IMP

Process View

Mus musculus

5 genes annotated in mouse

retinal bipolar neuron differentiation

The process in which a relatively unspecialized cell acquires specialized features of a bipolar cell, the last neuron to be generated in the retina.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "retinal bipolar neuron differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "retinal bipolar neuron differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
Tcfap2a	transcription factor AP-2, alpha	1.000
Pax6	paired box gene 6	1.000
Sox9	SRY-box containing gene 9	1.000
Msx1	homeobox, msh-like 1	1.000
Alx4	aristaless-like homeobox 4	0.999	Mouse
Alx1	ALX homeobox 1	0.999	Mouse
Shh	sonic hedgehog	0.999
Runx2	runt related transcription factor 2	0.999
Otx2	orthodenticle homolog 2 (Drosophila)	0.998
Fgfr2	fibroblast growth factor receptor 2	0.998
Alx3	aristaless-like homeobox 3	0.997	Mouse
Hand1	heart and neural crest derivatives expressed transcript 1	0.997
Gli3	GLI-Kruppel family member GLI3	0.997
Dlx5	distal-less homeobox 5	0.997
Msx2	homeobox, msh-like 2	0.994
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.992
Foxc1	forkhead box C1	0.991
Prrx1	paired related homeobox 1	0.991
Tbx15	T-box 15	0.989
Bmp7	bone morphogenetic protein 7	0.978
Bmp4	bone morphogenetic protein 4	0.960
Fgf8	fibroblast growth factor 8	0.891
Emx1	empty spiracles homolog 1 (Drosophila)	0.867
Sox2	SRY-box containing gene 2	0.832
Pax3	paired box gene 3	0.825
Tbx1	T-box 1	0.796
Irx1	Iroquois related homeobox 1 (Drosophila)	0.717	Mouse
Irx5	Iroquois related homeobox 5 (Drosophila)	0.695
Hand2	heart and neural crest derivatives expressed transcript 2	0.683
Smo	smoothened homolog (Drosophila)	0.683
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.669
Hes5	hairy and enhancer of split 5 (Drosophila)	0.665
Tcfap2c	transcription factor AP-2, gamma	0.662
Foxc2	forkhead box C2	0.573
Pitx2	paired-like homeodomain transcription factor 2	0.569
Pitx1	paired-like homeodomain transcription factor 1	0.568
Tgfb2	transforming growth factor, beta 2	0.541
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.479
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.467
Bmp2	bone morphogenetic protein 2	0.456
BC024139	cDNA sequence BC024139	0.413
Nkx6-1	NK6 homeobox 1	0.397
Wnt3a	wingless-related MMTV integration site 3A	0.360
Prrx2	paired related homeobox 2	0.337
Irx2	Iroquois related homeobox 2 (Drosophila)	0.323	Mouse
Tbx5	T-box 5	0.321
Fgfr3	fibroblast growth factor receptor 3	0.317
Bmper	BMP-binding endothelial regulator	0.311
Gsc	goosecoid homeobox	0.302
Lmx1b	LIM homeobox transcription factor 1 beta	0.298
Gja1	gap junction protein, alpha 1	0.293
Isl1	ISL1 transcription factor, LIM/homeodomain	0.288
Gli2	GLI-Kruppel family member GLI2	0.261
Foxg1	forkhead box G1	0.238
Btbd17	BTB (POZ) domain containing 17	0.235
Pou4f2	POU domain, class 4, transcription factor 2	0.228
Uncx	UNC homeobox	0.226
Dlx2	distal-less homeobox 2	0.225
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.223
Lhx9	LIM homeobox protein 9	0.194
Pax7	paired box gene 7	0.192
Eya1	eyes absent 1 homolog (Drosophila)	0.187
Neurog2	neurogenin 2	0.187
Otx1	orthodenticle homolog 1 (Drosophila)	0.177
Gbx2	gastrulation brain homeobox 2	0.170
Neurod1	neurogenic differentiation 1	0.159
Twist2	twist homolog 2 (Drosophila)	0.149
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.148
Rax	retina and anterior neural fold homeobox	0.144
Foxe3	forkhead box E3	0.136
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.134
Ntn1	netrin 1	0.131
Emx2	empty spiracles homolog 2 (Drosophila)	0.130
Ptch1	patched homolog 1	0.124
Insm1	insulinoma-associated 1	0.124
Lhx5	LIM homeobox protein 5	0.120
Hoxd1	homeobox D1	0.118
Irx6	Iroquois related homeobox 6 (Drosophila)	0.116
Nkx2-1	NK2 homeobox 1	0.115
Hoxd13	homeobox D13	0.112
Hoxa2	homeobox A2	0.107
Zic2	zinc finger protein of the cerebellum 2	0.102
Nr2e1	nuclear receptor subfamily 2, group E, member 1	0.101
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.101
Sall3	sal-like 3 (Drosophila)	0.101
H1foo	H1 histone family, member O, oocyte-specific	0.100
Pax9	paired box gene 9	0.099
Hoxb13	homeobox B13	0.095
Tbx3	T-box 3	0.095
Lef1	lymphoid enhancer binding factor 1	0.090
Col2a1	collagen, type II, alpha 1	0.089
Id4	inhibitor of DNA binding 4	0.088
En1	engrailed 1	0.086
Vstm2b	V-set and transmembrane domain containing 2B	0.086
Hmx1	H6 homeobox 1	0.078
Mnx1	motor neuron and pancreas homeobox 1	0.077
Irx3	Iroquois related homeobox 3 (Drosophila)	0.075	Mouse
Atoh7	atonal homolog 7 (Drosophila)	0.073
Ptf1a	pancreas specific transcription factor, 1a	0.072
Zic1	zinc finger protein of the cerebellum 1	0.066
Lmx1a	LIM homeobox transcription factor 1 alpha	0.066
Wnt9a	wingless-type MMTV integration site 9A	0.060
Dlx1	distal-less homeobox 1	0.059
Onecut1	one cut domain, family member 1	0.058
Hoxa1	homeobox A1	0.056
Hmx2	H6 homeobox 2	0.056
Sox11	SRY-box containing gene 11	0.056
Nkx2-2	NK2 transcription factor related, locus 2 (Drosophila)	0.055
Hmx3	H6 homeobox 3	0.054
Dlx6	distal-less homeobox 6	0.053
Kcns1	K+ voltage-gated channel, subfamily S, 1	0.053
Tlx3	T-cell leukemia, homeobox 3	0.052
Sox8	SRY-box containing gene 8	0.052
Foxa1	forkhead box A1	0.049
Pbx1	pre B-cell leukemia transcription factor 1	0.049
Col13a1	collagen, type XIII, alpha 1	0.046
Edar	ectodysplasin-A receptor	0.044
Scrt2	scratch homolog 2, zinc finger protein (Drosophila)	0.043
Rarb	retinoic acid receptor, beta	0.042
Gsx2	GS homeobox 2	0.041
Fgf17	fibroblast growth factor 17	0.040
Gja3	gap junction protein, alpha 3	0.038
Isl2	insulin related protein 2 (islet 2)	0.038
Six6	sine oculis-related homeobox 6 homolog (Drosophila)	0.038
Barhl1	BarH-like 1 (Drosophila)	0.037
Lhx1	LIM homeobox protein 1	0.037
Tlx1	T-cell leukemia, homeobox 1	0.037
Tcf15	transcription factor 15	0.036
Papln	papilin, proteoglycan-like sulfated glycoprotein	0.036
Aipl1	aryl hydrocarbon receptor-interacting protein-like 1	0.035
Lhx3	LIM homeobox protein 3	0.035
Grik3	glutamate receptor, ionotropic, kainate 3	0.035
Hoxd11	homeobox D11	0.035
Odf3	outer dense fiber of sperm tails 3	0.034
Adamts7	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 7	0.034
Gucy2e	guanylate cyclase 2e	0.034
Foxi3	forkhead box I3	0.034
Gata6	GATA binding protein 6	0.033
Hoxa10	homeobox A10	0.032
Barhl2	BarH-like 2 (Drosophila)	0.032
Irx4	Iroquois related homeobox 4 (Drosophila)	0.031	Mouse
Foxd2	forkhead box D2	0.031
Dll3	delta-like 3 (Drosophila)	0.031
Zic3	zinc finger protein of the cerebellum 3	0.030
Prph2	peripherin 2	0.030
Efna2	ephrin A2	0.030
Sox21	SRY-box containing gene 21	0.030
Tll2	tolloid-like 2	0.029
Rbp3	retinol binding protein 3, interstitial	0.029
Tbx4	T-box 4	0.029
Cdx1	caudal type homeobox 1	0.028
Nhlh1	nescient helix loop helix 1	0.028
Trp63	transformation related protein 63	0.027
Cnpy1	canopy 1 homolog (zebrafish)	0.027
Mn1	meningioma 1	0.027
Wnt9b	wingless-type MMTV integration site 9B	0.027
Cldn9	claudin 9	0.027
Cabp7	calcium binding protein 7	0.027
Pabpn1l	poly(A)binding protein nuclear 1-like	0.027
Aif1l	allograft inflammatory factor 1-like	0.027
Gsbs	G substrate	0.026
Dcc	deleted in colorectal carcinoma	0.026
Fgf15	fibroblast growth factor 15	0.025
Hoxd12	homeobox D12	0.025
Rhbdl3	rhomboid, veinlet-like 3 (Drosophila)	0.024
Unc5c	unc-5 homolog C (C. elegans)	0.024
BC027072	cDNA sequence BC027072	0.024
Cbln3	cerebellin 3 precursor protein	0.024
Glra1	glycine receptor, alpha 1 subunit	0.024
Ribc2	RIB43A domain with coiled-coils 2	0.023
Zeb1	zinc finger E-box binding homeobox 1	0.023
Gngt1	guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1	0.022
Mmel1	membrane metallo-endopeptidase-like 1	0.022
Ebf3	early B-cell factor 3	0.022
Sost	sclerostin	0.022
Fgf3	fibroblast growth factor 3	0.022
Efna4	ephrin A4	0.022
Wnt6	wingless-related MMTV integration site 6	0.021
Tbx20	T-box 20	0.021
Trpc5	transient receptor potential cation channel, subfamily C, member 5	0.021
Fgf10	fibroblast growth factor 10	0.021
Angpt4	angiopoietin 4	0.021
BC057022	cDNA sequence BC057022	0.021
Tctex1d4	Tctex1 domain containing 4	0.021
Scrt1	scratch homolog 1, zinc finger protein (Drosophila)	0.020
Chrd	chordin	0.020
Pou3f4	POU domain, class 3, transcription factor 4	0.020
Crabp2	cellular retinoic acid binding protein II	0.020
Nrtn	neurturin	0.020
Mixl1	Mix1 homeobox-like 1 (Xenopus laevis)	0.020
Sox3	SRY-box containing gene 3	0.019
Foxb1	forkhead box B1	0.019
Sim2	single-minded homolog 2 (Drosophila)	0.019
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.019
Jag1	jagged 1	0.019
Bhlhe23	basic helix-loop-helix family, member e23	0.018	Mouse
Sall1	sal-like 1 (Drosophila)	0.018
Foxf2	forkhead box F2	0.018
Lhx2	LIM homeobox protein 2	0.018
Zfp503	zinc finger protein 503	0.018
Hoxa13	homeobox A13	0.018
Npas3	neuronal PAS domain protein 3	0.018
Slc6a5	solute carrier family 6 (neurotransmitter transporter, glycine), member 5	0.017
Igfbpl1	insulin-like growth factor binding protein-like 1	0.017
Mab21l1	mab-21-like 1 (C. elegans)	0.017
Ednra	endothelin receptor type A	0.017
Crygn	crystallin, gamma N	0.017
Foxn4	forkhead box N4	0.017
Cntn2	contactin 2	0.017
Bnc1	basonuclin 1	0.017
Hes3	hairy and enhancer of split 3 (Drosophila)	0.016
Gas1	growth arrest specific 1	0.016
Evx1	even skipped homeotic gene 1 homolog	0.016
Gabrp	gamma-aminobutyric acid (GABA) A receptor, pi	0.016
Mmp20	matrix metallopeptidase 20 (enamelysin)	0.016
BC021785	cDNA sequence BC021785	0.016
Vgll2	vestigial like 2 homolog (Drosophila)	0.016
Fev	FEV (ETS oncogene family)	0.016
Cyp26a1	cytochrome P450, family 26, subfamily a, polypeptide 1	0.016
Myf5	myogenic factor 5	0.016
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.016
Hoxc13	homeobox C13	0.016
Neurog1	neurogenin 1	0.016
Pou3f3	POU domain, class 3, transcription factor 3	0.016
Pax2	paired box gene 2	0.015
Nkx2-4	NK2 transcription factor related, locus 4 (Drosophila)	0.015
Hoxa7	homeobox A7	0.015
Fbn2	fibrillin 2	0.015
Pyy	peptide YY	0.015
Hoxa11	homeobox A11	0.015
Wdr19	WD repeat domain 19	0.015
Onecut3	one cut domain, family member 3	0.015
Tulp1	tubby like protein 1	0.014
Dmrt3	doublesex and mab-3 related transcription factor 3	0.014
Hhat	hedgehog acyltransferase	0.014
Kif12	kinesin family member 12	0.014
Gdnf	glial cell line derived neurotrophic factor	0.014
Pou3f1	POU domain, class 3, transcription factor 1	0.014
Gata4	GATA binding protein 4	0.014
Wnt7a	wingless-related MMTV integration site 7A	0.014
Prph	peripherin	0.014
Kcne2	potassium voltage-gated channel, Isk-related subfamily, gene 2	0.014
En2	engrailed 2	0.014
Nrg3	neuregulin 3	0.014
Cabp2	calcium binding protein 2	0.014	Mouse
Cacna2d2	calcium channel, voltage-dependent, alpha 2/delta subunit 2	0.014
Col17a1	collagen, type XVII, alpha 1	0.013
Scube1	signal peptide, CUB domain, EGF-like 1	0.013
Spz1	spermatogenic leucine zipper 1	0.013
Scx	scleraxis	0.013
Aqp3	aquaporin 3	0.013
Lbx1	ladybird homeobox homolog 1 (Drosophila)	0.013
Foxd1	forkhead box D1	0.013
Satb2	special AT-rich sequence binding protein 2	0.013
Elavl2	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)	0.013
Tcfap2b	transcription factor AP-2 beta	0.013
Adra2b	adrenergic receptor, alpha 2b	0.013
Wnt16	wingless-related MMTV integration site 16	0.013
Krt15	keratin 15	0.013
Fscn2	fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)	0.013
Best2	bestrophin 2	0.013
Il17b	interleukin 17B	0.013
Foxf1a	forkhead box F1a	0.012
Htr1f	5-hydroxytryptamine (serotonin) receptor 1F	0.012
Sox14	SRY-box containing gene 14	0.012
Emilin3	elastin microfibril interfacer 3	0.012
Hoxb6	homeobox B6	0.012
Nhlh2	nescient helix loop helix 2	0.012
B3gat1	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	0.012
T	brachyury	0.012
Col9a2	collagen, type IX, alpha 2	0.012
Hoxb4	homeobox B4	0.012
Hoxb2	homeobox B2	0.012
Nrk	Nik related kinase	0.012
Cacna1f	calcium channel, voltage-dependent, alpha 1F subunit	0.012
Cplx4	complexin 4	0.012
Scn5a	sodium channel, voltage-gated, type V, alpha	0.012
Kcnk3	potassium channel, subfamily K, member 3	0.012
Tyrp1	tyrosinase-related protein 1	0.011
Hoxd4	homeobox D4	0.011
Slit1	slit homolog 1 (Drosophila)	0.011
Hs6st3	heparan sulfate 6-O-sulfotransferase 3	0.011
Cdh15	cadherin 15	0.011
Cited1	Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1	0.011
Col25a1	collagen, type XXV, alpha 1	0.011
Irs4	insulin receptor substrate 4	0.011
Fign	fidgetin	0.011
Usp43	ubiquitin specific peptidase 43	0.011
Hoxa3	homeobox A3	0.011
Fgf22	fibroblast growth factor 22	0.011
Zbtb7c	zinc finger and BTB domain containing 7C	0.011
Il11	interleukin 11	0.011
Rbfox3	RNA binding protein, fox-1 homolog (C. elegans) 3	0.011
Dmbx1	diencephalon/mesencephalon homeobox 1	0.011
Ecel1	endothelin converting enzyme-like 1	0.010
Nog	noggin	0.010
Tmprss5	transmembrane protease, serine 5 (spinesin)	0.010
Magix	MAGI family member, X-linked	0.010
Onecut2	one cut domain, family member 2	0.010
Dusp9	dual specificity phosphatase 9	0.010
Phlda2	pleckstrin homology-like domain, family A, member 2	0.010
Fgf9	fibroblast growth factor 9	0.010
Tbx2	T-box 2	0.010
Rsph6a	radial spoke head 6 homolog A (Chlamydomonas)	0.010
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.010