The network for 'convergent extension involved in gastrulation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

convergent extension involved in gastrulation

The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis usually resulting in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.

Danio rerio
Name Description Probability Func Analog Organism
wnt11 wingless-type MMTV integration site family, member 11 0.993
wnt5b wingless-type MMTV integration site family, member 5b 0.977
gpc4 glypican 4 0.968
tbx16 T-box gene 16 0.900
igf1rb insulin-like growth factor 1b receptor 0.893
gro1 groucho 1 0.890
bmp4 bone morphogenetic protein 4 0.886
ved ventrally expressed dharma/bozozok antagonist 0.880
spns2 spinster homolog 2 (Drosophila) 0.876
map2k4a mitogen-activated protein kinase kinase 4a 0.875
bmpr1aa bone morphogenetic protein receptor, type 1aa 0.852
smad9 MAD homolog 9 (Drosophila) 0.815
tbx1 T-box 1 0.785
lft2 lefty2 0.781
wls wntless homolog (Drosophila) 0.740
tbx20 T-box 20 0.733
vent ventral expressed homeobox 0.732
flh floating head 0.723
hnf1ba HNF1 homeobox Ba 0.695
chd chordin 0.687
twist1a twist1a 0.662
hoxd4a homeo box D4a 0.661
bmpr2b bone morphogenetic protein receptor, type II b (serine/threonine kinase) 0.660
lft1 lefty1 0.660
gro2 groucho 2 0.654
prickle1a prickle-like 1 (Drosophila) a 0.652
rarab retinoic acid receptor, alpha b 0.646
dkk1b dickkopf 1b 0.639
per3 period homolog 3 (Drosophila) 0.635
admp anti-dorsalizing morphogenic protein 0.621
ryk receptor-like tyrosine kinase 0.601
hhip hedgehog interacting protein 0.598
ntla no tail a 0.569
med12 mediator of RNA polymerase II transcription, subunit 12 homolog 0.568
snai1a snail homolog 1a (Drosophila) 0.566
ephb4b eph receptor B4b 0.547
fzd7b frizzled homolog 7b 0.537
wnt4a wingless-type MMTV integration site family, member 4a 0.533
ptk2.1 protein tyrosine kinase 2a 0.518
rfx2 regulatory factor X, 2 (influences HLA class II expression) 0.518
hapln1a hyaluronan and proteoglycan link protein 1a 0.516
ccm2 cerebral cavernous malformation 2 0.512
mapk1 mitogen-activated protein kinase 1 0.499
scrib scribbled homolog (Drosophila) 0.499
fn1 fibronectin 1 0.495
alcamb activated leukocyte cell adhesion molecule b 0.494
ndr2 nodal-related 2 0.475
lass2 LAG1 homolog, ceramide synthase 2 (S. cerevisiae) 0.468
fzd8b frizzled homolog 8b 0.464
ets1a v-ets erythroblastosis virus E26 oncogene homolog 1a 0.459
her5 hairy-related 5 0.436
spry2 sprouty homolog 2 0.432
smad5 MAD homolog 5 (Drosophila) 0.418
LOC566708 FL cytokine receptor-like 0.413
pdlim1 PDZ and LIM domain 1 (elfin) 0.409
vangl2 vang-like 2 (van gogh, Drosophila) 0.406
tpm4 tropomyosin 4 0.403
sox32 SRY-box containing gene 32 0.384
smad2 MAD homolog 2 (Drosophila) 0.370
pcdh8 protocadherin 8 0.368
sp5l Sp5 transcription factor-like 0.367
eve1 even-skipped-like1 0.364
ext1a exostoses (multiple) 1a 0.363
f2r coagulation factor II (thrombin) receptor 0.361
jak1 Janus kinase 1 0.345
mespa mesoderm posterior a 0.343
hmgcrb 3-hydroxy-3-methylglutaryl-Coenzyme A reductase b 0.340
sox19b SRY-box containing gene 19b 0.339
si:dkey-273o13.1 si:dkey-273o13.1 0.326
lmo4a LIM domain only 4a 0.324
ncor1 nuclear receptor co-repressor 1 0.314
runx2b runt-related transcription factor 2b 0.314
egr2b early growth response 2b 0.310
il7r interleukin 7 receptor 0.308
dyrk1b dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B 0.303
spry4 sprouty (Drosophila) homolog 4 0.302
sox17 SRY-box containing gene 17 0.300
lrrc6 leucine rich repeat containing 6 0.287
wnt5a wingless-type MMTV integration site family, member 5a 0.285
sdc2 syndecan 2 0.284
tll1 tolloid-like 1 0.281
zeb2a zinc finger E-box binding homeobox 2a 0.265
tmem2 transmembrane protein 2 0.261
cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 0.252
twist3 twist3 0.245
rnd3a Rho family GTPase 3a 0.238
sh3gl1b SH3-domain GRB2-like 1b 0.238
smad1 MAD homolog 1 (Drosophila) 0.234
bmp2a bone morphogenetic protein 2a 0.232
metap2 methionyl aminopeptidase 2 0.231
zgc:100838 zgc:100838 0.231
wnt3 wingless-type MMTV integration site family, member 3 0.230
wnt10b wingless-type MMTV integration site family, member 10b 0.230
ptpra protein tyrosine phosphatase, receptor type, A 0.227
si:ch211-173o4.2 si:ch211-173o4.2 0.225
col11a2 collagen type XI alpha-2 0.223
frzb frizzled-related protein 0.223
vox ventral homeobox 0.223
ptmab prothymosin, alpha b 0.221
fzd7a frizzled homolog 7a 0.219
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
ex expanded 0.413
fj four-jointed 0.244
Akt1 CG4006 gene product from transcript CG4006-RA 0.169
Src64B Src oncogene at 64B 0.160
Vang Van Gogh 0.143
wb wing blister 0.135
tkv thickveins 0.118
fz frizzled 0.114
htl heartless 0.111
not non-stop 0.109
usp ultraspiracle 0.088
Sdc Syndecan 0.087
smo smoothened 0.087
arm armadillo 0.086
Ptp69D Protein tyrosine phosphatase 69D 0.081
Wnt4 Wnt oncogene analog 4 0.080
otk off-track 0.079
Hop Hsp70/Hsp90 organizing protein homolog 0.075
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.074
rho rhomboid 0.070
gbb glass bottom boat 0.065
Pk61C Protein kinase 61C 0.065
Mtl Mig-2-like 0.059
if inflated 0.056
dgo diego 0.055
dsh dishevelled 0.053
mys myospheroid 0.053
Cdc42 CG12530 gene product from transcript CG12530-RA 0.049
ci cubitus interruptus 0.045
dally division abnormally delayed 0.042
spi spitz 0.041
Ras85D Ras oncogene at 85D 0.039
fy fuzzy 0.039
Kr Kruppel 0.039
Rac2 CG8556 gene product from transcript CG8556-RA 0.039
baz bazooka 0.038
inx2 innexin 2 0.038
Snoo Sno oncogene 0.037
pum pumilio 0.036
LanB1 CG7123 gene product from transcript CG7123-RA 0.036
par-1 CG8201 gene product from transcript CG8201-RA 0.035
G-oalpha47A G protein oalpha 47A 0.033
Peb Protein ejaculatory bulb 0.033
RYBP Ring and YY1 Binding Protein 0.033
hep hemipterous 0.032
CycE Cyclin E 0.032
dac dachshund 0.032
sd scalloped 0.030
Mrtf Myocardin-related transcription factor 0.030
Nrg Neuroglian 0.030
in inturned 0.030
robo3 CG5423 gene product from transcript CG5423-RA 0.030
slmb supernumerary limbs 0.029
kirre kin of irre 0.029
mew multiple edematous wings 0.029
Tsc1 CG6147 gene product from transcript CG6147-RA 0.028
beat-Ia beaten path Ia 0.028
drpr draper 0.027
scb scab 0.026
egh egghead 0.026
ttv tout-velu 0.026
Wnt5 Wnt oncogene analog 5 0.026
dome domeless 0.026
Wnt2 Wnt oncogene analog 2 0.025
CG11347 CG11347 gene product from transcript CG11347-RE 0.025
RpL3 Ribosomal protein L3 0.025
Rho1 CG8416 gene product from transcript CG8416-RB 0.024
Eip93F CG18389 gene product from transcript CG18389-RB 0.024
Ptpmeg CG1228 gene product from transcript CG1228-RD 0.024
Ef1gamma CG11901 gene product from transcript CG11901-RC 0.024
twi twist 0.024
bin biniou 0.024
dm diminutive 0.023
toc toucan 0.023
crb crumbs 0.023
hipk homeodomain interacting protein kinase 0.023
byn brachyenteron 0.023
Med Medea 0.022
LIMK1 LIM-kinase1 0.022
bab2 CG9102 gene product from transcript CG9102-RA 0.022
nmo nemo 0.022
Gef26 CG9491 gene product from transcript CG9491-RB 0.021
kni knirps 0.021
Nrx-IV Neurexin IV 0.020
pyr pyramus 0.020
Lim3 CG10699 gene product from transcript CG10699-RB 0.020
mirr mirror 0.020
Act57B Actin 57B 0.020
bif bifocal 0.020
Klp64D Kinesin-like protein at 64D 0.020
lgs legless 0.020
Krn Keren 0.019
cher cheerio 0.019
stumps CG31317 gene product from transcript CG31317-RC 0.019
plexB plexin B 0.019
CG34360 CG34360 gene product from transcript CG34360-RA 0.019
tld tolloid 0.019
Mlp84B Muscle LIM protein at 84B 0.019
wts warts 0.018
frc fringe connection 0.018
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 1.000
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.994
BCAR1 breast cancer anti-estrogen resistance 1 0.971
BMPR1A bone morphogenetic protein receptor, type IA 0.553
PTK2 PTK2 protein tyrosine kinase 2 0.537
FYN FYN oncogene related to SRC, FGR, YES 0.533
GRB2 growth factor receptor-bound protein 2 0.528
MED28 mediator complex subunit 28 0.492
CAV1 caveolin 1, caveolae protein, 22kDa 0.391
PTK2B PTK2B protein tyrosine kinase 2 beta 0.270
TRIP6 thyroid hormone receptor interactor 6 0.254
DSG2 desmoglein 2 0.238
SMAD1 SMAD family member 1 0.194
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.188
BMP1 bone morphogenetic protein 1 0.174
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.171
IFNAR2 interferon (alpha, beta and omega) receptor 2 0.156
BBS2 Bardet-Biedl syndrome 2 0.137
PCM1 pericentriolar material 1 0.128
SRCIN1 SRC kinase signaling inhibitor 1 0.108
BBS9 Bardet-Biedl syndrome 9 0.108
TNK2 tyrosine kinase, non-receptor, 2 0.102
IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor) 0.087
CTTN cortactin 0.085
BBS1 Bardet-Biedl syndrome 1 0.081
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.077
DST dystonin 0.075
FRS2 fibroblast growth factor receptor substrate 2 0.075
APC adenomatous polyposis coli 0.072
TJP2 tight junction protein 2 (zona occludens 2) 0.070
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.067
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.066
STAT5A signal transducer and activator of transcription 5A 0.061
ZMYND11 zinc finger, MYND-type containing 11 0.060
SPRR2A small proline-rich protein 2A 0.060
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.057
RPL10 ribosomal protein L10 0.057
SOCS1 suppressor of cytokine signaling 1 0.057
DCTN1 dynactin 1 0.056
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.054
PXN paxillin 0.052
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.052
LCK lymphocyte-specific protein tyrosine kinase 0.051
IFNGR1 interferon gamma receptor 1 0.051
EXOC7 exocyst complex component 7 0.050
STAT5B signal transducer and activator of transcription 5B 0.049
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.049
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.049
FYB FYN binding protein 0.048
MET met proto-oncogene (hepatocyte growth factor receptor) 0.046
SMAD3 SMAD family member 3 0.044
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.044
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.043
FZD1 frizzled homolog 1 (Drosophila) 0.043
LUM lumican 0.041
PDCD6IP programmed cell death 6 interacting protein 0.040
SMAD9 SMAD family member 9 0.040
QKI quaking homolog, KH domain RNA binding (mouse) 0.039
LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.039
TTC8 tetratricopeptide repeat domain 8 0.037
UNC119B unc-119 homolog B (C. elegans) 0.036
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.036
DSP desmoplakin 0.035
RPL13 ribosomal protein L13 0.035
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.034
RPL18 ribosomal protein L18 0.033
SPTBN1 spectrin, beta, non-erythrocytic 1 0.033
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.033
SH2D1A SH2 domain containing 1A 0.032
SKI v-ski sarcoma viral oncogene homolog (avian) 0.032
SOCS3 suppressor of cytokine signaling 3 0.032
GLTSCR2 glioma tumor suppressor candidate region gene 2 0.031
MAP2 microtubule-associated protein 2 0.030
MBNL1 muscleblind-like (Drosophila) 0.029
PPIL4 peptidylprolyl isomerase (cyclophilin)-like 4 0.029
FSTL1 follistatin-like 1 0.029
CSK c-src tyrosine kinase 0.029
ARHGAP32 Rho GTPase activating protein 32 0.028
CXXC5 CXXC finger protein 5 0.027
INPPL1 inositol polyphosphate phosphatase-like 1 0.027
JUP junction plakoglobin 0.026
PTPN21 protein tyrosine phosphatase, non-receptor type 21 0.026
RBM4 RNA binding motif protein 4 0.026
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.026
SH3KBP1 SH3-domain kinase binding protein 1 0.025
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.025
NOG noggin 0.025
CAV2 caveolin 2 0.024
PRKCQ protein kinase C, theta 0.024
TIMP2 TIMP metallopeptidase inhibitor 2 0.024
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.024
EIF3L eukaryotic translation initiation factor 3, subunit L 0.024
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.023
SCAMP1 secretory carrier membrane protein 1 0.023
MAPT microtubule-associated protein tau 0.022
IFNAR1 interferon (alpha, beta and omega) receptor 1 0.022
HIPK2 homeodomain interacting protein kinase 2 0.022
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa 0.022
CEP164 centrosomal protein 164kDa 0.021
ANKRD13A ankyrin repeat domain 13A 0.021
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism