The network for 'neural tube development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

neural tube development

The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium.

Mus musculus
Name Description Probability Func Analog Organism
Gli3 GLI-Kruppel family member GLI3 1.000
Shh sonic hedgehog 1.000
Vangl2 vang-like 2 (van gogh, Drosophila) 1.000
Otx2 orthodenticle homolog 2 (Drosophila) 1.000
Pitx2 paired-like homeodomain transcription factor 2 1.000
Foxc1 forkhead box C1 1.000
Fgfr2 fibroblast growth factor receptor 2 1.000
Pax6 paired box gene 6 1.000
Rnf2 ring finger protein 2 1.000
Pax2 paired box gene 2 1.000
Pax3 paired box gene 3 1.000
Gli2 GLI-Kruppel family member GLI2 0.999
Bmp4 bone morphogenetic protein 4 0.999
Ctnnb1 catenin (cadherin associated protein), beta 1 0.999
Tcfap2a transcription factor AP-2, alpha 0.999
Msx2 homeobox, msh-like 2 0.998
Nodal nodal 0.998
Zic3 zinc finger protein of the cerebellum 3 0.998
Psen1 presenilin 1 0.997
Pten phosphatase and tensin homolog 0.997
Fgf8 fibroblast growth factor 8 0.997
Sox2 SRY-box containing gene 2 0.997
Lhx1 LIM homeobox protein 1 0.996
Foxg1 forkhead box G1 0.994
Foxh1 forkhead box H1 0.994
Pbx1 pre B-cell leukemia transcription factor 1 0.994
Sall4 sal-like 4 (Drosophila) 0.994
Hand1 heart and neural crest derivatives expressed transcript 1 0.993
Alx4 aristaless-like homeobox 4 0.992
Fgfr1 fibroblast growth factor receptor 1 0.992
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.990
Mks1 Meckel syndrome, type 1 0.989
Pou5f1 POU domain, class 5, transcription factor 1 0.988
Foxc2 forkhead box C2 0.986
Otx1 orthodenticle homolog 1 (Drosophila) 0.985
Bmp7 bone morphogenetic protein 7 0.984
Rarg retinoic acid receptor, gamma 0.983
Notch1 Notch gene homolog 1 (Drosophila) 0.980
Efnb2 ephrin B2 0.980
Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.980
Chd7 chromodomain helicase DNA binding protein 7 0.978
Rybp RING1 and YY1 binding protein 0.977
Lrp6 low density lipoprotein receptor-related protein 6 0.977
Dvl3 dishevelled 3, dsh homolog (Drosophila) 0.976
Fgf10 fibroblast growth factor 10 0.974
Jag1 jagged 1 0.974
Chrd chordin 0.974
Kif3a kinesin family member 3A 0.972
Smo smoothened homolog (Drosophila) 0.969
Notch2 Notch gene homolog 2 (Drosophila) 0.967
Arid1a AT rich interactive domain 1A (SWI-like) 0.966
Smad4 MAD homolog 4 (Drosophila) 0.965
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.964
Megf8 multiple EGF-like-domains 8 0.960
Sox3 SRY-box containing gene 3 0.960
Dll1 delta-like 1 (Drosophila) 0.959
Lmx1b LIM homeobox transcription factor 1 beta 0.955
Lef1 lymphoid enhancer binding factor 1 0.954
Sfrp2 secreted frizzled-related protein 2 0.952
Gbx2 gastrulation brain homeobox 2 0.951
Eya1 eyes absent 1 homolog (Drosophila) 0.949
Lmx1a LIM homeobox transcription factor 1 alpha 0.948
Emx2 empty spiracles homolog 2 (Drosophila) 0.944
Ephb2 Eph receptor B2 0.941
Sox11 SRY-box containing gene 11 0.941
Apc adenomatosis polyposis coli 0.939
Wt1 Wilms tumor 1 homolog 0.938
Hoxa11 homeobox A11 0.937
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.934
Hoxa13 homeobox A13 0.934
En1 engrailed 1 0.932
Gdnf glial cell line derived neurotrophic factor 0.929
Tbx1 T-box 1 0.925
Pitx1 paired-like homeodomain transcription factor 1 0.924
Gata4 GATA binding protein 4 0.919
Lhx3 LIM homeobox protein 3 0.917
Neurod1 neurogenic differentiation 1 0.916
Wnt5a wingless-related MMTV integration site 5A 0.914
Wnt1 wingless-related MMTV integration site 1 0.912
Hes1 hairy and enhancer of split 1 (Drosophila) 0.912
Ptch1 patched homolog 1 0.907
Tbx15 T-box 15 0.906
Nog noggin 0.902
Smad3 MAD homolog 3 (Drosophila) 0.901
Dlx5 distal-less homeobox 5 0.897
Nanog Nanog homeobox 0.894
Prrx1 paired related homeobox 1 0.892
Meox2 mesenchyme homeobox 2 0.892
Msx1 homeobox, msh-like 1 0.890
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.876
Insm1 insulinoma-associated 1 0.870
Wnt3a wingless-related MMTV integration site 3A 0.868
Ptk7 PTK7 protein tyrosine kinase 7 0.866
Hoxd11 homeobox D11 0.861
Pax8 paired box gene 8 0.860
Zeb1 zinc finger E-box binding homeobox 1 0.858
Col2a1 collagen, type II, alpha 1 0.857
Hoxa1 homeobox A1 0.855
Apaf1 apoptotic peptidase activating factor 1 0.850
Fzd8 frizzled homolog 8 (Drosophila) 0.848
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
foxi1 forkhead box I1 0.999
shha sonic hedgehog a 0.998
tbx1 T-box 1 0.996
fgf3 fibroblast growth factor 3 0.994
gli2a GLI-Kruppel family member GLI2a 0.988
mib mind bomb 0.987
dla deltaA 0.985
wnt11 wingless-type MMTV integration site family, member 11 0.984
flh floating head 0.978
cdh2 cadherin 2, neuronal 0.973
sox2 SRY-box containing gene 2 0.963
notch3 notch homolog 3 0.962
chd chordin 0.959
hoxb1b homeo box B1b 0.959
sox3 SRY-box containing gene 3 0.958
foxj1a forkhead box J1a 0.957
gli1 GLI-Kruppel family member 1 0.956
foxd3 forkhead box D3 0.945
ndr2 nodal-related 2 0.943
foxa2 forkhead box A2 0.937
boc brother of CDO 0.937
lhx5 LIM homeobox 5 0.932
eng2a engrailed 2a 0.926
tbx16 T-box gene 16 0.916
pax2a paired box gene 2a 0.913
id2a inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a 0.912
med12 mediator of RNA polymerase II transcription, subunit 12 homolog 0.910
pax8 paired box gene 8 0.907
hnf1ba HNF1 homeobox Ba 0.901
dld deltaD 0.900
wnt5b wingless-type MMTV integration site family, member 5b 0.883
eya1 eyes absent homolog 1 0.881
otx2 orthodenticle homolog 2 0.870
zic4 zic family member 4 0.864
foxg1a forkhead box G1a 0.862
gata3 GATA-binding protein 3 0.862
zic2a zic family member 2 (odd-paired homolog, Drosophila), a 0.854
lrrc6 leucine rich repeat containing 6 0.853
isl1 islet1 0.846
fgf8a fibroblast growth factor 8 a 0.839
grhl2b grainyhead-like 2b (Drosophila) 0.836
irx3a iroquois homeobox protein 3a 0.835
dzip1 DAZ interacting protein 1 0.802
odz4 odd Oz/ten-m homolog 4 0.798
tbx2b T-box 2b 0.795
wnt8b wingless-type MMTV integration site family, member 8b 0.789
sox10 SRY-box containing gene 10 0.781
epb41l5 erythrocyte membrane protein band 4.1 like 5 0.781
mab21l2 mab-21-like 2 0.778
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.774
neurod neurogenic differentiation 0.754
egr2b early growth response 2b 0.751
fgf4 fibroblast growth factor 4 0.750
hoxb3a homeo box B3a 0.742
irx1a iroquois homeobox protein 1, a 0.724
foxa1 forkhead box A1 0.709
notch1a notch homolog 1a 0.707
cdx4 caudal type homeo box transcription factor 4 0.703
fzd7a frizzled homolog 7a 0.693
prdm1a PR domain containing 1a, with ZNF domain 0.677
lef1 lymphocyte enhancer binding factor 1 0.658
smo smoothened homolog (Drosophila) 0.652
skia nuclear oncoprotein skia 0.650
bmp7a bone morphogenetic protein 7a 0.639
fgfr3 fibroblast growth factor receptor 3 0.637
emx1 empty spiracles homeobox 1 0.630
wnt4a wingless-type MMTV integration site family, member 4a 0.618
pou3f3b POU class 3 homeobox 3b 0.606
wnt1 wingless-type MMTV integration site family, member 1 0.599
pcdh18b protocadherin 18b 0.591
alcamb activated leukocyte cell adhesion molecule b 0.589
tcf7l1a transcription factor 7-like 1a (T-cell specific, HMG-box) 0.587
rx3 retinal homeobox gene 3 0.587
spry4 sprouty (Drosophila) homolog 4 0.582
hhip hedgehog interacting protein 0.581
six3a sine oculis homeobox homolog 3a 0.580
dlx3b distal-less homeobox gene 3b 0.577
olig2 oligodendrocyte lineage transcription factor 2 0.571
etv5b ets variant 5b 0.568
atp1a1a.2 ATPase, Na+/K+ transporting, alpha 1a.2 polypeptide 0.553
jag2 jagged 2 0.543
her5 hairy-related 5 0.532
zic5 zic family member 5 (odd-paired homolog, Drosophila) 0.532
dharma dharma 0.531
zic2b zic family member 2 (odd-paired homolog, Drosophila) b 0.527
fn1 fibronectin 1 0.525
gbx2 gastrulation brain homeo box 2 0.522
ift88 intraflagellar transport 88 homolog 0.522
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.515
emx3 empty spiracles homeobox 3 0.512
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.512
her4.2 hairy-related 4.2 0.510
pkd2 polycystic kidney disease 2 0.509
lratb lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b) 0.508
her3 hairy-related 3 0.504
bhlhe22 basic helix-loop-helix family, member e22 0.504
irx1b iroquois homeobox protein 1, b 0.500
gpc4 glypican 4 0.499
hmx4 H6 family homeobox 4 0.499
disp1 dispatched homolog 1 (Drosophila) 0.498
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.998
PSEN1 presenilin 1 0.925
HDAC2 histone deacetylase 2 0.860
APC adenomatous polyposis coli 0.846
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.798
BCL2 B-cell CLL/lymphoma 2 0.647
AXIN1 axin 1 0.577
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.536
PRKCZ protein kinase C, zeta 0.482
SMAD3 SMAD family member 3 0.451
JAG1 jagged 1 0.432
ESR1 estrogen receptor 1 0.377
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.355
BECN1 beclin 1, autophagy related 0.318
INADL InaD-like (Drosophila) 0.285
GSK3B glycogen synthase kinase 3 beta 0.277
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.248
NOTCH3 notch 3 0.237
SQSTM1 sequestosome 1 0.205
PKD2 polycystic kidney disease 2 (autosomal dominant) 0.192
BAD BCL2-associated agonist of cell death 0.176
TSC2 tuberous sclerosis 2 0.175
STK4 serine/threonine kinase 4 0.175
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.159
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.150
SEC24D SEC24 family, member D (S. cerevisiae) 0.140
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) 0.132
LRRK2 leucine-rich repeat kinase 2 0.132
XIAP X-linked inhibitor of apoptosis 0.132
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.130
SMO smoothened homolog (Drosophila) 0.122
TRRAP transformation/transcription domain-associated protein 0.122
CTNND1 catenin (cadherin-associated protein), delta 1 0.120
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 0.118
CENPJ centromere protein J 0.114
PTCH1 patched 1 0.103
STK3 serine/threonine kinase 3 0.096
BCOR BCL6 corepressor 0.087
BCL2L1 BCL2-like 1 0.086
YAP1 Yes-associated protein 1 0.081
BMP7 bone morphogenetic protein 7 0.079
PKD1 polycystic kidney disease 1 (autosomal dominant) 0.077
SMAD4 SMAD family member 4 0.077
FZD1 frizzled homolog 1 (Drosophila) 0.074
FLNB filamin B, beta 0.069
TP53 tumor protein p53 0.069
C9orf89 chromosome 9 open reading frame 89 0.068
RASA1 RAS p21 protein activator (GTPase activating protein) 1 0.067
MEOX2 mesenchyme homeobox 2 0.064
USP9X ubiquitin specific peptidase 9, X-linked 0.062
SEC23A Sec23 homolog A (S. cerevisiae) 0.059
CREBBP CREB binding protein 0.057
DDX3X DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked 0.055
CDC27 cell division cycle 27 homolog (S. cerevisiae) 0.054
PKP4 plakophilin 4 0.052
MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 0.051
FLNA filamin A, alpha 0.051
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 0.047
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.047
SETD8 SET domain containing (lysine methyltransferase) 8 0.047
SKI v-ski sarcoma viral oncogene homolog (avian) 0.046
JUP junction plakoglobin 0.046
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.046
MBD2 methyl-CpG binding domain protein 2 0.046
BID BH3 interacting domain death agonist 0.045
IQGAP1 IQ motif containing GTPase activating protein 1 0.045
ACTB actin, beta 0.044
CTBP2 C-terminal binding protein 2 0.042
EP300 E1A binding protein p300 0.042
FOXA2 forkhead box A2 0.041
EFNA1 ephrin-A1 0.040
VHL von Hippel-Lindau tumor suppressor 0.040
AKAP11 A kinase (PRKA) anchor protein 11 0.037
WNT3A wingless-type MMTV integration site family, member 3A 0.037
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.037
DVL1 dishevelled, dsh homolog 1 (Drosophila) 0.036
ZFX zinc finger protein, X-linked 0.036
PPP1R16A protein phosphatase 1, regulatory (inhibitor) subunit 16A 0.035
SOX10 SRY (sex determining region Y)-box 10 0.035
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.033
STK36 serine/threonine kinase 36 0.033
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.031
ZYX zyxin 0.031
FKBP8 FK506 binding protein 8, 38kDa 0.031
HIC1 hypermethylated in cancer 1 0.030
SP1 Sp1 transcription factor 0.029
STRN3 striatin, calmodulin binding protein 3 0.029
POU3F2 POU class 3 homeobox 2 0.027
WASF2 WAS protein family, member 2 0.027
HDAC1 histone deacetylase 1 0.027
TCF4 transcription factor 4 0.026
FAT1 FAT tumor suppressor homolog 1 (Drosophila) 0.026
SLMAP sarcolemma associated protein 0.025
RANBP2 RAN binding protein 2 0.025
ACTG1 actin, gamma 1 0.025
PCM1 pericentriolar material 1 0.024
SGSM2 small G protein signaling modulator 2 0.024
CSNK1E casein kinase 1, epsilon 0.024
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.023
PARD3 par-3 partitioning defective 3 homolog (C. elegans) 0.023
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism