IMP

Process View

Mus musculus

1 genes annotated in mouse

negative regulation of pathway restricted smad protein phosphorylation

Any process that decreases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of pathway restricted smad protein phosphorylation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of pathway restricted smad protein phosphorylation" (in gray)

Name	Description	Probability	Func Analog Organism
Axin1	axin 1	0.819
Acvrl1	activin A receptor, type II-like 1	0.408
Smurf1	SMAD specific E3 ubiquitin protein ligase 1	0.386
Hes1	hairy and enhancer of split 1 (Drosophila)	0.225
Psmc6	proteasome (prosome, macropain) 26S subunit, ATPase, 6	0.182
Smad7	MAD homolog 7 (Drosophila)	0.164	Human
Emx2	empty spiracles homolog 2 (Drosophila)	0.150
Dll4	delta-like 4 (Drosophila)	0.109
Fgfr1	fibroblast growth factor receptor 1	0.107
Smad3	MAD homolog 3 (Drosophila)	0.096
Hes5	hairy and enhancer of split 5 (Drosophila)	0.095
Sox18	SRY-box containing gene 18	0.094
Sall1	sal-like 1 (Drosophila)	0.085
Tomm70a	translocase of outer mitochondrial membrane 70 homolog A (yeast)	0.078
Itga5	integrin alpha 5 (fibronectin receptor alpha)	0.070
Sox17	SRY-box containing gene 17	0.068
Ndufaf4	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 4	0.058
Efnb1	ephrin B1	0.056
En1	engrailed 1	0.055
Otx2	orthodenticle homolog 2 (Drosophila)	0.053
Tenc1	tensin like C1 domain-containing phosphatase	0.053
Tbx3	T-box 3	0.052
Gata2	GATA binding protein 2	0.046
Etf1	eukaryotic translation termination factor 1	0.041
Esam	endothelial cell-specific adhesion molecule	0.038
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.037
Cdh5	cadherin 5	0.035
Acvr1	activin A receptor, type 1	0.035
Flt1	FMS-like tyrosine kinase 1	0.034
Ptprb	protein tyrosine phosphatase, receptor type, B	0.033
Nos3	nitric oxide synthase 3, endothelial cell	0.033
Foxf1a	forkhead box F1a	0.031
Pax8	paired box gene 8	0.031
Tgfb1i1	transforming growth factor beta 1 induced transcript 1	0.031
Hoxd9	homeobox D9	0.031
Lrp5	low density lipoprotein receptor-related protein 5	0.031
Shh	sonic hedgehog	0.030
Slc12a4	solute carrier family 12, member 4	0.029
Uba2	ubiquitin-like modifier activating enzyme 2	0.029
Eif3j	eukaryotic translation initiation factor 3, subunit J	0.029
Bmpr2	bone morphogenic protein receptor, type II (serine/threonine kinase)	0.028
Notch1	Notch gene homolog 1 (Drosophila)	0.027
Psmd6	proteasome (prosome, macropain) 26S subunit, non-ATPase, 6	0.027
Fgfr3	fibroblast growth factor receptor 3	0.027
Tie1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.027
Gpr124	G protein-coupled receptor 124	0.026
Sox2	SRY-box containing gene 2	0.026
Adcy4	adenylate cyclase 4	0.025
Robo4	roundabout homolog 4 (Drosophila)	0.024
Cldn5	claudin 5	0.024
Bmp4	bone morphogenetic protein 4	0.024
Psmd12	proteasome (prosome, macropain) 26S subunit, non-ATPase, 12	0.023
Gtpbp4	GTP binding protein 4	0.023
Efna4	ephrin A4	0.022
Foxc2	forkhead box C2	0.022
Sox7	SRY-box containing gene 7	0.022
Isl1	ISL1 transcription factor, LIM/homeodomain	0.022
Wwc2	WW, C2 and coiled-coil domain containing 2	0.022
Egfl7	EGF-like domain 7	0.022
Smo	smoothened homolog (Drosophila)	0.022
Pdgfb	platelet derived growth factor, B polypeptide	0.021
Dag1	dystroglycan 1	0.021
Ece1	endothelin converting enzyme 1	0.021
Spry4	sprouty homolog 4 (Drosophila)	0.021
Snai1	snail homolog 1 (Drosophila)	0.021
Id3	inhibitor of DNA binding 3	0.021
Flt4	FMS-like tyrosine kinase 4	0.020
Eif1a	eukaryotic translation initiation factor 1A	0.020
Zbtb7a	zinc finger and BTB domain containing 7a	0.020
Tmem88	transmembrane protein 88	0.020
Fgf8	fibroblast growth factor 8	0.020
Hhex	hematopoietically expressed homeobox	0.019
Rrn3	RRN3 RNA polymerase I transcription factor homolog (yeast)	0.019
Kdr	kinase insert domain protein receptor	0.019
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.019
Gsk3b	glycogen synthase kinase 3 beta	0.019
Tbx2	T-box 2	0.018
Hey1	hairy/enhancer-of-split related with YRPW motif 1	0.018
Sod3	superoxide dismutase 3, extracellular	0.018
Cct6a	chaperonin containing Tcp1, subunit 6a (zeta)	0.018
Tgfbr2	transforming growth factor, beta receptor II	0.017
Sall4	sal-like 4 (Drosophila)	0.017
Pcdh1	protocadherin 1	0.017
Ski	ski sarcoma viral oncogene homolog (avian)	0.016
Ptk7	PTK7 protein tyrosine kinase 7	0.016
Id1	inhibitor of DNA binding 1	0.016
Axin2	axin2	0.016
Cdc42ep1	CDC42 effector protein (Rho GTPase binding) 1	0.016
Gli3	GLI-Kruppel family member GLI3	0.016
Tinagl1	tubulointerstitial nephritis antigen-like 1	0.016
Zfp36l2	zinc finger protein 36, C3H type-like 2	0.015
Ptch1	patched homolog 1	0.015
Hoxd11	homeobox D11	0.015
Ppp2ca	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	0.015
Col13a1	collagen, type XIII, alpha 1	0.015
Arap3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	0.014
Slc9a3r2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.014
Foxd2	forkhead box D2	0.014
Hoxb2	homeobox B2	0.014
Smurf2	SMAD specific E3 ubiquitin protein ligase 2	0.014
Ddx1	DEAD (Asp-Glu-Ala-Asp) box polypeptide 1	0.013
Jun	Jun oncogene	0.013
Rarg	retinoic acid receptor, gamma	0.013
Lrp6	low density lipoprotein receptor-related protein 6	0.013
Wnt11	wingless-related MMTV integration site 11	0.013
Dvl1	dishevelled, dsh homolog 1 (Drosophila)	0.013
Hic1	hypermethylated in cancer 1	0.013
Tspan9	tetraspanin 9	0.013
Fermt2	fermitin family homolog 2 (Drosophila)	0.013
Fosb	FBJ osteosarcoma oncogene B	0.013
Gpc3	glypican 3	0.013
Itgb3	integrin beta 3	0.012
Nae1	NEDD8 activating enzyme E1 subunit 1	0.012
Gbx2	gastrulation brain homeobox 2	0.012
Shank3	SH3/ankyrin domain gene 3	0.012
Ptp4a1	protein tyrosine phosphatase 4a1	0.012
Grasp	GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein	0.012
1300014I06Rik	RIKEN cDNA 1300014I06 gene	0.012
Klf2	Kruppel-like factor 2 (lung)	0.012
BC020535	cDNA sequence BC020535	0.012
Pdgfa	platelet derived growth factor, alpha	0.012
Bhlhe40	basic helix-loop-helix family, member e40	0.011
Tnks1bp1	tankyrase 1 binding protein 1	0.011
Tcf15	transcription factor 15	0.011
Rbpms	RNA binding protein gene with multiple splicing	0.011
Sh2b3	SH2B adaptor protein 3	0.011
Eya4	eyes absent 4 homolog (Drosophila)	0.011
Ephb4	Eph receptor B4	0.011
Ipo5	importin 5	0.011
Hesx1	homeobox gene expressed in ES cells	0.011
Hspa12b	heat shock protein 12B	0.011
Bcap29	B-cell receptor-associated protein 29	0.011
Rrs1	RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)	0.011
Gdnf	glial cell line derived neurotrophic factor	0.011
Lfng	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	0.011
Actn1	actinin, alpha 1	0.011
Serbp1	serpine1 mRNA binding protein 1	0.010
Nars	asparaginyl-tRNA synthetase	0.010
Chd7	chromodomain helicase DNA binding protein 7	0.010
Dll1	delta-like 1 (Drosophila)	0.010
Jag1	jagged 1	0.010
Vapa	vesicle-associated membrane protein, associated protein A	0.010
Efnb2	ephrin B2	0.010
Denr	density-regulated protein	0.010
Lef1	lymphoid enhancer binding factor 1	0.010