IMP

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Mus musculus

2 genes annotated in mouse

general adaptation syndrome

General adaptation syndrome is the set of changes in various organ systems of the body, especially the pituitary-endocrine system, in response to a wide range of strong external stimuli, both physiological and psychological. It is described as having three stages: alarm reaction, where the body detects the external stimulus; adaptation, where the body engages defensive countermeasures against the stressor; and exhaustion, where the body begins to run out of defenses.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "general adaptation syndrome"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "general adaptation syndrome" (in gray)

Name	Description	Probability	Func Analog Organism
Fosb	FBJ osteosarcoma oncogene B	0.281
Fos	FBJ osteosarcoma oncogene	0.227
Jun	Jun oncogene	0.201
Egr1	early growth response 1	0.195
Gabrq	gamma-aminobutyric acid (GABA) A receptor, subunit theta	0.195
Dusp1	dual specificity phosphatase 1	0.192
Cd247	CD247 antigen	0.170
Gpr27	G protein-coupled receptor 27	0.126
Ikzf4	IKAROS family zinc finger 4	0.123
Mmp24	matrix metallopeptidase 24	0.085
Btg2	B-cell translocation gene 2, anti-proliferative	0.078
Wnt2b	wingless related MMTV integration site 2b	0.077
Atf3	activating transcription factor 3	0.067
Cux2	cut-like homeobox 2	0.064
Ppyr1	pancreatic polypeptide receptor 1	0.062
Lhb	luteinizing hormone beta	0.061
Rhbdf1	rhomboid family 1 (Drosophila)	0.061
Mc5r	melanocortin 5 receptor	0.055
Kcnb1	potassium voltage gated channel, Shab-related subfamily, member 1	0.053
Htr6	5-hydroxytryptamine (serotonin) receptor 6	0.051
Cckbr	cholecystokinin B receptor	0.048
Rtbdn	retbindin	0.044
Agt	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	0.044
Junb	Jun-B oncogene	0.042
Klk4	kallikrein related-peptidase 4 (prostase, enamel matrix, prostate)	0.041
Kcnh1	potassium voltage-gated channel, subfamily H (eag-related), member 1	0.041
Nr4a2	nuclear receptor subfamily 4, group A, member 2	0.041
Cacng5	calcium channel, voltage-dependent, gamma subunit 5	0.039
Foxf1a	forkhead box F1a	0.038
Kcnk4	potassium channel, subfamily K, member 4	0.037
Smyd1	SET and MYND domain containing 1	0.037
Npy5r	neuropeptide Y receptor Y5	0.037
Cyr61	cysteine rich protein 61	0.036
Kcna6	potassium voltage-gated channel, shaker-related, subfamily, member 6	0.033
Adra2a	adrenergic receptor, alpha 2a	0.033
Prkcc	protein kinase C, gamma	0.033
Shc3	src homology 2 domain-containing transforming protein C3	0.032
Thrb	thyroid hormone receptor beta	0.032
Tnni2	troponin I, skeletal, fast 2	0.032
Drd2	dopamine receptor D2	0.032
Kcnj12	potassium inwardly-rectifying channel, subfamily J, member 12	0.031
Nog	noggin	0.031
Matn1	matrilin 1, cartilage matrix protein	0.030
Angpt1	angiopoietin 1	0.029
Adm	adrenomedullin	0.029
Sntb1	syntrophin, basic 1	0.028
Zfp787	zinc finger protein 787	0.027
Mchr1	melanin-concentrating hormone receptor 1	0.027
Zfp36	zinc finger protein 36	0.027
Pthlh	parathyroid hormone-like peptide	0.026
Th	tyrosine hydroxylase	0.026
Slc16a8	solute carrier family 16 (monocarboxylic acid transporters), member 8	0.026
Plcb1	phospholipase C, beta 1	0.026
Rorb	RAR-related orphan receptor beta	0.026
Kcnd1	potassium voltage-gated channel, Shal-related family, member 1	0.026
Tacr1	tachykinin receptor 1	0.026
Tek	endothelial-specific receptor tyrosine kinase	0.026
Rgs9	regulator of G-protein signaling 9	0.025
Csrnp1	cysteine-serine-rich nuclear protein 1	0.025
Gsx1	GS homeobox 1	0.025
Wnt10b	wingless related MMTV integration site 10b	0.025
Chrm1	cholinergic receptor, muscarinic 1, CNS	0.025
Adora2a	adenosine A2a receptor	0.024
Kcna2	potassium voltage-gated channel, shaker-related subfamily, member 2	0.024
Tac2	tachykinin 2	0.024
Kcnj4	potassium inwardly-rectifying channel, subfamily J, member 4	0.023
Htr7	5-hydroxytryptamine (serotonin) receptor 7	0.023
Gdnf	glial cell line derived neurotrophic factor	0.023
Des	desmin	0.023
Fosl2	fos-like antigen 2	0.023
Gpr3	G-protein coupled receptor 3	0.022
Tgfa	transforming growth factor alpha	0.022
Htr2c	5-hydroxytryptamine (serotonin) receptor 2C	0.022
Cbln1	cerebellin 1 precursor protein	0.022
Nhedc2	Na+/H+ exchanger domain containing 2	0.022
Klf4	Kruppel-like factor 4 (gut)	0.022
Crhr1	corticotropin releasing hormone receptor 1	0.022
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.022
Cacna1a	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	0.022
Fxyd7	FXYD domain-containing ion transport regulator 7	0.021
Htr1b	5-hydroxytryptamine (serotonin) receptor 1B	0.021
Spry4	sprouty homolog 4 (Drosophila)	0.021
Treml1	triggering receptor expressed on myeloid cells-like 1	0.021
Fam163b	family with sequence similarity 163, member B	0.021
Nrg3	neuregulin 3	0.021
Adcy8	adenylate cyclase 8	0.021
Mybpc3	myosin binding protein C, cardiac	0.020
Fgf16	fibroblast growth factor 16	0.020
Esrrb	estrogen related receptor, beta	0.020
Adrb1	adrenergic receptor, beta 1	0.020
Avp	arginine vasopressin	0.019
Tgfbr3	transforming growth factor, beta receptor III	0.019
Ier2	immediate early response 2	0.019
Lepr	leptin receptor	0.019
Rtn4r	reticulon 4 receptor	0.019
St8sia5	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5	0.019
Cox4i2	cytochrome c oxidase subunit IV isoform 2	0.019
Vipr2	vasoactive intestinal peptide receptor 2	0.019	Mouse
Pcdh12	protocadherin 12	0.018
Npas2	neuronal PAS domain protein 2	0.018
Tlr5	toll-like receptor 5	0.018
Apoa5	apolipoprotein A-V	0.018
Gfra2	glial cell line derived neurotrophic factor family receptor alpha 2	0.018
Oprk1	opioid receptor, kappa 1	0.018
Ptgs2	prostaglandin-endoperoxide synthase 2	0.017
Per1	period homolog 1 (Drosophila)	0.017
Gabra2	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2	0.017
Gfra3	glial cell line derived neurotrophic factor family receptor alpha 3	0.017
Grid1	glutamate receptor, ionotropic, delta 1	0.017
Gnao1	guanine nucleotide binding protein, alpha O	0.017
Kcne1l	potassium voltage-gated channel, Isk-related family, member 1-like, pseudogene	0.017
Dspp	dentin sialophosphoprotein	0.017
Zbtb46	zinc finger and BTB domain containing 46	0.017
Asgr1	asialoglycoprotein receptor 1	0.016
Pnoc	prepronociceptin	0.016
Cntn4	contactin 4	0.016
Mgat3	mannoside acetylglucosaminyltransferase 3	0.016
Cyp8b1	cytochrome P450, family 8, subfamily b, polypeptide 1	0.016
Tacr2	tachykinin receptor 2	0.016
Apc2	adenomatosis polyposis coli 2	0.016
Adra2c	adrenergic receptor, alpha 2c	0.016
Grid2	glutamate receptor, ionotropic, delta 2	0.016
Nfatc2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	0.016
Eda	ectodysplasin-A	0.016
Chrna6	cholinergic receptor, nicotinic, alpha polypeptide 6	0.016
P2rx1	purinergic receptor P2X, ligand-gated ion channel, 1	0.016
Bik	BCL2-interacting killer	0.016
Gnas	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	0.016
Lrfn1	leucine rich repeat and fibronectin type III domain containing 1	0.016
Slc5a5	solute carrier family 5 (sodium iodide symporter), member 5	0.016
Dnajb5	DnaJ (Hsp40) homolog, subfamily B, member 5	0.016
Dio2	deiodinase, iodothyronine, type II	0.015
Car5a	carbonic anhydrase 5a, mitochondrial	0.015
Kcnj6	potassium inwardly-rectifying channel, subfamily J, member 6	0.015
Serpind1	serine (or cysteine) peptidase inhibitor, clade D, member 1	0.015
Tll1	tolloid-like	0.015
Kif1a	kinesin family member 1A	0.015
Klk6	kallikrein related-peptidase 6	0.015
Gbx1	gastrulation brain homeobox 1	0.015
Sstr5	somatostatin receptor 5	0.015
Gem	GTP binding protein (gene overexpressed in skeletal muscle)	0.015
Npy2r	neuropeptide Y receptor Y2	0.015
Egr4	early growth response 4	0.015
Btbd17	BTB (POZ) domain containing 17	0.015
Nkx2-2	NK2 transcription factor related, locus 2 (Drosophila)	0.015
Trpc5	transient receptor potential cation channel, subfamily C, member 5	0.015
Kcnk3	potassium channel, subfamily K, member 3	0.015
Htr1a	5-hydroxytryptamine (serotonin) receptor 1A	0.015
Slc25a25	solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25	0.015
Olfr70	olfactory receptor 70	0.015
Prrt1	proline-rich transmembrane protein 1	0.015
Gabre	gamma-aminobutyric acid (GABA) A receptor, subunit epsilon	0.014
Atp7b	ATPase, Cu++ transporting, beta polypeptide	0.014
Plxna1	plexin A1	0.014
Ccbp2	chemokine binding protein 2	0.014
Syt10	synaptotagmin X	0.014
Grin2c	glutamate receptor, ionotropic, NMDA2C (epsilon 3)	0.014
Cdh6	cadherin 6	0.014
Ghrh	growth hormone releasing hormone	0.014
Smad9	MAD homolog 9 (Drosophila)	0.014
Lep	leptin	0.014
Gm996	predicted gene 996	0.014
Kcnj11	potassium inwardly rectifying channel, subfamily J, member 11	0.014
Ntrk3	neurotrophic tyrosine kinase, receptor, type 3	0.014
Nxph4	neurexophilin 4	0.014
Arnt2	aryl hydrocarbon receptor nuclear translocator 2	0.014
Cdh4	cadherin 4	0.014
Sstr4	somatostatin receptor 4	0.014
Ins2	insulin II	0.014
Cacng4	calcium channel, voltage-dependent, gamma subunit 4	0.014
Edil3	EGF-like repeats and discoidin I-like domains 3	0.013
Otp	orthopedia homolog (Drosophila)	0.013
Aspdh	aspartate dehydrogenase domain containing	0.013
Amh	anti-Mullerian hormone	0.013
Pomc	pro-opiomelanocortin-alpha	0.013
BC057022	cDNA sequence BC057022	0.013
Crtac1	cartilage acidic protein 1	0.013
Kcnq2	potassium voltage-gated channel, subfamily Q, member 2	0.013
Ptafr	platelet-activating factor receptor	0.013
Adam11	a disintegrin and metallopeptidase domain 11	0.013
Galr1	galanin receptor 1	0.013
Zfp444	zinc finger protein 444	0.013
Sstr2	somatostatin receptor 2	0.013
Egr2	early growth response 2	0.013
Ihh	Indian hedgehog	0.013
Fgf10	fibroblast growth factor 10	0.013
Nkx2-9	NK2 transcription factor related, locus 9 (Drosophila)	0.013
Rims4	regulating synaptic membrane exocytosis 4	0.013
Mrap2	melanocortin 2 receptor accessory protein 2	0.013
Sema6a	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	0.013
Muc5ac	mucin 5, subtypes A and C, tracheobronchial/gastric	0.012
S1pr1	sphingosine-1-phosphate receptor 1	0.012
Acan	aggrecan	0.012
Pvrl1	poliovirus receptor-related 1	0.012
Ctrb1	chymotrypsinogen B1	0.012
Ninj2	ninjurin 2	0.012
A530016L24Rik	RIKEN cDNA A530016L24 gene	0.012
Zp2	zona pellucida glycoprotein 2	0.012
Tmem132e	transmembrane protein 132E	0.012
Lalba	lactalbumin, alpha	0.012
Hgf	hepatocyte growth factor	0.012
Gck	glucokinase	0.012
Ccin	calicin	0.012
Slc25a29	solute carrier family 25 (mitochondrial carrier, palmitoylcarnitine transporter), member 29	0.012
Wnt1	wingless-related MMTV integration site 1	0.012
Ntn3	netrin 3	0.012
Ptprn2	protein tyrosine phosphatase, receptor type, N polypeptide 2	0.012
Tat	tyrosine aminotransferase	0.012
Slc22a8	solute carrier family 22 (organic anion transporter), member 8	0.012
Scube1	signal peptide, CUB domain, EGF-like 1	0.012
Zfp398	zinc finger protein 398	0.012
Syt7	synaptotagmin VII	0.012
Hrh3	histamine receptor H3	0.012
Otos	otospiralin	0.012
Epb4.1l4b	erythrocyte protein band 4.1-like 4b	0.012
Pde10a	phosphodiesterase 10A	0.012
Mmp16	matrix metallopeptidase 16	0.012
Slc13a3	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3	0.012
Has1	hyaluronan synthase1	0.012
Slurp1	secreted Ly6/Plaur domain containing 1	0.012
Ucp3	uncoupling protein 3 (mitochondrial, proton carrier)	0.012
Epas1	endothelial PAS domain protein 1	0.012
Lhx6	LIM homeobox protein 6	0.012
Spock1	sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1	0.012
Nrg2	neuregulin 2	0.012
A230065H16Rik	RIKEN cDNA A230065H16 gene	0.012
Fgf18	fibroblast growth factor 18	0.011
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.011
Kcnh3	potassium voltage-gated channel, subfamily H (eag-related), member 3	0.011
Neurog3	neurogenin 3	0.011
Vstm2b	V-set and transmembrane domain containing 2B	0.011
Oprm1	opioid receptor, mu 1	0.011
Bmp5	bone morphogenetic protein 5	0.011
Bhlha9	basic helix-loop-helix family, member a9	0.011
Aatk	apoptosis-associated tyrosine kinase	0.011
Pcdhb1	protocadherin beta 1	0.011
Gpr26	G protein-coupled receptor 26	0.011
Rel	reticuloendotheliosis oncogene	0.011
Ucn3	urocortin 3	0.011
Arc	activity regulated cytoskeletal-associated protein	0.011
Ednrb	endothelin receptor type B	0.011
Calb2	calbindin 2	0.011
4930451I11Rik	RIKEN cDNA 4930451I11 gene	0.011
Slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.011
Mpl	myeloproliferative leukemia virus oncogene	0.011
Ppara	peroxisome proliferator activated receptor alpha	0.011
Nppb	natriuretic peptide type B	0.011
Slc32a1	solute carrier family 32 (GABA vesicular transporter), member 1	0.011
Gzmm	granzyme M (lymphocyte met-ase 1)	0.011
Sema6d	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	0.011
Mc2r	melanocortin 2 receptor	0.011
Zfp92	zinc finger protein 92	0.011
Rya3	antimicrobial peptide RYA3	0.011
Igsf1	immunoglobulin superfamily, member 1	0.011
Chrm4	cholinergic receptor, muscarinic 4	0.011
Otof	otoferlin	0.011
Slc6a1	solute carrier family 6 (neurotransmitter transporter, GABA), member 1	0.011
Klf2	Kruppel-like factor 2 (lung)	0.011
Rasgrf2	RAS protein-specific guanine nucleotide-releasing factor 2	0.011
Sgcd	sarcoglycan, delta (dystrophin-associated glycoprotein)	0.011
Htr1d	5-hydroxytryptamine (serotonin) receptor 1D	0.010
Notum	notum pectinacetylesterase homolog (Drosophila)	0.010
Astn2	astrotactin 2	0.010
Bcl6b	B-cell CLL/lymphoma 6, member B	0.010
Gpr81	G protein-coupled receptor 81	0.010
Gfra1	glial cell line derived neurotrophic factor family receptor alpha 1	0.010
Tmem116	transmembrane protein 116	0.010
Uts2r	urotensin 2 receptor	0.010
Ncs1	neuronal calcium sensor 1	0.010
C1ql1	complement component 1, q subcomponent-like 1	0.010
Gpr165	G protein-coupled receptor 165	0.010
Slc7a2	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	0.010
Cacng7	calcium channel, voltage-dependent, gamma subunit 7	0.010
Syt17	synaptotagmin XVII	0.010
Adra1a	adrenergic receptor, alpha 1a	0.010
Nxph2	neurexophilin 2	0.010
Sp7	Sp7 transcription factor 7	0.010
Grik2	glutamate receptor, ionotropic, kainate 2 (beta 2)	0.010
Cdk5r2	cyclin-dependent kinase 5, regulatory subunit 2 (p39)	0.010
Cyp2b10	cytochrome P450, family 2, subfamily b, polypeptide 10	0.010
Cacna1e	calcium channel, voltage-dependent, R type, alpha 1E subunit	0.010
Aff2	AF4/FMR2 family, member 2	0.010
Aanat	arylalkylamine N-acetyltransferase	0.010
Pdx1	pancreatic and duodenal homeobox 1	0.010
Slc16a11	solute carrier family 16 (monocarboxylic acid transporters), member 11	0.010
Tnn	tenascin N	0.010
4921517D21Rik	RIKEN cDNA 4921517D21 gene	0.010
Ryr3	ryanodine receptor 3	0.010
Ptprt	protein tyrosine phosphatase, receptor type, T	0.010
Onecut1	one cut domain, family member 1	0.010