IMP

Process View

Mus musculus

9 genes annotated in mouse

Multi-species View

negative regulation of epidermis development

GO:0045683

Any process that stops, prevents, or reduces the frequency, rate or extent of epidermis development.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of epidermis development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of epidermis development" (in gray)

Name	Description	Probability	Func Analog Organism
Shh	sonic hedgehog	1.000
Fgfr2	fibroblast growth factor receptor 2	0.998
Notch1	Notch gene homolog 1 (Drosophila)	0.996
Eya1	eyes absent 1 homolog (Drosophila)	0.995
Fgfr1	fibroblast growth factor receptor 1	0.994
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.985
Gli3	GLI-Kruppel family member GLI3	0.976
Otx2	orthodenticle homolog 2 (Drosophila)	0.972
Pax3	paired box gene 3	0.967
Nog	noggin	0.963
Psen1	presenilin 1	0.954
Trp63	transformation related protein 63	0.940
Foxg1	forkhead box G1	0.923
Vangl2	vang-like 2 (van gogh, Drosophila)	0.912
Chd7	chromodomain helicase DNA binding protein 7	0.902
Foxc1	forkhead box C1	0.897
Tcfap2a	transcription factor AP-2, alpha	0.896
Emx1	empty spiracles homolog 1 (Drosophila)	0.888
Sox2	SRY-box containing gene 2	0.839
Hand1	heart and neural crest derivatives expressed transcript 1	0.832
Prrx1	paired related homeobox 1	0.810
Fgf8	fibroblast growth factor 8	0.795
Bmp7	bone morphogenetic protein 7	0.792
Foxc2	forkhead box C2	0.769
Trp53	transformation related protein 53	0.766	Mouse
Sox9	SRY-box containing gene 9	0.659
Emx2	empty spiracles homolog 2 (Drosophila)	0.649
Dlx5	distal-less homeobox 5	0.621
Msx1	homeobox, msh-like 1	0.621	Mouse
Dll1	delta-like 1 (Drosophila)	0.620
Rb1	retinoblastoma 1	0.602
Gli2	GLI-Kruppel family member GLI2	0.573
Bmp4	bone morphogenetic protein 4	0.572
Hand2	heart and neural crest derivatives expressed transcript 2	0.567
Hes1	hairy and enhancer of split 1 (Drosophila)	0.552
Smo	smoothened homolog (Drosophila)	0.541
Prrx2	paired related homeobox 2	0.514
Pitx2	paired-like homeodomain transcription factor 2	0.454
Fgfr3	fibroblast growth factor receptor 3	0.432
Tbx1	T-box 1	0.394
Tgfb2	transforming growth factor, beta 2	0.387
Ptk7	PTK7 protein tyrosine kinase 7	0.358
Zeb1	zinc finger E-box binding homeobox 1	0.309
Isl1	ISL1 transcription factor, LIM/homeodomain	0.288
Ece1	endothelin converting enzyme 1	0.275
Ctnnb1	catenin (cadherin associated protein), beta 1	0.271
Rbpj	recombination signal binding protein for immunoglobulin kappa J region	0.265
Meox2	mesenchyme homeobox 2	0.259
Lrp6	low density lipoprotein receptor-related protein 6	0.237
Wnt3a	wingless-related MMTV integration site 3A	0.231
Gja1	gap junction protein, alpha 1	0.230
Efnb2	ephrin B2	0.224
Etv4	ets variant gene 4 (E1A enhancer binding protein, E1AF)	0.194
Eed	embryonic ectoderm development	0.190
Gbx2	gastrulation brain homeobox 2	0.186
Egfr	epidermal growth factor receptor	0.185
Jag1	jagged 1	0.180	Mouse
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.178
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.175
Notch2	Notch gene homolog 2 (Drosophila)	0.155
Ptch1	patched homolog 1	0.154
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.148
Hes5	hairy and enhancer of split 5 (Drosophila)	0.145	Mouse
Lef1	lymphoid enhancer binding factor 1	0.140
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.138
Chrd	chordin	0.133
Msx2	homeobox, msh-like 2	0.119
Ntf3	neurotrophin 3	0.112
Gsc	goosecoid homeobox	0.108
Pax6	paired box gene 6	0.102
Stk38	serine/threonine kinase 38	0.095
Tgfbr2	transforming growth factor, beta receptor II	0.095
Dlx1	distal-less homeobox 1	0.089
Mn1	meningioma 1	0.088
Zg16	zymogen granule protein 16	0.088
Pax9	paired box gene 9	0.078
Gata4	GATA binding protein 4	0.075
2210010C04Rik	RIKEN cDNA 2210010C04 gene	0.074
Pitx1	paired-like homeodomain transcription factor 1	0.070
Alx4	aristaless-like homeobox 4	0.069
Lfng	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	0.068
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.064
Jarid2	jumonji, AT rich interactive domain 2	0.058
Lhx3	LIM homeobox protein 3	0.052
Otx1	orthodenticle homolog 1 (Drosophila)	0.047
En1	engrailed 1	0.046
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.044
Pten	phosphatase and tensin homolog	0.043
Nodal	nodal	0.042
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.041
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.041
Reg3g	regenerating islet-derived 3 gamma	0.040
Pax1	paired box gene 1	0.038
Rxra	retinoid X receptor alpha	0.036
Ms4a10	membrane-spanning 4-domains, subfamily A, member 10	0.036
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.036
Reg2	regenerating islet-derived 2	0.036	Mouse
Hes3	hairy and enhancer of split 3 (Drosophila)	0.036	Mouse
Krt14	keratin 14	0.035
Fgf15	fibroblast growth factor 15	0.034
Pkd1	polycystic kidney disease 1 homolog	0.034
Rarg	retinoic acid receptor, gamma	0.033
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.033
Sox11	SRY-box containing gene 11	0.032
Reg3a	regenerating islet-derived 3 alpha	0.031
Sp6	trans-acting transcription factor 6	0.031
Reg1	regenerating islet-derived 1	0.030	Mouse
Cdx2	caudal type homeobox 2	0.029
Trp73	transformation related protein 73	0.028	Mouse
Plac1	placental specific protein 1	0.028
Hr	hairless	0.027
Mesp2	mesoderm posterior 2	0.027
Gucy2c	guanylate cyclase 2c	0.026
Alx1	ALX homeobox 1	0.025
Mmp7	matrix metallopeptidase 7	0.025
Dmbt1	deleted in malignant brain tumors 1	0.025
Tbx3	T-box 3	0.024
Fgf10	fibroblast growth factor 10	0.024
Hesx1	homeobox gene expressed in ES cells	0.024
Nrarp	Notch-regulated ankyrin repeat protein	0.023
Cpa1	carboxypeptidase A1	0.023
Reg3d	regenerating islet-derived 3 delta	0.023	Mouse
Mtf2	metal response element binding transcription factor 2	0.023
Nr2f6	nuclear receptor subfamily 2, group F, member 6	0.023
Mycl1	v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)	0.023
Neurl1a	neuralized homolog 1A (Drosophila)	0.022
Tff2	trefoil factor 2 (spasmolytic protein 1)	0.022
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.022
Hoxa13	homeobox A13	0.020
Zbtb7c	zinc finger and BTB domain containing 7C	0.020
Ptch2	patched homolog 2	0.019
Ins1	insulin I	0.019
Gpa33	glycoprotein A33 (transmembrane)	0.019
Dlx2	distal-less homeobox 2	0.019
Fut2	fucosyltransferase 2	0.019
Reg3b	regenerating islet-derived 3 beta	0.018	Mouse
Rara	retinoic acid receptor, alpha	0.018
Gata3	GATA binding protein 3	0.017
Esr1	estrogen receptor 1 (alpha)	0.017
Iapp	islet amyloid polypeptide	0.017
Muc13	mucin 13, epithelial transmembrane	0.017
Sfn	stratifin	0.017
Krt27	keratin 27	0.017
Thbs1	thrombospondin 1	0.017
Hoxc9	homeobox C9	0.016
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.016
Hnrnpd	heterogeneous nuclear ribonucleoprotein D	0.016
Mnx1	motor neuron and pancreas homeobox 1	0.016
Sall4	sal-like 4 (Drosophila)	0.016
Lhx5	LIM homeobox protein 5	0.016
Eng	endoglin	0.015
Efnb1	ephrin B1	0.015
Tcfap2c	transcription factor AP-2, gamma	0.015
Aebp2	AE binding protein 2	0.015
Bmp2	bone morphogenetic protein 2	0.015
H2-M9	histocompatibility 2, M region locus 9	0.015
Bmp10	bone morphogenetic protein 10	0.015
Kcnq1	potassium voltage-gated channel, subfamily Q, member 1	0.014
Pvrl1	poliovirus receptor-related 1	0.014
Uncx	UNC homeobox	0.014
Efna4	ephrin A4	0.014
Magel2	melanoma antigen, family L, 2	0.014
Runx2	runt related transcription factor 2	0.014
Rarb	retinoic acid receptor, beta	0.014
Wnt11	wingless-related MMTV integration site 11	0.014
Itga3	integrin alpha 3	0.014
Bdnf	brain derived neurotrophic factor	0.014
Twist2	twist homolog 2 (Drosophila)	0.013
Pigr	polymeric immunoglobulin receptor	0.013
5430421N21Rik	RIKEN cDNA 5430421N21 gene	0.013
Nr5a2	nuclear receptor subfamily 5, group A, member 2	0.013
Yap1	yes-associated protein 1	0.013
Krt15	keratin 15	0.013
Lmx1b	LIM homeobox transcription factor 1 beta	0.013
Cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.013
Efna2	ephrin A2	0.013
Alx3	aristaless-like homeobox 3	0.012
Evx2	even skipped homeotic gene 2 homolog	0.012
Ednra	endothelin receptor type A	0.012
Grin2d	glutamate receptor, ionotropic, NMDA2D (epsilon 4)	0.012
Mia1	melanoma inhibitory activity 1	0.012
Pou4f3	POU domain, class 4, transcription factor 3	0.012
Csf2	colony stimulating factor 2 (granulocyte-macrophage)	0.012
Serpini2	serine (or cysteine) peptidase inhibitor, clade I, member 2	0.012
Irf6	interferon regulatory factor 6	0.012
Ptf1a	pancreas specific transcription factor, 1a	0.012
Cdx1	caudal type homeobox 1	0.011
Hhat	hedgehog acyltransferase	0.011
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.011
Zic2	zinc finger protein of the cerebellum 2	0.011
Cela2a	chymotrypsin-like elastase family, member 2A	0.011
Mt4	metallothionein 4	0.011
Pnliprp1	pancreatic lipase related protein 1	0.011
Dsc3	desmocollin 3	0.011
Lama5	laminin, alpha 5	0.011
Disp1	dispatched homolog 1 (Drosophila)	0.011
Clps	colipase, pancreatic	0.010
Sox10	SRY-box containing gene 10	0.010
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.010
Tmem54	transmembrane protein 54	0.010