The network for 'cranial nerve development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cranial nerve development

The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions.

Mus musculus
Name Description Probability Func Analog Organism
Otx2 orthodenticle homolog 2 (Drosophila) 1.000
Msx1 homeobox, msh-like 1 0.998
Eya1 eyes absent 1 homolog (Drosophila) 0.998
Hoxa1 homeobox A1 0.997
Tbx1 T-box 1 0.997
Shh sonic hedgehog 0.992
Gli3 GLI-Kruppel family member GLI3 0.986
Fgf8 fibroblast growth factor 8 0.980
Dlx5 distal-less homeobox 5 0.980
Pax3 paired box gene 3 0.980
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.975
Foxc2 forkhead box C2 0.969
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.966
Fgfr2 fibroblast growth factor receptor 2 0.958
Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.957
Hoxa2 homeobox A2 0.954
Isl1 ISL1 transcription factor, LIM/homeodomain 0.951
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.949
Hand1 heart and neural crest derivatives expressed transcript 1 0.948
Sox2 SRY-box containing gene 2 0.942
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.936
Hand2 heart and neural crest derivatives expressed transcript 2 0.934
Tcfap2a transcription factor AP-2, alpha 0.924
Pax2 paired box gene 2 0.923
Foxg1 forkhead box G1 0.922
Phox2b paired-like homeobox 2b 0.919
Gdnf glial cell line derived neurotrophic factor 0.891
Pax6 paired box gene 6 0.879
Pitx2 paired-like homeodomain transcription factor 2 0.878
Hoxb1 homeobox B1 0.874
Sall3 sal-like 3 (Drosophila) 0.844
Chd7 chromodomain helicase DNA binding protein 7 0.843
Hoxd3 homeobox D3 0.828
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.822
Chrd chordin 0.817
Ntf3 neurotrophin 3 0.802
Msx2 homeobox, msh-like 2 0.800
Ngfr nerve growth factor receptor (TNFR superfamily, member 16) 0.784
Efnb2 ephrin B2 0.760
Lhx9 LIM homeobox protein 9 0.757
Epha4 Eph receptor A4 0.754
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.752
Neurog1 neurogenin 1 0.735
Prrx1 paired related homeobox 1 0.732
Bdnf brain derived neurotrophic factor 0.703
Lhx1 LIM homeobox protein 1 0.703
Gbx2 gastrulation brain homeobox 2 0.696
Nog noggin 0.685
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.682
Hes5 hairy and enhancer of split 5 (Drosophila) 0.670
Tbx3 T-box 3 0.664
Dlx6 distal-less homeobox 6 0.664
Pbx1 pre B-cell leukemia transcription factor 1 0.657
Fgf3 fibroblast growth factor 3 0.644
Hmx1 H6 homeobox 1 0.637
Sox10 SRY-box containing gene 10 0.600
Dlx2 distal-less homeobox 2 0.594
Smo smoothened homolog (Drosophila) 0.577
Arhgef11 Rho guanine nucleotide exchange factor (GEF) 11 0.573
Nanog Nanog homeobox 0.565
Lmx1a LIM homeobox transcription factor 1 alpha 0.549
Pou4f2 POU domain, class 4, transcription factor 2 0.542
Ednra endothelin receptor type A 0.526
Gata4 GATA binding protein 4 0.525
Chrna3 cholinergic receptor, nicotinic, alpha polypeptide 3 0.524
Jag1 jagged 1 0.518
Zic3 zinc finger protein of the cerebellum 3 0.515
Emx2 empty spiracles homolog 2 (Drosophila) 0.506
Fgf10 fibroblast growth factor 10 0.505
Neurog2 neurogenin 2 0.492
Pou3f3 POU domain, class 3, transcription factor 3 0.480
Rarg retinoic acid receptor, gamma 0.474
Cdk5r1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) 0.474
Tlx3 T-cell leukemia, homeobox 3 0.473
Dcc deleted in colorectal carcinoma 0.466
Nkx1-2 NK1 transcription factor related, locus 2 (Drosophila) 0.462
Fgfr1 fibroblast growth factor receptor 1 0.452
Ebf3 early B-cell factor 3 0.439
Efna2 ephrin A2 0.432
Sall4 sal-like 4 (Drosophila) 0.413
Vangl2 vang-like 2 (van gogh, Drosophila) 0.401
Ret ret proto-oncogene 0.400
Prox1 prospero-related homeobox 1 0.393
Bmp7 bone morphogenetic protein 7 0.377
Lmx1b LIM homeobox transcription factor 1 beta 0.363
Lef1 lymphoid enhancer binding factor 1 0.362
Zic2 zinc finger protein of the cerebellum 2 0.362
Hmx3 H6 homeobox 3 0.361
Nrg1 neuregulin 1 0.354
Chrnb2 cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) 0.354
Wnt6 wingless-related MMTV integration site 6 0.347
Ntrk3 neurotrophic tyrosine kinase, receptor, type 3 0.340
Hoxb4 homeobox B4 0.336
Pcdh12 protocadherin 12 0.330
Sox3 SRY-box containing gene 3 0.330
Sema3f sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F 0.322
Kcnd2 potassium voltage-gated channel, Shal-related family, member 2 0.319
Gfra1 glial cell line derived neurotrophic factor family receptor alpha 1 0.319
Notch3 Notch gene homolog 3 (Drosophila) 0.318
Gfra3 glial cell line derived neurotrophic factor family receptor alpha 3 0.315
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
pax2a paired box gene 2a 0.980
sox10 SRY-box containing gene 10 0.956
atoh1a atonal homolog 1a 0.858
dla deltaA 0.821
six3b sine oculis homeobox homolog 3b 0.820
foxi1 forkhead box I1 0.762
eya1 eyes absent homolog 1 0.713
phox2a paired-like homeobox 2a 0.698
tbx1 T-box 1 0.667
erbb3b v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b 0.629
cntn2 contactin 2 0.608
atoh1b atonal homolog 1b 0.564
six4b sine oculis homeobox homolog 4b 0.563
dlx4a distal-less homeobox gene 4a 0.532
crestin crestin 0.489
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.441
gata3 GATA-binding protein 3 0.397
pitx2 paired-like homeodomain transcription factor 2 0.374
tgfb3 transforming growth factor, beta 3 0.373
dlx1a distal-less homeobox gene 1a 0.368
ret1 receptor tyrosine kinase 0.361
emx3 empty spiracles homeobox 3 0.356
smad1 MAD homolog 1 (Drosophila) 0.354
hmx3 homeo box (H6 family) 3 0.353
hapln1a hyaluronan and proteoglycan link protein 1a 0.345
hoxb4a homeo box B4a 0.338
hoxb3a homeo box B3a 0.331
nkx2.1a NK2 homeobox 1a 0.327
twist1a twist1a 0.326
tubb5 tubulin, beta 5 0.325
foxd3 forkhead box D3 0.324
neurod neurogenic differentiation 0.324
gcm2 glial cells missing homolog 2 (Drosophila) 0.315
tgfb2 transforming growth factor, beta 2 0.299
gli2a GLI-Kruppel family member GLI2a 0.298
nrp1a neuropilin 1a 0.285
tbx2b T-box 2b 0.284
erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog 0.273
dld deltaD 0.269
sox21b SRY-box containing gene 21 b 0.269
rx3 retinal homeobox gene 3 0.261
ndr2 nodal-related 2 0.253
kitb kit receptor b 0.249
msxe muscle segment homeobox E 0.244
dpysl2b dihydropyrimidinase-like 2b 0.243
pou3f3b POU class 3 homeobox 3b 0.242
robo1 roundabout homolog 1 0.231
slc17a7 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7 0.229
rest RE1-silencing transcription factor 0.229
pax6b paired box gene 6b 0.227
nr2e1 nuclear receptor subfamily 2, group E, member 1 0.227
foxa1 forkhead box A1 0.226
six4a sine oculis homeobox homolog 4a 0.221
sox9a SRY-box containing gene 9a 0.214
hoxa3a homeo box A3a 0.213
grem2 gremlin 2, cysteine knot superfamily 0.208
alcama activated leukocyte cell adhesion molecule a 0.200
foxa2 forkhead box A2 0.199
isl1 islet1 0.189
ek1 eph-like kinase 1 0.188
zic1 zic family member 1 (odd-paired homolog, Drosophila) 0.183
st8sia1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 0.183
nkx3.2 NK3 homeobox 2 0.182
pcdh18b protocadherin 18b 0.182
nr2f5 nuclear receptor subfamily 2, group F, member 5 0.180
fgf3 fibroblast growth factor 3 0.180
tp63 tumor protein p63 0.176
ptf1a pancreas specific transcription factor, 1a 0.174
hoxb1a homeo box B1a 0.173
efnb2a ephrin B2a 0.173
dlx2a distal-less homeobox gene 2a 0.171
stmn2b stathmin-like 2b 0.162
six3a sine oculis homeobox homolog 3a 0.161
phox2b paired-like homeobox 2b 0.160
ptpra protein tyrosine phosphatase, receptor type, A 0.157
notch2 notch homolog 2 0.156
nrg1 neuregulin 1 0.154
cdh4 cadherin 4, retinal 0.149
gpr126 G protein-coupled receptor 126 0.149
shhb sonic hedgehog b 0.149
olig2 oligodendrocyte lineage transcription factor 2 0.147
crabp2a cellular retinoic acid binding protein 2, a 0.147
foxc1a forkhead box C1a 0.144
m17 IL-6 subfamily cytokine M17 0.141
nadl1.1 neural adhesion molecule L1.1 0.135
fgfr3 fibroblast growth factor receptor 3 0.134
tal1 T-cell acute lymphocytic leukemia 1 0.132
hoxa1a homeo box A1a 0.130
mecom MDS1 and EVI1 complex locus 0.125
cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.125
nrp1b neuropilin 1b 0.125
spry4 sprouty (Drosophila) homolog 4 0.125
pax8 paired box gene 8 0.123
wu:fv91b12 wu:fv91b12 0.122
epha4b eph receptor A4b 0.122
nrp2a neuropilin 2a 0.121
bhlhe22 basic helix-loop-helix family, member e22 0.121
hoxb5b homeo box B5b 0.121
tcf21 transcription factor 21 0.121
cntn1b contactin 1b 0.120
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Drosophila melanogaster
Name Description Probability Func Analog Organism
E(spl) Enhancer of split 0.986
HLHm7 E(spl) region transcript m7 0.865
HLHmdelta E(spl) region transcript mdelta 0.792
ac achaete 0.566
HLHmgamma E(spl) region transcript mgamma 0.555
m4 E(spl) region transcript m4 0.390
ptc patched 0.355
ato atonal 0.342
sd scalloped 0.327
malpha E(spl) region transcript malpha 0.325
m2 E(spl) region transcript m2 0.283
Poxn Pox neuro 0.235
bnl branchless 0.230
eya eyes absent 0.226
HLHmbeta E(spl) region transcript mbeta 0.191
sca scabrous 0.186
klu klumpfuss 0.185
vvl ventral veins lacking 0.180
sens senseless 0.170
wit wishful thinking 0.147
vg vestigial 0.144
amos absent MD neurons and olfactory sensilla 0.141
HLHm3 E(spl) region transcript m3 0.139
ss spineless 0.135
sc scute 0.108
lz lozenge 0.101
kuz kuzbanian 0.096
ro rough 0.095
nub nubbin 0.087
Ser Serrate 0.083
salm spalt major 0.083
Lim1 CG11354 gene product from transcript CG11354-RA 0.079
rho rhomboid 0.077
ase asense 0.077
Fak56D Focal Adhesion Kinase 0.074
nrv2 nervana 2 0.074
htl heartless 0.074
kek1 kekkon-1 0.069
sty sprouty 0.068
Tom Twin of m4 0.063
al aristaless 0.062
robo roundabout 0.062
dsf dissatisfaction 0.061
Abd-B Abdominal B 0.059
Spn77Ba Serpin 77Ba 0.057
Irk2 Inwardly rectifying potassium channel 2 0.053
tan tantalus 0.051
Tollo CG6890 gene product from transcript CG6890-RA 0.049
wgn wengen 0.049
l(2)k16918 lethal (2) k16918 0.048
Wnt2 Wnt oncogene analog 2 0.048
HLHm5 E(spl) region transcript m5 0.047
ey eyeless 0.046
dan distal antenna 0.046
CG10200 CG10200 gene product from transcript CG10200-RB 0.044
repo reversed polarity 0.044
nau nautilus 0.043
stj straightjacket 0.043
gpp grappa 0.043
net CG11450 gene product from transcript CG11450-RB 0.043
sev sevenless 0.042
dpp decapentaplegic 0.042
CkIIalpha Casein kinase II alpha subunit 0.041
stumps CG31317 gene product from transcript CG31317-RC 0.041
hrg hiiragi 0.039
Toll-7 CG8595 gene product from transcript CG8595-RA 0.038
CG13627 CG13627 gene product from transcript CG13627-RA 0.038
en engrailed 0.038
sv shaven 0.037
LanB2 Laminin B2 0.036
CaMKII Calcium/calmodulin-dependent protein kinase II 0.036
stan starry night 0.035
bi bifid 0.035
noc no ocelli 0.035
Appl beta amyloid protein precursor-like 0.034
trio CG18214 gene product from transcript CG18214-RA 0.034
Cpr97Eb Cuticular protein 97Eb 0.034
emc extra macrochaetae 0.034
Irk3 Inwardly rectifying potassium channel 3 0.033
rn rotund 0.033
Grip Glutamate receptor binding protein 0.033
plx pollux 0.032
pb proboscipedia 0.032
tin tinman 0.032
tutl turtle 0.032
Cp190 Centrosomal protein 190kD 0.032
seq sequoia 0.032
Sox102F CG11153 gene product from transcript CG11153-RB 0.032
B-H1 BarH1 0.031
elB elbow B 0.030
eg eagle 0.030
cv-2 crossveinless 2 0.030
wb wing blister 0.029
btl breathless 0.029
loqs loquacious 0.028
Nedd4 CG42279 gene product from transcript CG42279-RJ 0.028
sr stripe 0.027
Hmgcr HMG Coenzyme A reductase 0.027
cpo couch potato 0.027
fred friend of echinoid 0.027
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Homo sapiens
Name Description Probability Func Analog Organism
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 1.000
EGFR epidermal growth factor receptor 1.000
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 1.000
DTNA dystrobrevin, alpha 0.996
POU5F1 POU class 5 homeobox 1 0.996
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.995
GRB7 growth factor receptor-bound protein 7 0.992
SUFU suppressor of fused homolog (Drosophila) 0.987
CHD8 chromodomain helicase DNA binding protein 8 0.978
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome) 0.976
EP300 E1A binding protein p300 0.975
PPARA peroxisome proliferator-activated receptor alpha 0.959
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.956
CHD7 chromodomain helicase DNA binding protein 7 0.954
PTCH1 patched 1 0.932
MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) 0.895
HOXA5 homeobox A5 0.894
STK36 serine/threonine kinase 36 0.849
GATA2 GATA binding protein 2 0.847
GATA4 GATA binding protein 4 0.831
HOXB5 homeobox B5 0.823
SETD8 SET domain containing (lysine methyltransferase) 8 0.805
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.791
SOX2 SRY (sex determining region Y)-box 2 0.788
VEGFA vascular endothelial growth factor A 0.758
MYOD1 myogenic differentiation 1 0.738
SIX6 SIX homeobox 6 0.723
PTK6 PTK6 protein tyrosine kinase 6 0.717
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.701
INSR insulin receptor 0.696
HAND2 heart and neural crest derivatives expressed 2 0.661
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.653
KLF4 Kruppel-like factor 4 (gut) 0.648
NGF nerve growth factor (beta polypeptide) 0.579
AKAP2 A kinase (PRKA) anchor protein 2 0.558
PLCG1 phospholipase C, gamma 1 0.546
TNS3 tensin 3 0.535
HOXB9 homeobox B9 0.534
HOXD12 homeobox D12 0.528
TMSB4X thymosin beta 4, X-linked 0.505
PDX1 pancreatic and duodenal homeobox 1 0.495
HOXA3 homeobox A3 0.483
IER2 immediate early response 2 0.476
PAX6 paired box 6 0.468
ZFYVE9 zinc finger, FYVE domain containing 9 0.467
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein 0.466
FGF1 fibroblast growth factor 1 (acidic) 0.464
ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.456
HOXA4 homeobox A4 0.447
LPXN leupaxin 0.444
HDAC6 histone deacetylase 6 0.443
MDFI MyoD family inhibitor 0.441
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.440
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.415
POU4F2 POU class 4 homeobox 2 0.411
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 0.400
FGB fibrinogen beta chain 0.392
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) 0.391
NEUROG1 neurogenin 1 0.391
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 0.383
RUNX1 runt-related transcription factor 1 0.381
HOXD13 homeobox D13 0.363
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 0.361
SH3BP4 SH3-domain binding protein 4 0.361
HOXD9 homeobox D9 0.340
FEV FEV (ETS oncogene family) 0.340
HOXA9 homeobox A9 0.338
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta) 0.332
SYK spleen tyrosine kinase 0.331
ALX4 ALX homeobox 4 0.322
HOXA11 homeobox A11 0.321
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.321
HOXB6 homeobox B6 0.298
C11orf73 chromosome 11 open reading frame 73 0.292
FGF2 fibroblast growth factor 2 (basic) 0.288
TUBB3 tubulin, beta 3 0.286
BBS10 Bardet-Biedl syndrome 10 0.284
EPHB1 EPH receptor B1 0.283
HOXB3 homeobox B3 0.280
PRR13 proline rich 13 0.279
ZIC1 Zic family member 1 (odd-paired homolog, Drosophila) 0.276
TAL1 T-cell acute lymphocytic leukemia 1 0.273
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.265
CYLD cylindromatosis (turban tumor syndrome) 0.257
DTNB dystrobrevin, beta 0.243
HOXB4 homeobox B4 0.239
POU4F3 POU class 4 homeobox 3 0.238
KCTD1 potassium channel tetramerisation domain containing 1 0.236
HOXD11 homeobox D11 0.235
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 0.233
BARX1 BARX homeobox 1 0.228
HOXC11 homeobox C11 0.220
PITX2 paired-like homeodomain 2 0.218
TMEM30B transmembrane protein 30B 0.217
EYA2 eyes absent homolog 2 (Drosophila) 0.213
NRP2 neuropilin 2 0.205
FRS2 fibroblast growth factor receptor substrate 2 0.200
CABLES1 Cdk5 and Abl enzyme substrate 1 0.197
JUN jun proto-oncogene 0.196
ECEL1 endothelin converting enzyme-like 1 0.194
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Rattus norvegicus
Name Description Probability Func Analog Organism
Egr1 early growth response 1 0.012
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism