The network for 'brain development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

brain development

The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).

Danio rerio
Name Description Probability Func Analog Organism
hnf1ba HNF1 homeobox Ba 1.000
gata3 GATA-binding protein 3 1.000
pitx3 paired-like homeodomain transcription factor 3 0.999
foxd3 forkhead box D3 0.999
fgf3 fibroblast growth factor 3 0.999
shha sonic hedgehog a 0.999
eya1 eyes absent homolog 1 0.998
pax8 paired box gene 8 0.998
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.998
olig2 oligodendrocyte lineage transcription factor 2 0.998
otx2 orthodenticle homolog 2 0.997
hoxb3a homeo box B3a 0.996
epha4a eph receptor A4a 0.995
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.993
fgf8a fibroblast growth factor 8 a 0.993
tbx1 T-box 1 0.992
fezf2 FEZ family zinc finger 2 0.992
tbx16 T-box gene 16 0.991
lef1 lymphocyte enhancer binding factor 1 0.991
cdh2 cadherin 2, neuronal 0.990
otpb orthopedia homolog b 0.986
wnt8b wingless-type MMTV integration site family, member 8b 0.983
wnt11 wingless-type MMTV integration site family, member 11 0.983
fgfr2 fibroblast growth factor receptor 2 0.983
ndr2 nodal-related 2 0.982
sox10 SRY-box containing gene 10 0.979
rx3 retinal homeobox gene 3 0.978
hoxc6a homeo box C6a 0.977
myod1 myogenic differentiation 1 0.975
wnt5b wingless-type MMTV integration site family, member 5b 0.973
neurod neurogenic differentiation 0.973
tfap2a transcription factor AP-2 alpha 0.973
gbx2 gastrulation brain homeo box 2 0.972
dlc deltaC 0.967
epb41l5 erythrocyte membrane protein band 4.1 like 5 0.966
dlx2a distal-less homeobox gene 2a 0.964
six3b sine oculis homeobox homolog 3b 0.963
six4b sine oculis homeobox homolog 4b 0.962
sox3 SRY-box containing gene 3 0.961
pax2a paired box gene 2a 0.960
isl2a islet2a 0.959
otpa orthopedia homolog a 0.958
hoxb5b homeo box B5b 0.957
jag2 jagged 2 0.956
fzd8a frizzled homolog 8a 0.955
gli2a GLI-Kruppel family member GLI2a 0.955
kif17 kinesin family member 17 0.955
crabp2a cellular retinoic acid binding protein 2, a 0.952
dla deltaA 0.951
her5 hairy-related 5 0.950
chd chordin 0.946
meis2.1 myeloid ecotropic viral integration site 2.1 0.945
six3a sine oculis homeobox homolog 3a 0.943
neurod4 neurogenic differentiation 4 0.943
lhx5 LIM homeobox 5 0.942
hoxb5a homeo box B5a 0.942
pbx1a pre-B-cell leukemia transcription factor 1a 0.941
hoxa3a homeo box A3a 0.941
atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.941
dlx3b distal-less homeobox gene 3b 0.939
gata2a GATA-binding protein 2a 0.939
dld deltaD 0.936
mab21l2 mab-21-like 2 0.936
egr2b early growth response 2b 0.936
guca1c guanylate cyclase activator 1C 0.936
hoxb1b homeo box B1b 0.933
eve1 even-skipped-like1 0.933
cxcr4a chemokine (C-X-C motif) receptor 4a 0.932
zic2a zic family member 2 (odd-paired homolog, Drosophila), a 0.930
prickle1a prickle-like 1 (Drosophila) a 0.929
sox11b SRY-box containing gene 11b 0.927
foxp2 forkhead box P2 0.924
ift88 intraflagellar transport 88 homolog 0.921
foxa2 forkhead box A2 0.920
fzd7a frizzled homolog 7a 0.919
sp5l Sp5 transcription factor-like 0.918
boc brother of CDO 0.914
tbx2b T-box 2b 0.910
gdf6a growth differentiation factor 6a 0.908
dlb deltaB 0.904
cdh1 cadherin 1, epithelial 0.904
neo1 neogenin 1 0.902
gli1 GLI-Kruppel family member 1 0.902
wnt4a wingless-type MMTV integration site family, member 4a 0.902
dlx4b distal-less homeobox gene 4b 0.900
sox2 SRY-box containing gene 2 0.899
raraa retinoic acid receptor, alpha a 0.895
mib mind bomb 0.895
pax6a paired box gene 6a 0.895
gbx1 gastrulation brain homeobox 1 0.894
her15.1 hairy and enhancer of split-related 15.1 0.893
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.890
irx7 iroquois homeobox protein 7 0.889
ntla no tail a 0.886
cdx4 caudal type homeo box transcription factor 4 0.876
mapk3 mitogen-activated protein kinase 3 0.875
phox2a paired-like homeobox 2a 0.874
spry4 sprouty (Drosophila) homolog 4 0.874
mespa mesoderm posterior a 0.872
atoh1a atonal homolog 1a 0.870
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
dac dachshund 0.998
wg wingless 0.997
Egfr Epidermal growth factor receptor 0.996
E(spl) Enhancer of split 0.995
spi spitz 0.994
shi shibire 0.992
ato atonal 0.992
drl derailed 0.989
Fmr1 CG6203 gene product from transcript CG6203-RC 0.978
Dscam Down syndrome cell adhesion molecule 0.977
eyg eyegone 0.976
robo roundabout 0.968
rst roughest 0.968
babo baboon 0.966
tkv thickveins 0.964
esg escargot 0.961
numb CG3779 gene product from transcript CG3779-RB 0.960
Dad Daughters against dpp 0.950
Dhc64C Dynein heavy chain 64C 0.945
amos absent MD neurons and olfactory sensilla 0.934
Ten-a Tenascin accessory 0.932
vvl ventral veins lacking 0.928
argos CG4531 gene product from transcript CG4531-RA 0.917
LIMK1 LIM-kinase1 0.906
Su(H) Suppressor of Hairless 0.906
lola longitudinals lacking 0.902
sle slender lobes 0.899
InR Insulin-like receptor 0.898
mam mastermind 0.898
stan starry night 0.895
Fas2 Fasciclin 2 0.894
fkh fork head 0.889
trio CG18214 gene product from transcript CG18214-RA 0.887
vap vacuolar peduncle 0.887
N Notch 0.887
Khc Kinesin heavy chain 0.885
ey eyeless 0.882
ara araucan 0.851
sca scabrous 0.845
ems empty spiracles 0.844
ro rough 0.842
drpr draper 0.841
dsh dishevelled 0.837
nej nejire 0.832
sgl sugarless 0.832
tefu telomere fusion 0.829
oc ocelliless 0.827
Nup153 Nucleoporin 153 0.817
Ras85D Ras oncogene at 85D 0.815
lea leak 0.811
rg rugose 0.805
dpp decapentaplegic 0.795
slp1 sloppy paired 1 0.795
rho rhomboid 0.795
Ptpmeg CG1228 gene product from transcript CG1228-RD 0.789
hkb huckebein 0.777
klu klumpfuss 0.774
gbb glass bottom boat 0.758
hbs hibris 0.758
chico CG5686 gene product from transcript CG5686-RB 0.757
dock dreadlocks 0.756
ph-p polyhomeotic proximal 0.748
cas castor 0.744
HLHm5 E(spl) region transcript m5 0.735
ari-2 ariadne 2 0.732
arm armadillo 0.727
grim CG4345 gene product from transcript CG4345-RA 0.722
Poxn Pox neuro 0.718
pb proboscipedia 0.709
eya eyes absent 0.709
Mad Mothers against dpp 0.706
Gsc Goosecoid 0.702
Lis-1 Lissencephaly-1 0.692
MAN1 CG3167 gene product from transcript CG3167-RA 0.689
norpA no receptor potential A 0.688
Antp Antennapedia 0.678
S6kII RPS6-protein kinase-II 0.669
tup tailup 0.666
Tao-1 CG14217 gene product from transcript CG14217-RF 0.665
Act5C Actin 5C 0.659
stau staufen 0.658
Exp6 Exportin 6 0.655
drk downstream of receptor kinase 0.646
katanin-60 katanin 60 0.645
Ephrin CG1862 gene product from transcript CG1862-RA 0.643
Ubx Ultrabithorax 0.634
pyd polychaetoid 0.629
eff effete 0.623
sev sevenless 0.622
abd-A abdominal A 0.606
Alk CG8250 gene product from transcript CG8250-RA 0.601
ss spineless 0.597
jeb jelly belly 0.587
pasha partner of drosha 0.573
Src42A Src oncogene at 42A 0.562
sens senseless 0.562
p53 CG33336 gene product from transcript CG33336-RB 0.562
HLHm7 E(spl) region transcript m7 0.557
arr arrow 0.540
trx trithorax 0.539
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
TP53 tumor protein p53 0.999
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.994
EGFR epidermal growth factor receptor 0.969
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.957
ESR1 estrogen receptor 1 0.945
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.902
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.897
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.889
FGFR2 fibroblast growth factor receptor 2 0.808
PKM2 pyruvate kinase, muscle 0.796
HDAC2 histone deacetylase 2 0.772
APC adenomatous polyposis coli 0.757
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.625
CREBBP CREB binding protein 0.608
SMAD3 SMAD family member 3 0.607
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.559
POU3F2 POU class 3 homeobox 2 0.518
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.505
SMAD2 SMAD family member 2 0.501
MYOD1 myogenic differentiation 1 0.500
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.476
FGFR1 fibroblast growth factor receptor 1 0.475
ZNF43 zinc finger protein 43 0.465
ATXN1 ataxin 1 0.460
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.452
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.450
DAXX death-domain associated protein 0.447
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.445
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.444
TAL1 T-cell acute lymphocytic leukemia 1 0.431
SORBS3 sorbin and SH3 domain containing 3 0.426
RB1 retinoblastoma 1 0.422
BCL2L1 BCL2-like 1 0.391
PSEN1 presenilin 1 0.388
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.377
ATN1 atrophin 1 0.376
SOX11 SRY (sex determining region Y)-box 11 0.371
LBX1 ladybird homeobox 1 0.364
MDFI MyoD family inhibitor 0.361
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.346
SOX1 SRY (sex determining region Y)-box 1 0.331
BMP2 bone morphogenetic protein 2 0.331
FLNA filamin A, alpha 0.318
FGF1 fibroblast growth factor 1 (acidic) 0.303
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.299
TP73 tumor protein p73 0.295
AXIN1 axin 1 0.278
JAG1 jagged 1 0.277
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 0.277
NCOA1 nuclear receptor coactivator 1 0.276
LAMB1 laminin, beta 1 0.266
SKI v-ski sarcoma viral oncogene homolog (avian) 0.260
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.258
MAPK1 mitogen-activated protein kinase 1 0.257
ZMYND11 zinc finger, MYND-type containing 11 0.251
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.250
PBX1 pre-B-cell leukemia homeobox 1 0.248
UBR1 ubiquitin protein ligase E3 component n-recognin 1 0.247
FOXD3 forkhead box D3 0.244
IGF1R insulin-like growth factor 1 receptor 0.242
TRRAP transformation/transcription domain-associated protein 0.240
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.239
XIAP X-linked inhibitor of apoptosis 0.235
CAV1 caveolin 1, caveolae protein, 22kDa 0.235
SIX3 SIX homeobox 3 0.234
EPAS1 endothelial PAS domain protein 1 0.232
BMP7 bone morphogenetic protein 7 0.228
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.227
HMGA2 high mobility group AT-hook 2 0.223
S100B S100 calcium binding protein B 0.223
GATA4 GATA binding protein 4 0.221
TBX5 T-box 5 0.219
FGF3 fibroblast growth factor 3 0.217
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.215
CRHR1 corticotropin releasing hormone receptor 1 0.214
FKBP1A FK506 binding protein 1A, 12kDa 0.214
PEX19 peroxisomal biogenesis factor 19 0.210
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.208
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.207
ATP5O ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit 0.207
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.206
SOCS3 suppressor of cytokine signaling 3 0.206
SIX6 SIX homeobox 6 0.206
AKR1C2 aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III) 0.205
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.200
SFRP1 secreted frizzled-related protein 1 0.200
NTRK3 neurotrophic tyrosine kinase, receptor, type 3 0.196
PDX1 pancreatic and duodenal homeobox 1 0.192
LDHA lactate dehydrogenase A 0.190
JUN jun proto-oncogene 0.189
PAX3 paired box 3 0.187
PAX2 paired box 2 0.186
LRP6 low density lipoprotein receptor-related protein 6 0.186
QKI quaking homolog, KH domain RNA binding (mouse) 0.185
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.183
ZNF273 zinc finger protein 273 0.178
S100A9 S100 calcium binding protein A9 0.178
PAX8 paired box 8 0.178
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.177
RAX retina and anterior neural fold homeobox 0.177
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Fgfr2 fibroblast growth factor receptor 2 0.773
Gria4 glutamate receptor, ionotrophic, AMPA 4 0.711
Cdk5r1 cyclin-dependent kinase 5, regulatory subunit 1 0.689
Dlg4 discs, large homolog 4 (Drosophila) 0.684
Syt4 synaptotagmin IV 0.680
Gabra1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 0.662
Atxn1 ataxin 1 0.632
Hcn1 hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 0.599
Epor erythropoietin receptor 0.558
Ctnnd2 catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein) 0.519
Itgam integrin, alpha M 0.495
Trim29 tripartite motif-containing 29 0.492
Crhr1 corticotropin releasing hormone receptor 1 0.464
Robo2 roundabout homolog 2 (Drosophila) 0.463
LOC246267 resection-induced TPI (rs11) 0.460
Adra2c adrenergic, alpha-2C-, receptor 0.456
Gabrg1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 0.455
Gad2 glutamate decarboxylase 2 0.454
Grik1 glutamate receptor, ionotropic, kainate 1 0.453
Crx cone-rod homeobox 0.445
Ncan neurocan 0.443
Grm7 glutamate receptor, metabotropic 7 0.441
Drd1a dopamine receptor D1A 0.441
Unc5b unc-5 homolog B (C. elegans) 0.439
Gabrb3 gamma-aminobutyric acid (GABA) A receptor, beta 3 0.433
Cga glycoprotein hormones, alpha polypeptide 0.428
Ahr aryl hydrocarbon receptor 0.411
Cap1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.405
Hoxa2 homeo box A2 0.395
Nfasc neurofascin 0.395
St18 suppression of tumorigenicity 18 0.394
Slc6a11 solute carrier family 6 (neurotransmitter transporter, GABA), member 11 0.393
Sirpa signal-regulatory protein alpha 0.391
Creb1 cAMP responsive element binding protein 1 0.388
Tmod2 tropomodulin 2 0.371
Kcnc2 potassium voltage gated channel, Shaw-related subfamily, member 2 0.371
Sdc3 syndecan 3 0.365
Ptafr platelet-activating factor receptor 0.355
P2rx2 purinergic receptor P2X, ligand-gated ion channel, 2 0.354
Gabbr1 gamma-aminobutyric acid (GABA) B receptor 1 0.354
Dlgap3 discs, large (Drosophila) homolog-associated protein 3 0.351
Id3 inhibitor of DNA binding 3 0.348
Rhobtb2 Rho-related BTB domain containing 2 0.346
Kcnj4 potassium inwardly-rectifying channel, subfamily J, member 4 0.343
Cd4 Cd4 molecule 0.336
Slit1 slit homolog 1 (Drosophila) 0.335
Prdm2 PR domain containing 2, with ZNF domain 0.332
Hrh4 histamine receptor H4 0.332
Mpp2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.332
Cntn4 contactin 4 0.331
Pip4k2b phosphatidylinositol-5-phosphate 4-kinase, type II, beta 0.328
Galr3 galanin receptor 3 0.328
Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 0.327
Faim2 Fas apoptotic inhibitory molecule 2 0.326
Ar androgen receptor 0.323
Odf4 outer dense fiber of sperm tails 4 0.321
Chrna7 cholinergic receptor, nicotinic, alpha 7 0.320
Nedd4 neural precursor cell expressed, developmentally down-regulated 4 0.319
Sstr2 somatostatin receptor 2 0.315
Mapre1 microtubule-associated protein, RP/EB family, member 1 0.310
Kcna1 potassium voltage-gated channel, shaker-related subfamily, member 1 0.310
Grin2b glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.307
Hapln1 hyaluronan and proteoglycan link protein 1 0.306
Olr1078 olfactory receptor 1078 0.302
Htr1a 5-hydroxytryptamine (serotonin) receptor 1A 0.296
C1qc complement component 1, q subcomponent, C chain 0.294
Kcnq2 potassium voltage-gated channel, KQT-like subfamily, member 2 0.291
Crhbp corticotropin releasing hormone binding protein 0.291
Nrarp Notch-regulated ankyrin repeat protein 0.290
Ppp1r9a protein phosphatase 1, regulatory (inhibitor) subunit 9A 0.288
Syt9 synaptotagmin IX 0.286
Igfals insulin-like growth factor binding protein, acid labile subunit 0.284
Cntfr ciliary neurotrophic factor receptor 0.282
Hoxc4 homeo box C4 0.282
Spock2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2 0.281
Cacng5 calcium channel, voltage-dependent, gamma subunit 5 0.279
Adora3 adenosine A3 receptor 0.279
Prlhr prolactin releasing hormone receptor 0.276
Prdx1 peroxiredoxin 1 0.275
Grm5 glutamate receptor, metabotropic 5 0.271
Gabra5 gamma-aminobutyric acid (GABA) A receptor, alpha 5 0.269
Ager advanced glycosylation end product-specific receptor 0.268
Tacr3 tachykinin receptor 3 0.264
Dlgap1 discs, large (Drosophila) homolog-associated protein 1 0.263
Pou3f2 POU class 3 homeobox 2 0.261
Grin2a glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.260
Rph3a rabphilin 3A 0.260
Agtr1a angiotensin II receptor, type 1a 0.259
Npy1r neuropeptide Y receptor Y1 0.258
A3galt2 alpha 1,3-galactosyltransferase 2 0.256
Marcksl1 MARCKS-like 1 0.255
Stc1 stanniocalcin 1 0.255
Grin3a glutamate receptor, ionotropic, N-methyl-D-aspartate 3A 0.252
Kcnt1 potassium channel, subfamily T, member 1 0.251
Npy5r neuropeptide Y receptor Y5 0.251
Nalcn sodium leak channel, non-selective 0.249
Mchr1 melanin-concentrating hormone receptor 1 0.248
Chrm1 cholinergic receptor, muscarinic 1 0.248
Insrr insulin receptor-related receptor 0.248
Lama5 laminin, alpha 5 0.247
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism