The network for 'gamma delta t cell activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

gamma delta t cell activation

The change in morphology and behavior of a gamma-delta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.

Homo sapiens
Name Description Probability Func Analog Organism
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.997
PILRA paired immunoglobin-like type 2 receptor alpha 0.975
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.971
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.912
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 0.889
LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.695
FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.657
INSR insulin receptor 0.494
CD22 CD22 molecule 0.450
EPOR erythropoietin receptor 0.401
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 0.316
CSK c-src tyrosine kinase 0.263
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 0.261
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D 0.237
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.234
STAP2 signal transducing adaptor family member 2 0.188
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 0.164
IL2RB interleukin 2 receptor, beta 0.163
GFI1B growth factor independent 1B transcription repressor 0.159
SH2D2A SH2 domain containing 2A 0.151
CD33 CD33 molecule 0.151
LGALS3 lectin, galactoside-binding, soluble, 3 0.146
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.146
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 0.142
PTAFR platelet-activating factor receptor 0.142
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 0.127
SH3BP2 SH3-domain binding protein 2 0.120
PECAM1 platelet/endothelial cell adhesion molecule 0.106
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 0.098
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.091
CTBP2 C-terminal binding protein 2 0.090
PRKCQ protein kinase C, theta 0.086
LCK lymphocyte-specific protein tyrosine kinase 0.080
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 0.076
BLNK B-cell linker 0.068
UBASH3B ubiquitin associated and SH3 domain containing B 0.065
HK3 hexokinase 3 (white cell) 0.064
CD247 CD247 molecule 0.057
ROS1 c-ros oncogene 1 , receptor tyrosine kinase 0.050
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.050
SMAD7 SMAD family member 7 0.049
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.045
LILRA3 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 0.043
SIRPB1 signal-regulatory protein beta 1 0.040
SIGLEC10 sialic acid binding Ig-like lectin 10 0.032
AOAH acyloxyacyl hydrolase (neutrophil) 0.032
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.031
SIGLEC7 sialic acid binding Ig-like lectin 7 0.029
NMI N-myc (and STAT) interactor 0.029
JAK2 Janus kinase 2 0.028
TYMP thymidine phosphorylase 0.027
NOTCH3 notch 3 0.026
AIF1 allograft inflammatory factor 1 0.026
CD72 CD72 molecule 0.026
LAT linker for activation of T cells 0.025
VAV1 vav 1 guanine nucleotide exchange factor 0.025
NOD2 nucleotide-binding oligomerization domain containing 2 0.025
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.025
CD300A CD300a molecule 0.025
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 0.025
CD48 CD48 molecule 0.025
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 0.024
AQP9 aquaporin 9 0.023
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 0.023
NLRP3 NLR family, pyrin domain containing 3 0.022
FCN1 ficolin (collagen/fibrinogen domain containing) 1 0.022
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.021
EMR1 egf-like module containing, mucin-like, hormone receptor-like 1 0.021
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) 0.021
CD1D CD1d molecule 0.021
ATN1 atrophin 1 0.021
EGR2 early growth response 2 0.021
TLR8 toll-like receptor 8 0.021
SPRY4 sprouty homolog 4 (Drosophila) 0.020
HCK hemopoietic cell kinase 0.020
SIRPA signal-regulatory protein alpha 0.018
FPR2 formyl peptide receptor 2 0.018
GHR growth hormone receptor 0.018
MICA MHC class I polypeptide-related sequence A 0.018
TREM1 triggering receptor expressed on myeloid cells 1 0.018
CAV1 caveolin 1, caveolae protein, 22kDa 0.017
CD4 CD4 molecule 0.017
CCR1 chemokine (C-C motif) receptor 1 0.017
VSIG4 V-set and immunoglobulin domain containing 4 0.017
MET met proto-oncogene (hepatocyte growth factor receptor) 0.017
LTBP4 latent transforming growth factor beta binding protein 4 0.016
IL4R interleukin 4 receptor 0.016
BTK Bruton agammaglobulinemia tyrosine kinase 0.015
MICB MHC class I polypeptide-related sequence B 0.015
VNN2 vanin 2 0.015
CD86 CD86 molecule 0.015
PLEK pleckstrin 0.014
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.014
CD52 CD52 molecule 0.014
CD38 CD38 molecule 0.014
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 0.014
MYH14 myosin, heavy chain 14, non-muscle 0.013
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.013
FYB FYN binding protein 0.013
MS4A4A membrane-spanning 4-domains, subfamily A, member 4 0.013
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Fyn Fyn proto-oncogene 0.997
Notch1 Notch gene homolog 1 (Drosophila) 0.927
Lck lymphocyte protein tyrosine kinase 0.857
Cd247 CD247 antigen 0.684
Inpp5d inositol polyphosphate-5-phosphatase D 0.530
Ptprc protein tyrosine phosphatase, receptor type, C 0.502
Dll1 delta-like 1 (Drosophila) 0.427
Foxp3 forkhead box P3 0.409
Fas Fas (TNF receptor superfamily member 6) 0.393
Was Wiskott-Aldrich syndrome homolog (human) 0.354
Cbl Casitas B-lineage lymphoma 0.327
Ccr6 chemokine (C-C motif) receptor 6 0.312
Irf9 interferon regulatory factor 9 0.307
Notch2 Notch gene homolog 2 (Drosophila) 0.294
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.248
Ikzf1 IKAROS family zinc finger 1 0.187
Il2rg interleukin 2 receptor, gamma chain 0.183
Il2 interleukin 2 0.174
Lat linker for activation of T cells 0.169
Tcra T-cell receptor alpha chain 0.148
Hcls1 hematopoietic cell specific Lyn substrate 1 0.143
Nab2 Ngfi-A binding protein 2 0.141
Ptgs2 prostaglandin-endoperoxide synthase 2 0.129
Grb2 growth factor receptor bound protein 2 0.126
Egr2 early growth response 2 0.117
Zap70 zeta-chain (TCR) associated protein kinase 0.100
Ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.094
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.092
Ptk2 PTK2 protein tyrosine kinase 2 0.089
Plcg2 phospholipase C, gamma 2 0.086
Cd28 CD28 antigen 0.079
Vav1 vav 1 oncogene 0.073
Tnf tumor necrosis factor 0.072
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.070
Dok2 docking protein 2 0.065
Myd88 myeloid differentiation primary response gene 88 0.065
Dok1 docking protein 1 0.061
Efs embryonal Fyn-associated substrate 0.059
Lepr leptin receptor 0.059
Cd79a CD79A antigen (immunoglobulin-associated alpha) 0.057
Ahr aryl-hydrocarbon receptor 0.056
Blnk B-cell linker 0.054
Cd4 CD4 antigen 0.054
Fyb FYN binding protein 0.049
Il2rb interleukin 2 receptor, beta chain 0.048
Cd8a CD8 antigen, alpha chain 0.048
Stat3 signal transducer and activator of transcription 3 0.048
Igh immunoglobulin heavy chain complex 0.048
Fos FBJ osteosarcoma oncogene 0.047
Itk IL2-inducible T-cell kinase 0.046
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.044
Jak2 Janus kinase 2 0.040
Lfng LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 0.039
Ar androgen receptor 0.039
Pik3r1 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) 0.038
Rgs14 regulator of G-protein signaling 14 0.037
Tbx18 T-box18 0.035
Neurl1a neuralized homolog 1A (Drosophila) 0.035
Ebi3 Epstein-Barr virus induced gene 3 0.032
Ptk2b PTK2 protein tyrosine kinase 2 beta 0.032
Ager advanced glycosylation end product-specific receptor 0.031
Mmp9 matrix metallopeptidase 9 0.031
Gata4 GATA binding protein 4 0.031
Arhgap9 Rho GTPase activating protein 9 0.030
Cdh1 cadherin 1 0.030
Jak3 Janus kinase 3 0.030
Itgal integrin alpha L 0.030
Cd44 CD44 antigen 0.029
Trim21 tripartite motif-containing 21 0.029
Agap2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 0.028
Kit kit oncogene 0.027
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.027
Tlr4 toll-like receptor 4 0.027
Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.026
Rag1 recombination activating gene 1 0.026
Nrarp Notch-regulated ankyrin repeat protein 0.026
Gata3 GATA binding protein 3 0.025
Ptpre protein tyrosine phosphatase, receptor type, E 0.025
9430031J16Rik RIKEN cDNA 9430031J16 gene 0.025
Nab1 Ngfi-A binding protein 1 0.025
Rasal1 RAS protein activator like 1 (GAP1 like) 0.024
Lyz2 lysozyme 2 0.024
Jup junction plakoglobin 0.024
Hes1 hairy and enhancer of split 1 (Drosophila) 0.023
Map4k1 mitogen-activated protein kinase kinase kinase kinase 1 0.023
Cd3e CD3 antigen, epsilon polypeptide 0.023
Ptpra protein tyrosine phosphatase, receptor type, A 0.022
Lcp2 lymphocyte cytosolic protein 2 0.022
Foxn1 forkhead box N1 0.022
Il1r1 interleukin 1 receptor, type I 0.021
Robo4 roundabout homolog 4 (Drosophila) 0.021
Hr hairless 0.020
Dll4 delta-like 4 (Drosophila) 0.020
Esrp2 epithelial splicing regulatory protein 2 0.020
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.020
Fosb FBJ osteosarcoma oncogene B 0.020
Prkce protein kinase C, epsilon 0.020
Efnb2 ephrin B2 0.020
Nfam1 Nfat activating molecule with ITAM motif 1 0.019
Il6 interleukin 6 0.019
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism