The network for 'regulation of type i interferon production' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of type i interferon production

Any process that modulates the frequency, rate, or extent of interferon type I production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.

Homo sapiens
Name Description Probability Func Analog Organism
IRAK1 interleukin-1 receptor-associated kinase 1 0.973
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.904
MYD88 myeloid differentiation primary response gene (88) 0.805
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.695
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.650
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.600
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 0.509
SP110 SP110 nuclear body protein 0.494
PILRA paired immunoglobin-like type 2 receptor alpha 0.454
TRIM21 tripartite motif containing 21 0.432
STAT1 signal transducer and activator of transcription 1, 91kDa 0.389
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.324
IRF1 interferon regulatory factor 1 0.322
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 0.313
TBK1 TANK-binding kinase 1 0.280
CYLD cylindromatosis (turban tumor syndrome) 0.279
CHUK conserved helix-loop-helix ubiquitous kinase 0.224
TICAM2 toll-like receptor adaptor molecule 2 0.213
PIAS4 protein inhibitor of activated STAT, 4 0.202
STAT2 signal transducer and activator of transcription 2, 113kDa 0.183
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.179
RANBP3 RAN binding protein 3 0.137
IRF3 interferon regulatory factor 3 0.137
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 0.132
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.129
IRF7 interferon regulatory factor 7 0.120
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.116
BIRC3 baculoviral IAP repeat containing 3 0.107
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.097
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.092
MAVS mitochondrial antiviral signaling protein 0.068
NLRC5 NLR family, CARD domain containing 5 0.066
UBE2D4 ubiquitin-conjugating enzyme E2D 4 (putative) 0.062
ZNF263 zinc finger protein 263 0.062
MED15 mediator complex subunit 15 0.059
TRAF2 TNF receptor-associated factor 2 0.057
TRIM5 tripartite motif containing 5 0.057
SIGLEC7 sialic acid binding Ig-like lectin 7 0.056
CALCOCO2 calcium binding and coiled-coil domain 2 0.055
TRIM39 tripartite motif containing 39 0.051
CDC37 cell division cycle 37 homolog (S. cerevisiae) 0.048
PTAFR platelet-activating factor receptor 0.048
NLRP3 NLR family, pyrin domain containing 3 0.047
CCR1 chemokine (C-C motif) receptor 1 0.046
PARP12 poly (ADP-ribose) polymerase family, member 12 0.044
KAT2B K(lysine) acetyltransferase 2B 0.044
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 0.043
MEFV Mediterranean fever 0.043
TRIM25 tripartite motif containing 25 0.041
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 0.041
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.040
TMEM173 transmembrane protein 173 0.037
TRIM26 tripartite motif containing 26 0.037
IRF9 interferon regulatory factor 9 0.036
IRF2 interferon regulatory factor 2 0.036
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.035
ZNF473 zinc finger protein 473 0.035
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.035
TLR4 toll-like receptor 4 0.033
PML promyelocytic leukemia 0.029
ZNFX1 zinc finger, NFX1-type containing 1 0.029
TYMP thymidine phosphorylase 0.029
TANK TRAF family member-associated NFKB activator 0.029
TRAF6 TNF receptor-associated factor 6 0.028
BRAP BRCA1 associated protein 0.028
TNRC6C trinucleotide repeat containing 6C 0.027
NLRC4 NLR family, CARD domain containing 4 0.025
NOD2 nucleotide-binding oligomerization domain containing 2 0.025
HK3 hexokinase 3 (white cell) 0.025
SPI1 spleen focus forming virus (SFFV) proviral integration oncogene spi1 0.025
FCN1 ficolin (collagen/fibrinogen domain containing) 1 0.025
CD40 CD40 molecule, TNF receptor superfamily member 5 0.024
IRF8 interferon regulatory factor 8 0.023
IFI35 interferon-induced protein 35 0.023
MR1 major histocompatibility complex, class I-related 0.022
CSK c-src tyrosine kinase 0.022
EIF2C2 eukaryotic translation initiation factor 2C, 2 0.022
FAS Fas (TNF receptor superfamily, member 6) 0.022
PRKD2 protein kinase D2 0.021
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.021
C19orf66 chromosome 19 open reading frame 66 0.021
TARBP2 TAR (HIV-1) RNA binding protein 2 0.020
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1 0.019
TLR2 toll-like receptor 2 0.019
TLR1 toll-like receptor 1 0.019
MX1 myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) 0.019
RTP4 receptor (chemosensory) transporter protein 4 0.019
IFI44 interferon-induced protein 44 0.019
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.018
UBA7 ubiquitin-like modifier activating enzyme 7 0.017
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.017
CD33 CD33 molecule 0.017
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 0.017
POLR3H polymerase (RNA) III (DNA directed) polypeptide H (22.9kD) 0.017
BAX BCL2-associated X protein 0.017
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1 0.017
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.016
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha 0.016
TRIM32 tripartite motif containing 32 0.016
SP100 SP100 nuclear antigen 0.016
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
LOC557072 caspase recruitment domain-containing protein 11-like 0.055
zfp36l1a zinc finger protein 36, C3H type-like 1a 0.053
caspa caspase a 0.041
waca WW domain containing adaptor with coiled-coil a 0.038
LOC100534776 toll-like receptor 7-like 0.038
hspa9 heat shock protein 9 0.036
tlr18 toll-like receptor 18 0.034
phb prohibitin 0.028
ticam1 toll-like receptor adaptor molecule 1 0.022
usp10 ubiquitin specific peptidase 10 0.021
cd40 CD40 antigen 0.017
zgc:66100 zgc:66100 0.017
tlr20a toll-like receptor 20a 0.016
tirap toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.015
fubp1 far upstream element (FUSE) binding protein 1 0.015
hspe1 heat shock 10 protein 1 (chaperonin 10) 0.015
tlr20f toll-like receptor 20f 0.015
il6r interleukin 6 receptor 0.014
upf1 upf1 regulator of nonsense transcripts homolog (yeast) 0.014
dvl3 dishevelled, dsh homolog 3 (Drosophila) 0.014
atp6v0ca ATPase, H+ transporting, lysosomal, V0 subunit c, a 0.014
stat1b signal transducer and activator of transcription 1b 0.014
tlr2 toll-like receptor 2 0.014
card9 caspase recruitment domain family, member 9 0.014
adrb2a adrenergic receptor, beta 2a 0.013
nos2b nitric oxide synthase 2b, inducible 0.013
hspa5 heat shock protein 5 0.013
LOC794824 hypothetical protein LOC794824 0.013
traf6 TNF receptor-associated factor 6 0.013
nos2a nitric oxide synthase 2a, inducible 0.013
ifng1-2 interferon, gamma 1-2 0.012
ap2a1 adaptor-related protein complex 2, alpha 1 subunit 0.012
cd40lg CD40 ligand 0.012
slc11a2 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 0.012
anxa2a annexin A2a 0.012
prmt1 protein arginine methyltransferase 1 0.012
atp2b1a ATPase, Ca++ transporting, plasma membrane 1a 0.012
dvl2 dishevelled, dsh homolog 2 (Drosophila) 0.011
dennd5b DENN/MADD domain containing 5B 0.011
pkz protein kinase containing Z-DNA binding domains 0.011
il6st interleukin 6 signal transducer 0.011
dntt deoxynucleotidyltransferase, terminal 0.011
tia1l cytotoxic granule-associated RNA binding protein 1, like 0.011
nar no arches 0.010
cotl1 coactosin-like 1 (Dictyostelium) 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.916
Myd88 myeloid differentiation primary response gene 88 0.899
Casp1 caspase 1 0.889
Ddx60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.712
Tlr4 toll-like receptor 4 0.642
Oasl2 2'-5' oligoadenylate synthetase-like 2 0.614
Irgm2 immunity-related GTPase family M member 2 0.612
Irgm1 immunity-related GTPase family M member 1 0.557
Mavs mitochondrial antiviral signaling protein 0.547
Stat1 signal transducer and activator of transcription 1 0.488
Gbp7 guanylate binding protein 7 0.441
Iigp1 interferon inducible GTPase 1 0.394
Trim21 tripartite motif-containing 21 0.390
Ikbkg inhibitor of kappaB kinase gamma 0.369
Parp14 poly (ADP-ribose) polymerase family, member 14 0.360
Ticam1 toll-like receptor adaptor molecule 1 0.306
Trim30a tripartite motif-containing 30A 0.305
Igtp interferon gamma induced GTPase 0.300
Birc3 baculoviral IAP repeat-containing 3 0.295
Parp9 poly (ADP-ribose) polymerase family, member 9 0.287
Igh immunoglobulin heavy chain complex 0.281
Samd9l sterile alpha motif domain containing 9-like 0.239
Gbp6 guanylate binding protein 6 0.232
Gbp3 guanylate binding protein 3 0.230
Aim2 absent in melanoma 2 0.225
Ifit1 interferon-induced protein with tetratricopeptide repeats 1 0.214
Unc93b1 unc-93 homolog B1 (C. elegans) 0.203
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.202
Rtp4 receptor transporter protein 4 0.201
Ifi44 interferon-induced protein 44 0.173
Gbp10 guanylate-binding protein 10 0.162
Stat2 signal transducer and activator of transcription 2 0.134
Ddx58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.134
Pik3ap1 phosphoinositide-3-kinase adaptor protein 1 0.129
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.116
Ifi47 interferon gamma inducible protein 47 0.109
Uba7 ubiquitin-like modifier activating enzyme 7 0.101
Cd40 CD40 antigen 0.100
Ifih1 interferon induced with helicase C domain 1 0.100
Erap1 endoplasmic reticulum aminopeptidase 1 0.099
Irf9 interferon regulatory factor 9 0.098
Hspa9 heat shock protein 9 0.096
Traf3 TNF receptor-associated factor 3 0.093
Samhd1 SAM domain and HD domain, 1 0.091
Dhx58 DEXH (Asp-Glu-X-His) box polypeptide 58 0.091
Ccl4 chemokine (C-C motif) ligand 4 0.090
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.088
H2-Q7 histocompatibility 2, Q region locus 7 0.082
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.080
Dtx3l deltex 3-like (Drosophila) 0.078
Gbp2 guanylate binding protein 2 0.075
Irak1 interleukin-1 receptor-associated kinase 1 0.075
Chuk conserved helix-loop-helix ubiquitous kinase 0.073
BC006779 cDNA sequence BC006779 0.070
Nmi N-myc (and STAT) interactor 0.066
Tor3a torsin family 3, member A 0.060
Trim25 tripartite motif-containing 25 0.059
Zbp1 Z-DNA binding protein 1 0.058
Traf6 TNF receptor-associated factor 6 0.057
Usp18 ubiquitin specific peptidase 18 0.057
Parp10 poly (ADP-ribose) polymerase family, member 10 0.051
Irak4 interleukin-1 receptor-associated kinase 4 0.050
Nlrc5 NLR family, CARD domain containing 5 0.048
Psmb8 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) 0.047
Sfpi1 SFFV proviral integration 1 0.046
Ifi203 interferon activated gene 203 0.045
Traf3ip2 TRAF3 interacting protein 2 0.044
Tlr2 toll-like receptor 2 0.041
Cxcl10 chemokine (C-X-C motif) ligand 10 0.041
Tgtp2 T-cell specific GTPase 2 0.041
Rnf135 ring finger protein 135 0.040
Ikbkb inhibitor of kappaB kinase beta 0.037
Sykb spleen tyrosine kinase 0.036
D14Ertd668e DNA segment, Chr 14, ERATO Doi 668, expressed 0.035
Ifit2 interferon-induced protein with tetratricopeptide repeats 2 0.034
Cmpk2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 0.033
Herc6 hect domain and RLD 6 0.032
Epsti1 epithelial stromal interaction 1 (breast) 0.031
Cd274 CD274 antigen 0.029
Oas1b 2'-5' oligoadenylate synthetase 1B 0.027
Ifi35 interferon-induced protein 35 0.027
Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 0.027
Irf8 interferon regulatory factor 8 0.026
Csf1 colony stimulating factor 1 (macrophage) 0.025
Tnfrsf13b tumor necrosis factor receptor superfamily, member 13b 0.025
BC013712 cDNA sequence BC013712 0.024
1810019J16Rik RIKEN cDNA 1810019J16 gene 0.024
Btk Bruton agammaglobulinemia tyrosine kinase 0.023
Traf2 TNF receptor-associated factor 2 0.023
Tax1bp1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.023
Card11 caspase recruitment domain family, member 11 0.023
Plagl2 pleiomorphic adenoma gene-like 2 0.023
Oas3 2'-5' oligoadenylate synthetase 3 0.022
Ikzf1 IKAROS family zinc finger 1 0.022
Slamf8 SLAM family member 8 0.022
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.022
Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.022
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.021
Vwa5a von Willebrand factor A domain containing 5A 0.021
Trim12c tripartite motif-containing 12C 0.021
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism