The network for 'leukocyte mediated cytotoxicity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

leukocyte mediated cytotoxicity

The directed killing of a target cell by a leukocyte.

Mus musculus
Name Description Probability Func Analog Organism
B2m beta-2 microglobulin 0.994
Slamf1 signaling lymphocytic activation molecule family member 1 0.974
H2-K1 histocompatibility 2, K1, K region 0.967
Fasl Fas ligand (TNF superfamily, member 6) 0.941
H2-D1 histocompatibility 2, D region locus 1 0.934
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.933
Klra9 killer cell lectin-like receptor subfamily A, member 9 0.930
Prf1 perforin 1 (pore forming protein) 0.908
Tapbp TAP binding protein 0.901
Rab27a RAB27A, member RAS oncogene family 0.889
Klrg1 killer cell lectin-like receptor subfamily G, member 1 0.815
Pnp2 purine-nucleoside phosphorylase 2 0.814
Gzmb granzyme B 0.783
Klrc1 killer cell lectin-like receptor subfamily C, member 1 0.779
Ccr1 chemokine (C-C motif) receptor 1 0.773
H2-Q7 histocompatibility 2, Q region locus 7 0.767
Mcpt8 mast cell protease 8 0.757
Itk IL2-inducible T-cell kinase 0.669
Il18rap interleukin 18 receptor accessory protein 0.626
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.612
Lyz2 lysozyme 2 0.582
Gzmk granzyme K 0.572
Stat5b signal transducer and activator of transcription 5B 0.566
Trim21 tripartite motif-containing 21 0.551
Psmb8 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) 0.546
Pias1 protein inhibitor of activated STAT 1 0.507
Il2rg interleukin 2 receptor, gamma chain 0.470
Stat5a signal transducer and activator of transcription 5A 0.457
Ctsb cathepsin B 0.431
Stat1 signal transducer and activator of transcription 1 0.422
Casp8 caspase 8 0.418
Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.408
Ncr1 natural cytotoxicity triggering receptor 1 0.375
Fyn Fyn proto-oncogene 0.356
Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) 0.352
Arrb1 arrestin, beta 1 0.348
Il2rb interleukin 2 receptor, beta chain 0.335
Stat3 signal transducer and activator of transcription 3 0.328
Inpp5d inositol polyphosphate-5-phosphatase D 0.323
Xcl1 chemokine (C motif) ligand 1 0.322
Cpa3 carboxypeptidase A3, mast cell 0.311
Bex6 brain expressed gene 6 0.302
Ctsz cathepsin Z 0.300
Klra5 killer cell lectin-like receptor, subfamily A, member 5 0.300
Stx11 syntaxin 11 0.297
Gm2a GM2 ganglioside activator protein 0.293
Ubd ubiquitin D 0.291
Klra7 killer cell lectin-like receptor, subfamily A, member 7 0.287
Klrb1b killer cell lectin-like receptor subfamily B member 1B 0.280
Cst7 cystatin F (leukocystatin) 0.265
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.255
Gzma granzyme A 0.253
Ctsw cathepsin W 0.251
Cd80 CD80 antigen 0.250
H2-Q5 histocompatibility 2, Q region locus 5 0.249
Ccr3 chemokine (C-C motif) receptor 3 0.249
Gcet2 germinal center expressed transcript 2 0.244
Camp cathelicidin antimicrobial peptide 0.242
Itgb3 integrin beta 3 0.230
Mpo myeloperoxidase 0.229
Klrb1a killer cell lectin-like receptor subfamily B member 1A 0.226
Il6 interleukin 6 0.223
Aoah acyloxyacyl hydrolase 0.222
H2-Q6 histocompatibility 2, Q region locus 6 0.221
Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.218
Cd160 CD160 antigen 0.215
Cd22 CD22 antigen 0.214
Selp selectin, platelet 0.212
Cd3g CD3 antigen, gamma polypeptide 0.204
Gzmc granzyme C 0.194
Glrp1 glutamine repeat protein 1 0.189
Sh2d1b1 SH2 domain protein 1B1 0.189
Spna1 spectrin alpha 1 0.180
Il2ra interleukin 2 receptor, alpha chain 0.180
Cidec cell death-inducing DFFA-like effector c 0.179
Il12rb1 interleukin 12 receptor, beta 1 0.174
Fpr1 formyl peptide receptor 1 0.172
Lcn4 lipocalin 4 0.169
Irf9 interferon regulatory factor 9 0.162
Psmb10 proteasome (prosome, macropain) subunit, beta type 10 0.160
Hgf hepatocyte growth factor 0.160
Sh2d2a SH2 domain protein 2A 0.158
Cd96 CD96 antigen 0.154
Il3 interleukin 3 0.153
Il1rn interleukin 1 receptor antagonist 0.149
Klre1 killer cell lectin-like receptor family E member 1 0.149
Gfi1 growth factor independent 1 0.148
Cd84 CD84 antigen 0.148
Gbp2 guanylate binding protein 2 0.146
Irf8 interferon regulatory factor 8 0.143
Prg2 proteoglycan 2, bone marrow 0.143
Gbp1 guanylate binding protein 1 0.142
Cd244 CD244 natural killer cell receptor 2B4 0.142
Lair1 leukocyte-associated Ig-like receptor 1 0.138
Nckap1l NCK associated protein 1 like 0.136
H2-Q8 histocompatibility 2, Q region locus 8 0.136
Grb2 growth factor receptor bound protein 2 0.136
Itgb2 integrin beta 2 0.135
Mmp13 matrix metallopeptidase 13 0.135
Klrb1c killer cell lectin-like receptor subfamily B member 1C 0.133
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
zgc:64115 zgc:64115 0.391
rhogb ras homolog gene family, member Gb 0.239
creb3l3l cAMP responsive element binding protein 3-like 3 like 0.214
zgc:110010 zgc:110010 0.175
sqstm1 sequestosome 1 0.124
ctsz cathepsin Z 0.098
lrrc33 leucine rich repeat containing 33 0.072
zgc:55891 zgc:55891 0.069
scpep1 serine carboxypeptidase 1 0.063
asah1b N-acylsphingosine amidohydrolase (acid ceramidase) 1b 0.057
edem1 ER degradation enhancer, mannosidase alpha-like 1 0.049
zgc:63831 zgc:63831 0.045
pdcd6ip programmed cell death 6 interacting protein 0.044
lratb lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b) 0.042
gstal glutathione S-transferase, alpha-like 0.040
trim25 tripartite motif-containing 25 0.039
fxr2 fragile X mental retardation, autosomal homolog 2 0.039
g6pd glucose-6-phosphate dehydrogenase 0.039
tcf12 transcription factor 12 0.037
pgd phosphogluconate hydrogenase 0.037
itln1 intelectin 1 0.036
zgc:64161 zgc:64161 0.036
zgc:174863 zgc:174863 0.036
kpna3 karyopherin (importin) alpha 3 0.035
tbc1d15 TBC1 domain family, member 15 0.035
nitr8 novel immune-type receptor 8 0.033
npy4r neuropeptide Y receptor Y4 0.032
ctsba cathepsin B, a 0.032
gnpda1 glucosamine-6-phosphate deaminase 1 0.031
psap prosaposin 0.031
npy7r neuropeptide Y receptor Y7 0.030
ppp2r5ea protein phosphatase 2, regulatory subunit B', epsilon isoform a 0.030
c3c complement component c3c 0.030
LOC566020 Gig2-like protein DreO 0.029
ptk6a PTK6 protein tyrosine kinase 6a 0.029
litaf lipopolysaccharide-induced TNF factor 0.029
zgc:152830 zgc:152830 0.029
itm2bb integral membrane protein 2Bb 0.028
c3b complement component c3b 0.028
mst1rb macrophage stimulating 1 receptor (c-met-related tyrosine kinase), b 0.028
pepd peptidase D 0.028
cndp2 CNDP dipeptidase 2 (metallopeptidase M20 family) 0.027
coro1a coronin, actin binding protein, 1A 0.027
f2rl1.2 coagulation factor II (thrombin) receptor-like 1.2 0.027
psma6b proteasome (prosome, macropain) subunit, alpha type, 6b 0.027
slc12a10.1 solute carrier family 12 (sodium/potassium/chloride transporters), member 10.1 0.026
styk1 serine/threonine/tyrosine kinase 1 0.026
sb:cb183 sb:cb183 0.026
etnk1 ethanolamine kinase 1 0.025
chmp5 chromatin modifying protein 5 0.025
im:7141132 im:7141132 0.025
zgc:101598 zgc:101598 0.025
fhl2a four and a half LIM domains 2a 0.025
nitr4a novel immune-type receptor 4a 0.024
gclc glutamate-cysteine ligase, catalytic subunit 0.024
zgc:63691 zgc:63691 0.024
myl9 myosin, light polypeptide 9, regulatory 0.024
atoh8 atonal homolog 8 0.024
wu:fb80e01 wu:fb80e01 0.024
wasb Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b 0.024
cyp2n13 cytochrome P450, family 2, subfamily N, polypeptide 13 0.023
maff v-maf musculoaponeurotic fibrosarcoma oncogene homolog f (avian) 0.023
scamp2 secretory carrier membrane protein 2 0.023
polr2d polymerase (RNA) II (DNA directed) polypeptide D 0.023
illr1 immune-related, lectin-like receptor 1 0.023
ifnphi1 interferon phi 1 0.023
krml2.2 Kreisler (mouse) maf-related leucine zipper homolog 2.2 0.023
foxp3a forkhead box P3a 0.023
b2m beta-2-microglobulin 0.023
lipf lipase, gastric 0.023
si:ch211-140f21.1 si:ch211-140f21.1 0.022
bpnt1 bisphosphate nucleotidase 1 0.022
zgc:162329 zgc:162329 0.022
ryk receptor-like tyrosine kinase 0.022
snx1 sorting nexin 1 0.022
wasa Wiskott-Aldrich syndrome (eczema-thrombocytopenia) a 0.022
illr4 immune-related, lectin-like receptor 4 0.022
eomesb eomesodermin homolog b 0.022
cxcr3.2 chemokine (C-X-C motif) receptor 3.2 0.022
ugt5c2 UDP glucuronosyltransferase 5 family, polypeptide C2 0.022
cd209 CD209 molecule 0.022
zgc:112992 zgc:112992 0.022
mep1a.1 meprin A, alpha.1 0.022
LOC794786 interferon-induced protein with tetratricopeptide repeats 1-like 0.021
c1qb complement component 1, q subcomponent, B chain 0.021
psmb9a proteasome (prosome, macropain) subunit, beta type, 9a 0.021
syngr1a synaptogyrin 1a 0.021
si:dkey-21e7.2 si:dkey-21e7.2 0.021
nos2a nitric oxide synthase 2a, inducible 0.021
psme2 proteasome activator subunit 2 0.021
wnt5a wingless-type MMTV integration site family, member 5a 0.021
cd40lg CD40 ligand 0.021
zgc:103710 zgc:103710 0.021
sult1st4 sulfotransferase family 1, cytosolic sulfotransferase 4 0.021
msxa muscle segment homeobox A 0.021
gpr143 G protein-coupled receptor 143 0.021
tlr9 toll-like receptor 9 0.021
tfec transcription factor EC 0.020
kirrelb kin of IRRE like b 0.020
waca WW domain containing adaptor with coiled-coil a 0.020
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
B2M beta-2-microglobulin 0.968
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.962
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.939
HLA-C major histocompatibility complex, class I, C 0.864
HLA-A major histocompatibility complex, class I, A 0.824
HLA-B major histocompatibility complex, class I, B 0.737
FASLG Fas ligand (TNF superfamily, member 6) 0.728
IL8 interleukin 8 0.724
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.666
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.590
CXCL3 chemokine (C-X-C motif) ligand 3 0.557
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) 0.544
PILRA paired immunoglobin-like type 2 receptor alpha 0.511
TAPBP TAP binding protein (tapasin) 0.508
HLA-F major histocompatibility complex, class I, F 0.505
HLA-G major histocompatibility complex, class I, G 0.498
CCL4 chemokine (C-C motif) ligand 4 0.441
KLRD1 killer cell lectin-like receptor subfamily D, member 1 0.430
CCR1 chemokine (C-C motif) receptor 1 0.394
HLA-E major histocompatibility complex, class I, E 0.389
IL2RB interleukin 2 receptor, beta 0.383
SLAMF1 signaling lymphocytic activation molecule family member 1 0.372
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.307
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.293
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.271
CCL5 chemokine (C-C motif) ligand 5 0.257
CXCL9 chemokine (C-X-C motif) ligand 9 0.201
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.189
KLRK1 killer cell lectin-like receptor subfamily K, member 1 0.187
LCK lymphocyte-specific protein tyrosine kinase 0.172
FAS Fas (TNF receptor superfamily, member 6) 0.167
SRGN serglycin 0.162
CCL13 chemokine (C-C motif) ligand 13 0.156
CXCL2 chemokine (C-X-C motif) ligand 2 0.150
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 0.140
CCR7 chemokine (C-C motif) receptor 7 0.139
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.133
IFNG interferon, gamma 0.128
DPP4 dipeptidyl-peptidase 4 0.128
ARRB1 arrestin, beta 1 0.116
SNAP23 synaptosomal-associated protein, 23kDa 0.110
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) 0.102
CD2 CD2 molecule 0.101
ICAM1 intercellular adhesion molecule 1 0.100
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 0.097
CD84 CD84 molecule 0.090
IL23A interleukin 23, alpha subunit p19 0.088
CXCL10 chemokine (C-X-C motif) ligand 10 0.087
SYK spleen tyrosine kinase 0.085
CCR5 chemokine (C-C motif) receptor 5 0.084
GZMK granzyme K (granzyme 3; tryptase II) 0.081
PTAFR platelet-activating factor receptor 0.077
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.077
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.075
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 0.075
NKG7 natural killer cell group 7 sequence 0.064
PVRL4 poliovirus receptor-related 4 0.064
GARS glycyl-tRNA synthetase 0.064
KLRC3 killer cell lectin-like receptor subfamily C, member 3 0.064
PRF1 perforin 1 (pore forming protein) 0.063
CXCL6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.062
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.057
LGALS3 lectin, galactoside-binding, soluble, 3 0.056
CD33 CD33 molecule 0.052
IL18RAP interleukin 18 receptor accessory protein 0.048
PVRL3 poliovirus receptor-related 3 0.047
CCL7 chemokine (C-C motif) ligand 7 0.047
TJP1 tight junction protein 1 (zona occludens 1) 0.045
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.044
CCL8 chemokine (C-C motif) ligand 8 0.044
KLRC2 killer cell lectin-like receptor subfamily C, member 2 0.043
IGSF6 immunoglobulin superfamily, member 6 0.040
INSR insulin receptor 0.039
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.038
HK3 hexokinase 3 (white cell) 0.038
CXCL11 chemokine (C-X-C motif) ligand 11 0.038
GNLY granulysin 0.038
SIGLEC7 sialic acid binding Ig-like lectin 7 0.037
KLRB1 killer cell lectin-like receptor subfamily B, member 1 0.036
VCAM1 vascular cell adhesion molecule 1 0.036
IL1B interleukin 1, beta 0.036
CD72 CD72 molecule 0.034
CD22 CD22 molecule 0.034
IL1RN interleukin 1 receptor antagonist 0.033
TYMP thymidine phosphorylase 0.033
GPR65 G protein-coupled receptor 65 0.031
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene) 0.030
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) 0.030
EMR1 egf-like module containing, mucin-like, hormone receptor-like 1 0.029
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 0.029
CFLAR CASP8 and FADD-like apoptosis regulator 0.028
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 0.028
FPR3 formyl peptide receptor 3 0.028
EPOR erythropoietin receptor 0.028
RAB14 RAB14, member RAS oncogene family 0.028
CD8A CD8a molecule 0.028
NLRP3 NLR family, pyrin domain containing 3 0.028
CXCL13 chemokine (C-X-C motif) ligand 13 0.027
ITM2B integral membrane protein 2B 0.027
VAMP4 vesicle-associated membrane protein 4 0.027
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Rattus norvegicus
Name Description Probability Func Analog Organism
Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) 0.810
RT1-EC2 RT1 class Ib, locus EC2 0.640
Cxcl10 chemokine (C-X-C motif) ligand 10 0.189
RT1-CE12 RT1 class I, locus CE12 0.115
Hsph1 heat shock 105/110 protein 1 0.084
Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.055
Gzmb granzyme B 0.046
Fth1 ferritin, heavy polypeptide 1 0.042
Psmb8 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) 0.041
Nkg7 natural killer cell group 7 sequence 0.038
Stip1 stress-induced phosphoprotein 1 0.038
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.034
Cd53 Cd53 molecule 0.033
Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.033
Slfn2 schlafen 2 0.027
Hspb1 heat shock protein 1 0.026
Dnajb1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.026
Casp1 caspase 1 0.025
RT1-Cl RT1 class Ib, locus Cl 0.025
Klrb1a killer cell lectin-like receptor subfamily B, member 1A 0.024
Klra5 killer cell lectin-like receptor, subfamily A, member 5 0.023
Rt1.aa MHC class I RT1.Aa alpha-chain 0.023
Spn sialophorin 0.023
RT1-S3 RT1 class Ib, locus S3 0.022
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.022
Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.020
Gzmk granzyme K 0.019
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.019
Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C 0.019
Ccl7 chemokine (C-C motif) ligand 7 0.016
Cd8a CD8a molecule 0.016
RT1-N3 RT1 class Ib, locus N3 0.014
Mcpt8 mast cell protease 8 0.013
Igsf6 immunoglobulin superfamily, member 6 0.013
Ly6c Ly6-C antigen 0.013
B2m beta-2 microglobulin 0.013
Bcl2a1d B-cell leukemia/lymphoma 2 related protein A1d 0.013
Il1b interleukin 1 beta 0.012
Ccl5 chemokine (C-C motif) ligand 5 0.012
Cd74 Cd74 molecule, major histocompatibility complex, class II invariant chain 0.012
Blnk B-cell linker 0.012
Dnaja1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.012
Kmo kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 0.012
Dcaf7 DDB1 and CUL4 associated factor 7 0.012
Neurl3 neuralized homolog 3 (Drosophila) 0.011
Ccr2 chemokine (C-C motif) receptor 2 0.011
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.011
Mmp12 matrix metallopeptidase 12 0.011
Xcl1 chemokine (C motif) ligand 1 0.011
Sept1 septin 1 0.010
Cd2 Cd2 molecule 0.010
Gbp2 guanylate binding protein 2 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism