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Danio rerio

10 genes annotated in zebrafish

negative regulation of endopeptidase activity

Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of endopeptidase activity"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of endopeptidase activity" (in gray)

Name	Description	Probability	Func Analog Organism
igf1ra	insulin-like growth factor 1a receptor	0.606
bhmt	betaine-homocysteine methyltransferase	0.243
notum3	notum 3	0.234
adipoql	adiponectin, C1Q and collagen domain containing, like	0.229	Zebrafish
adipor2	adiponectin receptor 2	0.215
furina	furin (paired basic amino acid cleaving enzyme) a	0.210	Human
fgg	fibrinogen, gamma polypeptide	0.186
bcl2l1	bcl2-like 1	0.164
ppp1r12a	protein phosphatase 1, regulatory (inhibitor) subunit 12A	0.163
igf1rb	insulin-like growth factor 1b receptor	0.139
insrb	insulin receptor b	0.108	Zebrafish
nfkbiab	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b	0.104
wu:fv91b12	wu:fv91b12	0.097
wu:fl55e11	wu:fl55e11	0.093
dcc	deleted in colorectal carcinoma	0.087
shmt2	serine hydroxymethyltransferase 2 (mitochondrial)	0.086
fga	fibrinogen alpha chain	0.080
adipor1b	adiponectin receptor 1b	0.078
ptf1a	pancreas specific transcription factor, 1a	0.073
cdh4	cadherin 4, retinal	0.073
hhip	hedgehog interacting protein	0.072
per2	period homolog 2 (Drosophila)	0.069
ctsba	cathepsin B, a	0.065
rhag	Rhesus blood group-associated glycoprotein	0.063
trim13	tripartite motif-containing 13	0.062
hgfb	hepatocyte growth factor b	0.062
itih2	inter-alpha (globulin) inhibitor H2	0.061
rnasel1	ribonuclease like 1	0.060
bbc3	BCL2 binding component 3	0.059
zgc:56530	zgc:56530	0.059	Human
LOC569045	novel protein similar to vertebrate WD repeat domain 44 (WDR44)	0.058
ncoa2	nuclear receptor coactivator 2	0.055
ldb1a	LIM-domain binding factor 1a	0.054
nphs1l	nephrosis 1, congenital, Finnish type (nephrin)-like	0.053
adipoql2	adiponectin, C1Q and collagen domain containing, like 2	0.053	Zebrafish
arhgef7b	Rho guanine nucleotide exchange factor (GEF) 7b	0.052
sulf2l	sulfatase 2, like	0.052
pklr	pyruvate kinase, liver and RBC	0.050
pcsk5b	proprotein convertase subtilisin/kexin type 5b	0.048
elovl5	ELOVL family member 5, elongation of long chain fatty acids (yeast)	0.047
ihha	Indian hedgehog homolog a	0.044
LOC562316	klotho-like	0.043
ghra	growth hormone receptor a	0.043
lmx1b.2	LIM homeobox transcription factor 1, beta 2	0.039
mcl1b	myeloid cell leukemia sequence 1b	0.039
nrg1	neuregulin 1	0.037
sall1a	sal-like 1a (Drosophila)	0.037
oc90	otoconin 90	0.037
ces2	carboxylesterase 2 (intestine, liver)	0.036
ascl1a	achaete-scute complex-like 1a (Drosophila)	0.035
vwf	von Willebrand factor	0.034
wnt2bb	wingless-type MMTV integration site family, member 2Bb	0.034
glmna	glomulin, FKBP associated protein a	0.033
wtip	Wilms tumor 1 interacting protein	0.033
mst1	macrophage stimulating 1 (hepatocyte growth factor-like)	0.032
zbtb4	zinc finger and BTB domain containing 4	0.032
barx1	BarH-like homeobox 1	0.031
lmx1b.1	LIM homeobox transcription factor 1, beta 1	0.031
zgc:85866	zgc:85866	0.031
ccm2	cerebral cavernous malformation 2	0.030
plg	plasminogen	0.030
dlb	deltaB	0.030
fcho2	FCH domain only 2	0.029
cp	ceruloplasmin	0.028
eng2a	engrailed 2a	0.028
pyya	peptide YYa	0.028
slc2a1b	solute carrier family 2 (facilitated glucose transporter), member 1b	0.027
sepp1b	selenoprotein P, plasma, 1b	0.027
cntfr	ciliary neurotrophic factor receptor	0.027
ptgs1	prostaglandin-endoperoxide synthase 1	0.027
crybb1	crystallin, beta B1	0.026
met	met proto-oncogene (hepatocyte growth factor receptor)	0.025
atic	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	0.025
nr5a1b	nuclear receptor subfamily 5, group A, member 1b	0.025
crygmxl2	crystallin, gamma MX, like 2	0.025
nf1a	neurofibromin 1a	0.024
bmp15	bone morphogenetic protein 15	0.024
LOC566708	FL cytokine receptor-like	0.024
mdm2	transformed 3T3 cell double minute 2 homolog (mouse)	0.024
cyp19a1a	cytochrome P450, family 19, subfamily A, polypeptide 1a	0.024
vtg1	vitellogenin 1	0.023
foxe3	forkhead box E3	0.023
pmaip1	phorbol-12-myristate-13-acetate-induced protein 1	0.023
olfm2	olfactomedin 2	0.022
hp	haptoglobin	0.022
henmt1	HEN1 methyltransferase homolog 1 (Arabidopsis)	0.022
cldng	claudin g	0.022
LOC100000332	e3 ubiquitin-protein ligase RNF182-like	0.022
tomm22	translocase of outer mitochondrial membrane 22 homolog (yeast)	0.022
baxa	bcl2-associated X protein, a	0.022	Zebrafish
bmpr1ab	bone morphogenetic protein receptor, type 1ab	0.022
bcl2l10	BCL2-like 10 (apoptosis facilitator)	0.021
neu4	sialidase 4	0.021
sardh	sarcosine dehydrogenase	0.021
slc7a6	solute carrier family 7 (cationic amino acid transporter, y+ system), member 6	0.021
furinb	furin (paired basic amino acid cleaving enzyme) b	0.021	Human
midn	midnolin	0.020
si:ch211-106h4.12	si:ch211-106h4.12	0.020
apom	apolipoprotein M	0.020
dusp5	dual specificity phosphatase 5	0.020
aplp2	amyloid beta (A4) precursor-like protein 2	0.019
calcr	calcitonin receptor	0.019
suclg1	succinate-CoA ligase, GDP-forming, alpha subunit	0.019
usp5	ubiquitin specific protease 5	0.019
smyd3	SET and MYND domain containing 3	0.019
gulp1	GULP, engulfment adaptor PTB domain containing 1	0.019
rxrbb	retinoid x receptor, beta b	0.019
igf2a	insulin-like growth factor 2a	0.019
atoh7	atonal homolog 7	0.018
cish	cytokine inducible SH2-containing protein	0.018
fgfr2	fibroblast growth factor receptor 2	0.018
nr4a3	nuclear receptor subfamily 4, group A, member 3	0.018
ela3l	elastase 3 like	0.018
arl6	ADP-ribosylation factor-like 6	0.018
sod2	superoxide dismutase 2, mitochondrial	0.018
diexf	digestive organ expansion factor homolog	0.018
hsp70	heat shock cognate 70-kd protein	0.017
LOC564872	monocarboxylate transporter 7-like	0.017
gip	gastric inhibitory polypeptide	0.017
cntn2	contactin 2	0.017
angptl2	angiopoietin-like 2	0.017
fgf22	fibroblast growth factor 22	0.016
hsf4	heat shock transcription factor 4	0.016
rspo1	R-spondin homolog (Xenopus laevis)	0.016
rag2	recombination activating gene 2	0.016
idh1	isocitrate dehydrogenase 1 (NADP+), soluble	0.016
cyp11a1	cytochrome P450, subfamily XIA, polypeptide 1	0.016
fbp1b	fructose-1,6-bisphosphatase 1b	0.015
lctla	lactase-like a	0.015
frem1a	Fras1 related extracellular matrix 1a	0.015
slmo2	slowmo homolog 2 (Drosophila)	0.015
brd2a	bromodomain-containing 2a	0.015
cdkn1a	cyclin-dependent kinase inhibitor 1A	0.015
akt2l	v-akt murine thymoma viral oncogene homolog 2, like	0.015	Rat
bactin1	bactin1	0.015
twf1a	twinfilin, actin-binding protein, homolog 1a	0.015
dzip1	DAZ interacting protein 1	0.015
tmie	transmembrane inner ear	0.015
mcl1a	myeloid cell leukemia sequence 1a	0.015
tp53bp2	tumor protein p53 binding protein, 2	0.015
s1pr2	sphingosine-1-phosphate receptor 2	0.014
neu3.3	sialidase 3.3	0.014
pdlim3b	PDZ and LIM domain 3b	0.014
neu3.2	sialidase 3.2	0.014
idh3b	isocitrate dehydrogenase 3 (NAD+) beta	0.014
numbl	numb homolog (Drosophila)-like	0.014
copeb	core promoter element binding protein	0.014
mst1rb	macrophage stimulating 1 receptor (c-met-related tyrosine kinase), b	0.014
chac1	ChaC, cation transport regulator-like 1	0.014
tax1bp3	Tax1 (human T-cell leukemia virus type I) binding protein 3	0.014
psmb5	proteasome (prosome, macropain) subunit, beta type, 5	0.014
rdh1	retinol dehydrogenase 1	0.014
ahi1	Abelson helper integration site 1	0.014
gro1	groucho 1	0.014
rorca	RAR-related orphan receptor C a	0.014
gpt2	glutamic pyruvate transaminase (alanine aminotransferase) 2	0.014
sst2	somatostatin 2	0.013
ripk2	receptor-interacting serine-threonine kinase 2	0.013
esd	esterase D/formylglutathione hydrolase	0.013
apoc2	apolipoprotein C-II	0.013
aqp12	aquaporin 12	0.013
kif5aa	kinesin family member 5A, a	0.013
appb	amyloid beta (A4) precursor protein b	0.013	Human
fos	v-fos FBJ murine osteosarcoma viral oncogene homolog	0.013
c9	complement component 9	0.013
crabp1a	cellular retinoic acid binding protein 1a	0.013
sox9b	SRY-box containing gene 9b	0.013
cldn15a	claudin 15a	0.013
tp73	tumor protein p73	0.013
pdlim4	PDZ and LIM domain 4	0.012
and1	actinodin1	0.012
si:ch211-173b8.2	si:ch211-173b8.2	0.012
masp2	mannan-binding lectin serine peptidase 2	0.012
ubin	ataxin-1 ubiquitin-like interacting protein	0.012
mpp6b	membrane protein, palmitoylated 6b (MAGUK p55 subfamily member 6)	0.012
sema6d	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	0.012
bag6	BCL2-associated athanogene 6	0.012
mipa	major intrinsic protein of lens fiber a	0.012
ada	adenosine deaminase	0.012
vdra	vitamin D receptor a	0.012
dab1a	disabled homolog 1a (Drosophila)	0.012
ptger4b	prostaglandin E receptor 4 (subtype EP4) b	0.012
adrb3a	adrenergic receptor, beta 3a	0.012
plrg1	pleiotropic regulator 1	0.012
kcmf1	potassium channel modulatory factor 1	0.012
aida	axin interaction partner and dorsalization antagonist	0.012
prickle1b	prickle homolog 1 (Drosophila) b	0.012
LOC796447	hypothetical protein LOC796447	0.012
zgc:101723	zgc:101723	0.012
nfkbiaa	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a	0.012
cfl2l	cofilin 2, like	0.011
ahrra	aryl-hydrocarbon receptor repressor a	0.011
csnk1a1	casein kinase 1, alpha 1	0.011
cldn15lb	claudin 15-like b	0.011
ube2q2	ubiquitin-conjugating enzyme E2Q family member 2	0.011
sept2	septin 2	0.011
zgc:77714	zgc:77714	0.011
gpx4b	glutathione peroxidase 4b	0.011
caprin1a	cell cycle associated protein 1a	0.011
pitx3	paired-like homeodomain transcription factor 3	0.011
psmd11b	proteasome (prosome, macropain) 216S subunit, non-ATPase, 11b	0.011
wt1b	wilms tumor 1b	0.011
zgc:103710	zgc:103710	0.011
uox	urate oxidase	0.011
cry2a	cryptochrome 2a	0.011
slc24a5	solute carrier family 24, member 5	0.011
itga2b	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B)	0.011
pias4a	protein inhibitor of activated STAT, 4a	0.011
chchd10	coiled-coil-helix-coiled-coil-helix domain containing 10	0.011
bida	BH3 interacting domain death agonist	0.011
nr2f1a	nuclear receptor subfamily 2, group F, member 1a	0.011
vps39	vacuolar protein sorting 39 homolog (S. cerevisiae)	0.011
asl	argininosuccinate lyase	0.011
grin1a	glutamate receptor, ionotropic, N-methyl D-aspartate 1a	0.010
zgc:110105	zgc:110105	0.010
scd	stearoyl-CoA desaturase (delta-9-desaturase)	0.010
tgif1	TGFB-induced factor homeobox 1	0.010
map2k4a	mitogen-activated protein kinase kinase 4a	0.010
gtpbp1l	GTP binding protein 1, like	0.010
zgc:152830	zgc:152830	0.010
cebpd	CCAAT/enhancer binding protein (C/EBP), delta	0.010
ptprk	protein tyrosine phosphatase, receptor type, K	0.010
zgc:56466	zgc:56466	0.010
stc1l	stanniocalcin 1, like	0.010
zgc:56518	zgc:56518	0.010
ifnphi1	interferon phi 1	0.010
neo1	neogenin 1	0.010
zgc:171674	zgc:171674	0.010