The network for 'liver development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

liver development

The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.

Danio rerio
Name Description Probability Func Analog Organism
tbx1 T-box 1 0.995
gata5 GATA-binding protein 5 0.983
gata6 GATA-binding protein 6 0.977
hnf1ba HNF1 homeobox Ba 0.970
bmp2a bone morphogenetic protein 2a 0.970
kdrl kinase insert domain receptor like 0.966
wnt5b wingless-type MMTV integration site family, member 5b 0.959
bmp2b bone morphogenetic protein 2b 0.942
flh floating head 0.929
ets1a v-ets erythroblastosis virus E26 oncogene homolog 1a 0.879
tp53 tumor protein p53 0.877
pwp2h PWP2 periodic tryptophan protein homolog (yeast) 0.842
met met proto-oncogene (hepatocyte growth factor receptor) 0.818
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.816
cdh1 cadherin 1, epithelial 0.809
foxa3 forkhead box A3 0.807
dkk1b dickkopf 1b 0.802
fgf3 fibroblast growth factor 3 0.757
sox9b SRY-box containing gene 9b 0.742
ahr2 aryl hydrocarbon receptor 2 0.733
fzd8a frizzled homolog 8a 0.717
jag2 jagged 2 0.685
ndr2 nodal-related 2 0.675
cdx4 caudal type homeo box transcription factor 4 0.656
egr2b early growth response 2b 0.649
jag1b jagged 1b 0.599
wnt4a wingless-type MMTV integration site family, member 4a 0.536
sox17 SRY-box containing gene 17 0.527
LOC560602 novel protein similar to vertebrate solute carrier family 2 (facilitated glucose transporter), member 6 (SLC2A6) 0.521
gata3 GATA-binding protein 3 0.517
pcdh8 protocadherin 8 0.491
fn1 fibronectin 1 0.489
fzd7a frizzled homolog 7a 0.477
slc2a13 solute carrier family 2 (facilitated glucose transporter), member 13 0.474
lft1 lefty1 0.470
tcf7l1a transcription factor 7-like 1a (T-cell specific, HMG-box) 0.433
dld deltaD 0.431
sfrp1a secreted frizzled-related protein 1a 0.427
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.425
ccm2 cerebral cavernous malformation 2 0.423
rarab retinoic acid receptor, alpha b 0.423
her7 hairy and enhancer of split related-7 0.421
gata4 GATA-binding protein 4 0.412
sfrp1b secreted frizzled-related protein 1b 0.408
nf1a neurofibromin 1a 0.403
ppp1r12a protein phosphatase 1, regulatory (inhibitor) subunit 12A 0.380
rbm19 RNA binding motif protein 19 0.376
hhex hematopoietically expressed homeobox 0.372
gli1 GLI-Kruppel family member 1 0.368
bhlhe40 basic helix-loop-helix family, member e40 0.363
spi1 spleen focus forming virus (SFFV) proviral integration oncogene spi1 0.359
gpia glucose phosphate isomerase a 0.355
mpx myeloid-specific peroxidase 0.352
ahctf1 AT hook containing transcription factor 1 0.350
slc2a12 solute carrier family 2 (facilitated glucose transporter), member 12 0.349
fgf10a fibroblast growth factor 10a 0.343
tal1 T-cell acute lymphocytic leukemia 1 0.335
bmpr1aa bone morphogenetic protein receptor, type 1aa 0.334
slc2a11b solute carrier family 2 (facilitated glucose transporter), member 11b 0.330
slc2a11l solute carrier family 2 (facilitated glucose transporter), member 11-like 0.329
slc2a1b solute carrier family 2 (facilitated glucose transporter), member 1b 0.320
LOC560358 solute carrier family 2, facilitated glucose transporter member 11-like 0.316
eya1 eyes absent homolog 1 0.311
klf4 Kruppel-like factor 4 0.310
tbx2b T-box 2b 0.307
wif1 wnt inhibitory factor 1 0.305
wnt3 wingless-type MMTV integration site family, member 3 0.300
tjp3 tight junction protein 3 0.297
wnt11 wingless-type MMTV integration site family, member 11 0.296
vps39 vacuolar protein sorting 39 homolog (S. cerevisiae) 0.296
copeb core promoter element binding protein 0.287
nfkbiab nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b 0.282
pax6b paired box gene 6b 0.282
sox2 SRY-box containing gene 2 0.279
gdf6a growth differentiation factor 6a 0.275
socs1 suppressor of cytokine signaling 1 0.274
neo1 neogenin 1 0.270
slc2a9l2 solute carrier family 2 (facilitated glucose transporter), member 9-like 2 0.269
smad3b MAD, mothers against decapentaplegic homolog 3b (Drosophila) 0.267
dharma dharma 0.266
crabp2a cellular retinoic acid binding protein 2, a 0.263
traf4a tnf receptor-associated factor 4a 0.262
cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 0.261
tyr tyrosinase 0.260
c11orf2 c11orf2 homolog (H. sapiens) 0.258
wnt8b wingless-type MMTV integration site family, member 8b 0.254
smad1 MAD homolog 1 (Drosophila) 0.254
gata2a GATA-binding protein 2a 0.250
bmp3 bone morphogenetic protein 3 0.247
vent ventral expressed homeobox 0.243
notch3 notch homolog 3 0.242
krt4 keratin 4 0.241
tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.237
lfng lunatic fringe homolog 0.225
prnprs3 prion protein, related sequence 3 0.225
gli2a GLI-Kruppel family member GLI2a 0.223
aldob aldolase b, fructose-bisphosphate 0.221
id1 inhibitor of DNA binding 1 0.221
dla deltaA 0.218
otpb orthopedia homolog b 0.214
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
NOTCH1 notch 1 0.359
CCNE1 cyclin E1 0.327
JAG1 jagged 1 0.249
HNF4A hepatocyte nuclear factor 4, alpha 0.207
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.150
GABPA GA binding protein transcription factor, alpha subunit 60kDa 0.127
NOTCH3 notch 3 0.101
DDIT3 DNA-damage-inducible transcript 3 0.098
SC4MOL sterol-C4-methyl oxidase-like 0.085
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.082
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.059
JUN jun proto-oncogene 0.057
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.053
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.053
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.052
IDI1 isopentenyl-diphosphate delta isomerase 1 0.051
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.049
MED25 mediator complex subunit 25 0.047
GARS glycyl-tRNA synthetase 0.042
BMPR1A bone morphogenetic protein receptor, type IA 0.039
CCND3 cyclin D3 0.037
DHCR7 7-dehydrocholesterol reductase 0.033
EGFR epidermal growth factor receptor 0.028
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.023
CDK6 cyclin-dependent kinase 6 0.022
PKD2 polycystic kidney disease 2 (autosomal dominant) 0.021
BRCA1 breast cancer 1, early onset 0.021
GHR growth hormone receptor 0.020
SMAD1 SMAD family member 1 0.020
BBS10 Bardet-Biedl syndrome 10 0.020
SETD7 SET domain containing (lysine methyltransferase) 7 0.019
FGF1 fibroblast growth factor 1 (acidic) 0.019
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.018
RXRA retinoid X receptor, alpha 0.017
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.017
PKD1 polycystic kidney disease 1 (autosomal dominant) 0.017
NOTCH2 notch 2 0.016
GET4 golgi to ER traffic protein 4 homolog (S. cerevisiae) 0.015
CCND1 cyclin D1 0.015
BBS1 Bardet-Biedl syndrome 1 0.015
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.014
CFLAR CASP8 and FADD-like apoptosis regulator 0.014
MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) 0.014
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.013
NCOA1 nuclear receptor coactivator 1 0.013
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.013
CSNK1E casein kinase 1, epsilon 0.013
PDX1 pancreatic and duodenal homeobox 1 0.012
KLF4 Kruppel-like factor 4 (gut) 0.012
NCK2 NCK adaptor protein 2 0.012
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.012
VAC14 Vac14 homolog (S. cerevisiae) 0.012
FN1 fibronectin 1 0.012
NCOR2 nuclear receptor corepressor 2 0.012
ATF3 activating transcription factor 3 0.011
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.011
ARNT aryl hydrocarbon receptor nuclear translocator 0.011
APOE apolipoprotein E 0.011
CDK2 cyclin-dependent kinase 2 0.011
SRF serum response factor (c-fos serum response element-binding transcription factor) 0.010
CDK19 cyclin-dependent kinase 19 0.010
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.010
ATF4 activating transcription factor 4 (tax-responsive enhancer element B67) 0.010
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Pten phosphatase and tensin homolog 0.993
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.987
Bmp4 bone morphogenetic protein 4 0.980
Gata4 GATA binding protein 4 0.977
Rxra retinoid X receptor alpha 0.975
Pitx2 paired-like homeodomain transcription factor 2 0.965
Pax3 paired box gene 3 0.948
Chd7 chromodomain helicase DNA binding protein 7 0.944
Hes1 hairy and enhancer of split 1 (Drosophila) 0.934
Apoe apolipoprotein E 0.911
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.904
Trp53 transformation related protein 53 0.902
Meox2 mesenchyme homeobox 2 0.895
Rarg retinoic acid receptor, gamma 0.885
Gli3 GLI-Kruppel family member GLI3 0.882
Acvr1 activin A receptor, type 1 0.874
Tgfbr2 transforming growth factor, beta receptor II 0.871
Onecut1 one cut domain, family member 1 0.861
Hhex hematopoietically expressed homeobox 0.856
Rb1 retinoblastoma 1 0.846
Stat3 signal transducer and activator of transcription 3 0.842
Pkd1 polycystic kidney disease 1 homolog 0.832
Apc adenomatosis polyposis coli 0.831
Fgfr2 fibroblast growth factor receptor 2 0.817
Foxc1 forkhead box C1 0.813
Smad4 MAD homolog 4 (Drosophila) 0.790
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.786
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.765
Shh sonic hedgehog 0.737
Alx4 aristaless-like homeobox 4 0.719
Fgf8 fibroblast growth factor 8 0.714
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.707
Notch1 Notch gene homolog 1 (Drosophila) 0.685
Vegfa vascular endothelial growth factor A 0.675
Tbx3 T-box 3 0.670
Hand2 heart and neural crest derivatives expressed transcript 2 0.664
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.654
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.652
Axl AXL receptor tyrosine kinase 0.640
Nf1 neurofibromatosis 1 0.618
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.616
Nos3 nitric oxide synthase 3, endothelial cell 0.612
Nodal nodal 0.605
Nog noggin 0.561
Gata6 GATA binding protein 6 0.549
Mks1 Meckel syndrome, type 1 0.547
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.547
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.524
Invs inversin 0.523
Sox4 SRY-box containing gene 4 0.510
Dll1 delta-like 1 (Drosophila) 0.505
Hnf4a hepatic nuclear factor 4, alpha 0.484
Apoa1 apolipoprotein A-I 0.482
Foxa2 forkhead box A2 0.468
Isl1 ISL1 transcription factor, LIM/homeodomain 0.461
Ptk2 PTK2 protein tyrosine kinase 2 0.454
Jag1 jagged 1 0.426
Fos FBJ osteosarcoma oncogene 0.415
Gdf5 growth differentiation factor 5 0.412
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.404
Sox17 SRY-box containing gene 17 0.402
Tef thyrotroph embryonic factor 0.392
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.391
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.389
Vangl2 vang-like 2 (van gogh, Drosophila) 0.389
Ptgs2 prostaglandin-endoperoxide synthase 2 0.364
Smad6 MAD homolog 6 (Drosophila) 0.362
Erbb2ip Erbb2 interacting protein 0.361
Tcfap2a transcription factor AP-2, alpha 0.361
Bmp7 bone morphogenetic protein 7 0.359
Cdk6 cyclin-dependent kinase 6 0.359
Ece1 endothelin converting enzyme 1 0.352
Tal1 T-cell acute lymphocytic leukemia 1 0.339
Kit kit oncogene 0.337
Col1a1 collagen, type I, alpha 1 0.321
Ctnnb1 catenin (cadherin associated protein), beta 1 0.320
Tgfb1 transforming growth factor, beta 1 0.318
Csf1 colony stimulating factor 1 (macrophage) 0.316
Lrp1 low density lipoprotein receptor-related protein 1 0.310
Hdac1 histone deacetylase 1 0.303
Bicc1 bicaudal C homolog 1 (Drosophila) 0.295
She src homology 2 domain-containing transforming protein E 0.293
Sox18 SRY-box containing gene 18 0.291
Gli2 GLI-Kruppel family member GLI2 0.284
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.282
Notch2 Notch gene homolog 2 (Drosophila) 0.265
Hand1 heart and neural crest derivatives expressed transcript 1 0.260
Tbx2 T-box 2 0.249
Alx3 aristaless-like homeobox 3 0.244
Tgfb2 transforming growth factor, beta 2 0.243
Nkx2-3 NK2 transcription factor related, locus 3 (Drosophila) 0.235
Psen1 presenilin 1 0.232
Tbx1 T-box 1 0.230
Axin2 axin2 0.228
Ptch1 patched homolog 1 0.227
Tyro3 TYRO3 protein tyrosine kinase 3 0.224
Eng endoglin 0.220
Fgfr1 fibroblast growth factor receptor 1 0.219
Pparg peroxisome proliferator activated receptor gamma 0.218
Mvd mevalonate (diphospho) decarboxylase 0.210
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 0.854
Plg plasminogen 0.762
Fabp1 fatty acid binding protein 1, liver 0.669
Kmo kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 0.667
Mbl2 mannose-binding lectin (protein C) 2 0.638
Slc10a1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 0.632
Azgp1 alpha-2-glycoprotein 1, zinc-binding 0.593
Mug1 murinoglobulin 1 0.584
Otc ornithine carbamoyltransferase 0.579
Pzp pregnancy-zone protein 0.563
Serpina1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.558
Cyp2c23 cytochrome P450, family 2, subfamily c, polypeptide 23 0.528
Dhfr dihydrofolate reductase 0.477
LOC293989 cytochrome P450-like 0.461
Gbp2 guanylate binding protein 2 0.460
Agxt2 alanine-glyoxylate aminotransferase 2 0.454
Ugt2b5 UDP glucuronosyltransferase 2 family, polypeptide B5 0.454
Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 0.435
Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 0.424
Ceacam1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.409
Sc4mol sterol-C4-methyl oxidase-like 0.395
Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C 0.395
Ugt2b UDP glycosyltransferase 2 family, polypeptide B 0.388
Aldob aldolase B, fructose-bisphosphate 0.373
Ugt2b36 UDP glucuronosyltransferase 2 family, polypeptide B36 0.364
Akr1c14 aldo-keto reductase family 1, member C14 0.356
Cyp51 cytochrome P450, family 51 0.350
Anpep alanyl (membrane) aminopeptidase 0.340
Ahsg alpha-2-HS-glycoprotein 0.331
Met met proto-oncogene 0.309
Serpina3k serine (or cysteine) peptidase inhibitor, clade A, member 3K 0.299
Lipc lipase, hepatic 0.290
Gsta5 glutathione S-transferase Yc2 subunit 0.281
Slco2a1 solute carrier organic anion transporter family, member 2a1 0.279
Htr1d 5-hydroxytryptamine (serotonin) receptor 1D 0.279
Cpb2 carboxypeptidase B2 (plasma) 0.277
Nr1d2 nuclear receptor subfamily 1, group D, member 2 0.264
Dbp D site of albumin promoter (albumin D-box) binding protein 0.262
Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 0.260
Nr1d1 nuclear receptor subfamily 1, group D, member 1 0.247
Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 0.242
Ptprq protein tyrosine phosphatase, receptor type, Q 0.237
Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 0.233
Ar androgen receptor 0.233
Ugt2b37 UDP-glucuronosyltransferase 2 family, member 37 0.230
Apob apolipoprotein B 0.229
Cyp2d2 cytochrome P450, family 2, subfamily d, polypeptide 2 0.227
Fgfr2 fibroblast growth factor receptor 2 0.225
Slc17a1 solute carrier family 17 (sodium phosphate), member 1 0.219
Ces1c carboxylesterase 1C 0.217
Sult1a1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 0.217
Sardh sarcosine dehydrogenase 0.215
Galm galactose mutarotase (aldose 1-epimerase) 0.211
Tgfbr2 transforming growth factor, beta receptor II 0.205
Mvp major vault protein 0.204
Dnase1l3 deoxyribonuclease 1-like 3 0.197
C8b complement component 8, beta polypeptide 0.197
Apoa2 apolipoprotein A-II 0.196
Gsta2 glutathione S-transferase A2 0.196
Mettl7b methyltransferase like 7B 0.194
Mbl1 mannose-binding lectin (protein A) 1 0.190
Prodh2 proline dehydrogenase (oxidase) 2 0.184
Il1rap interleukin 1 receptor accessory protein 0.183
Fbp1 fructose-1,6-bisphosphatase 1 0.181
Pklr pyruvate kinase, liver and RBC 0.180
Fga fibrinogen alpha chain 0.179
Mgst2 microsomal glutathione S-transferase 2 0.172
Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 0.169
Stat2 signal transducer and activator of transcription 2 0.167
RT1-EC2 RT1 class Ib, locus EC2 0.167
Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 0.165
Prlr prolactin receptor 0.164
LOC100365106 rCG32755-like 0.162
Hnf4a hepatocyte nuclear factor 4, alpha 0.162
Igfals insulin-like growth factor binding protein, acid labile subunit 0.160
Apoh apolipoprotein H (beta-2-glycoprotein I) 0.153
Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 0.152
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.150
Vom2r27 vomeronasal 2 receptor, 27 0.149
Casp12 caspase 12 0.149
Cyp2a2 cytochrome P450, family 2, subfamily a, polypeptide 2 0.147
Rup2 urinary protein 2 0.144
Cyp4a2 cytochrome P450, family 4, subfamily a, polypeptide 2 0.144
Nr1h4 nuclear receptor subfamily 1, group H, member 4 0.143
Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 0.142
Clps colipase, pancreatic 0.140
Gstm2 glutathione S-transferase mu 2 0.139
Gc group specific component 0.136
Serpina6 serine (or cysteine) peptidase inhibitor, clade A, member 6 0.135
Dpys dihydropyrimidinase 0.135
Ctsc cathepsin C 0.132
Ech1 enoyl coenzyme A hydratase 1, peroxisomal 0.129
Tpi1 triosephosphate isomerase 1 0.129
Dpep1 dipeptidase 1 (renal) 0.129
Anxa1 annexin A1 0.128
RGD1305347 similar to RIKEN cDNA 2610528J11 0.126
LOC100361864 UDP-glucuronosyltransferase 2B3-like 0.124
Ahnak AHNAK nucleoprotein 0.123
Bmp7 bone morphogenetic protein 7 0.123
Acox3 acyl-Coenzyme A oxidase 3, pristanoyl 0.122
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism