The network for 'cardiac muscle cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cardiac muscle cell differentiation

The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.

Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Fgf8 fibroblast growth factor 8 1.000
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 1.000
Pitx2 paired-like homeodomain transcription factor 2 1.000
Hand2 heart and neural crest derivatives expressed transcript 2 1.000
Foxc2 forkhead box C2 1.000
Tbx1 T-box 1 0.999
Isl1 ISL1 transcription factor, LIM/homeodomain 0.999
Pax3 paired box gene 3 0.999
Pax2 paired box gene 2 0.999
Foxc1 forkhead box C1 0.997
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.996
Nos3 nitric oxide synthase 3, endothelial cell 0.996
Bmp4 bone morphogenetic protein 4 0.996
Eya1 eyes absent 1 homolog (Drosophila) 0.995
Chd7 chromodomain helicase DNA binding protein 7 0.994
Otx2 orthodenticle homolog 2 (Drosophila) 0.994
Jag1 jagged 1 0.993
Fgfr2 fibroblast growth factor receptor 2 0.991
Efnb2 ephrin B2 0.991
Gli3 GLI-Kruppel family member GLI3 0.991
Gata4 GATA binding protein 4 0.990
Tbx3 T-box 3 0.989
Fgfr1 fibroblast growth factor receptor 1 0.988
Sox9 SRY-box containing gene 9 0.985
Rxra retinoid X receptor alpha 0.985
Tcfap2a transcription factor AP-2, alpha 0.983
Chrd chordin 0.982
Apc adenomatosis polyposis coli 0.982
Nodal nodal 0.978
Hoxa1 homeobox A1 0.977
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.974
Hand1 heart and neural crest derivatives expressed transcript 1 0.968
Lhx1 LIM homeobox protein 1 0.966
Ntf3 neurotrophin 3 0.966
Meox2 mesenchyme homeobox 2 0.962
Prrx1 paired related homeobox 1 0.957
Ctnnb1 catenin (cadherin associated protein), beta 1 0.956
Nog noggin 0.951
Gbx2 gastrulation brain homeobox 2 0.947
Notch1 Notch gene homolog 1 (Drosophila) 0.947
Tgfb2 transforming growth factor, beta 2 0.943
Mesp1 mesoderm posterior 1 0.939
Rarg retinoic acid receptor, gamma 0.936
Nf1 neurofibromatosis 1 0.935
Sox2 SRY-box containing gene 2 0.923
Vegfa vascular endothelial growth factor A 0.911
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.910
Tgfbr2 transforming growth factor, beta receptor II 0.895
Hey2 hairy/enhancer-of-split related with YRPW motif 2 0.888
Pax8 paired box gene 8 0.885
Bmp7 bone morphogenetic protein 7 0.884
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.872
Dlx5 distal-less homeobox 5 0.838
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.822
Cox6a2 cytochrome c oxidase, subunit VI a, polypeptide 2 0.816
Actc1 actin, alpha, cardiac muscle 1 0.815
Rarb retinoic acid receptor, beta 0.808
Fgf10 fibroblast growth factor 10 0.807
Gli2 GLI-Kruppel family member GLI2 0.800
Vangl2 vang-like 2 (van gogh, Drosophila) 0.799
Gsc goosecoid homeobox 0.788
Smad6 MAD homolog 6 (Drosophila) 0.786
Foxg1 forkhead box G1 0.780
Msx1 homeobox, msh-like 1 0.774
Notch2 Notch gene homolog 2 (Drosophila) 0.769
Tnnt3 troponin T3, skeletal, fast 0.749
T brachyury 0.746
Acvr1 activin A receptor, type 1 0.730
Ednra endothelin receptor type A 0.728
Cnn1 calponin 1 0.702
Sgca sarcoglycan, alpha (dystrophin-associated glycoprotein) 0.695
Tbx15 T-box 15 0.691
Ldb3 LIM domain binding 3 0.679
Wt1 Wilms tumor 1 homolog 0.676
Hoxa3 homeobox A3 0.672
Ece1 endothelin converting enzyme 1 0.663
Hoxa13 homeobox A13 0.656
Des desmin 0.655
Emx2 empty spiracles homolog 2 (Drosophila) 0.647
Ddx60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.641
Myl3 myosin, light polypeptide 3 0.638
Actn2 actinin alpha 2 0.627
Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.626
Pitx1 paired-like homeodomain transcription factor 1 0.617
Hoxa2 homeobox A2 0.608
Gata3 GATA binding protein 3 0.592
Tbx2 T-box 2 0.585
Wnt11 wingless-related MMTV integration site 11 0.585
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.583
Myl9 myosin, light polypeptide 9, regulatory 0.581
Wnt3a wingless-related MMTV integration site 3A 0.556
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.552
Cdx2 caudal type homeobox 2 0.552
Ret ret proto-oncogene 0.550
Gata5 GATA binding protein 5 0.548
Wnt4 wingless-related MMTV integration site 4 0.545
Zic3 zinc finger protein of the cerebellum 3 0.538
Hrc histidine rich calcium binding protein 0.511
Lmx1a LIM homeobox transcription factor 1 alpha 0.502
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
myod1 myogenic differentiation 1 0.999
nkx2.5 NK2 transcription factor related 5 0.999
bmp4 bone morphogenetic protein 4 0.997
ttna titin a 0.993
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.985
vmhc ventricular myosin heavy chain 0.981
myog myogenin 0.979
smyd1b SET and MYND domain containing 1b 0.966
tnnc1b troponin C type 1b (slow) 0.963
myf5 myogenic factor 5 0.940
myl7 myosin, light polypeptide 7, regulatory 0.938
pcdh8 protocadherin 8 0.936
myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha 0.928
pdlim7 PDZ and LIM domain 7 0.924
spaw southpaw 0.901
wt1a wilms tumor 1a 0.890
kdrl kinase insert domain receptor like 0.888
slc8a1a solute carrier family 8 (sodium/calcium exchanger), member 1a 0.881
unc45b unc-45 homolog B (C. elegans) 0.878
bmp2b bone morphogenetic protein 2b 0.860
mylz2 myosin, light polypeptide 2, skeletal muscle 0.852
smyhc1 slow myosin heavy chain 1 0.838
tbx5a T-box 5a 0.798
myl1 myosin, light chain 1, alkali; skeletal, fast 0.786
mef2cb myocyte enhancer factor 2cb 0.775
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.747
tnni2a.4 troponin I, skeletal, fast 2a.4 0.685
tnni1b troponin I, skeletal, slow b 0.668
osr1 odd-skipped related 1 (Drosophila) 0.668
wnt11r wingless-type MMTV integration site family, member 11, related 0.663
crabp2a cellular retinoic acid binding protein 2, a 0.662
tbx2a T-box gene 2a 0.657
itgb1b.2 integrin, beta 1b.2 0.649
rbfox1l RNA binding protein, fox-1 homolog (C. elegans) 1-like 0.646
actc1b actin, alpha, cardiac muscle 1b 0.642
tbx1 T-box 1 0.636
tbx18 T-box 18 0.601
smyhc2 slow myosin heavy chain 2 0.578
pax2a paired box gene 2a 0.569
actn3b actinin alpha 3b 0.553
tpma alpha-tropomyosin 0.543
tbx20 T-box 20 0.517
desma desmin a 0.516
tbx5b T-box 5b 0.504
ttnb titin b 0.468
erg v-ets erythroblastosis virus E26 oncogene like (avian) 0.460
wnt11 wingless-type MMTV integration site family, member 11 0.444
hoxa9a homeo box A9a 0.443
mef2ca myocyte enhancer factor 2ca 0.438
tnnt3b troponin T3b, skeletal, fast 0.438
hsp90a.1 heat shock protein 90-alpha 1 0.426
hand2 heart and neural crest derivatives expressed transcript 2 0.396
shha sonic hedgehog a 0.385
mespa mesoderm posterior a 0.383
scn12ab sodium channel, voltage gated, type XII, alpha b 0.371
dlc deltaC 0.358
synpo2lb synaptopodin 2-like b 0.353
myf6 myogenic factor 6 0.327
tnni1al troponin I, skeletal, slow like 0.324
rx3 retinal homeobox gene 3 0.318
neb nebulin 0.317
dmrt2a doublesex and mab-3 related transcription factor 2a 0.311
xirp1 xin actin-binding repeat containing 1 0.311
myhz2 myosin, heavy polypeptide 2, fast muscle specific 0.301
fezf2 FEZ family zinc finger 2 0.301
fgf8a fibroblast growth factor 8 a 0.301
isl1 islet1 0.299
chrna1 cholinergic receptor, nicotinic, alpha polypeptide 1 0.279
her3 hairy-related 3 0.274
pitx2 paired-like homeodomain transcription factor 2 0.272
gja3 gap junction protein, alpha 3 0.270
prickle1a prickle-like 1 (Drosophila) a 0.264
gapdh glyceraldehyde-3-phosphate dehydrogenase 0.259
dld deltaD 0.258
tnnc1a troponin C type 1a (slow) 0.229
gro1 groucho 1 0.218
tnnc2 troponin C type 2 (fast) 0.213
znf503 zinc finger protein 503 0.211
atp2a2a ATPase, Ca++ transporting, cardiac muscle, slow twitch 2a 0.210
txlnba taxilin beta a 0.207
aplnrb apelin receptor b 0.207
fgf3 fibroblast growth factor 3 0.197
neurog1 neurogenin 1 0.195
wt1b wilms tumor 1b 0.195
popdc2 popeye domain containing 2 0.190
rx2 retinal homeobox gene 2 0.188
hspb1 heat shock protein, alpha-crystallin-related, 1 0.186
adrb2a adrenergic receptor, beta 2a 0.178
dhrs3a dehydrogenase/reductase (SDR family) member 3a 0.166
actc1a actin, alpha, cardiac muscle 1a 0.164
lhx5 LIM homeobox 5 0.162
rarab retinoic acid receptor, alpha b 0.161
raraa retinoic acid receptor, alpha a 0.160
lhx1a LIM homeobox 1a 0.156
tnnt2a troponin T2a, cardiac 0.152
cxcl12b chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) 0.150
eng2a engrailed 2a 0.150
wnt5b wingless-type MMTV integration site family, member 5b 0.148
her1 hairy-related 1 0.147
ndr2 nodal-related 2 0.146
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Drosophila melanogaster
Name Description Probability Func Analog Organism
vg vestigial 0.019
LanB2 Laminin B2 0.017
kn knot 0.016
wupA wings up A 0.016
HLH54F CG5005 gene product from transcript CG5005-RA 0.015
Nlp Nucleoplasmin 0.015
Mhc Myosin heavy chain 0.014
numb CG3779 gene product from transcript CG3779-RB 0.014
Med Medea 0.014
sls sallimus 0.014
Actn alpha actinin 0.014
ci cubitus interruptus 0.014
Zasp52 Z band alternatively spliced PDZ-motif protein 52 0.014
CG12558 CG12558 gene product from transcript CG12558-RA 0.014
hth homothorax 0.014
mys myospheroid 0.014
if inflated 0.013
mew multiple edematous wings 0.013
kis kismet 0.013
how held out wings 0.013
Mlc2 Myosin light chain 2 0.013
capt capulet 0.013
Act88F Actin 88F 0.013
rols rolling pebbles 0.013
nau nautilus 0.012
up upheld 0.012
Mlc1 Myosin alkali light chain 1 0.012
dm diminutive 0.012
Moe Moesin 0.012
Zasp66 Z band alternatively spliced PDZ-motif protein 66 0.012
fng fringe 0.012
kuz kuzbanian 0.012
CG13627 CG13627 gene product from transcript CG13627-RA 0.012
hpo hippo 0.012
Trxr-1 Thioredoxin reductase-1 0.012
LanA Laminin A 0.012
grh grainy head 0.012
Orct2 Organic cation transporter 2 0.012
cora coracle 0.012
CG31226 CG31226 gene product from transcript CG31226-RB 0.012
bin biniou 0.012
pasha partner of drosha 0.012
LanB1 CG7123 gene product from transcript CG7123-RA 0.011
slou slouch 0.011
ap apterous 0.011
wg wingless 0.011
spdo sanpodo 0.011
CG14061 CG14061 gene product from transcript CG14061-RA 0.011
tin tinman 0.011
Hand CG18144 gene product from transcript CG18144-RA 0.011
vkg viking 0.011
l(3)82Fd CG32464 gene product from transcript CG32464-RR 0.011
twi twist 0.011
CG17658 CG17658 gene product from transcript CG17658-RA 0.011
wb wing blister 0.011
kst karst 0.011
Dll Distal-less 0.011
pigs pickled eggs 0.011
Lim1 CG11354 gene product from transcript CG11354-RA 0.011
Pvr PDGF- and VEGF-receptor related 0.011
fz frizzled 0.011
lea leak 0.011
pnt pointed 0.011
CG9705 CG9705 gene product from transcript CG9705-RA 0.011
CG15365 CG15365 gene product from transcript CG15365-RA 0.011
Fas2 Fasciclin 2 0.011
Su(z)2 Suppressor of zeste 2 0.011
insc inscuteable 0.011
Pabp2 CG2163 gene product from transcript CG2163-RA 0.011
CG2950 CG2950 gene product from transcript CG2950-RD 0.011
kibra kibra ortholog 0.011
kon kon-tiki 0.011
Dhc64C Dynein heavy chain 64C 0.010
Egfr Epidermal growth factor receptor 0.010
mbl muscleblind 0.010
Thiolase CG4581 gene product from transcript CG4581-RA 0.010
Rya-r44F Ryanodine receptor 44F 0.010
fln flightin 0.010
shn schnurri 0.010
CG5376 CG5376 gene product from transcript CG5376-RA 0.010
sima similar 0.010
Act5C Actin 5C 0.010
Lmpt Limpet 0.010
byn brachyenteron 0.010
CG11912 CG11912 gene product from transcript CG11912-RA 0.010
arm armadillo 0.010
pnr pannier 0.010
Bx Beadex 0.010
Pdi Protein disulfide isomerase 0.010
CG15631 CG15631 gene product from transcript CG15631-RA 0.010
Su(z)12 CG8013 gene product from transcript CG8013-RA 0.010
Ser Serrate 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
SRF serum response factor (c-fos serum response element-binding transcription factor) 0.998
RARA retinoic acid receptor, alpha 0.965
TTN titin 0.944
TRIM63 tripartite motif containing 63 0.895
RXRA retinoid X receptor, alpha 0.887
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.830
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.651
NOTCH1 notch 1 0.644
BMPR1A bone morphogenetic protein receptor, type IA 0.610
NRP1 neuropilin 1 0.608
TBX5 T-box 5 0.561
FKBP1A FK506 binding protein 1A, 12kDa 0.556
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.533
NCOA1 nuclear receptor coactivator 1 0.475
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.464
HDAC4 histone deacetylase 4 0.417
ZYX zyxin 0.396
COL4A2 collagen, type IV, alpha 2 0.395
BMP2 bone morphogenetic protein 2 0.335
MED25 mediator complex subunit 25 0.309
YAP1 Yes-associated protein 1 0.306
FSTL1 follistatin-like 1 0.259
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.259
COL4A1 collagen, type IV, alpha 1 0.230
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.218
LRP6 low density lipoprotein receptor-related protein 6 0.215
FLNA filamin A, alpha 0.210
JAG1 jagged 1 0.205
CDK2 cyclin-dependent kinase 2 0.202
SMAD7 SMAD family member 7 0.194
TGFB1 transforming growth factor, beta 1 0.190
ACTN1 actinin, alpha 1 0.166
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.162
MYOD1 myogenic differentiation 1 0.152
SPOP speckle-type POZ protein 0.121
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) 0.120
PDGFA platelet-derived growth factor alpha polypeptide 0.117
TGFB3 transforming growth factor, beta 3 0.108
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.107
SPEN spen homolog, transcriptional regulator (Drosophila) 0.106
TSC2 tuberous sclerosis 2 0.103
NCOR2 nuclear receptor corepressor 2 0.090
ESR1 estrogen receptor 1 0.088
MYOZ1 myozenin 1 0.086
COL4A6 collagen, type IV, alpha 6 0.076
HNF4A hepatocyte nuclear factor 4, alpha 0.072
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.063
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF 0.062
IFITM2 interferon induced transmembrane protein 2 (1-8D) 0.059
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 0.057
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 0.057
ACTN2 actinin, alpha 2 0.053
MYH9 myosin, heavy chain 9, non-muscle 0.049
GDF5 growth differentiation factor 5 0.047
MYOG myogenin (myogenic factor 4) 0.044
CREBBP CREB binding protein 0.044
PDGFC platelet derived growth factor C 0.043
NEB nebulin 0.041
NCOR1 nuclear receptor corepressor 1 0.040
COL4A5 collagen, type IV, alpha 5 0.037
ITGA7 integrin, alpha 7 0.036
FZD1 frizzled homolog 1 (Drosophila) 0.034
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.034
MYL9 myosin, light chain 9, regulatory 0.034
PRKD2 protein kinase D2 0.033
GATA4 GATA binding protein 4 0.033
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.033
GATAD2B GATA zinc finger domain containing 2B 0.032
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator 0.032
ACVR1 activin A receptor, type I 0.031
THBS1 thrombospondin 1 0.030
MKL1 megakaryoblastic leukemia (translocation) 1 0.029
PRKG1 protein kinase, cGMP-dependent, type I 0.029
TNRC6A trinucleotide repeat containing 6A 0.029
ATG12 ATG12 autophagy related 12 homolog (S. cerevisiae) 0.028
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 0.028
CAPN3 calpain 3, (p94) 0.028
ND1 NADH dehydrogenase, subunit 1 (complex I) 0.027
CDK1 cyclin-dependent kinase 1 0.026
NCK2 NCK adaptor protein 2 0.026
NOTCH3 notch 3 0.026
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.026
WDFY3 WD repeat and FYVE domain containing 3 0.025
AR androgen receptor 0.025
FLNB filamin B, beta 0.025
CCNB2 cyclin B2 0.025
ACTA2 actin, alpha 2, smooth muscle, aorta 0.025
LAMB1 laminin, beta 1 0.024
TCAP titin-cap (telethonin) 0.024
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.022
CCNA2 cyclin A2 0.022
CAV1 caveolin 1, caveolae protein, 22kDa 0.021
ENG endoglin 0.021
COL5A2 collagen, type V, alpha 2 0.020
TPM4 tropomyosin 4 0.020
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 0.019
VASP vasodilator-stimulated phosphoprotein 0.019
TGFBR1 transforming growth factor, beta receptor 1 0.018
MYPN myopalladin 0.018
CNN2 calponin 2 0.017
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Rattus norvegicus
Name Description Probability Func Analog Organism
Alb albumin 0.014
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism