The network for 'positive regulation of insulin like growth factor receptor signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of insulin like growth factor receptor signaling pathway

Any process that increases the frequency, rate or extent of insulin-like growth factor receptor signaling.

Homo sapiens
Name Description Probability Func Analog Organism
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 0.978
CTNND1 catenin (cadherin-associated protein), delta 1 0.963
INSR insulin receptor 0.961
GH1 growth hormone 1 0.958
IGF2R insulin-like growth factor 2 receptor 0.908
DSG2 desmoglein 2 0.890
GRB10 growth factor receptor-bound protein 10 0.822
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.809
CSHL1 chorionic somatomammotropin hormone-like 1 0.782
CSH2 chorionic somatomammotropin hormone 2 0.750
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.660
GH2 growth hormone 2 0.649
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.611
ITGB1BP3 integrin beta 1 binding protein 3 0.579
ADAM12 ADAM metallopeptidase domain 12 0.538
DCN decorin 0.537
FZD1 frizzled homolog 1 (Drosophila) 0.502
IGFBP5 insulin-like growth factor binding protein 5 0.459
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.453
JUP junction plakoglobin 0.417
IRS1 insulin receptor substrate 1 0.367
DSP desmoplakin 0.320
COL1A1 collagen, type I, alpha 1 0.274
IRS2 insulin receptor substrate 2 0.253
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.248
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.217
PKP1 plakophilin 1 (ectodermal dysplasia/skin fragility syndrome) 0.208
TF transferrin 0.206
FGF18 fibroblast growth factor 18 0.203
FOXO1 forkhead box O1 0.201
PTPRJ protein tyrosine phosphatase, receptor type, J 0.194
JAK2 Janus kinase 2 0.189
FAF1 Fas (TNFRSF6) associated factor 1 0.164
SFRP1 secreted frizzled-related protein 1 0.163
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit 0.137
LRP6 low density lipoprotein receptor-related protein 6 0.133
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 0.127
TGFA transforming growth factor, alpha 0.120
IHH Indian hedgehog 0.118
KRT14 keratin 14 0.107
MMP11 matrix metallopeptidase 11 (stromelysin 3) 0.095
PTGIS prostaglandin I2 (prostacyclin) synthase 0.093
LBX1 ladybird homeobox 1 0.093
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.090
RAX retina and anterior neural fold homeobox 0.088
FGF3 fibroblast growth factor 3 0.087
WNT1 wingless-type MMTV integration site family, member 1 0.087
NOV nephroblastoma overexpressed gene 0.083
FGF8 fibroblast growth factor 8 (androgen-induced) 0.077
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 0.075
IGF2 insulin-like growth factor 2 (somatomedin A) 0.074
FZD8 frizzled homolog 8 (Drosophila) 0.072
WNT3 wingless-type MMTV integration site family, member 3 0.071
WNT6 wingless-type MMTV integration site family, member 6 0.070
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 0.068
STAT5B signal transducer and activator of transcription 5B 0.068
CXCL14 chemokine (C-X-C motif) ligand 14 0.066
RHBG Rh family, B glycoprotein (gene/pseudogene) 0.064
IGF1R insulin-like growth factor 1 receptor 0.064
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.064
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa 0.063
TCF4 transcription factor 4 0.063
HOXC8 homeobox C8 0.063
TP73 tumor protein p73 0.062
PSEN1 presenilin 1 0.059
PKP2 plakophilin 2 0.059
CHRNA4 cholinergic receptor, nicotinic, alpha 4 0.059
KRT5 keratin 5 0.057
KREMEN2 kringle containing transmembrane protein 2 0.057
G6PC glucose-6-phosphatase, catalytic subunit 0.057
IRX4 iroquois homeobox 4 0.055
HS3ST6 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 0.054
JPH3 junctophilin 3 0.054
HSPG2 heparan sulfate proteoglycan 2 0.054
NDRG1 N-myc downstream regulated 1 0.053
FRMD5 FERM domain containing 5 0.053
FOXD3 forkhead box D3 0.053
PLCG1 phospholipase C, gamma 1 0.052
S1PR5 sphingosine-1-phosphate receptor 5 0.052
KCNJ5 potassium inwardly-rectifying channel, subfamily J, member 5 0.051
SOX21 SRY (sex determining region Y)-box 21 0.051
FBXO11 F-box protein 11 0.049
WIF1 WNT inhibitory factor 1 0.049
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome 0.049
ADRA1D adrenergic, alpha-1D-, receptor 0.048
CRELD2 cysteine-rich with EGF-like domains 2 0.048
HOXB1 homeobox B1 0.048
POU4F3 POU class 4 homeobox 3 0.047
TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) 0.046
ERG v-ets erythroblastosis virus E26 oncogene homolog (avian) 0.046
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.046
NBL1 neuroblastoma, suppression of tumorigenicity 1 0.045
TH tyrosine hydroxylase 0.045
NEUROG2 neurogenin 2 0.045
SOX1 SRY (sex determining region Y)-box 1 0.045
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 0.045
PKP3 plakophilin 3 0.044
KCNQ2 potassium voltage-gated channel, KQT-like subfamily, member 2 0.043
SLC18A3 solute carrier family 18 (vesicular acetylcholine), member 3 0.043
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.043
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
N Notch 0.232
wg wingless 0.060
Aos1 CG12276 gene product from transcript CG12276-RA 0.028
CG6610 CG6610 gene product from transcript CG6610-RA 0.015
SmF Small ribonucleoprotein particle protein SmF 0.013
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Mus musculus
Name Description Probability Func Analog Organism
Esr1 estrogen receptor 1 (alpha) 0.738
Trp63 transformation related protein 63 0.708
Pten phosphatase and tensin homolog 0.689
Trp73 transformation related protein 73 0.508
Trp53 transformation related protein 53 0.470
Emx2 empty spiracles homolog 2 (Drosophila) 0.256
Ghr growth hormone receptor 0.213
Fgfr2 fibroblast growth factor receptor 2 0.182
Ift57 intraflagellar transport 57 homolog (Chlamydomonas) 0.153
Wnt3a wingless-related MMTV integration site 3A 0.152
Col1a1 collagen, type I, alpha 1 0.119
Fcgrt Fc receptor, IgG, alpha chain transporter 0.101
Emx1 empty spiracles homolog 1 (Drosophila) 0.096
Braf Braf transforming gene 0.092
Ltbp4 latent transforming growth factor beta binding protein 4 0.078
Lrp1 low density lipoprotein receptor-related protein 1 0.078
Ar androgen receptor 0.060
Foxo1 forkhead box O1 0.057
Apc adenomatosis polyposis coli 0.057
Sfn stratifin 0.056
Apoe apolipoprotein E 0.056
Lef1 lymphoid enhancer binding factor 1 0.052
Ahr aryl-hydrocarbon receptor 0.052
Prlr prolactin receptor 0.051
Cbl Casitas B-lineage lymphoma 0.050
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.046
Fshr follicle stimulating hormone receptor 0.045
Aebp1 AE binding protein 1 0.045
Otx1 orthodenticle homolog 1 (Drosophila) 0.045
Otx2 orthodenticle homolog 2 (Drosophila) 0.044
Huwe1 HECT, UBA and WWE domain containing 1 0.043
Cdkn2a cyclin-dependent kinase inhibitor 2A 0.040
Pthlh parathyroid hormone-like peptide 0.038
Yap1 yes-associated protein 1 0.036
Rarg retinoic acid receptor, gamma 0.035
Rictor RPTOR independent companion of MTOR, complex 2 0.034
Prelp proline arginine-rich end leucine-rich repeat 0.032
Hoxa13 homeobox A13 0.032
Rxra retinoid X receptor alpha 0.032
Tenc1 tensin like C1 domain-containing phosphatase 0.032
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.030
Nbl1 neuroblastoma, suppression of tumorigenicity 1 0.030
Pitx2 paired-like homeodomain transcription factor 2 0.029
Dcn decorin 0.028
Stat5a signal transducer and activator of transcription 5A 0.025
Nos1 nitric oxide synthase 1, neuronal 0.024
Ift81 intraflagellar transport 81 homolog (Chlamydomonas) 0.024
Rara retinoic acid receptor, alpha 0.024
Gdf10 growth differentiation factor 10 0.024
Timp1 tissue inhibitor of metalloproteinase 1 0.023
Fgfr1 fibroblast growth factor receptor 1 0.023
Slc16a2 solute carrier family 16 (monocarboxylic acid transporters), member 2 0.023
Mdm4 transformed mouse 3T3 cell double minute 4 0.022
Lcor ligand dependent nuclear receptor corepressor 0.022
Tnxb tenascin XB 0.022
Tbx3 T-box 3 0.021
Kit kit oncogene 0.021
Smad3 MAD homolog 3 (Drosophila) 0.020
Pgr progesterone receptor 0.020
Thbs3 thrombospondin 3 0.019
Pou2f1 POU domain, class 2, transcription factor 1 0.018
Insr insulin receptor 0.018
Tcfap2c transcription factor AP-2, gamma 0.018
Pkd1 polycystic kidney disease 1 homolog 0.018
Axl AXL receptor tyrosine kinase 0.018
Pax6 paired box gene 6 0.018
Hhat hedgehog acyltransferase 0.017
Fzd8 frizzled homolog 8 (Drosophila) 0.017
Pikfyve phosphoinositide kinase, FYVE finger containing 0.017
Tyro3 TYRO3 protein tyrosine kinase 3 0.017
En2 engrailed 2 0.017
Zbtb37 zinc finger and BTB domain containing 37 0.017
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.016
Smoc1 SPARC related modular calcium binding 1 0.016
Gas1 growth arrest specific 1 0.016
Cdx2 caudal type homeobox 2 0.016
Gli3 GLI-Kruppel family member GLI3 0.016
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.016
Cep110 centrosomal protein 110 0.016
Ramp2 receptor (calcitonin) activity modifying protein 2 0.015
Mycl1 v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) 0.015
Nf1 neurofibromatosis 1 0.015
Rasip1 Ras interacting protein 1 0.015
Fxyd1 FXYD domain-containing ion transport regulator 1 0.014
Chst8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 0.014
Lrp6 low density lipoprotein receptor-related protein 6 0.014
Igf2 insulin-like growth factor 2 0.014
Tgfb1i1 transforming growth factor beta 1 induced transcript 1 0.014
Mll1 myeloid/lymphoid or mixed-lineage leukemia 1 0.014
Lamb2 laminin, beta 2 0.014
Amhr2 anti-Mullerian hormone type 2 receptor 0.013
Ncor2 nuclear receptor co-repressor 2 0.013
Lamc2 laminin, gamma 2 0.013
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.013
Emp2 epithelial membrane protein 2 0.013
Fbln2 fibulin 2 0.013
Zfp280d zinc finger protein 280D 0.012
Sall4 sal-like 4 (Drosophila) 0.012
Smarcd1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 0.012
Nr6a1 nuclear receptor subfamily 6, group A, member 1 0.012
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism