IMP

Process View

Mus musculus

4 genes annotated in mouse

Multi-species View

negative regulation of mast cell degranulation

GO:0043305

Any process that stops, prevents, or reduces the rate of mast cell degranulation.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of mast cell degranulation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of mast cell degranulation" (in gray)

Name	Description	Probability	Func Analog Organism
Mefv	Mediterranean fever	0.939
Pilrb1	paired immunoglobin-like type 2 receptor beta 1	0.584
Trem3	triggering receptor expressed on myeloid cells 3	0.556
Csf3r	colony stimulating factor 3 receptor (granulocyte)	0.484
Lgr4	leucine-rich repeat-containing G protein-coupled receptor 4	0.458
Pilra	paired immunoglobin-like type 2 receptor alpha	0.425
Dok3	docking protein 3	0.416
Mb	myoglobin	0.314
Fcgr4	Fc receptor, IgG, low affinity IV	0.311
Siglece	sialic acid binding Ig-like lectin E	0.301
Cd33	CD33 antigen	0.231
Il1f9	interleukin 1 family, member 9	0.195
Cd300ld	CD300 molecule-like family member d	0.177	Mouse
Nfam1	Nfat activating molecule with ITAM motif 1	0.163
Trpv1	transient receptor potential cation channel, subfamily V, member 1	0.162
Cd300a	CD300A antigen	0.157
Irg1	immunoresponsive gene 1	0.154
Csf2rb2	colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)	0.146
Slc11a1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	0.145
Fgr	Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog	0.139
Slamf8	SLAM family member 8	0.125
Clec4d	C-type lectin domain family 4, member d	0.122
Apoc2	apolipoprotein C-II	0.122
Msr1	macrophage scavenger receptor 1	0.121
Clec5a	C-type lectin domain family 5, member a	0.120
Lair1	leukocyte-associated Ig-like receptor 1	0.117
Clec7a	C-type lectin domain family 7, member a	0.117
Trem1	triggering receptor expressed on myeloid cells 1	0.115
Fpr1	formyl peptide receptor 1	0.104
Il1rn	interleukin 1 receptor antagonist	0.095
Cd300lb	CD300 antigen like family member B	0.094	Mouse
Clec4a2	C-type lectin domain family 4, member a2	0.094
Il1b	interleukin 1 beta	0.087
Klra2	killer cell lectin-like receptor, subfamily A, member 2	0.086
1810033B17Rik	RIKEN cDNA 1810033B17 gene	0.083
Clec4n	C-type lectin domain family 4, member n	0.080
AF251705	cDNA sequence AF251705	0.077	Mouse
C130050O18Rik	RIKEN cDNA C130050O18 gene	0.077
Slpi	secretory leukocyte peptidase inhibitor	0.074
Nlrp3	NLR family, pyrin domain containing 3	0.072
Emr4	EGF-like module containing, mucin-like, hormone receptor-like sequence 4	0.071
Tifab	TRAF-interacting protein with forkhead-associated domain, family member B	0.069
Tlr8	toll-like receptor 8	0.067
Igsf6	immunoglobulin superfamily, member 6	0.067
BC013712	cDNA sequence BC013712	0.065
Sirpb1a	signal-regulatory protein beta 1A	0.055
Cd177	CD177 antigen	0.055
P2ry13	purinergic receptor P2Y, G-protein coupled 13	0.053
Clec4e	C-type lectin domain family 4, member e	0.053
Apobr	apolipoprotein B receptor	0.052
Emr1	EGF-like module containing, mucin-like, hormone receptor-like sequence 1	0.050
Treml4	triggering receptor expressed on myeloid cells-like 4	0.048
Mmp8	matrix metallopeptidase 8	0.046
Tbxas1	thromboxane A synthase 1, platelet	0.044
Snx20	sorting nexin 20	0.041
Pax6	paired box gene 6	0.039
Niacr1	niacin receptor 1	0.039
Sfpi1	SFFV proviral integration 1	0.038
F10	coagulation factor X	0.038
Gm11428	predicted gene 11428	0.038
Tyrobp	TYRO protein tyrosine kinase binding protein	0.037
Hk3	hexokinase 3	0.037
Marco	macrophage receptor with collagenous structure	0.034
Klra17	killer cell lectin-like receptor, subfamily A, member 17	0.033
Aldh3b1	aldehyde dehydrogenase 3 family, member B1	0.033
Fpr2	formyl peptide receptor 2	0.032
Gpr35	G protein-coupled receptor 35	0.030
Tcfec	transcription factor EC	0.030
Plaur	plasminogen activator, urokinase receptor	0.028
Cd84	CD84 antigen	0.028
4833422F24Rik	RIKEN cDNA 4833422F24 gene	0.028
Cd5l	CD5 antigen-like	0.026
Runx1t1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	0.025
Gpr84	G protein-coupled receptor 84	0.025
Pira2	paired-Ig-like receptor A2	0.025
Ms4a8a	membrane-spanning 4-domains, subfamily A, member 8A	0.025
U46068	cDNA sequence U46068	0.025
Il1a	interleukin 1 alpha	0.024
Il2	interleukin 2	0.024
Bmp4	bone morphogenetic protein 4	0.023
Ly86	lymphocyte antigen 86	0.023
Slc15a3	solute carrier family 15, member 3	0.022
Csf2rb	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.021
Tlr13	toll-like receptor 13	0.021
Siglec1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.021
Cxcr2	chemokine (C-X-C motif) receptor 2	0.020
Pik3ap1	phosphoinositide-3-kinase adaptor protein 1	0.020
LOC100038947	signal-regulatory protein beta 1-like	0.020
Adamdec1	ADAM-like, decysin 1	0.020
Batf2	basic leucine zipper transcription factor, ATF-like 2	0.020
AI447881	expressed sequence AI447881	0.019
Hcst	hematopoietic cell signal transducer	0.019
Tnfsf14	tumor necrosis factor (ligand) superfamily, member 14	0.019
Parvg	parvin, gamma	0.019
P2ry12	purinergic receptor P2Y, G-protein coupled 12	0.019
Fcgr1	Fc receptor, IgG, high affinity I	0.019
Abcg3	ATP-binding cassette, sub-family G (WHITE), member 3	0.018
Meox2	mesenchyme homeobox 2	0.018
Cd200r1	CD200 receptor 1	0.018
Ccl9	chemokine (C-C motif) ligand 9	0.017
Cyp4f18	cytochrome P450, family 4, subfamily f, polypeptide 18	0.017
Ccl4	chemokine (C-C motif) ligand 4	0.017
Ly6i	lymphocyte antigen 6 complex, locus I	0.017
Kcnk13	potassium channel, subfamily K, member 13	0.016
Vnn3	vanin 3	0.016
Tnfaip8l2	tumor necrosis factor, alpha-induced protein 8-like 2	0.016
Tff2	trefoil factor 2 (spasmolytic protein 1)	0.016
Pram1	PML-RAR alpha-regulated adaptor molecule 1	0.016
Oasl1	2'-5' oligoadenylate synthetase-like 1	0.015
Cxcl1	chemokine (C-X-C motif) ligand 1	0.015
Clec4b1	C-type lectin domain family 4, member b1	0.015
Expi	extracellular proteinase inhibitor	0.015
Mrgpra2a	MAS-related GPR, member A2A	0.015
Gda	guanine deaminase	0.015
Snai1	snail homolog 1 (Drosophila)	0.015
Pdcd1lg2	programmed cell death 1 ligand 2	0.015
Ncf1	neutrophil cytosolic factor 1	0.015
Saa3	serum amyloid A 3	0.015
Oas3	2'-5' oligoadenylate synthetase 3	0.015
Ccl7	chemokine (C-C motif) ligand 7	0.014
Ifitm6	interferon induced transmembrane protein 6	0.014
Havcr2	hepatitis A virus cellular receptor 2	0.014
F7	coagulation factor VII	0.014
Trem2	triggering receptor expressed on myeloid cells 2	0.014	Mouse
Osm	oncostatin M	0.014
Naip6	NLR family, apoptosis inhibitory protein 6	0.014
Cd300lf	CD300 antigen like family member F	0.014	Mouse
Csf1r	colony stimulating factor 1 receptor	0.014
Slamf7	SLAM family member 7	0.014
Itgax	integrin alpha X	0.014
Lilrb3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.013
Adam8	a disintegrin and metallopeptidase domain 8	0.013
2210406H18Rik	RIKEN cDNA 2210406H18 gene	0.013
Tmprss2	transmembrane protease, serine 2	0.013
AB124611	cDNA sequence AB124611	0.013
Tnfrsf9	tumor necrosis factor receptor superfamily, member 9	0.013
Zeb1	zinc finger E-box binding homeobox 1	0.012
Fes	feline sarcoma oncogene	0.012
Ehf	ets homologous factor	0.012
Lilrb4	leukocyte immunoglobulin-like receptor, subfamily B, member 4	0.012
Tbx3	T-box 3	0.012
Furin	furin (paired basic amino acid cleaving enzyme)	0.012
Trpm2	transient receptor potential cation channel, subfamily M, member 2	0.012
Aif1	allograft inflammatory factor 1	0.012
Adam28	a disintegrin and metallopeptidase domain 28	0.012
Chi3l1	chitinase 3-like 1	0.012
March1	membrane-associated ring finger (C3HC4) 1	0.012
Fcrla	Fc receptor-like A	0.012
Adap2	ArfGAP with dual PH domains 2	0.012
Fam167b	family with sequence similarity 167, member B	0.012
Reg3g	regenerating islet-derived 3 gamma	0.012
Slamf9	SLAM family member 9	0.012
C5ar1	complement component 5a receptor 1	0.011
1100001G20Rik	RIKEN cDNA 1100001G20 gene	0.011
Pla2g2d	phospholipase A2, group IID	0.011
Clec4a3	C-type lectin domain family 4, member a3	0.011
Cnr2	cannabinoid receptor 2 (macrophage)	0.011
Ms4a6c	membrane-spanning 4-domains, subfamily A, member 6C	0.011
Tlr7	toll-like receptor 7	0.011
Cd53	CD53 antigen	0.011
Mmp12	matrix metallopeptidase 12	0.011
Ncr1	natural cytotoxicity triggering receptor 1	0.011
Cysltr1	cysteinyl leukotriene receptor 1	0.011
Zc3h12d	zinc finger CCCH type containing 12D	0.011
Notch4	Notch gene homolog 4 (Drosophila)	0.011
Lst1	leukocyte specific transcript 1	0.011
Ubd	ubiquitin D	0.011
Gm568	predicted gene 568	0.011
Atp6v0d2	ATPase, H+ transporting, lysosomal V0 subunit D2	0.010
Sirpa	signal-regulatory protein alpha	0.010
Alox5ap	arachidonate 5-lipoxygenase activating protein	0.010
Gpr182	G protein-coupled receptor 182	0.010
Tifa	TRAF-interacting protein with forkhead-associated domain	0.010
Hfe	hemochromatosis	0.010
Mmp19	matrix metallopeptidase 19	0.010
LOC677008	natural killer cell receptor 2B4-like	0.010
Hlx	H2.0-like homeobox	0.010