The network for 'positive regulation of immunoglobulin mediated immune response' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of immunoglobulin mediated immune response

Any process that activates or increases the frequency, rate, or extent of an immunoglobulin mediated immune response.

Homo sapiens
Name Description Probability Func Analog Organism
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 1.000
IL4R interleukin 4 receptor 1.000
SYK spleen tyrosine kinase 0.996
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.991
PVRL4 poliovirus receptor-related 4 0.989
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.975
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.958
PVRL3 poliovirus receptor-related 3 0.949
GRAP2 GRB2-related adaptor protein 2 0.914
TRAF3 TNF receptor-associated factor 3 0.878
ENG endoglin 0.855
LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.810
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 0.766
MDC1 mediator of DNA-damage checkpoint 1 0.755
H2AFX H2A histone family, member X 0.749
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C) 0.570
TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) 0.491
IL2RG interleukin 2 receptor, gamma 0.459
TP53BP1 tumor protein p53 binding protein 1 0.425
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 0.397
NCOA6 nuclear receptor coactivator 6 0.349
TJP1 tight junction protein 1 (zona occludens 1) 0.348
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila) 0.338
FSTL1 follistatin-like 1 0.315
CFH complement factor H 0.314
TGFBR1 transforming growth factor, beta receptor 1 0.308
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.246
FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.246
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 0.231
EPHB3 EPH receptor B3 0.192
SMC1A structural maintenance of chromosomes 1A 0.192
CD80 CD80 molecule 0.183
TNFRSF17 tumor necrosis factor receptor superfamily, member 17 0.180
IL4 interleukin 4 0.174
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 0.156
C16orf53 chromosome 16 open reading frame 53 0.155
THBS1 thrombospondin 1 0.151
TGFB3 transforming growth factor, beta 3 0.141
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D 0.140
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.128
LMO2 LIM domain only 2 (rhombotin-like 1) 0.118
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.115
NCAPD3 non-SMC condensin II complex, subunit D3 0.112
NOM1 nucleolar protein with MIF4G domain 1 0.106
MRAS muscle RAS oncogene homolog 0.106
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.106
TYROBP TYRO protein tyrosine kinase binding protein 0.104
UBASH3B ubiquitin associated and SH3 domain containing B 0.102
PLEK pleckstrin 0.094
MMP9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) 0.093
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.092
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 0.085
CFI complement factor I 0.084
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B) 0.081
CD163 CD163 molecule 0.080
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.075
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.070
TRAF5 TNF receptor-associated factor 5 0.070
RBBP5 retinoblastoma binding protein 5 0.068
MS4A1 membrane-spanning 4-domains, subfamily A, member 1 0.066
CFB complement factor B 0.061
CD22 CD22 molecule 0.060
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.059
EPHB2 EPH receptor B2 0.056
SLAMF1 signaling lymphocytic activation molecule family member 1 0.051
CD53 CD53 molecule 0.051
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) 0.050
TMEM173 transmembrane protein 173 0.049
AR androgen receptor 0.049
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.048
C3AR1 complement component 3a receptor 1 0.046
ATM ataxia telangiectasia mutated 0.046
IRF4 interferon regulatory factor 4 0.046
LST1 leukocyte specific transcript 1 0.043
NCAPG2 non-SMC condensin II complex, subunit G2 0.043
LMNB1 lamin B1 0.042
ILF3 interleukin enhancer binding factor 3, 90kDa 0.041
EPHA7 EPH receptor A7 0.040
KNTC1 kinetochore associated 1 0.040
NRP1 neuropilin 1 0.039
BLNK B-cell linker 0.038
IGSF6 immunoglobulin superfamily, member 6 0.038
TMEM194A transmembrane protein 194A 0.038
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 0.037
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.036
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene) 0.036
VSIG4 V-set and immunoglobulin domain containing 4 0.035
TLR1 toll-like receptor 1 0.034
CD14 CD14 molecule 0.033
EPHB6 EPH receptor B6 0.032
SART3 squamous cell carcinoma antigen recognized by T cells 3 0.032
FGL2 fibrinogen-like 2 0.032
GPR65 G protein-coupled receptor 65 0.032
CD40 CD40 molecule, TNF receptor superfamily member 5 0.032
CD48 CD48 molecule 0.031
C1S complement component 1, s subcomponent 0.031
MPHOSPH9 M-phase phosphoprotein 9 0.031
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.030
MLL2 myeloid/lymphoid or mixed-lineage leukemia 2 0.030
PILRA paired immunoglobin-like type 2 receptor alpha 0.030
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Cd40 CD40 antigen 0.956
Igh immunoglobulin heavy chain complex 0.938
Tnf tumor necrosis factor 0.935
Il10 interleukin 10 0.935
Lyz2 lysozyme 2 0.863
Lta lymphotoxin A 0.850
Il4 interleukin 4 0.811
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.757
Ifng interferon gamma 0.734
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.732
Ccr1 chemokine (C-C motif) receptor 1 0.631
Il6 interleukin 6 0.615
Foxp3 forkhead box P3 0.563
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.485
Cd28 CD28 antigen 0.466
Ptprc protein tyrosine phosphatase, receptor type, C 0.403
Il2 interleukin 2 0.367
Icos inducible T-cell co-stimulator 0.363
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.349
Cd19 CD19 antigen 0.308
Clec4n C-type lectin domain family 4, member n 0.295
Tcra T-cell receptor alpha chain 0.248
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.245
Clec4d C-type lectin domain family 4, member d 0.226
Ccl2 chemokine (C-C motif) ligand 2 0.223
Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 0.218
Cxcl13 chemokine (C-X-C motif) ligand 13 0.212
Ikzf1 IKAROS family zinc finger 1 0.204
Il2rg interleukin 2 receptor, gamma chain 0.202
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.194
Cxcr5 chemokine (C-X-C motif) receptor 5 0.179
Socs1 suppressor of cytokine signaling 1 0.158
Fyn Fyn proto-oncogene 0.158
Stat5b signal transducer and activator of transcription 5B 0.156
Ccl12 chemokine (C-C motif) ligand 12 0.141
Ltb lymphotoxin B 0.138
Ccr7 chemokine (C-C motif) receptor 7 0.136
Pdcd1 programmed cell death 1 0.128
Il1b interleukin 1 beta 0.127
Il1r1 interleukin 1 receptor, type I 0.124
Prf1 perforin 1 (pore forming protein) 0.123
Batf basic leucine zipper transcription factor, ATF-like 0.116
Il4ra interleukin 4 receptor, alpha 0.115
Stat5a signal transducer and activator of transcription 5A 0.111
Pitx1 paired-like homeodomain transcription factor 1 0.105
C3 complement component 3 0.098
Lck lymphocyte protein tyrosine kinase 0.097
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.096
Il2rb interleukin 2 receptor, beta chain 0.092
Folr2 folate receptor 2 (fetal) 0.092
Tyrobp TYRO protein tyrosine kinase binding protein 0.088
Ccl9 chemokine (C-C motif) ligand 9 0.083
Ccr6 chemokine (C-C motif) receptor 6 0.075
Cd6 CD6 antigen 0.069
Ccr5 chemokine (C-C motif) receptor 5 0.068
Il7 interleukin 7 0.067
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.067
Inpp5d inositol polyphosphate-5-phosphatase D 0.065
Msr1 macrophage scavenger receptor 1 0.064
Pitx2 paired-like homeodomain transcription factor 2 0.063
Irf9 interferon regulatory factor 9 0.061
Lat linker for activation of T cells 0.059
Ccl7 chemokine (C-C motif) ligand 7 0.059
Cd96 CD96 antigen 0.058
Apoe apolipoprotein E 0.056
Mefv Mediterranean fever 0.055
Rag2 recombination activating gene 2 0.053
Casp1 caspase 1 0.053
Ccl8 chemokine (C-C motif) ligand 8 0.052
Cd209b CD209b antigen 0.052
H2-Ab1 histocompatibility 2, class II antigen A, beta 1 0.051
Cd44 CD44 antigen 0.050
Mmp12 matrix metallopeptidase 12 0.050
Lyz1 lysozyme 1 0.048
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.048
C3ar1 complement component 3a receptor 1 0.045
Tlr2 toll-like receptor 2 0.042
Fasl Fas ligand (TNF superfamily, member 6) 0.042
Ccl22 chemokine (C-C motif) ligand 22 0.042
Ccl3 chemokine (C-C motif) ligand 3 0.041
Selp selectin, platelet 0.040
Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N 0.040
Il6st interleukin 6 signal transducer 0.039
Cd79a CD79A antigen (immunoglobulin-associated alpha) 0.038
Gpr132 G protein-coupled receptor 132 0.037
Fas Fas (TNF receptor superfamily member 6) 0.037
C1qb complement component 1, q subcomponent, beta polypeptide 0.036
Cd8a CD8 antigen, alpha chain 0.035
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.035
Cr2 complement receptor 2 0.034
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.034
Saa3 serum amyloid A 3 0.032
Xcl1 chemokine (C motif) ligand 1 0.032
Ccl6 chemokine (C-C motif) ligand 6 0.031
Ubd ubiquitin D 0.030
Btk Bruton agammaglobulinemia tyrosine kinase 0.030
Vpreb3 pre-B lymphocyte gene 3 0.029
Sh2d2a SH2 domain protein 2A 0.029
Itk IL2-inducible T-cell kinase 0.029
Zap70 zeta-chain (TCR) associated protein kinase 0.028
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Rattus norvegicus
Name Description Probability Func Analog Organism
Cd37 CD37 molecule 0.179
Trim47 tripartite motif-containing 47 0.173
Il1b interleukin 1 beta 0.145
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.126
Tnfrsf14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.121
Cxcr4 chemokine (C-X-C motif) receptor 4 0.112
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.108
Gnai2 guanine nucleotide binding protein (G protein), alpha inhibiting 2 0.097
Cd247 Cd247 molecule 0.091
Fga fibrinogen alpha chain 0.090
Apol3 apolipoprotein L, 3 0.074
Casp1 caspase 1 0.070
Spn sialophorin 0.068
Psgb1 pregnancy-specific beta 1-glycoprotein 0.067
Ncf1 neutrophil cytosolic factor 1 0.060
Ptafr platelet-activating factor receptor 0.058
Myh9 myosin, heavy chain 9, non-muscle 0.057
Ctse cathepsin E 0.055
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.055
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.054
RT1-Db1 RT1 class II, locus Db1 0.052
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.052
Gja4 gap junction protein, alpha 4 0.050
Hck hemopoietic cell kinase 0.050
Bin2 bridging integrator 2 0.049
Psd4 pleckstrin and Sec7 domain containing 4 0.043
LOC305103 cell surface glycoprotein gp42 0.041
Scamp2 secretory carrier membrane protein 2 0.040
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.039
Ccl3 chemokine (C-C motif) ligand 3 0.038
Clec9a C-type lectin domain family 9, member a 0.038
Cd53 Cd53 molecule 0.037
Slfn2 schlafen 2 0.036
Ly6c Ly6-C antigen 0.034
Mmp8 matrix metallopeptidase 8 0.034
Socs3 suppressor of cytokine signaling 3 0.034
Plcg2 phospholipase C, gamma 2 0.032
Bcl2l1 Bcl2-like 1 0.030
Ripk3 receptor-interacting serine-threonine kinase 3 0.030
Vom1r93 vomeronasal 1 receptor 93 0.028
Arl5c ADP-ribosylation factor-like 5C 0.028
Psg29 pregnancy-specific glycoprotein 29 0.028
Neurl3 neuralized homolog 3 (Drosophila) 0.028
Il2rb interleukin 2 receptor, beta 0.028
Mca32 mast cell antigen 32 0.028
Ctla2a cytotoxic T lymphocyte-associated protein 2 alpha 0.027
Srgn serglycin 0.027
Nos3 nitric oxide synthase 3, endothelial cell 0.027
Csn1s1 casein alpha s1 0.026
Pou2af1 POU class 2 associating factor 1 0.026
Ppard peroxisome proliferator-activated receptor delta 0.026
Ccl5 chemokine (C-C motif) ligand 5 0.026
Prss2 protease, serine, 2 0.026
S100a8 S100 calcium binding protein A8 0.025
Lepr leptin receptor 0.025
Tnfrsf26 tumor necrosis factor receptor superfamily, member 26 0.025
Tshb thyroid stimulating hormone, beta 0.024
Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 0.024
Itih4 inter alpha-trypsin inhibitor, heavy chain 4 0.024
Kmo kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 0.024
Il1a interleukin 1 alpha 0.024
Gzmb granzyme B 0.023
Fam26f family with sequence similarity 26, member F 0.023
Itgal integrin, alpha L 0.023
Havcr1 hepatitis A virus cellular receptor 1 0.023
Eng endoglin 0.023
Ptprc protein tyrosine phosphatase, receptor type, C 0.023
Il2rg interleukin 2 receptor, gamma 0.023
Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.023
Slc15a3 solute carrier family 15, member 3 0.023
Il7r interleukin 7 receptor 0.023
ND4 NADH dehydrogenase subunit 4 0.023
Tek TEK tyrosine kinase, endothelial 0.023
Il4ra interleukin 4 receptor, alpha 0.022
Hbg1 hemoglobin, gamma A 0.022
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.022
Cybb cytochrome b-245, beta polypeptide 0.022
Igsf6 immunoglobulin superfamily, member 6 0.022
Hes2 hairy and enhancer of split 2 (Drosophila) 0.021
Sdc1 syndecan 1 0.021
RT1-N3 RT1 class Ib, locus N3 0.021
Ccl4 chemokine (C-C motif) ligand 4 0.020
Prkch protein kinase C, eta 0.020
Epha2 Eph receptor A2 0.020
Tbc1d10c TBC1 domain family, member 10C 0.020
Ets1 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) 0.020
Ltb lymphotoxin beta (TNF superfamily, member 3) 0.020
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.019
Fgfr1 Fibroblast growth factor receptor 1 0.019
Accn5 amiloride-sensitive cation channel 5, intestinal 0.019
Hgf hepatocyte growth factor 0.019
Actg2 actin, gamma 2, smooth muscle, enteric 0.019
Wt1 Wilms tumor 1 0.019
Abi3 ABI family, member 3 0.019
LOC100364854 similar to RIKEN cDNA A430107P09 gene-like 0.019
Sell selectin L 0.018
Ly6b lymphocyte antigen 6 complex, locus B 0.018
Ucp2 uncoupling protein 2 (mitochondrial, proton carrier) 0.018
Rps6ka1 ribosomal protein S6 kinase polypeptide 1 0.018
Emcn endomucin 0.018
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism