IMP
Process View
The network for 'cardiac muscle hypertrophy' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
cardiac muscle hypertrophy
The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Nos3 | nitric oxide synthase 3, endothelial cell | 0.981 | |
| Jag1 | jagged 1 | 0.715 | |
| Rxra | retinoid X receptor alpha | 0.635 | |
| Gata4 | GATA binding protein 4 | 0.625 | |
| Adrb1 | adrenergic receptor, beta 1 | 0.613 | |
| Nkx2-5 | NK2 transcription factor related, locus 5 (Drosophila) | 0.559 | |
| Tgfb2 | transforming growth factor, beta 2 | 0.440 | |
| Pnpla2 | patatin-like phospholipase domain containing 2 | 0.426 | |
| Pparg | peroxisome proliferator activated receptor gamma | 0.415 | |
| Gata5 | GATA binding protein 5 | 0.410 | |
| Hand2 | heart and neural crest derivatives expressed transcript 2 | 0.316 | |
| Zfpm2 | zinc finger protein, multitype 2 | 0.292 | |
| Ptpn11 | protein tyrosine phosphatase, non-receptor type 11 | 0.277 | |
| Ntrk2 | neurotrophic tyrosine kinase, receptor, type 2 | 0.241 | |
| Ar | androgen receptor | 0.230 | |
| Bmp4 | bone morphogenetic protein 4 | 0.192 | |
| Hivep2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.190 | |
| Mef2d | myocyte enhancer factor 2D | 0.187 | |
| Hand1 | heart and neural crest derivatives expressed transcript 1 | 0.182 | |
| Abcc9 | ATP-binding cassette, sub-family C (CFTR/MRP), member 9 | 0.161 | |
| Hey2 | hairy/enhancer-of-split related with YRPW motif 2 | 0.160 | |
| Rhob | ras homolog gene family, member B | 0.146 | |
| Fgf8 | fibroblast growth factor 8 | 0.143 | |
| Dusp1 | dual specificity phosphatase 1 | 0.133 | |
| Ptprb | protein tyrosine phosphatase, receptor type, B | 0.132 | |
| Hdac4 | histone deacetylase 4 | 0.122 | |
| Ednra | endothelin receptor type A | 0.120 | |
| Lox | lysyl oxidase | 0.120 | |
| Gdf6 | growth differentiation factor 6 | 0.115 | |
| Efnb2 | ephrin B2 | 0.113 | |
| Kcnq1 | potassium voltage-gated channel, subfamily Q, member 1 | 0.109 | |
| Cav1 | caveolin 1, caveolae protein | 0.108 | |
| Epor | erythropoietin receptor | 0.107 | |
| Kcnk3 | potassium channel, subfamily K, member 3 | 0.105 | |
| Epas1 | endothelial PAS domain protein 1 | 0.101 | |
| Kcna2 | potassium voltage-gated channel, shaker-related subfamily, member 2 | 0.099 | |
| Adam19 | a disintegrin and metallopeptidase domain 19 (meltrin beta) | 0.097 | |
| Ppp3r1 | protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) | 0.097 | |
| Pax2 | paired box gene 2 | 0.095 | |
| Drd2 | dopamine receptor D2 | 0.094 | |
| Ush1g | Usher syndrome 1G homolog (human) | 0.094 | |
| Smad6 | MAD homolog 6 (Drosophila) | 0.094 | |
| Klf3 | Kruppel-like factor 3 (basic) | 0.094 | |
| Btg2 | B-cell translocation gene 2, anti-proliferative | 0.092 | |
| Mef2a | myocyte enhancer factor 2A | 0.089 | |
| Nppa | natriuretic peptide type A | 0.089 | |
| Msx1 | homeobox, msh-like 1 | 0.088 | |
| Zeb2 | zinc finger E-box binding homeobox 2 | 0.088 | |
| Apoe | apolipoprotein E | 0.084 | |
| Arid1b | AT rich interactive domain 1B (SWI-like) | 0.081 | |
| Pthlh | parathyroid hormone-like peptide | 0.080 | |
| Scn5a | sodium channel, voltage-gated, type V, alpha | 0.080 | |
| Gata6 | GATA binding protein 6 | 0.078 | |
| Ahr | aryl-hydrocarbon receptor | 0.073 | |
| March7 | membrane-associated ring finger (C3HC4) 7 | 0.073 | |
| Kcna4 | potassium voltage-gated channel, shaker-related subfamily, member 4 | 0.072 | |
| Epha3 | Eph receptor A3 | 0.070 | |
| Kif5b | kinesin family member 5B | 0.069 | |
| Siah2 | seven in absentia 2 | 0.069 | |
| Klf7 | Kruppel-like factor 7 (ubiquitous) | 0.067 | |
| Notch1 | Notch gene homolog 1 (Drosophila) | 0.067 | |
| Tnxb | tenascin XB | 0.063 | |
| Foxc2 | forkhead box C2 | 0.063 | |
| Gdf5 | growth differentiation factor 5 | 0.059 | |
| Grm2 | glutamate receptor, metabotropic 2 | 0.057 | |
| Zswim6 | zinc finger, SWIM domain containing 6 | 0.055 | |
| Slc12a1 | solute carrier family 12, member 1 | 0.054 | |
| Hbegf | heparin-binding EGF-like growth factor | 0.053 | |
| Tac2 | tachykinin 2 | 0.052 | |
| Foxc1 | forkhead box C1 | 0.051 | |
| Tbx15 | T-box 15 | 0.051 | |
| Rock2 | Rho-associated coiled-coil containing protein kinase 2 | 0.051 | |
| Atp2b1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.050 | |
| Ptprm | protein tyrosine phosphatase, receptor type, M | 0.049 | |
| Cxcl12 | chemokine (C-X-C motif) ligand 12 | 0.048 | |
| Edn3 | endothelin 3 | 0.047 | |
| Hrh1 | histamine receptor H1 | 0.046 | |
| Zfr2 | zinc finger RNA binding protein 2 | 0.046 | |
| Cebpa | CCAAT/enhancer binding protein (C/EBP), alpha | 0.045 | |
| Hoxb3 | homeobox B3 | 0.045 | |
| Axl | AXL receptor tyrosine kinase | 0.044 | |
| Shh | sonic hedgehog | 0.044 | |
| Gdf9 | growth differentiation factor 9 | 0.044 | |
| Prrx1 | paired related homeobox 1 | 0.043 | |
| Slc4a1 | solute carrier family 4 (anion exchanger), member 1 | 0.043 | |
| Nr4a1 | nuclear receptor subfamily 4, group A, member 1 | 0.043 | |
| Nppb | natriuretic peptide type B | 0.042 | |
| Adora2a | adenosine A2a receptor | 0.041 | |
| Bmp5 | bone morphogenetic protein 5 | 0.040 | |
| Ank1 | ankyrin 1, erythroid | 0.040 | |
| Cacna2d1 | calcium channel, voltage-dependent, alpha2/delta subunit 1 | 0.039 | |
| Mll5 | myeloid/lymphoid or mixed-lineage leukemia 5 | 0.039 | |
| Gfi1b | growth factor independent 1B | 0.039 | |
| Fos | FBJ osteosarcoma oncogene | 0.038 | |
| Fosb | FBJ osteosarcoma oncogene B | 0.038 | |
| Myl2 | myosin, light polypeptide 2, regulatory, cardiac, slow | 0.038 | |
| Has1 | hyaluronan synthase1 | 0.038 | |
| Sox17 | SRY-box containing gene 17 | 0.038 | |
| Kcns2 | K+ voltage-gated channel, subfamily S, 2 | 0.037 | |
| Axin1 | axin 1 | 0.037 |
Loading network...
Homo sapiens
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| CAMK2A | calcium/calmodulin-dependent protein kinase II alpha | 0.755 | |
| PRKAR2A | protein kinase, cAMP-dependent, regulatory, type II, alpha | 0.592 | |
| MYOZ1 | myozenin 1 | 0.563 | |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.472 | |
| PRKACA | protein kinase, cAMP-dependent, catalytic, alpha | 0.424 | |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | 0.415 | |
| BMPR1B | bone morphogenetic protein receptor, type IB | 0.301 | |
| ITGB1BP3 | integrin beta 1 binding protein 3 | 0.258 | |
| CAMK2B | calcium/calmodulin-dependent protein kinase II beta | 0.240 | |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.218 | |
| TRIM63 | tripartite motif containing 63 | 0.150 | |
| OBSCN | obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF | 0.142 | |
| BBS10 | Bardet-Biedl syndrome 10 | 0.107 | |
| HDAC4 | histone deacetylase 4 | 0.094 | |
| IGF2R | insulin-like growth factor 2 receptor | 0.088 | |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.083 | |
| WFIKKN2 | WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 | 0.082 | |
| NEB | nebulin | 0.075 | |
| MYOZ2 | myozenin 2 | 0.073 | |
| CALCA | calcitonin-related polypeptide alpha | 0.066 | |
| VPS29 | vacuolar protein sorting 29 homolog (S. cerevisiae) | 0.064 | |
| MAPK6 | mitogen-activated protein kinase 6 | 0.054 | |
| CAPN3 | calpain 3, (p94) | 0.051 | |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | 0.048 | |
| HDAC9 | histone deacetylase 9 | 0.048 | |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.048 | |
| OSGEP | O-sialoglycoprotein endopeptidase | 0.048 | |
| MEF2A | myocyte enhancer factor 2A | 0.047 | |
| NCOA3 | nuclear receptor coactivator 3 | 0.044 | |
| KLF13 | Kruppel-like factor 13 | 0.044 | |
| PRKACB | protein kinase, cAMP-dependent, catalytic, beta | 0.044 | |
| NCOA1 | nuclear receptor coactivator 1 | 0.044 | |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) | 0.040 | |
| MYOD1 | myogenic differentiation 1 | 0.039 | |
| AKAP6 | A kinase (PRKA) anchor protein 6 | 0.037 | |
| DLG2 | discs, large homolog 2 (Drosophila) | 0.036 | |
| TRPC3 | transient receptor potential cation channel, subfamily C, member 3 | 0.032 | |
| MAPK1 | mitogen-activated protein kinase 1 | 0.032 | |
| ANKRD2 | ankyrin repeat domain 2 (stretch responsive muscle) | 0.029 | |
| MAP3K1 | mitogen-activated protein kinase kinase kinase 1 | 0.028 | |
| MYLK2 | myosin light chain kinase 2 | 0.026 | |
| MBNL1 | muscleblind-like (Drosophila) | 0.025 | |
| KAT2B | K(lysine) acetyltransferase 2B | 0.025 | |
| CSNK1E | casein kinase 1, epsilon | 0.024 | |
| HIST1H3B | histone cluster 1, H3b | 0.022 | |
| GRIA4 | glutamate receptor, ionotrophic, AMPA 4 | 0.022 | |
| PKD2 | polycystic kidney disease 2 (autosomal dominant) | 0.021 | |
| FAF1 | Fas (TNFRSF6) associated factor 1 | 0.021 | |
| CIAPIN1 | cytokine induced apoptosis inhibitor 1 | 0.021 | |
| PARK2 | parkinson protein 2, E3 ubiquitin protein ligase (parkin) | 0.020 | |
| DCN | decorin | 0.020 | |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.020 | |
| PDPK1 | 3-phosphoinositide dependent protein kinase-1 | 0.018 | |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.018 | |
| WFIKKN1 | WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 | 0.017 | |
| JPH2 | junctophilin 2 | 0.017 | |
| OBSL1 | obscurin-like 1 | 0.017 | |
| NCOR1 | nuclear receptor corepressor 1 | 0.017 | |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.016 | |
| CRIP1 | cysteine-rich protein 1 (intestinal) | 0.016 | |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.016 | |
| HEXDC | hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing | 0.016 | |
| RPS6KA5 | ribosomal protein S6 kinase, 90kDa, polypeptide 5 | 0.016 | |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.015 | |
| FRZB | frizzled-related protein | 0.015 | |
| AXIN1 | axin 1 | 0.015 | |
| NRIP1 | nuclear receptor interacting protein 1 | 0.015 | |
| DEAF1 | deformed epidermal autoregulatory factor 1 (Drosophila) | 0.014 | |
| C16orf74 | chromosome 16 open reading frame 74 | 0.014 | |
| PRKCQ | protein kinase C, theta | 0.014 | |
| TRPC6 | transient receptor potential cation channel, subfamily C, member 6 | 0.014 | |
| HIST1H4F | histone cluster 1, H4f | 0.013 | |
| ACTN1 | actinin, alpha 1 | 0.013 | |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.012 | |
| CELF2 | CUGBP, Elav-like family member 2 | 0.012 | |
| TRPC5 | transient receptor potential cation channel, subfamily C, member 5 | 0.012 | |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.012 | |
| NOV | nephroblastoma overexpressed gene | 0.012 | |
| C16orf70 | chromosome 16 open reading frame 70 | 0.012 | |
| ARRB2 | arrestin, beta 2 | 0.011 | |
| SOX1 | SRY (sex determining region Y)-box 1 | 0.011 | |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | 0.011 | |
| ACTA1 | actin, alpha 1, skeletal muscle | 0.011 | |
| SVIL | supervillin | 0.011 | |
| TRPC4 | transient receptor potential cation channel, subfamily C, member 4 | 0.011 | |
| PCYT2 | phosphate cytidylyltransferase 2, ethanolamine | 0.011 | |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.011 | |
| TF | transferrin | 0.011 | |
| TNNI1 | troponin I type 1 (skeletal, slow) | 0.011 | |
| PTPRR | protein tyrosine phosphatase, receptor type, R | 0.011 | |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.010 | |
| MYPN | myopalladin | 0.010 | |
| MYOG | myogenin (myogenic factor 4) | 0.010 |
Loading network...
Rattus norvegicus
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| LOC100362824 | caveolin 2-like | 0.041 | |
| Ahsg | alpha-2-HS-glycoprotein | 0.018 | |
| Cav1 | caveolin 1, caveolae protein | 0.018 | |
| Vom2r27 | vomeronasal 2 receptor, 27 | 0.016 | |
| Cav2 | caveolin 2 | 0.015 | |
| Pfkfb2 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 | 0.013 | |
| Kcnq3 | potassium voltage-gated channel, KQT-like subfamily, member 3 | 0.013 | |
| Proc | protein C | 0.013 | |
| Alb | albumin | 0.013 | |
| Erbb4 | v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) | 0.013 | |
| Nos3 | nitric oxide synthase 3, endothelial cell | 0.013 | |
| Chp | calcium binding protein p22 | 0.013 | |
| Akr1c18 | aldo-keto reductase family 1, member C18 | 0.013 | |
| Prdm2 | PR domain containing 2, with ZNF domain | 0.012 | |
| Cit | citron | 0.011 |