The network for 'second messenger mediated signaling' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

second messenger mediated signaling

Any intracellular signal transduction in which the signal is passed on within the cell via a second messenger; a small molecule or ion that can be quickly generated or released from intracellular stores, and can diffuse within the cell. Second-messenger signaling includes production or release of the second messenger, and effectors downstream of the second messenger that further transmit the signal within the cell.

Homo sapiens
Name Description Probability Func Analog Organism
CCL5 chemokine (C-C motif) ligand 5 0.987
LAT linker for activation of T cells 0.975
PAX3 paired box 3 0.970
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.948
CCR5 chemokine (C-C motif) receptor 5 0.944
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.911
CXCL2 chemokine (C-X-C motif) ligand 2 0.901
IL8 interleukin 8 0.869
LCK lymphocyte-specific protein tyrosine kinase 0.869
CCL4 chemokine (C-C motif) ligand 4 0.859
GRB2 growth factor receptor-bound protein 2 0.844
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.843
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.841
MEOX2 mesenchyme homeobox 2 0.833
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.813
ARRB1 arrestin, beta 1 0.796
CXCL3 chemokine (C-X-C motif) ligand 3 0.780
CD247 CD247 molecule 0.762
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.761
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.743
CCL22 chemokine (C-C motif) ligand 22 0.711
FYB FYN binding protein 0.709
CXCL5 chemokine (C-X-C motif) ligand 5 0.685
GUCY1A3 guanylate cyclase 1, soluble, alpha 3 0.646
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.620
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.612
SPTB spectrin, beta, erythrocytic 0.583
CXCL9 chemokine (C-X-C motif) ligand 9 0.577
CD28 CD28 molecule 0.571
DPP4 dipeptidyl-peptidase 4 0.571
SH3BP2 SH3-domain binding protein 2 0.537
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O 0.520
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.505
CCR7 chemokine (C-C motif) receptor 7 0.488
SKP1 S-phase kinase-associated protein 1 0.482
CCR4 chemokine (C-C motif) receptor 4 0.477
FYN FYN oncogene related to SRC, FGR, YES 0.470
IFNG interferon, gamma 0.447
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.440
MPDZ multiple PDZ domain protein 0.438
IL1B interleukin 1, beta 0.437
TBXA2R thromboxane A2 receptor 0.435
GUCY1B3 guanylate cyclase 1, soluble, beta 3 0.432
CXCL10 chemokine (C-X-C motif) ligand 10 0.414
IL10 interleukin 10 0.406
SSTR2 somatostatin receptor 2 0.403
SSTR3 somatostatin receptor 3 0.397
CXCR5 chemokine (C-X-C motif) receptor 5 0.394
PTEN phosphatase and tensin homolog 0.392
CCL20 chemokine (C-C motif) ligand 20 0.377
CCL11 chemokine (C-C motif) ligand 11 0.366
HP haptoglobin 0.363
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 0.362
CCL7 chemokine (C-C motif) ligand 7 0.348
VAV1 vav 1 guanine nucleotide exchange factor 0.336
CALCA calcitonin-related polypeptide alpha 0.335
SYK spleen tyrosine kinase 0.316
POU5F1 POU class 5 homeobox 1 0.312
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 0.308
MAPT microtubule-associated protein tau 0.302
PLEK pleckstrin 0.299
CCL13 chemokine (C-C motif) ligand 13 0.298
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.292
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 0.289
IL2RB interleukin 2 receptor, beta 0.285
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.282
CCL2 chemokine (C-C motif) ligand 2 0.274
SOCS3 suppressor of cytokine signaling 3 0.260
CCR2 chemokine (C-C motif) receptor 2 0.260
TTN titin 0.259
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 0.257
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.255
INF2 inverted formin, FH2 and WH2 domain containing 0.253
CRH corticotropin releasing hormone 0.251
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.250
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.249
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF 0.246
CD3D CD3d molecule, delta (CD3-TCR complex) 0.244
NRP1 neuropilin 1 0.240
CCL3 chemokine (C-C motif) ligand 3 0.238
SETD8 SET domain containing (lysine methyltransferase) 8 0.235
FOXD3 forkhead box D3 0.232
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 0.231
NFE2L2 nuclear factor (erythroid-derived 2)-like 2 0.226
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.226
CCL8 chemokine (C-C motif) ligand 8 0.217
CXCL13 chemokine (C-X-C motif) ligand 13 0.209
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.207
NEUROD1 neurogenic differentiation 1 0.205
IL16 interleukin 16 (lymphocyte chemoattractant factor) 0.200
CXCR3 chemokine (C-X-C motif) receptor 3 0.197
SLC9A3R2 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 0.195
PSEN2 presenilin 2 (Alzheimer disease 4) 0.195
CD163 CD163 molecule 0.187
GFAP glial fibrillary acidic protein 0.184
APOC1 apolipoprotein C-I 0.182
PTPRB protein tyrosine phosphatase, receptor type, B 0.180
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.179
PKD1 polycystic kidney disease 1 (autosomal dominant) 0.171
PCDH17 protocadherin 17 0.170
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Slc34a1 solute carrier family 34 (sodium phosphate), member 1 0.938
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.932
Mef2d myocyte enhancer factor 2D 0.908
Kl klotho 0.851
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.848
Neurod1 neurogenic differentiation 1 0.838
Drd2 dopamine receptor D2 0.806
Nos3 nitric oxide synthase 3, endothelial cell 0.780
Mef2c myocyte enhancer factor 2C 0.690
Lepr leptin receptor 0.683
Adrb1 adrenergic receptor, beta 1 0.679
Ntf3 neurotrophin 3 0.669
Mt1 metallothionein 1 0.646
Clec4d C-type lectin domain family 4, member d 0.642
Mt2 metallothionein 2 0.638
Ccr1 chemokine (C-C motif) receptor 1 0.604
Nos1 nitric oxide synthase 1, neuronal 0.587
Ldb3 LIM domain binding 3 0.587
Pcdh12 protocadherin 12 0.577
Rgs9 regulator of G-protein signaling 9 0.573
Phex phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets) 0.568
Dlg4 discs, large homolog 4 (Drosophila) 0.547
Kcna2 potassium voltage-gated channel, shaker-related subfamily, member 2 0.525
Rims2 regulating synaptic membrane exocytosis 2 0.515
Kitl kit ligand 0.511
Ptprc protein tyrosine phosphatase, receptor type, C 0.503
Cckbr cholecystokinin B receptor 0.501
Mmp8 matrix metallopeptidase 8 0.500
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.495
Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus 0.488
Lcp2 lymphocyte cytosolic protein 2 0.486
Pthlh parathyroid hormone-like peptide 0.483
Zap70 zeta-chain (TCR) associated protein kinase 0.482
Gucy1b3 guanylate cyclase 1, soluble, beta 3 0.479
Htr7 5-hydroxytryptamine (serotonin) receptor 7 0.476
Pax6 paired box gene 6 0.472
Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide 0.468
Lep leptin 0.461
Homer1 homer homolog 1 (Drosophila) 0.458
Cd247 CD247 antigen 0.458
Trpc4 transient receptor potential cation channel, subfamily C, member 4 0.453
Il7r interleukin 7 receptor 0.441
Gp9 glycoprotein 9 (platelet) 0.439
Kcnmb1 potassium large conductance calcium-activated channel, subfamily M, beta member 1 0.423
Oxt oxytocin 0.419
Fgr Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog 0.415
Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit 0.414
Kiss1 KiSS-1 metastasis-suppressor 0.405
L1cam L1 cell adhesion molecule 0.400
Lhx6 LIM homeobox protein 6 0.389
Fas Fas (TNF receptor superfamily member 6) 0.388
Nppb natriuretic peptide type B 0.383
Plcb1 phospholipase C, beta 1 0.381
Neurog3 neurogenin 3 0.374
Grin2a glutamate receptor, ionotropic, NMDA2A (epsilon 1) 0.373
Hand1 heart and neural crest derivatives expressed transcript 1 0.370
Galnt6 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 0.369
Clec4e C-type lectin domain family 4, member e 0.365
Edn3 endothelin 3 0.362
Dnm1 dynamin 1 0.359
Kcna4 potassium voltage-gated channel, shaker-related subfamily, member 4 0.354
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.350
Sstr4 somatostatin receptor 4 0.349
Sim1 single-minded homolog 1 (Drosophila) 0.346
Dlg2 discs, large homolog 2 (Drosophila) 0.343
Csf3r colony stimulating factor 3 receptor (granulocyte) 0.342
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.338
Cybb cytochrome b-245, beta polypeptide 0.338
Msr1 macrophage scavenger receptor 1 0.337
Pdx1 pancreatic and duodenal homeobox 1 0.335
Mrvi1 MRV integration site 1 0.333
C3ar1 complement component 3a receptor 1 0.330
Jarid2 jumonji, AT rich interactive domain 2 0.329
AF251705 cDNA sequence AF251705 0.327
Shc3 src homology 2 domain-containing transforming protein C3 0.322
Npy2r neuropeptide Y receptor Y2 0.320
Prkg1 protein kinase, cGMP-dependent, type I 0.319
Edil3 EGF-like repeats and discoidin I-like domains 3 0.317
Tac2 tachykinin 2 0.314
Thrb thyroid hormone receptor beta 0.309
Pkd1 polycystic kidney disease 1 homolog 0.306
Selp selectin, platelet 0.306
Atp2a2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.301
P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 0.300
Tgfb2 transforming growth factor, beta 2 0.296
Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 0.294
Lck lymphocyte protein tyrosine kinase 0.292
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.292
Kcnc1 potassium voltage gated channel, Shaw-related subfamily, member 1 0.291
Kcnb1 potassium voltage gated channel, Shab-related subfamily, member 1 0.288
Kcnk3 potassium channel, subfamily K, member 3 0.288
Ldb2 LIM domain binding 2 0.288
Zfpm2 zinc finger protein, multitype 2 0.287
Gnao1 guanine nucleotide binding protein, alpha O 0.281
Gria1 glutamate receptor, ionotropic, AMPA1 (alpha 1) 0.278
Ccl3 chemokine (C-C motif) ligand 3 0.276
Cd86 CD86 antigen 0.267
Grm1 glutamate receptor, metabotropic 1 0.266
Prkcc protein kinase C, gamma 0.264
Camk2a calcium/calmodulin-dependent protein kinase II alpha 0.264
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Rattus norvegicus
Name Description Probability Func Analog Organism
Syt7 synaptotagmin VII 0.383
Shank2 SH3 and multiple ankyrin repeat domains 2 0.353
Cacna1a calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.299
Smr3a submaxillary gland androgen regulated protein 3A 0.292
Ncr3 natural cytotoxicity triggering receptor 3 0.228
St18 suppression of tumorigenicity 18 0.197
Adora2a adenosine A2a receptor 0.196
Gucy1a3 guanylate cyclase 1, soluble, alpha 3 0.195
Scn3a sodium channel, voltage-gated, type III, alpha 0.163
Calcrl calcitonin receptor-like 0.153
Kcnd2 potassium voltage-gated channel, Shal-related subfamily, member 2 0.151
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.149
Cd4 Cd4 molecule 0.140
Nfasc neurofascin 0.137
P2rx2 purinergic receptor P2X, ligand-gated ion channel, 2 0.136
Grpr gastrin releasing peptide receptor 0.133
Abcc8 ATP-binding cassette, subfamily C (CFTR/MRP), member 8 0.129
Pex5l peroxisomal biogenesis factor 5-like 0.125
Pde1b phosphodiesterase 1B, calmodulin-dependent 0.124
Rims1 regulating synaptic membrane exocytosis 1 0.123
Accn2 amiloride-sensitive cation channel 2, neuronal 0.122
Grp gastrin releasing peptide 0.120
Mc4r melanocortin 4 receptor 0.120
Prkcg protein kinase C, gamma 0.119
Gria1 glutamate receptor, ionotropic, AMPA 1 0.118
Il4 interleukin 4 0.112
Crhr2 corticotropin releasing hormone receptor 2 0.106
Map2 microtubule-associated protein 2 0.103
Gucy1b3 guanylate cyclase 1, soluble, beta 3 0.103
Grin3a glutamate receptor, ionotropic, N-methyl-D-aspartate 3A 0.103
Htr5b 5-hydroxytryptamine (serotonin) receptor 5B 0.102
Nrp2 neuropilin 2 0.101
Gnrhr gonadotropin releasing hormone receptor 0.101
Notch3 Notch homolog 3 (Drosophila) 0.101
Gzmk granzyme K 0.097
Sycp1 synaptonemal complex protein 1 0.095
Odf4 outer dense fiber of sperm tails 4 0.094
Gfra2 GDNF family receptor alpha 2 0.092
Grm2 glutamate receptor, metabotropic 2 0.092
Prdm2 PR domain containing 2, with ZNF domain 0.092
Oprl1 opiate receptor-like 1 0.090
Cacna1d calcium channel, voltage-dependent, L type, alpha 1D subunit 0.086
Grm8 glutamate receptor, metabotropic 8 0.085
Ccl4 chemokine (C-C motif) ligand 4 0.085
Acr acrosin 0.084
Neurod2 neurogenic differentiation 2 0.081
Iapp islet amyloid polypeptide 0.081
Sdc3 syndecan 3 0.081
Cldn1 claudin 1 0.080
Kcna1 potassium voltage-gated channel, shaker-related subfamily, member 1 0.080
Cx3cr1 chemokine (C-X3-C motif) receptor 1 0.080
Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 0.080
Robo2 roundabout homolog 2 (Drosophila) 0.079
RT1-A3 RT1 class I, locus A3 0.079
Celsr3 cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila) 0.079
Ephb1 Eph receptor B1 0.079
Pja2 praja 2, RING-H2 motif containing 0.078
Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 0.078
Tff1 trefoil factor 1 0.077
Prss2 protease, serine, 2 0.077
Kit v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 0.076
Hpca hippocalcin 0.074
Gabrr1 gamma-aminobutyric acid (GABA) receptor, rho 1 0.074
Olr287 olfactory receptor 287 0.074
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.074
Semg1 semenogelin I 0.069
Il6 interleukin 6 0.068
Atp2b1 ATPase, Ca++ transporting, plasma membrane 1 0.068
Ucp3 uncoupling protein 3 (mitochondrial, proton carrier) 0.066
Gjb4 gap junction protein, beta 4 0.066
Gabrg1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 0.066
Sell selectin L 0.065
Cacnb1 calcium channel, voltage-dependent, beta 1 subunit 0.065
Il1a interleukin 1 alpha 0.065
Cnga3 cyclic nucleotide gated channel alpha 3 0.064
Faim2 Fas apoptotic inhibitory molecule 2 0.064
Hrh2 histamine receptor H 2 0.064
Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 0.064
Shox2 short stature homeobox 2 0.063
Phkg1 phosphorylase kinase, gamma 1 0.063
Znf483 zinc finger protein 483 0.062
Olr416 olfactory receptor 416 0.062
Ddn dendrin 0.062
B3gat1 beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) 0.061
Cntn3 contactin 3 (plasmacytoma associated) 0.061
Atp2b2 ATPase, Ca++ transporting, plasma membrane 2 0.061
Kcnj4 potassium inwardly-rectifying channel, subfamily J, member 4 0.060
Kcna3 potassium voltage-gated channel, shaker-related subfamily, member 3 0.060
Erbb4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.059
Adora1 adenosine A1 receptor 0.058
Ednra endothelin receptor type A 0.058
Chrna3 cholinergic receptor, nicotinic, alpha 3 0.057
Ptgfr prostaglandin F receptor 0.057
Umod uromodulin 0.057
Grm5 glutamate receptor, metabotropic 5 0.057
Ar androgen receptor 0.056
Atp2b3 ATPase, Ca++ transporting, plasma membrane 3 0.056
Cadps Ca++-dependent secretion activator 0.055
Pde3a phosphodiesterase 3A, cGMP inhibited 0.055
Gng7 guanine nucleotide binding protein (G protein), gamma 7 0.054
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism