The network for 'embryonic skeletal joint development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

embryonic skeletal joint development

The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeletal joints over time, from formation to mature structure.

Danio rerio
Name Description Probability Func Analog Organism
fgf10a fibroblast growth factor 10a 0.816
col2a1a collagen type II, alpha-1a 0.798
hoxa13b homeo box A13b 0.780
hoxa9b homeo box A9b 0.739
tbx18 T-box 18 0.688
bmp4 bone morphogenetic protein 4 0.673
hoxd10a homeo box D10a 0.661
hoxa11a homeo box A11a 0.640
tbx5a T-box 5a 0.604
hoxa10b homeo box A10b 0.589
hoxa11b homeo box A11b 0.545
hoxd11a homeo box D11a 0.532
hoxd13a homeo box D13a 0.489
hoxd9a homeo box D9a 0.477
wt1a wilms tumor 1a 0.339
evx1 even-skipped homeobox 1 0.320
gja3 gap junction protein, alpha 3 0.317
hoxd12a homeo box D12a 0.309
fgf24 fibroblast growth factor 24 0.295
dcc deleted in colorectal carcinoma 0.274
wnt5b wingless-type MMTV integration site family, member 5b 0.262
twist3 twist3 0.261
hoxa13a homeo box A13a 0.259
col10a1 collagen, type X, alpha 1 0.231
boc brother of CDO 0.221
bmp2b bone morphogenetic protein 2b 0.218
osr2 odd-skipped related 2 (Drosophila) 0.186
pkd2 polycystic kidney disease 2 0.182
bhlhe41 basic helix-loop-helix family, member e41 0.180
ptch1 patched 1 0.180
cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 0.179
sall4 sal-like 4 (Drosophila) 0.177
gpr126 G protein-coupled receptor 126 0.173
shha sonic hedgehog a 0.171
sulf1 sulfatase 1 0.169
twist1a twist1a 0.160
lepr leptin receptor 0.156
tcf4 transcription factor 4 0.154
csnk1a1 casein kinase 1, alpha 1 0.151
atoh1a atonal homolog 1a 0.140
fzd7b frizzled homolog 7b 0.137
rest RE1-silencing transcription factor 0.135
slit3 slit (Drosophila) homolog 3 0.129
tbx1 T-box 1 0.119
notch1a notch homolog 1a 0.115
evx2 even-skipped homeobox 2 0.114
foxj1b forkhead box J1b 0.113
sox9a SRY-box containing gene 9a 0.113
cx55.5 connexin 55.5 0.112
plcg1 phospholipase C, gamma 1 0.108
pnx posterior neuron-specific homeobox 0.105
pea3 ETS-domain transcription factor pea3 0.103
gli2b GLI-Kruppel family member GLI2b 0.102
gli1 GLI-Kruppel family member 1 0.097
efna5a ephrin A5a 0.096
efnb2a ephrin B2a 0.093
mecom MDS1 and EVI1 complex locus 0.092
gh1 growth hormone 1 0.092
ptch2 patched 2 0.092
egr2b early growth response 2b 0.087
sox9b SRY-box containing gene 9b 0.086
pax8 paired box gene 8 0.085
efnb3b ephrin B3b 0.083
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.080
bmp2a bone morphogenetic protein 2a 0.078
pdzrn3 PDZ domain containing RING finger 3 and PDZ domain containing ring finger 3 0.076
tmem2 transmembrane protein 2 0.073
tcf7l1a transcription factor 7-like 1a (T-cell specific, HMG-box) 0.073
plxna3 plexin A3 0.072
hoxb1a homeo box B1a 0.072
tgfb3 transforming growth factor, beta 3 0.070
ret1 receptor tyrosine kinase 0.069
lmna lamin A 0.069
plod2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.068
myod1 myogenic differentiation 1 0.067
runx2a runt-related transcription factor 2a 0.067
sp7 Sp7 transcription factor 0.066
cx39.9 connexin 39.9 0.066
scrib scribbled homolog (Drosophila) 0.065
egr1 early growth response 1 0.064
wnt2ba wingless-type MMTV integration site family, member 2Ba 0.064
chrm2a cholinergic receptor, muscarinic 2a 0.063
si:ch211-173b8.2 si:ch211-173b8.2 0.062
sim1a single-minded homolog 1a (Drosophila) 0.061
wnt9a wingless-type MMTV integration site family, member 9A 0.059
acvr1l activin A receptor, type I like 0.058
srf serum response factor 0.057
nav3 neuron navigator 3 0.057
rad21 RAD21 homolog (S. pombe) 0.055
prdm1a PR domain containing 1a, with ZNF domain 0.055
barx1 BarH-like homeobox 1 0.054
dlx5a distal-less homeobox gene 5a 0.054
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.053
tbx15 T-box 15 0.053
gsna gelsolin a 0.053
hoxa2b homeo box A2b 0.053
spry1 sprouty homolog 1 (Drosophila) 0.053
vasp vasodilator-stimulated phosphoprotein 0.053
flh floating head 0.052
drd2l dopamine receptor D2 like 0.052
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
COL3A1 collagen, type III, alpha 1 0.998
COL4A1 collagen, type IV, alpha 1 0.992
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.989
COL1A1 collagen, type I, alpha 1 0.985
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.982
COL5A1 collagen, type V, alpha 1 0.976
COL1A2 collagen, type I, alpha 2 0.972
TJP1 tight junction protein 1 (zona occludens 1) 0.971
DDR2 discoidin domain receptor tyrosine kinase 2 0.921
COL5A2 collagen, type V, alpha 2 0.911
COL4A2 collagen, type IV, alpha 2 0.905
LOX lysyl oxidase 0.510
SMAD7 SMAD family member 7 0.484
COL6A1 collagen, type VI, alpha 1 0.450
PXDN peroxidasin homolog (Drosophila) 0.425
APC adenomatous polyposis coli 0.356
POSTN periostin, osteoblast specific factor 0.340
GSK3B glycogen synthase kinase 3 beta 0.286
CSNK1E casein kinase 1, epsilon 0.279
LAMB1 laminin, beta 1 0.231
BMP2 bone morphogenetic protein 2 0.216
BMP7 bone morphogenetic protein 7 0.206
OCLN occludin 0.185
COL16A1 collagen, type XVI, alpha 1 0.175
NOG noggin 0.169
COL11A1 collagen, type XI, alpha 1 0.164
GLIS2 GLIS family zinc finger 2 0.155
COL6A3 collagen, type VI, alpha 3 0.153
ADAM12 ADAM metallopeptidase domain 12 0.151
NID2 nidogen 2 (osteonidogen) 0.149
FSTL1 follistatin-like 1 0.141
MXRA5 matrix-remodelling associated 5 0.131
TCF4 transcription factor 4 0.127
THY1 Thy-1 cell surface antigen 0.124
HOXA10 homeobox A10 0.118
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.111
FNDC1 fibronectin type III domain containing 1 0.101
NID1 nidogen 1 0.094
ZFYVE9 zinc finger, FYVE domain containing 9 0.092
COL6A2 collagen, type VI, alpha 2 0.090
COL2A1 collagen, type II, alpha 1 0.089
UNC5B unc-5 homolog B (C. elegans) 0.086
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.078
YAP1 Yes-associated protein 1 0.077
BTRC beta-transducin repeat containing 0.076
COL7A1 collagen, type VII, alpha 1 0.072
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.069
CAV2 caveolin 2 0.066
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.061
BGN biglycan 0.058
EMD emerin 0.056
DVL1 dishevelled, dsh homolog 1 (Drosophila) 0.055
DVL2 dishevelled, dsh homolog 2 (Drosophila) 0.051
MFAP2 microfibrillar-associated protein 2 0.050
COL18A1 collagen, type XVIII, alpha 1 0.049
TWIST1 twist homolog 1 (Drosophila) 0.049
CTHRC1 collagen triple helix repeat containing 1 0.049
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 0.048
TJP2 tight junction protein 2 (zona occludens 2) 0.043
IGFBP3 insulin-like growth factor binding protein 3 0.043
SOX11 SRY (sex determining region Y)-box 11 0.042
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 0.042
WWTR1 WW domain containing transcription regulator 1 0.041
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.041
PLXDC1 plexin domain containing 1 0.040
BMPR1A bone morphogenetic protein receptor, type IA 0.039
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.039
AR androgen receptor 0.038
PTK7 PTK7 protein tyrosine kinase 7 0.037
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.034
PDGFA platelet-derived growth factor alpha polypeptide 0.034
HOXC6 homeobox C6 0.033
CAV1 caveolin 1, caveolae protein, 22kDa 0.033
CNTF ciliary neurotrophic factor 0.031
COL10A1 collagen, type X, alpha 1 0.031
MCC mutated in colorectal cancers 0.031
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 0.030
LTBP1 latent transforming growth factor beta binding protein 1 0.030
FERMT2 fermitin family member 2 0.028
CD248 CD248 molecule, endosialin 0.028
HOXB5 homeobox B5 0.027
DACT1 dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis) 0.027
VMP1 vacuole membrane protein 1 0.027
FOXF2 forkhead box F2 0.027
SMO smoothened homolog (Drosophila) 0.026
DAXX death-domain associated protein 0.025
HOXC10 homeobox C10 0.025
COL12A1 collagen, type XII, alpha 1 0.025
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.025
OLFML3 olfactomedin-like 3 0.025
PRKCDBP protein kinase C, delta binding protein 0.025
FKBP10 FK506 binding protein 10, 65 kDa 0.025
GLT8D2 glycosyltransferase 8 domain containing 2 0.024
HOXD13 homeobox D13 0.024
CRMP1 collapsin response mediator protein 1 0.023
TGFB1I1 transforming growth factor beta 1 induced transcript 1 0.023
GJD3 gap junction protein, delta 3, 31.9kDa 0.023
FBN1 fibrillin 1 0.022
LOXL1 lysyl oxidase-like 1 0.022
MXRA8 matrix-remodelling associated 8 0.021
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Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Bmp7 bone morphogenetic protein 7 1.000
Gli3 GLI-Kruppel family member GLI3 1.000
Fgfr2 fibroblast growth factor receptor 2 0.999
Fgfr3 fibroblast growth factor receptor 3 0.996
Bmp4 bone morphogenetic protein 4 0.996
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.986
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.982
Sox9 SRY-box containing gene 9 0.980
Gli2 GLI-Kruppel family member GLI2 0.980
Ctnnb1 catenin (cadherin associated protein), beta 1 0.969
Hoxa11 homeobox A11 0.968
Msx1 homeobox, msh-like 1 0.967
Runx2 runt related transcription factor 2 0.948
Fgfr1 fibroblast growth factor receptor 1 0.945
Foxc1 forkhead box C1 0.941
Prrx1 paired related homeobox 1 0.941
Smo smoothened homolog (Drosophila) 0.885
Hand1 heart and neural crest derivatives expressed transcript 1 0.872
Apc adenomatosis polyposis coli 0.851
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.767
Tgfb2 transforming growth factor, beta 2 0.744
Lrp6 low density lipoprotein receptor-related protein 6 0.726
Ptch1 patched homolog 1 0.631
Chrd chordin 0.596
Pax2 paired box gene 2 0.560
Prrx2 paired related homeobox 2 0.549
Dlx5 distal-less homeobox 5 0.547
Msx2 homeobox, msh-like 2 0.506
Fgf9 fibroblast growth factor 9 0.493
Alx4 aristaless-like homeobox 4 0.448
Gsk3b glycogen synthase kinase 3 beta 0.446
Kif3a kinesin family member 3A 0.417
Hoxd11 homeobox D11 0.390
Zeb1 zinc finger E-box binding homeobox 1 0.365
Tbx15 T-box 15 0.358
Pthlh parathyroid hormone-like peptide 0.311
Lef1 lymphoid enhancer binding factor 1 0.287
Foxc2 forkhead box C2 0.277
Gdf1 growth differentiation factor 1 0.269
Nodal nodal 0.248
Pax3 paired box gene 3 0.240
Meox2 mesenchyme homeobox 2 0.209
Otx2 orthodenticle homolog 2 (Drosophila) 0.207
Hand2 heart and neural crest derivatives expressed transcript 2 0.197
Gas1 growth arrest specific 1 0.192
Smad3 MAD homolog 3 (Drosophila) 0.190
Lhx1 LIM homeobox protein 1 0.176
Col2a1 collagen, type II, alpha 1 0.167
Alx1 ALX homeobox 1 0.160
Cdon cell adhesion molecule-related/down-regulated by oncogenes 0.155
Tbx1 T-box 1 0.139
Phex phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets) 0.137
Bmpr1a bone morphogenetic protein receptor, type 1A 0.131
Pax9 paired box gene 9 0.121
Smad6 MAD homolog 6 (Drosophila) 0.104
Tgfbr2 transforming growth factor, beta receptor II 0.103
Gm13290 predicted gene 13290 0.099
Hoxd13 homeobox D13 0.098
Smad7 MAD homolog 7 (Drosophila) 0.089
Emx2 empty spiracles homolog 2 (Drosophila) 0.086
Bmp2 bone morphogenetic protein 2 0.083
Foxh1 forkhead box H1 0.074
Pitx1 paired-like homeodomain transcription factor 1 0.072
Tcfap2a transcription factor AP-2, alpha 0.066
Smad2 MAD homolog 2 (Drosophila) 0.063
Tbx3 T-box 3 0.063
Tdgf1 teratocarcinoma-derived growth factor 1 0.061
Htt huntingtin 0.056
Ret ret proto-oncogene 0.053
Fgf8 fibroblast growth factor 8 0.051
Gdf3 growth differentiation factor 3 0.050
Rnf111 ring finger 111 0.050
Smad4 MAD homolog 4 (Drosophila) 0.045
Zic3 zinc finger protein of the cerebellum 3 0.044
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.043
Bmper BMP-binding endothelial regulator 0.043
Rara retinoic acid receptor, alpha 0.043
Twsg1 twisted gastrulation homolog 1 (Drosophila) 0.039
Acvr1 activin A receptor, type 1 0.039
Wnt5a wingless-related MMTV integration site 5A 0.038
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.036
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.034
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.033
Hoxa13 homeobox A13 0.033
Psen1 presenilin 1 0.032
Wt1 Wilms tumor 1 homolog 0.032
Npr2 natriuretic peptide receptor 2 0.031
Eomes eomesodermin homolog (Xenopus laevis) 0.031
Rpgrip1l Rpgrip1-like 0.031
Gsc goosecoid homeobox 0.030
Fgfrl1 fibroblast growth factor receptor-like 1 0.027
Dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.027
Twist2 twist homolog 2 (Drosophila) 0.024
Col1a1 collagen, type I, alpha 1 0.024
Pitx2 paired-like homeodomain transcription factor 2 0.023
En1 engrailed 1 0.023
Smpd3 sphingomyelin phosphodiesterase 3, neutral 0.022
Vangl2 vang-like 2 (van gogh, Drosophila) 0.022
Efnb2 ephrin B2 0.022
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism