The network for 'endoderm formation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

endoderm formation

The formation of the endoderm during gastrulation.

Danio rerio
Name Description Probability Func Analog Organism
chd chordin 0.947
bmp2b bone morphogenetic protein 2b 0.946
flh floating head 0.942
emx3 empty spiracles homeobox 3 0.822
cxcr4a chemokine (C-X-C motif) receptor 4a 0.792
fli1a friend leukemia integration 1a 0.712
dusp6 dual specificity phosphatase 6 0.689
ndr1 nodal-related 1 0.682
fgf17 fibroblast growth factor 17 0.675
foxh1 forkhead box H1 0.667
cdh2 cadherin 2, neuronal 0.567
fgf3 fibroblast growth factor 3 0.567
cdh1 cadherin 1, epithelial 0.556
snai1a snail homolog 1a (Drosophila) 0.515
mmp2 matrix metalloproteinase 2 0.485
pax2a paired box gene 2a 0.472
spry4 sprouty (Drosophila) homolog 4 0.471
ntla no tail a 0.461
ndr2 nodal-related 2 0.461
wnt5b wingless-type MMTV integration site family, member 5b 0.453
fn1 fibronectin 1 0.451
lft1 lefty1 0.450
bon bonnie and clyde 0.441
vent ventral expressed homeobox 0.429
klf4 Kruppel-like factor 4 0.365
dact2 dapper homolog 2, antagonist of beta-catenin (xenopus) 0.329
gro2 groucho 2 0.307
etv2 ets variant gene 2 0.295
pcdh8 protocadherin 8 0.293
mespa mesoderm posterior a 0.284
gbx2 gastrulation brain homeo box 2 0.284
tll1 tolloid-like 1 0.281
her7 hairy and enhancer of split related-7 0.281
og9x OG9 homeobox gene 0.270
sox32 SRY-box containing gene 32 0.248
fzd5 frizzled homolog 5 0.236
bmp3 bone morphogenetic protein 3 0.229
mib mind bomb 0.225
fgf8a fibroblast growth factor 8 a 0.224
hmx4 H6 family homeobox 4 0.223
oep one-eyed pinhead 0.223
bmp4 bone morphogenetic protein 4 0.214
pea3 ETS-domain transcription factor pea3 0.212
tbx16 T-box gene 16 0.209
dlc deltaC 0.206
bmpr2b bone morphogenetic protein receptor, type II b (serine/threonine kinase) 0.199
rarab retinoic acid receptor, alpha b 0.195
wnt11 wingless-type MMTV integration site family, member 11 0.183
acvr1b activin A receptor, type IB 0.175
msxb muscle segment homeobox B 0.174
aplnra apelin receptor a 0.169
dharma dharma 0.164
ephb4b eph receptor B4b 0.158
tbx6 T-box gene 6 0.153
eya1 eyes absent homolog 1 0.152
cdx4 caudal type homeo box transcription factor 4 0.149
btg2 B-cell translocation gene 2 0.144
her1 hairy-related 1 0.143
wls wntless homolog (Drosophila) 0.137
pou5f1 POU domain, class 5, transcription factor 1 0.135
wnt10a wingless-type MMTV integration site family, member 10a 0.129
jag2 jagged 2 0.129
fzd8b frizzled homolog 8b 0.129
foxd5 forkhead box D5 0.125
hnf1ba HNF1 homeobox Ba 0.122
rasl11b RAS-like, family 11, member B 0.120
sox3 SRY-box containing gene 3 0.118
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.116
smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.114
tbx1 T-box 1 0.113
dhrs3a dehydrogenase/reductase (SDR family) member 3a 0.111
ved ventrally expressed dharma/bozozok antagonist 0.110
tbx20 T-box 20 0.107
tp63 tumor protein p63 0.107
chrna2a cholinergic receptor, nicotinic, alpha polypeptide 2a (neuronal) 0.106
mxtx2 mix-type homeobox gene 2 0.105
tgfbi transforming growth factor, beta-induced 0.103
bmp2a bone morphogenetic protein 2a 0.102
tbx2b T-box 2b 0.101
lhx1b LIM homeobox 1b 0.101
eomesa eomesodermin homolog a 0.099
runx2b runt-related transcription factor 2b 0.099
igfbp3 insulin-like growth factor binding protein 3 0.098
has2 hyaluronan synthase 2 0.098
nkx2.5 NK2 transcription factor related 5 0.094
osr2 odd-skipped related 2 (Drosophila) 0.094
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.093
lhx1a LIM homeobox 1a 0.092
six4b sine oculis homeobox homolog 4b 0.091
spry2 sprouty homolog 2 0.090
foxa3 forkhead box A3 0.090
bmpr2a bone morphogenetic protein receptor, type II a (serine/threonine kinase) 0.090
gata5 GATA-binding protein 5 0.089
gro1 groucho 1 0.087
msgn1 mesogenin 1 0.086
gata3 GATA-binding protein 3 0.083
lft2 lefty2 0.083
spns2 spinster homolog 2 (Drosophila) 0.082
foxi1 forkhead box I1 0.082
etv5b ets variant 5b 0.081
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Mad Mothers against dpp 0.979
tkv thickveins 0.972
wg wingless 0.747
Dad Daughters against dpp 0.410
tld tolloid 0.407
shn schnurri 0.385
Med Medea 0.343
cact cactus 0.342
gbb glass bottom boat 0.300
rho rhomboid 0.297
sgg shaggy 0.253
LanA Laminin A 0.229
bnl branchless 0.194
retn retained 0.189
arm armadillo 0.161
srp serpent 0.154
baz bazooka 0.150
Gug Grunge 0.150
ci cubitus interruptus 0.136
sgl sugarless 0.133
eya eyes absent 0.128
Egfr Epidermal growth factor receptor 0.121
LanB2 Laminin B2 0.120
sbb scribbler 0.107
zfh2 Zn finger homeodomain 2 0.104
mew multiple edematous wings 0.100
Doc2 Dorsocross2 0.099
mbc myoblast city 0.095
ush u-shaped 0.092
dpp decapentaplegic 0.090
aop anterior open 0.087
Fak56D Focal Adhesion Kinase 0.086
sog short gastrulation 0.082
frc fringe connection 0.080
lin lines 0.080
zip zipper 0.078
babo baboon 0.076
sax saxophone 0.075
rib ribbon 0.074
en engrailed 0.074
beta-Spec beta Spectrin 0.073
Btk29A Btk family kinase at 29A 0.073
Rac1 CG2248 gene product from transcript CG2248-RA 0.071
dia diaphanous 0.070
Abl Abl tyrosine kinase 0.069
atms antimeros 0.069
Sra-1 specifically Rac1-associated protein 1 0.067
myoglianin CG1838 gene product from transcript CG1838-RD 0.067
wb wing blister 0.065
Tl Toll 0.065
fj four-jointed 0.063
csw corkscrew 0.062
aux auxillin 0.061
zfh1 Zn finger homeodomain 1 0.061
LanB1 CG7123 gene product from transcript CG7123-RA 0.060
scb scab 0.058
htl heartless 0.058
osp outspread 0.057
sr stripe 0.054
sd scalloped 0.053
osa CG7467 gene product from transcript CG7467-RD 0.052
CG3194 CG3194 gene product from transcript CG3194-RB 0.052
ftz-f1 ftz transcription factor 1 0.049
if inflated 0.049
bowl brother of odd with entrails limited 0.049
dos daughter of sevenless 0.049
ovo CG6824 gene product from transcript CG6824-RE 0.049
CG5591 CG5591 gene product from transcript CG5591-RA 0.049
emc extra macrochaetae 0.048
G-oalpha47A G protein oalpha 47A 0.047
Acsl Acyl-CoA synthetase long-chain 0.046
jing CG9397 gene product from transcript CG9397-RI 0.044
Src42A Src oncogene at 42A 0.042
Gef26 CG9491 gene product from transcript CG9491-RB 0.041
c11.1 CG12132 gene product from transcript CG12132-RA 0.041
Imp IGF-II mRNA-binding protein 0.041
smo smoothened 0.039
numb CG3779 gene product from transcript CG3779-RB 0.039
fas faint sausage 0.039
Mes2 CG11100 gene product from transcript CG11100-RB 0.039
Bre1 CG10542 gene product from transcript CG10542-RA 0.038
rasp CG11495 gene product from transcript CG11495-RA 0.037
mbl muscleblind 0.037
daw dawdle 0.037
cno canoe 0.036
fliI flightless I 0.036
kn knot 0.035
hipk homeodomain interacting protein kinase 0.035
ttv tout-velu 0.034
Myo31DF Myosin 31DF 0.034
argos CG4531 gene product from transcript CG4531-RA 0.033
Irk2 Inwardly rectifying potassium channel 2 0.033
Mef2 Myocyte enhancer factor 2 0.033
orb oo18 RNA-binding protein 0.033
wit wishful thinking 0.033
byn brachyenteron 0.032
wdb widerborst 0.032
Rab11 Rab-protein 11 0.031
ex expanded 0.031
LamC Lamin C 0.031
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Homo sapiens
Name Description Probability Func Analog Organism
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 1.000
COL1A1 collagen, type I, alpha 1 1.000
COL1A2 collagen, type I, alpha 2 0.997
COL4A1 collagen, type IV, alpha 1 0.996
SMAD2 SMAD family member 2 0.995
FHL2 four and a half LIM domains 2 0.995
BMP2 bone morphogenetic protein 2 0.982
COL3A1 collagen, type III, alpha 1 0.971
PAX3 paired box 3 0.971
SP1 Sp1 transcription factor 0.970
COL7A1 collagen, type VII, alpha 1 0.963
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.955
SMAD7 SMAD family member 7 0.952
COL4A2 collagen, type IV, alpha 2 0.947
THBS1 thrombospondin 1 0.939
FGF1 fibroblast growth factor 1 (acidic) 0.932
POU3F2 POU class 3 homeobox 2 0.930
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.926
SMAD3 SMAD family member 3 0.918
COL6A1 collagen, type VI, alpha 1 0.913
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.841
BMPR1A bone morphogenetic protein receptor, type IA 0.839
JAG1 jagged 1 0.831
PDIA3 protein disulfide isomerase family A, member 3 0.827
TNRC6A trinucleotide repeat containing 6A 0.807
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.804
SYK spleen tyrosine kinase 0.759
DDR2 discoidin domain receptor tyrosine kinase 2 0.747
COL5A2 collagen, type V, alpha 2 0.724
SOX10 SRY (sex determining region Y)-box 10 0.699
HSPG2 heparan sulfate proteoglycan 2 0.698
COL5A1 collagen, type V, alpha 1 0.693
DVL1 dishevelled, dsh homolog 1 (Drosophila) 0.629
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.621
BMP1 bone morphogenetic protein 1 0.614
PXN paxillin 0.575
SMAD4 SMAD family member 4 0.574
FOXD3 forkhead box D3 0.571
LZTS2 leucine zipper, putative tumor suppressor 2 0.557
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.556
SMAD5 SMAD family member 5 0.554
NOTCH3 notch 3 0.514
POU5F1 POU class 5 homeobox 1 0.502
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.490
ITGB4 integrin, beta 4 0.489
COL4A6 collagen, type IV, alpha 6 0.487
LTBP2 latent transforming growth factor beta binding protein 2 0.474
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.467
CSNK1E casein kinase 1, epsilon 0.440
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) 0.428
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.427
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.414
COL4A4 collagen, type IV, alpha 4 0.412
PXDN peroxidasin homolog (Drosophila) 0.412
SMAD1 SMAD family member 1 0.403
COL11A1 collagen, type XI, alpha 1 0.387
MMP1 matrix metallopeptidase 1 (interstitial collagenase) 0.382
SOX11 SRY (sex determining region Y)-box 11 0.377
COL6A2 collagen, type VI, alpha 2 0.374
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.372
COL16A1 collagen, type XVI, alpha 1 0.370
SOX2 SRY (sex determining region Y)-box 2 0.364
LAMC2 laminin, gamma 2 0.362
BMPR1B bone morphogenetic protein receptor, type IB 0.360
FN1 fibronectin 1 0.356
COL4A5 collagen, type IV, alpha 5 0.338
LCK lymphocyte-specific protein tyrosine kinase 0.336
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.332
GDF5 growth differentiation factor 5 0.306
RTF1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.303
COL18A1 collagen, type XVIII, alpha 1 0.301
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.295
ZNF512B zinc finger protein 512B 0.292
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.289
CTGF connective tissue growth factor 0.285
AR androgen receptor 0.275
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.271
PLAU plasminogen activator, urokinase 0.268
BMP7 bone morphogenetic protein 7 0.264
TNC tenascin C 0.261
ELN elastin 0.234
APC adenomatous polyposis coli 0.233
COL2A1 collagen, type II, alpha 1 0.226
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.213
LAMA5 laminin, alpha 5 0.207
FKBP1A FK506 binding protein 1A, 12kDa 0.207
TLN1 talin 1 0.206
FBN1 fibrillin 1 0.200
WISP1 WNT1 inducible signaling pathway protein 1 0.199
LAMB1 laminin, beta 1 0.194
LOX lysyl oxidase 0.187
ENG endoglin 0.187
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.185
COL6A3 collagen, type VI, alpha 3 0.176
HMGA1 high mobility group AT-hook 1 0.174
TGFB2 transforming growth factor, beta 2 0.173
THBS2 thrombospondin 2 0.173
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 0.168
LAMB3 laminin, beta 3 0.165
FAP fibroblast activation protein, alpha 0.159
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Mus musculus
Name Description Probability Func Analog Organism
Nodal nodal 1.000
Otx2 orthodenticle homolog 2 (Drosophila) 0.999
Pitx2 paired-like homeodomain transcription factor 2 0.999
Shh sonic hedgehog 0.997
Fgf8 fibroblast growth factor 8 0.997
Fgfr2 fibroblast growth factor receptor 2 0.996
Hand1 heart and neural crest derivatives expressed transcript 1 0.995
Gli3 GLI-Kruppel family member GLI3 0.992
Pax3 paired box gene 3 0.982
Chd7 chromodomain helicase DNA binding protein 7 0.974
Gata4 GATA binding protein 4 0.972
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.970
Tbx3 T-box 3 0.967
Smad4 MAD homolog 4 (Drosophila) 0.964
Ctnnb1 catenin (cadherin associated protein), beta 1 0.938
Lhx1 LIM homeobox protein 1 0.927
Alx4 aristaless-like homeobox 4 0.893
Hand2 heart and neural crest derivatives expressed transcript 2 0.889
Bmp4 bone morphogenetic protein 4 0.885
Msx1 homeobox, msh-like 1 0.883
Isl1 ISL1 transcription factor, LIM/homeodomain 0.879
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.807
Prrx1 paired related homeobox 1 0.781
Tcfap2a transcription factor AP-2, alpha 0.780
Foxc1 forkhead box C1 0.770
Fgfr1 fibroblast growth factor receptor 1 0.768
Apc adenomatosis polyposis coli 0.764
Sox2 SRY-box containing gene 2 0.749
Vangl2 vang-like 2 (van gogh, Drosophila) 0.737
Pax2 paired box gene 2 0.734
Nog noggin 0.717
Dlx5 distal-less homeobox 5 0.701
Pitx1 paired-like homeodomain transcription factor 1 0.692
Hes1 hairy and enhancer of split 1 (Drosophila) 0.687
Foxc2 forkhead box C2 0.674
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.667
Smad1 MAD homolog 1 (Drosophila) 0.665
Foxh1 forkhead box H1 0.661
Wnt3a wingless-related MMTV integration site 3A 0.661
Chrd chordin 0.654
Runx2 runt related transcription factor 2 0.650
Snai1 snail homolog 1 (Drosophila) 0.645
Lef1 lymphoid enhancer binding factor 1 0.641
Col4a1 collagen, type IV, alpha 1 0.635
Lhx3 LIM homeobox protein 3 0.614
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.607
Eya1 eyes absent 1 homolog (Drosophila) 0.586
Tbx1 T-box 1 0.584
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.584
Foxn1 forkhead box N1 0.542
Sox9 SRY-box containing gene 9 0.539
Col5a1 collagen, type V, alpha 1 0.517
Zic3 zinc finger protein of the cerebellum 3 0.480
Lrp6 low density lipoprotein receptor-related protein 6 0.463
Smo smoothened homolog (Drosophila) 0.460
Rarg retinoic acid receptor, gamma 0.456
Msx2 homeobox, msh-like 2 0.441
Hoxd13 homeobox D13 0.433
Tbx2 T-box 2 0.423
Gbx2 gastrulation brain homeobox 2 0.414
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.393
Hoxa13 homeobox A13 0.391
Smad6 MAD homolog 6 (Drosophila) 0.388
Pax6 paired box gene 6 0.387
Hoxa1 homeobox A1 0.386
Bptf bromodomain PHD finger transcription factor 0.383
Foxg1 forkhead box G1 0.378
Prrx2 paired related homeobox 2 0.374
Axin1 axin 1 0.374
En1 engrailed 1 0.351
Meox2 mesenchyme homeobox 2 0.341
Col2a1 collagen, type II, alpha 1 0.336
Col3a1 collagen, type III, alpha 1 0.323
Wnt6 wingless-related MMTV integration site 6 0.317
Col1a1 collagen, type I, alpha 1 0.316
Pou3f3 POU domain, class 3, transcription factor 3 0.308
Pax1 paired box gene 1 0.303
Fgfr3 fibroblast growth factor receptor 3 0.299
Wt1 Wilms tumor 1 homolog 0.294
Smad3 MAD homolog 3 (Drosophila) 0.288
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.274
Gdnf glial cell line derived neurotrophic factor 0.270
Tgfb2 transforming growth factor, beta 2 0.266
Pou5f1 POU domain, class 5, transcription factor 1 0.256
Dll4 delta-like 4 (Drosophila) 0.256
Hoxa11 homeobox A11 0.249
Mmp2 matrix metallopeptidase 2 0.243
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.238
Fbn1 fibrillin 1 0.237
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.230
Acvr1 activin A receptor, type 1 0.230
Col6a2 collagen, type VI, alpha 2 0.222
Foxf1a forkhead box F1a 0.216
Tbx15 T-box 15 0.205
Emx2 empty spiracles homolog 2 (Drosophila) 0.203
Bmp1 bone morphogenetic protein 1 0.201
Col6a3 collagen, type VI, alpha 3 0.200
Col1a2 collagen, type I, alpha 2 0.192
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.190
Gata6 GATA binding protein 6 0.185
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism