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Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of hepatocyte differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of hepatocyte differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
Gopc	golgi associated PDZ and coiled-coil motif containing	0.987
Wnt5a	wingless-related MMTV integration site 5A	0.969
Gli3	GLI-Kruppel family member GLI3	0.851
Gpc3	glypican 3	0.804
Fzd7	frizzled homolog 7 (Drosophila)	0.674	Mouse
Sfrp1	secreted frizzled-related protein 1	0.651
Dlg4	discs, large homolog 4 (Drosophila)	0.646
Fzd8	frizzled homolog 8 (Drosophila)	0.611	Mouse
Fzd1	frizzled homolog 1 (Drosophila)	0.598	Mouse
Smad6	MAD homolog 6 (Drosophila)	0.459
Grb10	growth factor receptor bound protein 10	0.442
Gas1	growth arrest specific 1	0.408
Ptk7	PTK7 protein tyrosine kinase 7	0.375
Fgfr2	fibroblast growth factor receptor 2	0.344
Ror1	receptor tyrosine kinase-like orphan receptor 1	0.332
Hoxd9	homeobox D9	0.317
Col4a5	collagen, type IV, alpha 5	0.314
Fbln1	fibulin 1	0.307
Ephb2	Eph receptor B2	0.276
Emp2	epithelial membrane protein 2	0.274
Fzd2	frizzled homolog 2 (Drosophila)	0.255	Mouse
Npr3	natriuretic peptide receptor 3	0.214
Prrx1	paired related homeobox 1	0.207
Tcf7l2	transcription factor 7-like 2, T-cell specific, HMG-box	0.205
Efs	embryonal Fyn-associated substrate	0.204
Dlg2	discs, large homolog 2 (Drosophila)	0.200
Hoxb6	homeobox B6	0.200
Hes1	hairy and enhancer of split 1 (Drosophila)	0.178
Sema5a	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	0.171
Tead2	TEA domain family member 2	0.171
Gjc1	gap junction protein, gamma 1	0.150
Acvr1	activin A receptor, type 1	0.148
Nr2f2	nuclear receptor subfamily 2, group F, member 2	0.137
Smad3	MAD homolog 3 (Drosophila)	0.123
Mrc2	mannose receptor, C type 2	0.116
Capn6	calpain 6	0.108
Tbx2	T-box 2	0.108
Tgfbr3	transforming growth factor, beta receptor III	0.105
Dbn1	drebrin 1	0.104
Cachd1	cache domain containing 1	0.104
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.101
Sfrp2	secreted frizzled-related protein 2	0.100
Efna2	ephrin A2	0.098
Efnb1	ephrin B1	0.085
Bmpr1b	bone morphogenetic protein receptor, type 1B	0.085
Fjx1	four jointed box 1 (Drosophila)	0.083
Efna4	ephrin A4	0.083
Six5	sine oculis-related homeobox 5 homolog (Drosophila)	0.081
Tspan12	tetraspanin 12	0.081
Dlg1	discs, large homolog 1 (Drosophila)	0.077
Mfap2	microfibrillar-associated protein 2	0.075
Zfhx4	zinc finger homeodomain 4	0.075
Hoxd8	homeobox D8	0.071
Sema3c	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	0.071
Gli2	GLI-Kruppel family member GLI2	0.071
Hoxb3	homeobox B3	0.070
Twist1	twist homolog 1 (Drosophila)	0.069
Bmp4	bone morphogenetic protein 4	0.069
Irs1	insulin receptor substrate 1	0.065
Zfp185	zinc finger protein 185	0.064
Ddr2	discoidin domain receptor family, member 2	0.064
Sema6a	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	0.064
Zfp503	zinc finger protein 503	0.063
Ddah2	dimethylarginine dimethylaminohydrolase 2	0.062
Sema3a	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	0.060
Atp1b2	ATPase, Na+/K+ transporting, beta 2 polypeptide	0.060
Gdf10	growth differentiation factor 10	0.058
Amotl2	angiomotin-like 2	0.055
Mfap4	microfibrillar-associated protein 4	0.054
Tbx3	T-box 3	0.052
Ephb3	Eph receptor B3	0.052
Fzd6	frizzled homolog 6 (Drosophila)	0.052	Mouse
Vegfa	vascular endothelial growth factor A	0.051
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.051
Hoxd10	homeobox D10	0.050
Smo	smoothened homolog (Drosophila)	0.048
Cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.048
Vangl2	vang-like 2 (van gogh, Drosophila)	0.047
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.046
Smoc2	SPARC related modular calcium binding 2	0.046
Tpbg	trophoblast glycoprotein	0.046
Ephb4	Eph receptor B4	0.046
Fzd4	frizzled homolog 4 (Drosophila)	0.045	Mouse
Col11a1	collagen, type XI, alpha 1	0.045
Pbx1	pre B-cell leukemia transcription factor 1	0.043
Slc16a2	solute carrier family 16 (monocarboxylic acid transporters), member 2	0.043
Cdh6	cadherin 6	0.042
Zfhx3	zinc finger homeobox 3	0.042
Plxna3	plexin A3	0.041
Sstr4	somatostatin receptor 4	0.039
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.039
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.039
Ctnnal1	catenin (cadherin associated protein), alpha-like 1	0.039
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.038
Arhgef25	Rho guanine nucleotide exchange factor (GEF) 25	0.037
Wnt7b	wingless-related MMTV integration site 7B	0.037
Ntn1	netrin 1	0.037
Igfbp2	insulin-like growth factor binding protein 2	0.037
Twist2	twist homolog 2 (Drosophila)	0.036
Col12a1	collagen, type XII, alpha 1	0.036
Timp2	tissue inhibitor of metalloproteinase 2	0.035
Etv4	ets variant gene 4 (E1A enhancer binding protein, E1AF)	0.034
Fbn2	fibrillin 2	0.033
S1pr3	sphingosine-1-phosphate receptor 3	0.033
Dkk2	dickkopf homolog 2 (Xenopus laevis)	0.033
Ghr	growth hormone receptor	0.031
St3gal2	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	0.031
Tcf7l1	transcription factor 7-like 1 (T-cell specific, HMG box)	0.031
Tgfb2	transforming growth factor, beta 2	0.031
Pcdh18	protocadherin 18	0.030
Prkd1	protein kinase D1	0.030
Gli1	GLI-Kruppel family member GLI1	0.030
Hoxd4	homeobox D4	0.029
Ptprk	protein tyrosine phosphatase, receptor type, K	0.028
Neo1	neogenin	0.028
Ptpru	protein tyrosine phosphatase, receptor type, U	0.028
Ebf3	early B-cell factor 3	0.028
Sardh	sarcosine dehydrogenase	0.028
Per3	period homolog 3 (Drosophila)	0.028
Ptgfr	prostaglandin F receptor	0.028
Ptch2	patched homolog 2	0.027
Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.027
Tex19.1	testis expressed gene 19.1	0.026
Tnfrsf19	tumor necrosis factor receptor superfamily, member 19	0.026
Smad5	MAD homolog 5 (Drosophila)	0.026
Cacna2d1	calcium channel, voltage-dependent, alpha2/delta subunit 1	0.026
Apcdd1	adenomatosis polyposis coli down-regulated 1	0.025
Slc2a4	solute carrier family 2 (facilitated glucose transporter), member 4	0.025
Itga8	integrin alpha 8	0.025
Hoxa2	homeobox A2	0.025
Ctf1	cardiotrophin 1	0.024
Hoxb5	homeobox B5	0.024
Nrcam	neuron-glia-CAM-related cell adhesion molecule	0.024
Plcd1	phospholipase C, delta 1	0.024
Ptrf	polymerase I and transcript release factor	0.024
Mmp11	matrix metallopeptidase 11	0.024
Hoxa9	homeobox A9	0.023
Bmpr2	bone morphogenic protein receptor, type II (serine/threonine kinase)	0.023
Tcf15	transcription factor 15	0.023
Osr1	odd-skipped related 1 (Drosophila)	0.023
Maf	avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog	0.022
Kcnd3	potassium voltage-gated channel, Shal-related family, member 3	0.022
Yap1	yes-associated protein 1	0.022
Angpt1	angiopoietin 1	0.022
Arhgap29	Rho GTPase activating protein 29	0.022
Hoxa11	homeobox A11	0.022
Matn4	matrilin 4	0.021
Lrig1	leucine-rich repeats and immunoglobulin-like domains 1	0.021
Sema3b	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B	0.021
Efna3	ephrin A3	0.021
Arnt2	aryl hydrocarbon receptor nuclear translocator 2	0.021
Sh3d19	SH3 domain protein D19	0.020
Sh3rf1	SH3 domain containing ring finger 1	0.020
Ptprz1	protein tyrosine phosphatase, receptor type Z, polypeptide 1	0.020
Ocln	occludin	0.020
Pou3f3	POU domain, class 3, transcription factor 3	0.020
Has2	hyaluronan synthase 2	0.019
Slc7a2	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	0.019
Zcchc3	zinc finger, CCHC domain containing 3	0.019
Lama5	laminin, alpha 5	0.019
Gata6	GATA binding protein 6	0.018
Dlk1	delta-like 1 homolog (Drosophila)	0.018
Meis2	Meis homeobox 2	0.018
Wnt4	wingless-related MMTV integration site 4	0.018
Cldn8	claudin 8	0.018
Lpar1	lysophosphatidic acid receptor 1	0.018
Cnn1	calponin 1	0.018
Sox2	SRY-box containing gene 2	0.018
Lrp2	low density lipoprotein receptor-related protein 2	0.018
Ednrb	endothelin receptor type B	0.018
Nbl1	neuroblastoma, suppression of tumorigenicity 1	0.018
Prx	periaxin	0.018
Npnt	nephronectin	0.017
Bmp5	bone morphogenetic protein 5	0.017
Axin2	axin2	0.017
Hic1	hypermethylated in cancer 1	0.017
Nfia	nuclear factor I/A	0.017
Pitx3	paired-like homeodomain transcription factor 3	0.017
Kcne1l	potassium voltage-gated channel, Isk-related family, member 1-like, pseudogene	0.017
Hoxa10	homeobox A10	0.017
Plagl1	pleiomorphic adenoma gene-like 1	0.017
Wnt5b	wingless-related MMTV integration site 5B	0.017
Mtap1b	microtubule-associated protein 1B	0.017
Plxna1	plexin A1	0.017
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.016
Grin2a	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	0.016
Arvcf	armadillo repeat gene deleted in velo-cardio-facial syndrome	0.016
Wwtr1	WW domain containing transcription regulator 1	0.016
St8sia2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.016
Rarg	retinoic acid receptor, gamma	0.016
Socs5	suppressor of cytokine signaling 5	0.016
Nck2	non-catalytic region of tyrosine kinase adaptor protein 2	0.016
Irx3	Iroquois related homeobox 3 (Drosophila)	0.015
Pdlim3	PDZ and LIM domain 3	0.015
Folr1	folate receptor 1 (adult)	0.015
Ptprg	protein tyrosine phosphatase, receptor type, G	0.015
Myl9	myosin, light polypeptide 9, regulatory	0.015
Epha7	Eph receptor A7	0.015
Lce1a2	late cornified envelope 1A2	0.015
Ncoa2	nuclear receptor coactivator 2	0.015
Myo10	myosin X	0.015
Id4	inhibitor of DNA binding 4	0.015
Mid2	midline 2	0.015
Cul7	cullin 7	0.015
Zbtb12	zinc finger and BTB domain containing 12	0.015
Mdk	midkine	0.015
Rnf208	ring finger protein 208	0.015
Stra6	stimulated by retinoic acid gene 6	0.014
Slc27a3	solute carrier family 27 (fatty acid transporter), member 3	0.014
Scx	scleraxis	0.014
Rcn3	reticulocalbin 3, EF-hand calcium binding domain	0.014
Fgf18	fibroblast growth factor 18	0.014
Pcgf2	polycomb group ring finger 2	0.014
Bmp6	bone morphogenetic protein 6	0.014
Foxd3	forkhead box D3	0.014
Cldn6	claudin 6	0.014
Nxn	nucleoredoxin	0.014
Efna5	ephrin A5	0.014
Mpdz	multiple PDZ domain protein	0.014
Kcna1	potassium voltage-gated channel, shaker-related subfamily, member 1	0.014
Sox4	SRY-box containing gene 4	0.014
Jag1	jagged 1	0.014
Foxd1	forkhead box D1	0.013
Igfbp3	insulin-like growth factor binding protein 3	0.013
Rbfox2	RNA binding protein, fox-1 homolog (C. elegans) 2	0.013
Sgcd	sarcoglycan, delta (dystrophin-associated glycoprotein)	0.013
Lpar4	lysophosphatidic acid receptor 4	0.013
Kcnk2	potassium channel, subfamily K, member 2	0.013
Epha4	Eph receptor A4	0.013
Met	met proto-oncogene	0.013
Acvr2b	activin receptor IIB	0.013
Des	desmin	0.013
Angptl1	angiopoietin-like 1	0.013
Dach1	dachshund 1 (Drosophila)	0.013
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.013
Dll1	delta-like 1 (Drosophila)	0.013
Wfdc2	WAP four-disulfide core domain 2	0.013
Prkci	protein kinase C, iota	0.012
Fign	fidgetin	0.012
Hs3st3a1	heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1	0.012
Pcsk6	proprotein convertase subtilisin/kexin type 6	0.012
Chrna7	cholinergic receptor, nicotinic, alpha polypeptide 7	0.012
Epha3	Eph receptor A3	0.012
Smtn	smoothelin	0.012
Btbd3	BTB (POZ) domain containing 3	0.012
Podxl	podocalyxin-like	0.012
Tcfap2c	transcription factor AP-2, gamma	0.012
Ptgfrn	prostaglandin F2 receptor negative regulator	0.012
Cntfr	ciliary neurotrophic factor receptor	0.012
Nes	nestin	0.012
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.012
Fbln2	fibulin 2	0.012
Rab34	RAB34, member of RAS oncogene family	0.012
Hoxc8	homeobox C8	0.012
Hoxd3	homeobox D3	0.011
Upk3b	uroplakin 3B	0.011
Cmtm8	CKLF-like MARVEL transmembrane domain containing 8	0.011
Nkain1	Na+/K+ transporting ATPase interacting 1	0.011
Ltbp3	latent transforming growth factor beta binding protein 3	0.011
Boc	biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein	0.011
Pdgfb	platelet derived growth factor, B polypeptide	0.011
Aplnr	apelin receptor	0.011
Hoxb4	homeobox B4	0.011
Mia1	melanoma inhibitory activity 1	0.011
Thbs3	thrombospondin 3	0.011
Dtna	dystrobrevin alpha	0.011
Phkb	phosphorylase kinase beta	0.011
Eya1	eyes absent 1 homolog (Drosophila)	0.011
Col8a1	collagen, type VIII, alpha 1	0.011
Nog	noggin	0.011
Fndc1	fibronectin type III domain containing 1	0.010
Mgat3	mannoside acetylglucosaminyltransferase 3	0.010
Sema3e	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E	0.010
Dkk3	dickkopf homolog 3 (Xenopus laevis)	0.010
Bmp7	bone morphogenetic protein 7	0.010
Sema6c	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C	0.010
Gdnf	glial cell line derived neurotrophic factor	0.010
Ppara	peroxisome proliferator activated receptor alpha	0.010
Fkbp11	FK506 binding protein 11	0.010
Efna1	ephrin A1	0.010
Egfr	epidermal growth factor receptor	0.010
Gpc4	glypican 4	0.010
Wwc2	WW, C2 and coiled-coil domain containing 2	0.010
Ryk	receptor-like tyrosine kinase	0.010
Crabp2	cellular retinoic acid binding protein II	0.010
Cdh3	cadherin 3	0.010