The network for 'forebrain neuron differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

forebrain neuron differentiation

The process in which a relatively unspecialized cell acquires specialized features of a neuron that will reside in the forebrain.

Homo sapiens
Name Description Probability Func Analog Organism
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 1.000
FGF1 fibroblast growth factor 1 (acidic) 0.992
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.902
EIF2C2 eukaryotic translation initiation factor 2C, 2 0.873
ARID1A AT rich interactive domain 1A (SWI-like) 0.866
TAL1 T-cell acute lymphocytic leukemia 1 0.857
VEGFA vascular endothelial growth factor A 0.806
FGF10 fibroblast growth factor 10 0.736
ADORA2A adenosine A2a receptor 0.685
POU5F1 POU class 5 homeobox 1 0.683
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 0.649
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.629
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.606
FOXD3 forkhead box D3 0.574
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.561
FGF7 fibroblast growth factor 7 0.535
TCF4 transcription factor 4 0.516
RUNX1 runt-related transcription factor 1 0.483
HNF4A hepatocyte nuclear factor 4, alpha 0.478
FGF2 fibroblast growth factor 2 (basic) 0.477
PPP1R9B protein phosphatase 1, regulatory (inhibitor) subunit 9B 0.477
TCEAL5 transcription elongation factor A (SII)-like 5 0.447
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.404
FGFR2 fibroblast growth factor receptor 2 0.398
PAX8 paired box 8 0.395
TRIB3 tribbles homolog 3 (Drosophila) 0.383
SH3RF3 SH3 domain containing ring finger 3 0.380
PDX1 pancreatic and duodenal homeobox 1 0.368
CPE carboxypeptidase E 0.365
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.341
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.296
PBRM1 polybromo 1 0.291
POU3F2 POU class 3 homeobox 2 0.281
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.265
FGF3 fibroblast growth factor 3 0.246
ARRB1 arrestin, beta 1 0.221
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.207
SLC6A3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.206
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.194
ARID1B AT rich interactive domain 1B (SWI1-like) 0.192
TP63 tumor protein p63 0.190
EIF2C1 eukaryotic translation initiation factor 2C, 1 0.183
LBX1 ladybird homeobox 1 0.183
TRO trophinin 0.182
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.180
HES1 hairy and enhancer of split 1, (Drosophila) 0.180
TP73 tumor protein p73 0.177
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.174
TNRC6B trinucleotide repeat containing 6B 0.174
NKX6-1 NK6 homeobox 1 0.167
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.166
FGFR1 fibroblast growth factor receptor 1 0.160
HOXC8 homeobox C8 0.159
SOX11 SRY (sex determining region Y)-box 11 0.159
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.156
PGF placental growth factor 0.156
SIX3 SIX homeobox 3 0.152
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.151
PLCG1 phospholipase C, gamma 1 0.149
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.143
FRS2 fibroblast growth factor receptor substrate 2 0.142
SOX1 SRY (sex determining region Y)-box 1 0.142
TNRC6A trinucleotide repeat containing 6A 0.142
FGFR3 fibroblast growth factor receptor 3 0.140
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.139
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 0.138
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 0.137
FEZF2 FEZ family zinc finger 2 0.137
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.134
KCTD1 potassium channel tetramerisation domain containing 1 0.133
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.131
DLG2 discs, large homolog 2 (Drosophila) 0.130
SH3BP4 SH3-domain binding protein 4 0.128
CHN2 chimerin (chimaerin) 2 0.125
SMAD7 SMAD family member 7 0.123
SOX2 SRY (sex determining region Y)-box 2 0.122
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator 0.122
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 0.118
RAX retina and anterior neural fold homeobox 0.115
ALX3 ALX homeobox 3 0.113
KCNA1 potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) 0.111
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.106
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 0.105
HOXD12 homeobox D12 0.105
FZD1 frizzled homolog 1 (Drosophila) 0.103
HES2 hairy and enhancer of split 2 (Drosophila) 0.102
MSX1 msh homeobox 1 0.099
CTBP2 C-terminal binding protein 2 0.098
GBX2 gastrulation brain homeobox 2 0.097
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.097
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 0.095
POU3F3 POU class 3 homeobox 3 0.093
PAX6 paired box 6 0.093
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.092
SALL2 sal-like 2 (Drosophila) 0.091
CARM1 coactivator-associated arginine methyltransferase 1 0.090
TNRC6C trinucleotide repeat containing 6C 0.090
LHX2 LIM homeobox 2 0.089
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.089
HNF1B HNF1 homeobox B 0.088
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
lhx2b LIM homeobox 2b 0.935
dla deltaA 0.856
dlx2a distal-less homeobox gene 2a 0.802
tbx1 T-box 1 0.746
lef1 lymphocyte enhancer binding factor 1 0.707
wnt1 wingless-type MMTV integration site family, member 1 0.608
barhl2 BarH-like 2 0.597
wnt8b wingless-type MMTV integration site family, member 8b 0.554
gli1 GLI-Kruppel family member 1 0.552
lhx5 LIM homeobox 5 0.531
foxp2 forkhead box P2 0.522
dbx1a developing brain homeobox 1a 0.499
dld deltaD 0.493
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.482
pitx3 paired-like homeodomain transcription factor 3 0.444
otx2 orthodenticle homolog 2 0.418
eya1 eyes absent homolog 1 0.418
fgf3 fibroblast growth factor 3 0.401
otpb orthopedia homolog b 0.399
sfrp1a secreted frizzled-related protein 1a 0.362
fezf2 FEZ family zinc finger 2 0.343
rx3 retinal homeobox gene 3 0.342
otx1b orthodenticle homolog 1b 0.336
nr2e1 nuclear receptor subfamily 2, group E, member 1 0.322
oprd1b opioid receptor, delta 1b 0.307
sim1a single-minded homolog 1a (Drosophila) 0.297
arx aristaless related homeobox 0.281
shha sonic hedgehog a 0.276
zic1 zic family member 1 (odd-paired homolog, Drosophila) 0.274
ephb4b eph receptor B4b 0.264
notch2 notch homolog 2 0.258
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.256
wnt7ba wingless-type MMTV integration site family, member 7Ba 0.253
dlx1a distal-less homeobox gene 1a 0.252
notch1a notch homolog 1a 0.250
robo3 roundabout homolog 3 0.231
gbx2 gastrulation brain homeo box 2 0.220
lratb lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b) 0.219
wnt3 wingless-type MMTV integration site family, member 3 0.217
olig2 oligodendrocyte lineage transcription factor 2 0.212
pax6a paired box gene 6a 0.211
gli2a GLI-Kruppel family member GLI2a 0.209
ascl1a achaete-scute complex-like 1a (Drosophila) 0.204
fgfr3 fibroblast growth factor receptor 3 0.198
wnt3a wingless-type MMTV integration site family, member 3A 0.188
wnt4a wingless-type MMTV integration site family, member 4a 0.183
met met proto-oncogene (hepatocyte growth factor receptor) 0.178
nrp2b neuropilin 2b 0.166
nkx2.1a NK2 homeobox 1a 0.163
foxg1a forkhead box G1a 0.159
six2a sine oculis-related homeobox 2a 0.152
myf5 myogenic factor 5 0.152
lhx1a LIM homeobox 1a 0.142
zic3 zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila) 0.142
sema3aa semaphorin 3aa 0.139
mib mind bomb 0.135
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.133
smad1 MAD homolog 1 (Drosophila) 0.131
eomesa eomesodermin homolog a 0.129
sox1a SRY-box containing gene 1a 0.122
pcdh10b protocadherin 10b 0.121
atoh1b atonal homolog 1b 0.119
rest RE1-silencing transcription factor 0.107
nkx2.1b NK2 homeobox 1b 0.101
dlx2b distal-less homeobox gene 2b 0.096
ndr2 nodal-related 2 0.095
sox2 SRY-box containing gene 2 0.090
hmx4 H6 family homeobox 4 0.089
isl1 islet1 0.088
dlx6a distal-less homeobox gene 6a 0.088
hmgcrb 3-hydroxy-3-methylglutaryl-Coenzyme A reductase b 0.086
robo2 roundabout homolog 2 0.086
elavl3 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C) 0.085
jag2 jagged 2 0.084
ephb3a eph receptor B3a 0.083
notch3 notch homolog 3 0.082
fgfr4 fibroblast growth factor receptor 4 0.082
foxc1a forkhead box C1a 0.082
cdh2 cadherin 2, neuronal 0.078
wnt5b wingless-type MMTV integration site family, member 5b 0.076
pou3f1 POU class 3 homeobox 1 0.076
six3a sine oculis homeobox homolog 3a 0.075
gro1 groucho 1 0.074
eng2a engrailed 2a 0.073
sox21b SRY-box containing gene 21 b 0.073
cdkn1c cyclin-dependent kinase inhibitor 1C (p57, Kip2) 0.072
shhb sonic hedgehog b 0.069
sst1.1 somatostatin 1, tandem duplicate 1 0.069
spry2 sprouty homolog 2 0.068
wnt2 wingless-type MMTV integration site family member 2 0.068
epha4a eph receptor A4a 0.067
tal1 T-cell acute lymphocytic leukemia 1 0.067
nkx2.2a NK2 transcription factor related 2a 0.066
znf503 zinc finger protein 503 0.065
spry4 sprouty (Drosophila) homolog 4 0.065
fgfr2 fibroblast growth factor receptor 2 0.064
boc brother of CDO 0.064
fzd7a frizzled homolog 7a 0.063
med12 mediator of RNA polymerase II transcription, subunit 12 homolog 0.063
wif1 wnt inhibitory factor 1 0.062
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Otx2 orthodenticle homolog 2 (Drosophila) 1.000
Fgfr2 fibroblast growth factor receptor 2 1.000
Shh sonic hedgehog 1.000
Gli3 GLI-Kruppel family member GLI3 1.000
Isl1 ISL1 transcription factor, LIM/homeodomain 1.000
Fgf8 fibroblast growth factor 8 1.000
Pax2 paired box gene 2 1.000
Pitx2 paired-like homeodomain transcription factor 2 1.000
Hand1 heart and neural crest derivatives expressed transcript 1 1.000
Pax3 paired box gene 3 0.999
Sox9 SRY-box containing gene 9 0.999
Msx1 homeobox, msh-like 1 0.999
Dlx5 distal-less homeobox 5 0.999
Emx1 empty spiracles homolog 1 (Drosophila) 0.998
Tcfap2a transcription factor AP-2, alpha 0.998
Hand2 heart and neural crest derivatives expressed transcript 2 0.998
Pax6 paired box gene 6 0.997
Rarg retinoic acid receptor, gamma 0.997
Sox2 SRY-box containing gene 2 0.996
Nog noggin 0.996
Eya1 eyes absent 1 homolog (Drosophila) 0.996
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.995
Tbx3 T-box 3 0.995
Gli2 GLI-Kruppel family member GLI2 0.994
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.994
Foxg1 forkhead box G1 0.993
Fgf3 fibroblast growth factor 3 0.993
Foxc1 forkhead box C1 0.993
Pax8 paired box gene 8 0.989
Lhx3 LIM homeobox protein 3 0.989
Sall3 sal-like 3 (Drosophila) 0.987
Emx2 empty spiracles homolog 2 (Drosophila) 0.987
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.986
Fgfr1 fibroblast growth factor receptor 1 0.986
Dlx6 distal-less homeobox 6 0.984
Gata4 GATA binding protein 4 0.984
Sall4 sal-like 4 (Drosophila) 0.983
Pitx1 paired-like homeodomain transcription factor 1 0.983
Hoxa1 homeobox A1 0.982
Tgfb2 transforming growth factor, beta 2 0.977
Lhx1 LIM homeobox protein 1 0.975
Msx2 homeobox, msh-like 2 0.974
Prrx1 paired related homeobox 1 0.973
Alx4 aristaless-like homeobox 4 0.968
Bmp4 bone morphogenetic protein 4 0.965
Smo smoothened homolog (Drosophila) 0.964
Wnt1 wingless-related MMTV integration site 1 0.963
Hoxa2 homeobox A2 0.961
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.957
Rarb retinoic acid receptor, beta 0.952
Fgf10 fibroblast growth factor 10 0.951
Tlx3 T-cell leukemia, homeobox 3 0.940
Foxc2 forkhead box C2 0.939
Pax9 paired box gene 9 0.939
Tbx1 T-box 1 0.932
Phox2b paired-like homeobox 2b 0.927
Ednra endothelin receptor type A 0.927
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.925
Jag1 jagged 1 0.924
Ctnnb1 catenin (cadherin associated protein), beta 1 0.920
Chd7 chromodomain helicase DNA binding protein 7 0.916
Hoxd3 homeobox D3 0.900
Six3 sine oculis-related homeobox 3 homolog (Drosophila) 0.898
Chrd chordin 0.896
T brachyury 0.895
Gsc goosecoid homeobox 0.882
Rara retinoic acid receptor, alpha 0.881
Ret ret proto-oncogene 0.867
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.865
Rxra retinoid X receptor alpha 0.863
Foxa2 forkhead box A2 0.861
Gbx2 gastrulation brain homeobox 2 0.852
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.851
Lmx1a LIM homeobox transcription factor 1 alpha 0.841
Dlx1 distal-less homeobox 1 0.841
Hes5 hairy and enhancer of split 5 (Drosophila) 0.830
Adrb1 adrenergic receptor, beta 1 0.828
Drd2 dopamine receptor D2 0.827
Sim1 single-minded homolog 1 (Drosophila) 0.825
Lhx5 LIM homeobox protein 5 0.822
Uncx UNC homeobox 0.820
Otx1 orthodenticle homolog 1 (Drosophila) 0.814
Sox1 SRY-box containing gene 1 0.806
Dlx2 distal-less homeobox 2 0.806
Hoxb1 homeobox B1 0.806
Alx3 aristaless-like homeobox 3 0.799
Pou5f1 POU domain, class 5, transcription factor 1 0.795
Hmx3 H6 homeobox 3 0.790
Nkx2-1 NK2 homeobox 1 0.787
Nodal nodal 0.780
Hoxd13 homeobox D13 0.773
Sox3 SRY-box containing gene 3 0.762
Bdnf brain derived neurotrophic factor 0.758
En1 engrailed 1 0.755
Gdnf glial cell line derived neurotrophic factor 0.752
Hes1 hairy and enhancer of split 1 (Drosophila) 0.748
Lmx1b LIM homeobox transcription factor 1 beta 0.740
Lhx9 LIM homeobox protein 9 0.739
Dcc deleted in colorectal carcinoma 0.727
Pou3f2 POU domain, class 3, transcription factor 2 0.721
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Rattus norvegicus
Name Description Probability Func Analog Organism
Dlgap3 discs, large (Drosophila) homolog-associated protein 3 0.222
Hoxb7 homeo box B7 0.095
Gdf11 growth differentiation factor 11 0.061
Unc5b unc-5 homolog B (C. elegans) 0.059
Sox17 SRY (sex determining region Y)-box 17 0.042
Arhgef7 Rho guanine nucleotide exchange factor (GEF7) 0.035
Ppy pancreatic polypeptide 0.032
Hand2 heart and neural crest derivatives expressed 2 0.031
Nr4a1 nuclear receptor subfamily 4, group A, member 1 0.031
Ton tonin 0.031
Barhl2 BarH-like homeobox 2 0.030
Galr3 galanin receptor 3 0.030
Foxi2 forkhead box I2 0.028
Gata3 GATA binding protein 3 0.026
Hes3 hairy and enhancer of split 3 (Drosophila) 0.026
Prss2 protease, serine, 2 0.025
Hpcal4 hippocalcin-like 4 0.024
Mycs myc-like oncogene, s-myc protein 0.024
Nfib nuclear factor I/B 0.023
Kalrn kalirin, RhoGEF kinase 0.022
Adarb2 adenosine deaminase, RNA-specific, B2 0.022
Lhx1 LIM homeobox 1 0.021
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.021
Grm5 glutamate receptor, metabotropic 5 0.021
Rftn2 raftlin family member 2 0.020
Pax8 paired box 8 0.020
Hrh1 histamine receptor H 1 0.019
Fgfr2 fibroblast growth factor receptor 2 0.019
Gata6 GATA binding protein 6 0.019
Ehf ets homologous factor 0.018
Nfia nuclear factor I/A 0.018
Sdc3 syndecan 3 0.017
Grm8 glutamate receptor, metabotropic 8 0.017
Nlgn2 neuroligin 2 0.016
Bmp6 bone morphogenetic protein 6 0.016
Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 0.015
Pnliprp1 pancreatic lipase-related protein 1 0.015
Ugt8 UDP glycosyltransferase 8 0.015
Glg1 golgi apparatus protein 1 0.015
Hoxc4 homeo box C4 0.015
Ucn urocortin 0.015
Sgp158 proline-rich glycoprotein (sgp158) 0.015
Mgat5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.014
Socs3 suppressor of cytokine signaling 3 0.014
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.013
Smad7 SMAD family member 7 0.013
Adrb1 adrenergic, beta-1-, receptor 0.013
Arhgef11 Rho guanine nucleotide exchange factor (GEF) 11 0.013
Tgfbr2 transforming growth factor, beta receptor II 0.013
RGD1563136 similar to Cystatin-related protein 2 precursor (Prostatic 22 kDa glycoprotein P22K15) 0.013
Synpo synaptopodin 0.012
Gcm1 glial cells missing homolog 1 (Drosophila) 0.012
Grin2d glutamate receptor, ionotropic, N-methyl D-aspartate 2D 0.012
Dcc deleted in colorectal carcinoma 0.012
Cntfr ciliary neurotrophic factor receptor 0.012
Foxe3 forkhead box E3 0.012
Slc28a1 solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 0.011
Gria4 glutamate receptor, ionotrophic, AMPA 4 0.011
Scarf2 scavenger receptor class F, member 2 0.011
Myo1c myosin IC 0.011
Ahr aryl hydrocarbon receptor 0.011
Syn3 synapsin III 0.011
Itpkb inositol 1,4,5-trisphosphate 3-kinase B 0.011
Dchs1 dachsous 1 (Drosophila) 0.010
Chrm4 cholinergic receptor, muscarinic 4 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism