The network for 'negative regulation of small gtpase mediated signal transduction' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of small gtpase mediated signal transduction

Any process that stops, prevents, or reduces the frequency, rate or extent of small GTPase mediated signal transduction.

Homo sapiens
Name Description Probability Func Analog Organism
MAPK1 mitogen-activated protein kinase 1 0.995
MAPK14 mitogen-activated protein kinase 14 0.985
HDAC1 histone deacetylase 1 0.938
CBX5 chromobox homolog 5 0.494
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial) 0.381
DUSP1 dual specificity phosphatase 1 0.248
CBX1 chromobox homolog 1 0.242
C19orf50 chromosome 19 open reading frame 50 0.237
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.190
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.189
NCOA3 nuclear receptor coactivator 3 0.150
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.141
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.137
MAPK3 mitogen-activated protein kinase 3 0.133
RIN1 Ras and Rab interactor 1 0.129
MAP2K1 mitogen-activated protein kinase kinase 1 0.127
PDCD6IP programmed cell death 6 interacting protein 0.114
GBP3 guanylate binding protein 3 0.110
KIF1B kinesin family member 1B 0.099
KCTD10 potassium channel tetramerisation domain containing 10 0.095
E2F6 E2F transcription factor 6 0.092
DUSP3 dual specificity phosphatase 3 0.084
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.081
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.075
MARCH5 membrane-associated ring finger (C3HC4) 5 0.069
FHL2 four and a half LIM domains 2 0.062
ARRB2 arrestin, beta 2 0.061
DUSP7 dual specificity phosphatase 7 0.055
ATF2 activating transcription factor 2 0.052
SH3KBP1 SH3-domain kinase binding protein 1 0.049
NCOA1 nuclear receptor coactivator 1 0.045
PTPRR protein tyrosine phosphatase, receptor type, R 0.043
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.038
GSK3B glycogen synthase kinase 3 beta 0.038
PEA15 phosphoprotein enriched in astrocytes 15 0.038
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.038
NCOR2 nuclear receptor corepressor 2 0.035
SPRY2 sprouty homolog 2 (Drosophila) 0.034
HDAC2 histone deacetylase 2 0.033
RBBP4 retinoblastoma binding protein 4 0.033
MBD3 methyl-CpG binding domain protein 3 0.033
E2F4 E2F transcription factor 4, p107/p130-binding 0.032
YBX1 Y box binding protein 1 0.029
RICTOR RPTOR independent companion of MTOR, complex 2 0.029
ZFP36L1 zinc finger protein 36, C3H type-like 1 0.029
LBR lamin B receptor 0.028
RB1 retinoblastoma 1 0.027
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.025
EGFR epidermal growth factor receptor 0.025
RANBP3 RAN binding protein 3 0.024
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.021
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.021
PCDH9 protocadherin 9 0.021
PTPN7 protein tyrosine phosphatase, non-receptor type 7 0.020
PRKCA protein kinase C, alpha 0.020
PPAP2B phosphatidic acid phosphatase type 2B 0.020
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.019
VPS24 vacuolar protein sorting 24 homolog (S. cerevisiae) 0.019
MAP2K4 mitogen-activated protein kinase kinase 4 0.018
RHOB ras homolog gene family, member B 0.018
MBP myelin basic protein 0.017
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 0.017
ADNP activity-dependent neuroprotector homeobox 0.017
CSNK2A1 casein kinase 2, alpha 1 polypeptide 0.016
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.016
MED31 mediator complex subunit 31 0.016
ITGB4 integrin, beta 4 0.016
ATN1 atrophin 1 0.015
RXRA retinoid X receptor, alpha 0.015
IQGAP1 IQ motif containing GTPase activating protein 1 0.014
HDAC5 histone deacetylase 5 0.014
PTPRJ protein tyrosine phosphatase, receptor type, J 0.014
RASA1 RAS p21 protein activator (GTPase activating protein) 1 0.014
SOX4 SRY (sex determining region Y)-box 4 0.013
BAIAP2 BAI1-associated protein 2 0.013
EEF2K eukaryotic elongation factor-2 kinase 0.013
XPO6 exportin 6 0.013
HDAC6 histone deacetylase 6 0.013
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae) 0.013
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) 0.013
PXN paxillin 0.012
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.012
DUSP6 dual specificity phosphatase 6 0.012
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.012
AKAP9 A kinase (PRKA) anchor protein (yotiao) 9 0.012
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 0.011
AKT1S1 AKT1 substrate 1 (proline-rich) 0.011
C10orf116 chromosome 10 open reading frame 116 0.011
CBLB Cas-Br-M (murine) ecotropic retroviral transforming sequence b 0.011
ARHGAP9 Rho GTPase activating protein 9 0.011
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.011
KCTD13 potassium channel tetramerisation domain containing 13 0.011
ATXN3 ataxin 3 0.010
TOP2B topoisomerase (DNA) II beta 180kDa 0.010
OPA1 optic atrophy 1 (autosomal dominant) 0.010
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 0.010
GATAD2B GATA zinc finger domain containing 2B 0.010
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
itgb1b.2 integrin, beta 1b.2 0.983
itgb1b integrin, beta 1b 0.874
itgb1a integrin, beta 1a 0.740
lpar1 lysophosphatidic acid receptor 1 0.495
itgb1b.1 integrin, beta 1b.1 0.379
insrb insulin receptor b 0.364
akap12b A kinase (PRKA) anchor protein (gravin) 12b 0.291
nf1a neurofibromin 1a 0.278
igfbp6b insulin-like growth factor binding protein 6b 0.218
hmcn1 hemicentin 1 0.210
LOC567638 hypothetical LOC567638 0.203
mfn2 mitofusin 2 0.179
igfbp6a insulin-like growth factor binding protein 6a 0.176
im:7136220 im:7136220 0.167
whsc1 Wolf-Hirschhorn syndrome candidate 1 0.152
trim33 tripartite motif-containing 33 0.148
LOC100003330 melanocortin-2 receptor accessory protein 2-like 0.135
mtmr8 myotubularin related protein 8 0.131
cbx2 chromobox homolog 2 (Drosophila Pc class) 0.128
ptger2a prostaglandin E receptor 2a (subtype EP2) 0.111
kdm5c lysine (K)-specific demethylase 5C 0.110
ewsr1a Ewing sarcoma breakpoint region 1a 0.108
mc5rb melanocortin 5b receptor 0.105
marcksa myristoylated alanine rich protein kinase C substrate a 0.105
disp1 dispatched homolog 1 (Drosophila) 0.103
ap2a1 adaptor-related protein complex 2, alpha 1 subunit 0.102
akap8l A kinase (PRKA) anchor protein 8-like 0.099
kpna4 karyopherin alpha 4 (importin alpha 3) 0.099
zgc:91976 zgc:91976 0.099
zgc:101071 zgc:101071 0.092
cnot1 CCR4-NOT transcription complex, subunit 1 0.091
usp1 ubiquitin specific protease 1 0.090
lmnb1 lamin B1 0.089
zgc:162126 zgc:162126 0.089
frem1a Fras1 related extracellular matrix 1a 0.083
b2m beta-2-microglobulin 0.082
si:ch211-184m19.1 si:ch211-184m19.1 0.081
hmga1a high mobility group AT-hook 1a 0.080
rif1 RAP1 interacting factor homolog (yeast) 0.074
si:ch211-152c2.3 si:ch211-152c2.3 0.071
extl3 exostoses (multiple)-like 3 0.069
wu:fi25h02 wu:fi25h02 0.069
ext1b exostoses (multiple) 1b 0.068
api5 apoptosis inhibitor 5 0.068
tcea1 transcription elongation factor A (SII), 1 0.066
yes1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 0.065
pde10a phosphodiesterase 10A 0.064
vcp valosin containing protein 0.063
dip2c DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.062
rbb4 retinoblastoma binding protein 4 0.058
tubg1 tubulin, gamma 1 0.058
pkp2 plakophilin 2 0.057
ppig peptidyl-prolyl isomerase G (cyclophilin G) 0.057
vgll4l vestigial like 4 like 0.056
prrx1b paired related homeobox 1b 0.055
akt2 v-akt murine thymoma viral oncogene homolog 2 0.055
ythdf1 YTH domain family, member 1 0.054
hpd 4-hydroxyphenylpyruvate dioxygenase 0.054
prpf8 pre-mRNA processing factor 8 0.053
mc5ra melanocortin 5a receptor 0.053
tfdp1a transcription factor Dp-1, a 0.053
mcm7 MCM7 minichromosome maintenance deficient 7 (S. cerevisiae) 0.053
zgc:114199 zgc:114199 0.053
gatad2a GATA zinc finger domain containing 2A 0.053
insra insulin receptor a 0.052
dopey1 dopey family member 1 0.052
smtnb smoothelin b 0.051
rsrc2 arginine/serine-rich coiled-coil 2 0.050
sfswap splicing factor, suppressor of white-apricot homolog (Drosophila) 0.050
arfgef1 ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited) 0.050
fgfrl1b fibroblast growth factor receptor-like 1b 0.050
caprin1a cell cycle associated protein 1a 0.050
otud7b OTU domain containing 7B 0.050
zgc:56306 zgc:56306 0.049
fcho2 FCH domain only 2 0.049
spred1 sprouty-related, EVH1 domain containing 1 0.048
zgc:66440 zgc:66440 0.048
srsf11 serine/arginine-rich splicing factor 11 0.047
sh3pxd2b SH3 and PX domains 2B 0.047
nf1b neurofibromin 1b 0.046
vps39 vacuolar protein sorting 39 homolog (S. cerevisiae) 0.046
acin1a apoptotic chromatin condensation inducer 1a 0.045
atrx alpha thalassemia/mental retardation syndrome X-linked homolog (human) 0.045
atxn7l3 ataxin 7-like 3 0.044
calcrla calcitonin receptor-like a 0.044
si:ch1073-351m12.1 si:ch1073-351m12.1 0.044
lef1 lymphocyte enhancer binding factor 1 0.043
zgc:55468 zgc:55468 0.043
nup107 nucleoporin 107 0.043
rbm39a RNA binding motif protein 39a 0.043
abcc5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 0.043
slc2a12 solute carrier family 2 (facilitated glucose transporter), member 12 0.043
rrbp1 ribosome binding protein 1 homolog (dog) 0.043
zgc:85727 zgc:85727 0.043
agtr2 angiotensin II receptor, type 2 0.043
por P450 (cytochrome) oxidoreductase 0.042
ptpra protein tyrosine phosphatase, receptor type, A 0.042
dedd1 death effector domain-containing 1 0.042
wdr82 WD repeat domain containing 82 0.041
znf711 zinc finger protein 711 0.041
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Drosophila melanogaster
Name Description Probability Func Analog Organism
S6kII RPS6-protein kinase-II 0.397
dm diminutive 0.312
CG7928 CG7928 gene product from transcript CG7928-RA 0.195
scb scab 0.183
Dsor1 Downstream of raf1 0.176
NFAT NFAT homolog 0.173
CG5180 CG5180 gene product from transcript CG5180-RB 0.139
Pk61C Protein kinase 61C 0.131
CG4813 CG4813 gene product from transcript CG4813-RA 0.117
Snr1 Snf5-related 1 0.103
mbt mushroom bodies tiny 0.101
Eip63E Ecdysone-induced protein 63E 0.097
Atg1 Autophagy-specific gene 1 0.091
CG14667 CG14667 gene product from transcript CG14667-RA 0.086
wb wing blister 0.081
Cdc42 CG12530 gene product from transcript CG12530-RA 0.078
Su(z)2 Suppressor of zeste 2 0.074
hipk homeodomain interacting protein kinase 0.070
CG2662 CG2662 gene product from transcript CG2662-RA 0.070
vri vrille 0.069
Shc SHC-adaptor protein 0.069
Sdc Syndecan 0.064
Su(var)3-7 Suppressor of variegation 3-7 0.061
rg rugose 0.051
rod rough deal 0.051
CTCF CG8591 gene product from transcript CG8591-RA 0.051
lqf liquid facets 0.051
CG9797 CG9797 gene product from transcript CG9797-RA 0.049
drpr draper 0.047
Aly CG1101 gene product from transcript CG1101-RA 0.047
mri mrityu 0.047
aop anterior open 0.046
C3G CG42328 gene product from transcript CG42328-RC 0.042
Rho1 CG8416 gene product from transcript CG8416-RB 0.042
CG4424 CG4424 gene product from transcript CG4424-RA 0.039
CG8273 CG8273 gene product from transcript CG8273-RA 0.038
NetB Netrin-B 0.037
CG11696 CG11696 gene product from transcript CG11696-RA 0.036
slik Sterile20-like kinase 0.035
robo3 CG5423 gene product from transcript CG5423-RA 0.035
Rab7 Rab-protein 7 0.034
Akt1 CG4006 gene product from transcript CG4006-RA 0.032
kay kayak 0.032
RanBPM Ran-binding protein M 0.031
Alk CG8250 gene product from transcript CG8250-RA 0.030
CG9650 CG9650 gene product from transcript CG9650-RG 0.029
ck crinkled 0.028
CG16812 CG16812 gene product from transcript CG16812-RA 0.028
dup double parked 0.028
CG8965 CG8965 gene product from transcript CG8965-RA 0.027
puc puckered 0.027
MBD-like CG8208 gene product from transcript CG8208-RA 0.026
tsg twisted gastrulation 0.026
jeb jelly belly 0.025
CG31961 CG31961 gene product from transcript CG31961-RA 0.025
B-H1 BarH1 0.025
nrv1 nervana 1 0.025
CG1792 CG1792 gene product from transcript CG1792-RA 0.025
CG15167 CG15167 gene product from transcript CG15167-RA 0.025
Smg5 CG8954 gene product from transcript CG8954-RA 0.024
sw short wing 0.024
Myo31DF Myosin 31DF 0.023
insc inscuteable 0.023
wdb widerborst 0.023
CG10366 CG10366 gene product from transcript CG10366-RA 0.022
CG2129 CG2129 gene product from transcript CG2129-RA 0.022
enok enoki mushroom 0.022
svp seven up 0.022
cyc cycle 0.022
Mkp3 Mitogen-activated protein kinase phosphatase 3 0.022
CG4730 CG4730 gene product from transcript CG4730-RA 0.021
Abl Abl tyrosine kinase 0.021
CG15601 CG15601 gene product from transcript CG15601-RA 0.021
CG14711 CG14711 gene product from transcript CG14711-RA 0.020
simj simjang 0.020
crol crooked legs 0.020
chico CG5686 gene product from transcript CG5686-RB 0.020
InR Insulin-like receptor 0.020
rin rasputin 0.019
Lnk CG17367 gene product from transcript CG17367-RC 0.019
CG6792 CG6792 gene product from transcript CG6792-RA 0.019
hang hangover 0.019
pall pallbearer 0.019
alph alphabet 0.019
Ravus CG15889 gene product from transcript CG15889-RA 0.019
mys myospheroid 0.018
az2 CG1605 gene product from transcript CG1605-RA 0.018
Gem2 Gemin2 0.018
pyd polychaetoid 0.018
CG13367 CG13367 gene product from transcript CG13367-RA 0.018
cno canoe 0.018
ttk tramtrack 0.018
tutl turtle 0.017
ed echinoid 0.017
Fim Fimbrin 0.017
Rip11 Rab11 interacting protein 0.017
Cep135 CG17081 gene product from transcript CG17081-RB 0.017
Ets97D Ets at 97D 0.017
CG12424 CG12424 gene product from transcript CG12424-RC 0.017
l(1)G0232 lethal (1) G0232 0.016
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
IRA1 Ira1p 0.172
CDC24 Cdc24p 0.147
GPB2 Gpb2p 0.129
PKC1 Pkc1p 0.088
CDC25 Cdc25p 0.087
ACK1 Ack1p 0.085
RHO1 Rho1p 0.080
MKK1 Mkk1p 0.066
ROM2 Rom2p 0.064
IRA2 Ira2p 0.063
SLG1 Slg1p 0.063
MDS3 Mds3p 0.058
FYV8 Fyv8p 0.055
GPR1 Gpr1p 0.055
CYR1 Cyr1p 0.051
SAC7 Sac7p 0.048
BEM2 Bem2p 0.036
RIM15 Rim15p 0.025
BEM3 Bem3p 0.025
SRD1 Srd1p 0.020
CYK3 Cyk3p 0.020
TAO3 Tao3p 0.019
YAR068W hypothetical protein 0.019
LEU2 Leu2p 0.018
YOL038C-A hypothetical protein 0.018
MER1 Mer1p 0.018
SAK1 Sak1p 0.016
ARP10 Arp10p 0.016
PRS2 Prs2p 0.016
PEP5 Pep5p 0.016
YLR264C-A hypothetical protein 0.016
MSS11 Mss11p 0.016
PCL9 Pcl9p 0.015
YLR162W hypothetical protein 0.015
SPL2 Spl2p 0.015
YNL058C hypothetical protein 0.015
MKS1 Mks1p 0.015
ARG8 Arg8p 0.014
BST1 Bst1p 0.014
YBR013C hypothetical protein 0.014
ICS2 Ics2p 0.013
ZPS1 Zps1p 0.013
YAR066W hypothetical protein 0.013
CPD1 Cpd1p 0.013
AUA1 Aua1p 0.013
HPF1 Hpf1p 0.013
BRN1 Brn1p 0.013
TSC11 Tsc11p 0.013
ATP6 Atp6p 0.013
GIC2 Gic2p 0.013
HXT3 Hxt3p 0.012
YNL234W hypothetical protein 0.012
CUP1-1 Cup1-1p 0.012
YLR042C hypothetical protein 0.012
SPR6 Spr6p 0.012
HOR2 Hor2p 0.012
YOL013W-A hypothetical protein 0.012
YBR016W hypothetical protein 0.012
FMT1 Fmt1p 0.011
SCM4 Scm4p 0.011
YKR017C hypothetical protein 0.011
AVL9 Avl9p 0.011
BIT61 Bit61p 0.011
IML1 Iml1p 0.011
YIL151C hypothetical protein 0.011
YPR157W hypothetical protein 0.011
SGE1 Sge1p 0.011
IQG1 Iqg1p 0.011
UPS3 Ups3p 0.011
YPL066W hypothetical protein 0.011
GYL1 Gyl1p 0.011
BAT2 Bat2p 0.011
YIL001W hypothetical protein 0.011
ARE2 Are2p 0.011
UFO1 Ufo1p 0.011
PRM4 Prm4p 0.011
SSP1 Ssp1p 0.011
OPT2 Opt2p 0.011
RGD2 Rgd2p 0.010
GID7 Gid7p 0.010
PCL2 Pcl2p 0.010
IZH4 Izh4p 0.010
AAD6 Aad6p 0.010
TYE7 Tye7p 0.010
PMA2 Pma2p 0.010
YKR075C hypothetical protein 0.010
PCT1 Pct1p 0.010
YLR040C hypothetical protein 0.010
CHA1 Cha1p 0.010
BSC1 Bsc1p 0.010
YPL067C hypothetical protein 0.010