IMP

Process View

Mus musculus

7 genes annotated in mouse

t helper 17 cell differentiation

The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 17 (Th17) cell. A Th17 cell is a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "t helper 17 cell differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "t helper 17 cell differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
Ifng	interferon gamma	0.739
Tnf	tumor necrosis factor	0.672
Igh	immunoglobulin heavy chain complex	0.648
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.289
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.286
Irf4	interferon regulatory factor 4	0.277
Uba7	ubiquitin-like modifier activating enzyme 7	0.275
Stat1	signal transducer and activator of transcription 1	0.274
Il21r	interleukin 21 receptor	0.241
Stat2	signal transducer and activator of transcription 2	0.236
Cd19	CD19 antigen	0.229
Igtp	interferon gamma induced GTPase	0.228
Cd40	CD40 antigen	0.222
Mmp9	matrix metallopeptidase 9	0.180
Stat3	signal transducer and activator of transcription 3	0.154
Tnfrsf9	tumor necrosis factor receptor superfamily, member 9	0.143
Ikzf1	IKAROS family zinc finger 1	0.122
Sfpi1	SFFV proviral integration 1	0.114
Psmb9	proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)	0.111
Il12b	interleukin 12b	0.098
Ifit1	interferon-induced protein with tetratricopeptide repeats 1	0.094
Ccl2	chemokine (C-C motif) ligand 2	0.093
Il10	interleukin 10	0.091
Fas	Fas (TNF receptor superfamily member 6)	0.080
Mx2	myxovirus (influenza virus) resistance 2	0.077
Irf5	interferon regulatory factor 5	0.076	Mouse
Rag1	recombination activating gene 1	0.075
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.074
Card11	caspase recruitment domain family, member 11	0.073
Foxp3	forkhead box P3	0.062
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.056
Pdcd1	programmed cell death 1	0.056
Ptgs2	prostaglandin-endoperoxide synthase 2	0.054
1810019J16Rik	RIKEN cDNA 1810019J16 gene	0.047
Usp18	ubiquitin specific peptidase 18	0.045
Myd88	myeloid differentiation primary response gene 88	0.044
Atxn1	ataxin 1	0.044
Bcl6	B-cell leukemia/lymphoma 6	0.042
Icam1	intercellular adhesion molecule 1	0.038
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.037
Socs1	suppressor of cytokine signaling 1	0.035
Isg15	ISG15 ubiquitin-like modifier	0.035
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.033
Batf	basic leucine zipper transcription factor, ATF-like	0.032
Tap2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	0.031
Ccl4	chemokine (C-C motif) ligand 4	0.029
Bcl3	B-cell leukemia/lymphoma 3	0.027
Il27ra	interleukin 27 receptor, alpha	0.027
Zbp1	Z-DNA binding protein 1	0.026
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.025
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.023
Rel	reticuloendotheliosis oncogene	0.023
Cd86	CD86 antigen	0.023
Psmb8	proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)	0.022
Batf3	basic leucine zipper transcription factor, ATF-like 3	0.022	Mouse
Irgm2	immunity-related GTPase family M member 2	0.021
Tnfrsf4	tumor necrosis factor receptor superfamily, member 4	0.021
Prkcd	protein kinase C, delta	0.020
Traf2	TNF receptor-associated factor 2	0.018
Icos	inducible T-cell co-stimulator	0.018
Tor3a	torsin family 3, member A	0.018
Tnfrsf13b	tumor necrosis factor receptor superfamily, member 13b	0.018
Il4	interleukin 4	0.018
Tapbp	TAP binding protein	0.018
Irgm1	immunity-related GTPase family M member 1	0.017
Oas2	2'-5' oligoadenylate synthetase 2	0.017
Plcg2	phospholipase C, gamma 2	0.016
Cd28	CD28 antigen	0.016
H2-DMa	histocompatibility 2, class II, locus DMa	0.016
Trim21	tripartite motif-containing 21	0.016
Cxcl10	chemokine (C-X-C motif) ligand 10	0.015
Jak3	Janus kinase 3	0.014
Irf8	interferon regulatory factor 8	0.014	Mouse
Ptpn6	protein tyrosine phosphatase, non-receptor type 6	0.014
Pten	phosphatase and tensin homolog	0.013
H2-DMb2	histocompatibility 2, class II, locus Mb2	0.013
Il2	interleukin 2	0.013
Socs3	suppressor of cytokine signaling 3	0.013
Fut7	fucosyltransferase 7	0.013
Ciita	class II transactivator	0.012
Nlrp3	NLR family, pyrin domain containing 3	0.012
Ifit3	interferon-induced protein with tetratricopeptide repeats 3	0.012
Il6st	interleukin 6 signal transducer	0.012
Traf3ip2	TRAF3 interacting protein 2	0.012
Ifi47	interferon gamma inducible protein 47	0.012
Traf6	TNF receptor-associated factor 6	0.012
Spp1	secreted phosphoprotein 1	0.011
Lta	lymphotoxin A	0.011
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.011
Cd79b	CD79B antigen	0.011
Rsad2	radical S-adenosyl methionine domain containing 2	0.011
Cd79a	CD79A antigen (immunoglobulin-associated alpha)	0.011
Inpp5d	inositol polyphosphate-5-phosphatase D	0.011
Unc93b1	unc-93 homolog B1 (C. elegans)	0.011
Tcrb	T-cell receptor beta chain	0.011
Ptf1a	pancreas specific transcription factor, 1a	0.010
Prf1	perforin 1 (pore forming protein)	0.010
Csf1	colony stimulating factor 1 (macrophage)	0.010
Ccl17	chemokine (C-C motif) ligand 17	0.010
Cxcl9	chemokine (C-X-C motif) ligand 9	0.010
Il4ra	interleukin 4 receptor, alpha	0.010
Cd40lg	CD40 ligand	0.010