The network for 'regulation of hormone metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of hormone metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any hormone.

Mus musculus
Name Description Probability Func Analog Organism
Pax8 paired box gene 8 0.978
Esr1 estrogen receptor 1 (alpha) 0.524
Drd2 dopamine receptor D2 0.376
Thrb thyroid hormone receptor beta 0.353
Ush1g Usher syndrome 1G homolog (human) 0.235
Fgfr2 fibroblast growth factor receptor 2 0.199
Ar androgen receptor 0.188
Fgf10 fibroblast growth factor 10 0.184
Lhx1 LIM homeobox protein 1 0.178
Ghr growth hormone receptor 0.158
Wnt4 wingless-related MMTV integration site 4 0.155
Kiss1 KiSS-1 metastasis-suppressor 0.146
Wnt9b wingless-type MMTV integration site 9B 0.118
Bmp7 bone morphogenetic protein 7 0.108
Tcf7 transcription factor 7, T-cell specific 0.104
Kl klotho 0.099
Thra thyroid hormone receptor alpha 0.088
Duox2 dual oxidase 2 0.088
Ahr aryl-hydrocarbon receptor 0.088
Fgfr1 fibroblast growth factor receptor 1 0.085
Adam17 a disintegrin and metallopeptidase domain 17 0.083
Wnt3a wingless-related MMTV integration site 3A 0.077
Rarg retinoic acid receptor, gamma 0.076
Atp2b2 ATPase, Ca++ transporting, plasma membrane 2 0.076
Kcne1 potassium voltage-gated channel, Isk-related subfamily, member 1 0.070
Lmx1a LIM homeobox transcription factor 1 alpha 0.070
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.070
Grb10 growth factor receptor bound protein 10 0.065
Gnaq guanine nucleotide binding protein, alpha q polypeptide 0.065
Prlr prolactin receptor 0.062
Ret ret proto-oncogene 0.060
Pax2 paired box gene 2 0.058
Kcnq1 potassium voltage-gated channel, subfamily Q, member 1 0.056
Wnt5a wingless-related MMTV integration site 5A 0.053
Slc17a8 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8 0.049
T brachyury 0.047
Tmc1 transmembrane channel-like gene family 1 0.043
Hoxd11 homeobox D11 0.043
Igf2 insulin-like growth factor 2 0.043
Pgr progesterone receptor 0.042
Alx4 aristaless-like homeobox 4 0.041
Tbx1 T-box 1 0.039
Kcna1 potassium voltage-gated channel, shaker-related subfamily, member 1 0.038
Shh sonic hedgehog 0.037
Cdh23 cadherin 23 (otocadherin) 0.037
Emx2 empty spiracles homolog 2 (Drosophila) 0.036
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.036
Tg thyroglobulin 0.035
Igf2r insulin-like growth factor 2 receptor 0.035
Rarb retinoic acid receptor, beta 0.032
Sox9 SRY-box containing gene 9 0.032
Rab25 RAB25, member RAS oncogene family 0.031
Wnt1 wingless-related MMTV integration site 1 0.031
Amhr2 anti-Mullerian hormone type 2 receptor 0.031
Hoxa11 homeobox A11 0.030
Wnt10b wingless related MMTV integration site 10b 0.030
Ppp2r1a protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform 0.029
Lhx3 LIM homeobox protein 3 0.029
Igf1 insulin-like growth factor 1 0.028
Barx2 BarH-like homeobox 2 0.027
Nkx2-1 NK2 homeobox 1 0.026
Bglap bone gamma carboxyglutamate protein 0.026
Lif leukemia inhibitory factor 0.026
Insr insulin receptor 0.026
Hand1 heart and neural crest derivatives expressed transcript 1 0.025
Pcsk4 proprotein convertase subtilisin/kexin type 4 0.025
Plcb1 phospholipase C, beta 1 0.025
Htt huntingtin 0.025
Foxc1 forkhead box C1 0.025
Kdm2b lysine (K)-specific demethylase 2B 0.025
Hoxa2 homeobox A2 0.025
Foxi1 forkhead box I1 0.024
Bnc1 basonuclin 1 0.023
Epas1 endothelial PAS domain protein 1 0.023
Tshr thyroid stimulating hormone receptor 0.023
Cga glycoprotein hormones, alpha subunit 0.023
Cdkn1c cyclin-dependent kinase inhibitor 1C (P57) 0.022
Bcl2 B-cell leukemia/lymphoma 2 0.020
Gfi1b growth factor independent 1B 0.020
Cbln3 cerebellin 3 precursor protein 0.020
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.020
Hbb-b1 hemoglobin, beta adult major chain 0.020
Fgf3 fibroblast growth factor 3 0.020
4833422F24Rik RIKEN cDNA 4833422F24 gene 0.019
Cacnb2 calcium channel, voltage-dependent, beta 2 subunit 0.018
Adra2a adrenergic receptor, alpha 2a 0.018
Mgmt O-6-methylguanine-DNA methyltransferase 0.018
Cacnb4 calcium channel, voltage-dependent, beta 4 subunit 0.018
Ryr1 ryanodine receptor 1, skeletal muscle 0.018
Onecut1 one cut domain, family member 1 0.018
Gpc3 glypican 3 0.017
Cacna1d calcium channel, voltage-dependent, L type, alpha 1D subunit 0.017
Trp63 transformation related protein 63 0.017
Pcsk5 proprotein convertase subtilisin/kexin type 5 0.017
Fshb follicle stimulating hormone beta 0.017
Nostrin nitric oxide synthase trafficker 0.017
Fam83f family with sequence similarity 83, member F 0.017
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.017
Porcn porcupine homolog (Drosophila) 0.017
Fzd8 frizzled homolog 8 (Drosophila) 0.016
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
sox9b SRY-box containing gene 9b 0.499
bmp2b bone morphogenetic protein 2b 0.463
rspo1 R-spondin homolog (Xenopus laevis) 0.207
bmp4 bone morphogenetic protein 4 0.189
ocrl oculocerebrorenal syndrome of Lowe 0.131
gro2 groucho 2 0.129
paqr8 progestin and adipoQ receptor family member VIII 0.082
ephb4b eph receptor B4b 0.073
nanos3 nanos homolog 3 0.073
axin1 axin 1 0.070
tal1 T-cell acute lymphocytic leukemia 1 0.066
rag1 recombination activating gene 1 0.060
atp1b1b ATPase, Na+/K+ transporting, beta 1b polypeptide 0.059
gpr126 G protein-coupled receptor 126 0.058
six2a sine oculis-related homeobox 2a 0.054
lhcgr luteinizing hormone/choriogonadotropin receptor 0.053
inha inhibin, alpha 0.042
trpm7 transient receptor potential cation channel, subfamily M, member 7 0.041
LOC100000433 hypothetical LOC100000433 0.040
cx30.3 connexin 30.3 0.038
hmx4 H6 family homeobox 4 0.037
notch3 notch homolog 3 0.036
plcg1 phospholipase C, gamma 1 0.030
ptgs1 prostaglandin-endoperoxide synthase 1 0.029
sf3b1 splicing factor 3b, subunit 1 0.029
cldn2 claudin 2 0.029
mt2 metallothionein 2 0.029
hmx2 H6 family homeobox 2 0.028
igf3 insulin-like growth factor 3 0.028
cdh17 cadherin 17, LI cadherin (liver-intestine) 0.028
atp1a1a.4 ATPase, Na+/K+ transporting, alpha 1a.4 polypeptide 0.028
lama5 laminin, alpha 5 0.027
star steroidogenic acute regulatory protein 0.026
rorab RAR-related orphan receptor A, paralog b 0.026
gpia glucose phosphate isomerase a 0.024
cyp17a1 cytochrome P450, family 17, subfamily A, polypeptide 1 0.024
tp53bp2 tumor protein p53 binding protein, 2 0.024
hsd17b12b hydroxysteroid (17-beta) dehydrogenase 12b 0.022
vsx2 visual system homeobox 2 0.021
hmx3 homeo box (H6 family) 3 0.021
enc1 ectodermal-neural cortex (with BTB-like domain) 0.021
slc12a2 solute carrier family 12 (potassium/chloride transporters), member 2 0.021
grifin galectin related inter-fiber protein 0.020
evx1 even-skipped homeobox 1 0.018
henmt1 HEN1 methyltransferase homolog 1 (Arabidopsis) 0.018
acvr2b activin receptor IIb 0.017
hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 0.017
fzd5 frizzled homolog 5 0.017
slc15a2 solute carrier family 15 (H+/peptide transporter), member 2 0.016
kiss1 KiSS-1 metastasis-suppressor 0.015
fabp6 fatty acid binding protein 6, ileal (gastrotropin) 0.015
kiss1rb KISS1 receptor b 0.015
aldh1a3 aldehyde dehydrogenase 1 family, member A3 0.014
paqr7b progestin and adipoQ receptor family member VII, b 0.014
ryk receptor-like tyrosine kinase 0.013
ndrg1 N-myc downstream regulated gene 1 0.013
dacha dachshund a 0.013
si:dkeyp-7c9.1 si:dkeyp-7c9.1 0.013
wnt4b wingless-type MMTV integration site family, member 4b 0.013
rx1 retinal homeobox gene 1 0.012
ptgesl prostaglandin E synthase 2-like 0.012
bambib BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) b 0.012
wnt10a wingless-type MMTV integration site family, member 10a 0.012
slc12a3 solute carrier family 12 (sodium/chloride transporters), member 3 0.011
bmp7b bone morphogenetic protein 7b 0.011
jag2 jagged 2 0.011
jag1b jagged 1b 0.011
cldna claudin a 0.011
notch1a notch homolog 1a 0.011
ip6k2 inositol hexaphosphate kinase 2 0.011
ascl1a achaete-scute complex-like 1a (Drosophila) 0.011
gli1 GLI-Kruppel family member 1 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
TAL1 T-cell acute lymphocytic leukemia 1 0.967
EPAS1 endothelial PAS domain protein 1 0.955
AKR1C1 aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) 0.942
AKR1C2 aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III) 0.911
BMPR1A bone morphogenetic protein receptor, type IA 0.665
GH1 growth hormone 1 0.538
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 0.473
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.427
CSHL1 chorionic somatomammotropin hormone-like 1 0.403
AHR aryl hydrocarbon receptor 0.392
CBLB Cas-Br-M (murine) ecotropic retroviral transforming sequence b 0.314
AKR1C3 aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) 0.303
GH2 growth hormone 2 0.293
CSH2 chorionic somatomammotropin hormone 2 0.284
EGLN1 egl nine homolog 1 (C. elegans) 0.260
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.219
MEOX1 mesenchyme homeobox 1 0.207
BMPR1B bone morphogenetic protein receptor, type IB 0.200
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.160
EGLN3 egl nine homolog 3 (C. elegans) 0.156
ITGB1BP3 integrin beta 1 binding protein 3 0.146
VHL von Hippel-Lindau tumor suppressor 0.142
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.117
CLOCK clock homolog (mouse) 0.114
ARNT aryl hydrocarbon receptor nuclear translocator 0.113
ESR1 estrogen receptor 1 0.111
AR androgen receptor 0.109
IGF2R insulin-like growth factor 2 receptor 0.108
NOG noggin 0.087
TBX5 T-box 5 0.085
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.075
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.073
SSX4 synovial sarcoma, X breakpoint 4 0.071
NKX2-1 NK2 homeobox 1 0.069
ITCH itchy E3 ubiquitin protein ligase homolog (mouse) 0.066
SMAD3 SMAD family member 3 0.061
RUNX1 runt-related transcription factor 1 0.057
WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 0.055
TGFB1 transforming growth factor, beta 1 0.052
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit 0.043
SGK3 serum/glucocorticoid regulated kinase family, member 3 0.042
RCOR1 REST corepressor 1 0.042
CREBBP CREB binding protein 0.041
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 0.040
HIC1 hypermethylated in cancer 1 0.038
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.038
ARHGAP22 Rho GTPase activating protein 22 0.038
SFRP1 secreted frizzled-related protein 1 0.035
SH3GL3 SH3-domain GRB2-like 3 0.035
FGF4 fibroblast growth factor 4 0.033
PRKCQ protein kinase C, theta 0.029
CD2 CD2 molecule 0.029
BMP4 bone morphogenetic protein 4 0.028
ALX4 ALX homeobox 4 0.027
TCF4 transcription factor 4 0.027
NDRG1 N-myc downstream regulated 1 0.026
KLF13 Kruppel-like factor 13 0.026
FGF18 fibroblast growth factor 18 0.026
MET met proto-oncogene (hepatocyte growth factor receptor) 0.026
COL2A1 collagen, type II, alpha 1 0.024
SOX1 SRY (sex determining region Y)-box 1 0.024
MTA3 metastasis associated 1 family, member 3 0.023
GRB10 growth factor receptor-bound protein 10 0.023
GDNF glial cell derived neurotrophic factor 0.022
FAF1 Fas (TNFRSF6) associated factor 1 0.022
MMP11 matrix metallopeptidase 11 (stromelysin 3) 0.021
FSTL1 follistatin-like 1 0.021
SFRP5 secreted frizzled-related protein 5 0.020
NRP1 neuropilin 1 0.020
PRMT6 protein arginine methyltransferase 6 0.020
FBLN1 fibulin 1 0.020
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.020
BLNK B-cell linker 0.020
SH3GL2 SH3-domain GRB2-like 2 0.019
GATA2 GATA binding protein 2 0.019
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 0.018
GLP1R glucagon-like peptide 1 receptor 0.017
TRAF4 TNF receptor-associated factor 4 0.016
WNT10A wingless-type MMTV integration site family, member 10A 0.016
FOXE1 forkhead box E1 (thyroid transcription factor 2) 0.016
SLC6A2 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 0.015
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.015
PAX7 paired box 7 0.014
BAG1 BCL2-associated athanogene 0.014
TUBB2B tubulin, beta 2B 0.014
SPRY2 sprouty homolog 2 (Drosophila) 0.014
PAX3 paired box 3 0.014
TP73 tumor protein p73 0.014
IHH Indian hedgehog 0.013
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.013
LCK lymphocyte-specific protein tyrosine kinase 0.013
CARHSP1 calcium regulated heat stable protein 1, 24kDa 0.013
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.013
HOXB1 homeobox B1 0.013
WT1 Wilms tumor 1 0.013
HSPA1B heat shock 70kDa protein 1B 0.012
ARTN artemin 0.012
SPIB Spi-B transcription factor (Spi-1/PU.1 related) 0.012
PDCD6IP programmed cell death 6 interacting protein 0.012
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 0.012
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism