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Danio rerio

2 genes annotated in zebrafish

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negative regulation of innate immune response

GO:0045824

Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of innate immune response"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of innate immune response" (in gray)

Name	Description	Probability	Func Analog Organism
adra2db	adrenergic, alpha-2D-, receptor b	0.713	Worm
adra2b	adrenergic, alpha-2B-, receptor	0.374	Worm
fabp11a	fatty acid binding protein 11a	0.298
atf3	activating transcription factor 3	0.254
adra2da	adrenergic, alpha-2D-, receptor a	0.151
junb	jun B proto-oncogene	0.151
esr2a	estrogen receptor 2a	0.145
socs3a	suppressor of cytokine signaling 3a	0.131	Zebrafish
jun	jun proto-oncogene	0.122
pth2	parathyroid hormone 2	0.108
nfkbiaa	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a	0.093
ccm2	cerebral cavernous malformation 2	0.088
gadd45bb	growth arrest and DNA-damage-inducible, beta b	0.085
fos	v-fos FBJ murine osteosarcoma viral oncogene homolog	0.085
zgc:64051	zgc:64051	0.081
nkx6.2	NK6 transcription factor related, locus 2	0.079
rag2	recombination activating gene 2	0.075
npy8br	neuropeptide Y receptor Y8b	0.066
junbl	jun B proto-oncogene, like	0.065
vipr2	vasoactive intestinal peptide receptor 2	0.059
aqp12	aquaporin 12	0.059
ahsg	alpha-2-HS-glycoprotein	0.057
stat3	signal transduction and activation of transcription 3	0.055
si:dkey-228g21.4	si:dkey-228g21.4	0.054
adra2a	adrenergic, alpha-2A-, receptor	0.053	Worm
tnfrsfa	tumor necrosis factor receptor superfamily, member a	0.052
mc2r	melanocortin 2 receptor	0.050
gadd45ba	growth arrest and DNA-damage-inducible, beta a	0.050
zgc:153997	zgc:153997	0.049
cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.049
mstnb	myostatin b	0.049
wu:fj82b07	wu:fj82b07	0.048
zgc:92851	zgc:92851	0.047
fosl2	fos-like antigen 2	0.046
gata6	GATA-binding protein 6	0.044
pyya	peptide YYa	0.041
slc6a8	solute carrier family 6 (neurotransmitter transporter, creatine), member 8	0.038
oclna	occludin a	0.036
tlr21	toll-like receptor 21	0.035
cx52.6	connexin 52.6	0.035
abcb3l1	ATP-binding cassette, sub-family B (MDR/TAP), member 3 like 1	0.035
chrm2a	cholinergic receptor, muscarinic 2a	0.034
irf11	interferon regulatory factor 11	0.034
smarca4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.033
si:dkeyp-50f5.1	si:dkeyp-50f5.1	0.031
hgfa	hepatocyte growth factor a	0.030
myh11a	myosin, heavy polypeptide 11, smooth muscle a	0.029
zgc:162213	zgc:162213	0.027
bmpr1aa	bone morphogenetic protein receptor, type 1aa	0.027
egfra	epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	0.027
fbln4	fibulin 4	0.027
yrk	Yes-related kinase	0.027
gb:bm036580	gb:bm036580	0.026
prrc1	proline-rich coiled-coil 1	0.026
esr1	estrogen receptor 1	0.026
tmprss4a	transmembrane protease, serine 4a	0.026
avpl	arginine vasopressin-like	0.026
angptl1	angiopoietin-like 1	0.026
zgc:171553	zgc:171553	0.026
rpl37	ribosomal protein L37	0.025
krit1	KRIT1, ankyrin repeat containing	0.025
si:dkey-222f8.3	si:dkey-222f8.3	0.025
arhgef7b	Rho guanine nucleotide exchange factor (GEF) 7b	0.024
vtg1	vitellogenin 1	0.024
mkrn4	makorin, ring finger protein, 4	0.024
serpinf2	serine (or cysteine) peptidase inhibitor, clade F, member 2	0.024
wu:fj39b01	wu:fj39b01	0.024
serinc2	serine incorporator 2	0.024
mcl1a	myeloid cell leukemia sequence 1a	0.023
tagln	transgelin	0.023
ddx41	DEAD (Asp-Glu-Ala-Asp) box polypeptide 41	0.023
zgc:77744	zgc:77744	0.023
dvl3	dishevelled, dsh homolog 3 (Drosophila)	0.023
oclnb	occludin b	0.022
zgc:101598	zgc:101598	0.022
eppk1	epiplakin 1	0.021
cx55.5	connexin 55.5	0.021
ldb1a	LIM-domain binding factor 1a	0.021
aldh1a3	aldehyde dehydrogenase 1 family, member A3	0.021
mga	MAX gene associated	0.021
asb3	ankyrin repeat and SOCS box-containing 3	0.020
adcyap1r1a	adenylate cyclase activating polypeptide 1 receptor 1a	0.020
sgk1	serum/glucocorticoid regulated kinase 1	0.020
arl4ab	ADP-ribosylation factor-like 4ab	0.020
npy4r	neuropeptide Y receptor Y4	0.020
cebpd	CCAAT/enhancer binding protein (C/EBP), delta	0.019
poldip2	polymerase (DNA-directed), delta interacting protein 2	0.019
LOC567678	avidin-like	0.019
dusp2	dual specificity phosphatase 2	0.019
lipc	lipase, hepatic	0.018
socs3b	suppressor of cytokine signaling 3b	0.018	Zebrafish
dedd1	death effector domain-containing 1	0.018
sb:cb134	sb:cb134	0.018
LOC100000332	e3 ubiquitin-protein ligase RNF182-like	0.018
im:7153552	im:7153552	0.018
fam3c	family with sequence similarity 3, member C	0.018
rtf1	Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.018
vdra	vitamin D receptor a	0.017
elf2b	E74-like factor 2b (ets domain transcription factor)	0.017
slco1f1	solute carrier organic anion transporter family, member 1F1	0.017
sh3gl1b	SH3-domain GRB2-like 1b	0.017
gdnf	glial cell derived neurotrophic factor	0.017
plagl2	pleiomorphic adenoma gene-like 2	0.017
kiss1rb	KISS1 receptor b	0.017
pard6gb	par-6 partitioning defective 6 homolog gamma B (C. elegans)	0.017
duox	dual oxidase	0.016
thap11	THAP domain containing 11	0.016
mep1a.1	meprin A, alpha.1	0.016
cpne1	copine I	0.016
scn1a	sodium channel, voltage-gated, type I, alpha	0.016
map4k5	mitogen-activated protein kinase kinase kinase kinase 5	0.016
c20orf11	c20orf11 homolog (H. sapiens)	0.016
dyrk1aa	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A, a	0.016
gja3	gap junction protein, alpha 3	0.015
ca15a	carbonic anhydrase XV a	0.015
acta2	actin, alpha 2, smooth muscle, aorta	0.015
si:dkey-223d9.2	si:dkey-223d9.2	0.015
pgam5	phosphoglycerate mutase family member 5	0.015
ahr1a	aryl hydrocarbon receptor 1a	0.015
zgc:92086	zgc:92086	0.015
cnnm2a	cyclin M2a	0.015
syce2	synaptonemal complex central element protein 2	0.015
adra2c	adrenergic, alpha-2C-, receptor	0.015
ncoa2	nuclear receptor coactivator 2	0.015
slc2a11l	solute carrier family 2 (facilitated glucose transporter), member 11-like	0.015
zgc:158252	zgc:158252	0.014
npas2	neuronal PAS domain protein 2	0.014
adrb1	adrenergic receptor, beta 1	0.014
igf2bp3	insulin-like growth factor 2 mRNA binding protein 3	0.014
dbh	dopamine beta hydroxylase	0.014
sufu	suppressor of fused homolog (Drosophila)	0.014
si:ch211-89f7.4	si:ch211-89f7.4	0.014
lsr	lipolysis stimulated lipoprotein receptor	0.014
zgc:85882	zgc:85882	0.014
entpd1	ectonucleoside triphosphate diphosphohydrolase 1	0.014
hs6st1a	heparan sulfate 6-O-sulfotransferase 1a	0.014
ncor1	nuclear receptor co-repressor 1	0.014
nupl1	nucleoporin like 1	0.014
zgc:161969	zgc:161969	0.014
cnr1	cannabinoid receptor 1	0.014
foxf1	forkhead box F1	0.014
tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.013
sb:cb429	sb:cb429	0.013
clock	clock	0.013
ctbp1	C-terminal binding protein 1	0.013
ext2	exostoses (multiple) 2	0.013
cxc46	CXC chemokine 46	0.013
rhcgb	Rhesus blood group, C glycoprotein b	0.013
stat5.1	signal transducer and activator of transcription 5.1	0.013
supt6h	suppressor of Ty 6 homolog	0.013
slc39a3	solute carrier family 39 (zinc transporter), member 3	0.013
lass5	LAG1 homolog, ceramide synthase 5 (S. cerevisiae)	0.013
vdrb	vitamin D receptor b	0.013
daxx	death-associated protein 6	0.013
si:ch73-60e21.1	si:ch73-60e21.1	0.013
zgc:110259	zgc:110259	0.013
lratb	lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)	0.013
tdh	L-threonine dehydrogenase	0.013
ikbkg	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.013
cish	cytokine inducible SH2-containing protein	0.013
prpf4b	PRP4 pre-mRNA processing factor 4 homolog B	0.013
bmp15	bone morphogenetic protein 15	0.013
wisp3	WNT1 inducible signaling pathway protein 3	0.012
nr5a5	nuclear receptor subfamily 5, group A, member 5	0.012
kirrela	kin of IRRE like a	0.012
sf3a1	splicing factor 3a, subunit 1	0.012
wu:fa04h02	wu:fa04h02	0.012
stab2	stabilin 2	0.012
zgc:73273	zgc:73273	0.012
pdcd6	programmed cell death 6	0.012
cd22	cd22 molecule	0.012
pias4b	protein inhibitor of activated STAT, 4b	0.012	Zebrafish
prkci	protein kinase C, iota	0.012
zmat2	zinc finger, matrin type 2	0.012
copeb	core promoter element binding protein	0.012
hbegfa	heparin-binding EGF-like growth factor a	0.012
vhl	von Hippel-Lindau tumor suppressor	0.012
slc17a7	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7	0.012
ms4a17a.11	membrane-spanning 4-domains, subfamily A, member 17A.11	0.012
nrbf2	nuclear receptor binding factor 2	0.012
lss	lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)	0.012
cldnd	claudin d	0.012
prdm2b	PR domain containing 2, with ZNF domain b	0.012
c1qc	complement component 1, q subcomponent, C chain	0.012
pygb	phosphorylase, glycogen; brain	0.012
zgc:110340	zgc:110340	0.012
arrdc1a	arrestin domain containing 1a	0.012
rfx1b	regulatory factor X, 1b (influences HLA class II expression)	0.012
bnc1	basonuclin 1	0.012
si:dkeyp-104h9.6	si:dkeyp-104h9.6	0.012
szl	sizzled	0.011
btg4	B-cell translocation gene 4	0.011
zgc:56630	zgc:56630	0.011
irf9	interferon regulatory factor 9	0.011
vipr1	vasoactive intestinal peptide receptor 1	0.011
timp2a	tissue inhibitor of metalloproteinase 2a	0.011
pdcd7	programmed cell death 7	0.011
zgc:110234	zgc:110234	0.011
upf1	upf1 regulator of nonsense transcripts homolog (yeast)	0.011
pdlim1	PDZ and LIM domain 1 (elfin)	0.011
zgc:112211	zgc:112211	0.011
gadd45g	growth arrest and DNA-damage-inducible, gamma	0.011
gatad2a	GATA zinc finger domain containing 2A	0.011
kptn	kaptin (actin binding protein)	0.011
ftsj1	FtsJ homolog 1 (E. coli)	0.011
cstf3	cleavage stimulation factor, 3' pre-RNA, subunit 3	0.011
zgc:77056	zgc:77056	0.011
lamp2	lysosomal membrane glycoprotein 2	0.011
wu:fc69a03	wu:fc69a03	0.011
eaf1	ELL associated factor 1	0.011
slc26a3	solute carrier family 26, member 3	0.011
ubxn7	UBX domain protein 7	0.011
zbtb2b	zinc finger and BTB domain containing 2b	0.011
LOC799612	prolactin 2	0.011
LOC566020	Gig2-like protein DreO	0.011
zgc:66447	zgc:66447	0.011
pcbp2	poly(rC) binding protein 2	0.011
socs1	suppressor of cytokine signaling 1	0.011
xrn1	5'-3' exoribonuclease 1	0.011
slc25a27	solute carrier family 25, member 27	0.011
gabpb2a	GA repeat binding protein, beta 2a	0.011
aqp11	aquaporin 11	0.011
zc3h14	zinc finger CCCH-type containing 14	0.011
timp2b	tissue inhibitor of metalloproteinase 2b	0.011
traf7	TNF receptor-associated factor 7	0.011
lin7c	lin-7 homolog C (C. elegans)	0.011
kiaa0907	KIAA0907 protein	0.011
zgc:92203	zgc:92203	0.011
cmtm6	CKLF-like MARVEL transmembrane domain containing 6	0.011
lsm14aa	LSM14 homolog Aa (SCD6, S. cerevisiae)	0.011
zgc:91985	zgc:91985	0.011
si:ch211-212m21.5	si:ch211-212m21.5	0.011
accs	1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)	0.011
polr2a	polymerase (RNA) II (DNA directed) polypeptide A	0.011
irf5	interferon regulatory factor 5	0.010
tm9sf1	transmembrane 9 superfamily member 1	0.010
zgc:111821	zgc:111821	0.010
ube2i2	ubiquitin-conjugating enzyme E2I2	0.010
hmcn1	hemicentin 1	0.010
drd1	dopamine receptor D1	0.010
zgc:91862	zgc:91862	0.010
erf	Ets2 repressor factor	0.010
dbr1	debranching enzyme homolog 1 (S. cerevisiae)	0.010
frem2a	Fras1 related extracellular matrix protein 2a	0.010
med4	mediator complex subunit 4	0.010
dynll2a	dynein, light chain, LC8-type 2a	0.010
diaph2	diaphanous homolog 2 (Drosophila)	0.010
ptpn21	protein tyrosine phosphatase, non-receptor type 21	0.010
rnd3b	Rho family GTPase 3b	0.010
ghrhrl	growth hormone releasing hormone receptor, like	0.010
sb:cb819	sb:cb819	0.010
angptl2	angiopoietin-like 2	0.010
rltpr	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing	0.010
sqstm1	sequestosome 1	0.010
usp10	ubiquitin specific peptidase 10	0.010
LOC569770	cytochrome c oxidase subunit 8B, mitochondrial-like	0.010
btg2	B-cell translocation gene 2	0.010
stard3	START domain containing 3	0.010
scyl3	SCY1-like 3 (S. cerevisiae)	0.010
si:ch211-159p3.1	si:ch211-159p3.1	0.010
ugt5b4	UDP glucuronosyltransferase 5 family, polypeptide B4	0.010
smad5	MAD homolog 5 (Drosophila)	0.010
ppm1d	protein phosphatase 1D magnesium-dependent, delta isoform	0.010