The network for 'positive regulation of phospholipase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of phospholipase activity

Any process that increases the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid.

Homo sapiens
Name Description Probability Func Analog Organism
FGF1 fibroblast growth factor 1 (acidic) 1.000
FGFR2 fibroblast growth factor receptor 2 1.000
FGFR1 fibroblast growth factor receptor 1 0.999
ARRB1 arrestin, beta 1 0.960
CCR5 chemokine (C-C motif) receptor 5 0.954
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.926
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.867
CCL2 chemokine (C-C motif) ligand 2 0.768
PLCG1 phospholipase C, gamma 1 0.738
CCL5 chemokine (C-C motif) ligand 5 0.734
CXCL9 chemokine (C-X-C motif) ligand 9 0.712
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.689
CCL4 chemokine (C-C motif) ligand 4 0.659
CTGF connective tissue growth factor 0.641
ARFIP2 ADP-ribosylation factor interacting protein 2 0.588
SPRR2A small proline-rich protein 2A 0.540
FGF7 fibroblast growth factor 7 0.448
ANG angiogenin, ribonuclease, RNase A family, 5 0.411
CCL8 chemokine (C-C motif) ligand 8 0.387
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.355
PTEN phosphatase and tensin homolog 0.326
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.321
RNASE4 ribonuclease, RNase A family, 4 0.271
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.253
VEGFA vascular endothelial growth factor A 0.246
LAT linker for activation of T cells 0.244
MPDZ multiple PDZ domain protein 0.235
FGF10 fibroblast growth factor 10 0.226
PTPRB protein tyrosine phosphatase, receptor type, B 0.223
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.196
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.195
CCL13 chemokine (C-C motif) ligand 13 0.192
CDH5 cadherin 5, type 2 (vascular endothelium) 0.191
SELE selectin E 0.170
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 0.169
CCL19 chemokine (C-C motif) ligand 19 0.169
RLN3 relaxin 3 0.163
DARC Duffy blood group, chemokine receptor 0.142
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.135
ARCN1 archain 1 0.133
CCR7 chemokine (C-C motif) receptor 7 0.131
TMED2 transmembrane emp24 domain trafficking protein 2 0.123
NRP1 neuropilin 1 0.116
IDE insulin-degrading enzyme 0.113
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.112
IL6 interleukin 6 (interferon, beta 2) 0.110
FGFR3 fibroblast growth factor receptor 3 0.089
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c 0.087
SOS1 son of sevenless homolog 1 (Drosophila) 0.085
CCL11 chemokine (C-C motif) ligand 11 0.085
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.082
IL10 interleukin 10 0.077
TIMP3 TIMP metallopeptidase inhibitor 3 0.074
IFNG interferon, gamma 0.072
BCAR1 breast cancer anti-estrogen resistance 1 0.068
IL1B interleukin 1, beta 0.067
VCAM1 vascular cell adhesion molecule 1 0.066
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 0.066
BET1 blocked early in transport 1 homolog (S. cerevisiae) 0.066
GAB1 GRB2-associated binding protein 1 0.062
CCR3 chemokine (C-C motif) receptor 3 0.060
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.058
GHR growth hormone receptor 0.057
CPA3 carboxypeptidase A3 (mast cell) 0.057
FGF2 fibroblast growth factor 2 (basic) 0.056
IL18RAP interleukin 18 receptor accessory protein 0.056
CCR1 chemokine (C-C motif) receptor 1 0.053
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.053
COPB2 coatomer protein complex, subunit beta 2 (beta prime) 0.052
SHB Src homology 2 domain containing adaptor protein B 0.051
STAT4 signal transducer and activator of transcription 4 0.051
PTPRJ protein tyrosine phosphatase, receptor type, J 0.051
CCL7 chemokine (C-C motif) ligand 7 0.050
MAPK10 mitogen-activated protein kinase 10 0.050
CCL3 chemokine (C-C motif) ligand 3 0.049
SPAG9 sperm associated antigen 9 0.049
ADORA3 adenosine A3 receptor 0.048
IL2RB interleukin 2 receptor, beta 0.047
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 0.047
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.047
CXCL13 chemokine (C-X-C motif) ligand 13 0.046
CCL22 chemokine (C-C motif) ligand 22 0.044
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.043
CLN3 ceroid-lipofuscinosis, neuronal 3 0.040
HPGDS hematopoietic prostaglandin D synthase 0.039
ARF4 ADP-ribosylation factor 4 0.038
AKT2 v-akt murine thymoma viral oncogene homolog 2 0.038
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.037
NKG7 natural killer cell group 7 sequence 0.035
CXCL10 chemokine (C-X-C motif) ligand 10 0.035
FRS2 fibroblast growth factor receptor substrate 2 0.034
SLA Src-like-adaptor 0.034
CCR4 chemokine (C-C motif) receptor 4 0.033
KLRD1 killer cell lectin-like receptor subfamily D, member 1 0.033
ARRDC3 arrestin domain containing 3 0.033
IL7R interleukin 7 receptor 0.032
GNLY granulysin 0.032
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.031
FPR3 formyl peptide receptor 3 0.031
CH25H cholesterol 25-hydroxylase 0.031
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
kdr kinase insert domain receptor (a type III receptor tyrosine kinase) 0.024
fgfr2 fibroblast growth factor receptor 2 0.016
elmo1 engulfment and cell motility 1 (ced-12 homolog, C. elegans) 0.011
sfrp1a secreted frizzled-related protein 1a 0.011
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Fgfr3 fibroblast growth factor receptor 3 0.943
Cbl Casitas B-lineage lymphoma 0.920
Lepr leptin receptor 0.904
Runx2 runt related transcription factor 2 0.848
Fyn Fyn proto-oncogene 0.799
Sox9 SRY-box containing gene 9 0.781
Pten phosphatase and tensin homolog 0.714
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.616
Ctnnb1 catenin (cadherin associated protein), beta 1 0.560
Ren1 renin 1 structural 0.558
Pard3 par-3 (partitioning defective 3) homolog (C. elegans) 0.508
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.503
Prrx1 paired related homeobox 1 0.437
Ctgf connective tissue growth factor 0.410
Ptk2 PTK2 protein tyrosine kinase 2 0.379
Adamts1 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1 0.312
Fgfrl1 fibroblast growth factor receptor-like 1 0.286
Vdr vitamin D receptor 0.283
Ptgs2 prostaglandin-endoperoxide synthase 2 0.235
Gli3 GLI-Kruppel family member GLI3 0.230
Cd247 CD247 antigen 0.226
Csf1 colony stimulating factor 1 (macrophage) 0.226
Tcra T-cell receptor alpha chain 0.219
Ptprc protein tyrosine phosphatase, receptor type, C 0.206
Trp53 transformation related protein 53 0.201
Apc adenomatosis polyposis coli 0.200
Fgfr1 fibroblast growth factor receptor 1 0.191
Tnfrsf11b tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) 0.190
Ikzf1 IKAROS family zinc finger 1 0.174
Dok2 docking protein 2 0.170
Duox2 dual oxidase 2 0.168
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.165
Bmp2 bone morphogenetic protein 2 0.159
Fgf7 fibroblast growth factor 7 0.155
Cyr61 cysteine rich protein 61 0.154
Nos2 nitric oxide synthase 2, inducible 0.153
Blnk B-cell linker 0.151
Jun Jun oncogene 0.149
Prkce protein kinase C, epsilon 0.146
Ldlr low density lipoprotein receptor 0.143
Pdgfb platelet derived growth factor, B polypeptide 0.136
Fgfr4 fibroblast growth factor receptor 4 0.134
Snai1 snail homolog 1 (Drosophila) 0.132
Thbs1 thrombospondin 1 0.131
Cd3d CD3 antigen, delta polypeptide 0.128
Gli2 GLI-Kruppel family member GLI2 0.122
Cybb cytochrome b-245, beta polypeptide 0.118
Acvr1 activin A receptor, type 1 0.115
Foxa2 forkhead box A2 0.109
Bmp4 bone morphogenetic protein 4 0.108
Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 0.108
Il2rg interleukin 2 receptor, gamma chain 0.105
Selp selectin, platelet 0.102
Hcls1 hematopoietic cell specific Lyn substrate 1 0.101
Ptch1 patched homolog 1 0.097
Igf1r insulin-like growth factor I receptor 0.097
Ptpre protein tyrosine phosphatase, receptor type, E 0.096
Bmp5 bone morphogenetic protein 5 0.096
Itgax integrin alpha X 0.094
Aqp2 aquaporin 2 0.094
Lox lysyl oxidase 0.094
Amotl2 angiomotin-like 2 0.094
Nos3 nitric oxide synthase 3, endothelial cell 0.092
Tll1 tolloid-like 0.091
Pthlh parathyroid hormone-like peptide 0.089
Thra thyroid hormone receptor alpha 0.088
Kiss1 KiSS-1 metastasis-suppressor 0.087
Fgfr2 fibroblast growth factor receptor 2 0.087
F3 coagulation factor III 0.083
Thrb thyroid hormone receptor beta 0.076
Umod uromodulin 0.075
Thbs2 thrombospondin 2 0.074
Crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.073
Rarb retinoic acid receptor, beta 0.073
Nkx3-2 NK3 homeobox 2 0.071
Bdkrb1 bradykinin receptor, beta 1 0.070
Cd79a CD79A antigen (immunoglobulin-associated alpha) 0.069
Ncr1 natural cytotoxicity triggering receptor 1 0.069
Tbx3 T-box 3 0.067
Bmpr2 bone morphogenic protein receptor, type II (serine/threonine kinase) 0.067
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.066
Nrp1 neuropilin 1 0.066
Pvrl3 poliovirus receptor-related 3 0.065
Il10ra interleukin 10 receptor, alpha 0.065
Il2rb interleukin 2 receptor, beta chain 0.064
Col12a1 collagen, type XII, alpha 1 0.064
Cmklr1 chemokine-like receptor 1 0.063
Rag1 recombination activating gene 1 0.062
Pgr progesterone receptor 0.062
Vegfa vascular endothelial growth factor A 0.061
Clnk cytokine-dependent hematopoietic cell linker 0.060
Prrx2 paired related homeobox 2 0.060
Plcg2 phospholipase C, gamma 2 0.059
Fcgr1 Fc receptor, IgG, high affinity I 0.059
Nr2f2 nuclear receptor subfamily 2, group F, member 2 0.059
P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 0.058
Lmna lamin A 0.057
Sgpl1 sphingosine phosphate lyase 1 0.057
Gpr97 G protein-coupled receptor 97 0.055
Abl1 c-abl oncogene 1, non-receptor tyrosine kinase 0.055
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Rattus norvegicus
Name Description Probability Func Analog Organism
Gna12 guanine nucleotide binding protein (G protein) alpha 12 0.121
Alb albumin 0.057
Rnase4 ribonuclease, RNase A family 4 0.046
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.039
Fgfr2 fibroblast growth factor receptor 2 0.034
Cd4 Cd4 molecule 0.030
Ahsg alpha-2-HS-glycoprotein 0.027
Rup2 urinary protein 2 0.025
Spp2 secreted phosphoprotein 2 0.025
Akt2 v-akt murine thymoma viral oncogene homolog 2 0.024
Tmed2 transmembrane emp24 domain trafficking protein 2 0.024
Epas1 endothelial PAS domain protein 1 0.019
Phkg1 phosphorylase kinase, gamma 1 0.018
Slc14a2 solute carrier family 14 (urea transporter), member 2 0.017
Foxa1 forkhead box A1 0.016
Hk1 hexokinase 1 0.016
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.015
Pak2 p21 protein (Cdc42/Rac)-activated kinase 2 0.015
Ccr5 chemokine (C-C motif) receptor 5 0.014
Slc22a7 solute carrier family 22 (organic anion transporter), member 7 0.014
Tgfb1 transforming growth factor, beta 1 0.014
Slco2b1 solute carrier organic anion transporter family, member 2b1 0.014
Apoa5 apolipoprotein A-V 0.013
Btg2 BTG family, member 2 0.013
Eef2 eukaryotic translation elongation factor 2 0.013
Map3k3 mitogen activated protein kinase kinase kinase 3 0.012
Gc group specific component 0.012
Gpr116 G protein-coupled receptor 116 0.012
Tgfbr2 transforming growth factor, beta receptor II 0.012
Ms4a2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) 0.012
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.012
Testin testin gene 0.012
Dag1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.012
RGD1564327 similar to integrin alpha 8 0.011
Flt1 FMS-related tyrosine kinase 1 0.011
Grm7 glutamate receptor, metabotropic 7 0.011
Cyp2c13 cytochrome P450, family 2, subfamily c, polypeptide 13 0.011
Mpeg1 macrophage expressed 1 0.011
Serpina3k serine (or cysteine) peptidase inhibitor, clade A, member 3K 0.011
Elovl5 ELOVL family member 5, elongation of long chain fatty acids (yeast) 0.011
Clic4 chloride intracellular channel 4 0.010
Gabrb3 gamma-aminobutyric acid (GABA) A receptor, beta 3 0.010
Gja6 gap junction protein, alpha 6 0.010
Myo1c myosin IC 0.010
Gnb2 guanine nucleotide binding protein (G protein), beta polypeptide 2 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism