hdac5	histone deacetylase 5	0.011
Stxbp3a	syntaxin binding protein 3A	0.011	Mouse
Grik5	glutamate receptor, ionotropic, kainate 5 (gamma 2)	0.011
Epb4.1l3	erythrocyte protein band 4.1-like 3	0.010
Mapk3	mitogen-activated protein kinase 3	0.010
Pcsk1n	proprotein convertase subtilisin/kexin type 1 inhibitor	0.010
Scn1a	sodium channel, voltage-gated, type I, alpha	0.010
Pfkm	phosphofructokinase, muscle	0.010
Rara	retinoic acid receptor, alpha	0.010
Rab5b	RAB5B, member RAS oncogene family	0.010	Fly
Bace1	beta-site APP cleaving enzyme 1	0.010
Vim	vimentin	0.010
Scg3	secretogranin III	0.010
Inppl1	inositol polyphosphate phosphatase-like 1	0.010
Plcb1	phospholipase C, beta 1	0.010
Eno1	enolase 1, alpha non-neuron	0.010
Tub	tubby candidate gene	0.010
Atp6ap2	ATPase, H+ transporting, lysosomal accessory protein 2	0.010
Kif5a	kinesin family member 5A	0.010
Mtmr7	myotubularin related protein 7	0.010
Tubb2a	tubulin, beta 2A	0.010
Ccdc64b	coiled-coil domain containing 64B	0.010