IMP

Process View

Homo sapiens

4 genes annotated in human

heart induction

The close range interaction between mesoderm and endoderm or ectoderm that causes cells to change their fates and specify the development of the heart.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "heart induction"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "heart induction" (in gray)

Name	Description	Probability	Func Analog Organism
DVL1	dishevelled, dsh homolog 1 (Drosophila)	0.999	Fly
DVL3	dishevelled, dsh homolog 3 (Drosophila)	0.982	Fly
CSNK1E	casein kinase 1, epsilon	0.976
SP1	Sp1 transcription factor	0.970
BMPR1A	bone morphogenetic protein receptor, type IA	0.943
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.939
FOXD3	forkhead box D3	0.929
AXIN1	axin 1	0.908
LRP6	low density lipoprotein receptor-related protein 6	0.905
LRRK2	leucine-rich repeat kinase 2	0.841
APC	adenomatous polyposis coli	0.819
NCOA2	nuclear receptor coactivator 2	0.672
SOX10	SRY (sex determining region Y)-box 10	0.627
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.501
GSK3B	glycogen synthase kinase 3 beta	0.484
HCFC1	host cell factor C1 (VP16-accessory protein)	0.484
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.470
PAX3	paired box 3	0.461
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.446	Fly
SOX2	SRY (sex determining region Y)-box 2	0.434
CTNNBIP1	catenin, beta interacting protein 1	0.416
FSTL1	follistatin-like 1	0.380
ZFYVE9	zinc finger, FYVE domain containing 9	0.359
CEP164	centrosomal protein 164kDa	0.335
WT1	Wilms tumor 1	0.325
GLIS2	GLIS family zinc finger 2	0.293
ZNF512B	zinc finger protein 512B	0.282
PRPF3	PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae)	0.270
FZD1	frizzled homolog 1 (Drosophila)	0.228
TCF4	transcription factor 4	0.144
SMAD7	SMAD family member 7	0.111
EP300	E1A binding protein p300	0.100
MYST2	MYST histone acetyltransferase 2	0.092
SMAD3	SMAD family member 3	0.085
RHOXF2	Rhox homeobox family, member 2	0.084
PSEN1	presenilin 1	0.065
PIK3CB	phosphoinositide-3-kinase, catalytic, beta polypeptide	0.064
MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	0.061
HMGA1	high mobility group AT-hook 1	0.059
CSNK1D	casein kinase 1, delta	0.058
CDH2	cadherin 2, type 1, N-cadherin (neuronal)	0.054
FBXW11	F-box and WD repeat domain containing 11	0.053
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.048
PITX1	paired-like homeodomain 1	0.046
HTT	huntingtin	0.046
BTRC	beta-transducin repeat containing	0.046
GABPA	GA binding protein transcription factor, alpha subunit 60kDa	0.044
MCC	mutated in colorectal cancers	0.044
SNIP1	Smad nuclear interacting protein 1	0.041
BAHD1	bromo adjacent homology domain containing 1	0.041
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.039
FERMT2	fermitin family member 2	0.036
FZD8	frizzled homolog 8 (Drosophila)	0.035
CTNND1	catenin (cadherin-associated protein), delta 1	0.035
DIDO1	death inducer-obliterator 1	0.035
SOX1	SRY (sex determining region Y)-box 1	0.034
SOX11	SRY (sex determining region Y)-box 11	0.034
SOX21	SRY (sex determining region Y)-box 21	0.033
TAOK1	TAO kinase 1	0.032
NOG	noggin	0.031
OTP	orthopedia homeobox	0.028
NKD2	naked cuticle homolog 2 (Drosophila)	0.028
ADARB1	adenosine deaminase, RNA-specific, B1	0.028
DPPA4	developmental pluripotency associated 4	0.028
FAM110A	family with sequence similarity 110, member A	0.028
CADM4	cell adhesion molecule 4	0.027
CREBBP	CREB binding protein	0.026
JUP	junction plakoglobin	0.026	Fly
TP73	tumor protein p73	0.025
FOXO1	forkhead box O1	0.024
MAP2K6	mitogen-activated protein kinase kinase 6	0.024
EMD	emerin	0.024
YAP1	Yes-associated protein 1	0.023
NR0B1	nuclear receptor subfamily 0, group B, member 1	0.023
ETS2	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)	0.023
AR	androgen receptor	0.023
C9orf100	chromosome 9 open reading frame 100	0.023
POU3F2	POU class 3 homeobox 2	0.023	Human
HIC1	hypermethylated in cancer 1	0.022
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.022
DVL2	dishevelled, dsh homolog 2 (Drosophila)	0.022	Fly
MDFI	MyoD family inhibitor	0.022
NOVA2	neuro-oncological ventral antigen 2	0.021
ASCL1	achaete-scute complex homolog 1 (Drosophila)	0.021
ELF1	E74-like factor 1 (ets domain transcription factor)	0.021
FOXE1	forkhead box E1 (thyroid transcription factor 2)	0.021
POU3F3	POU class 3 homeobox 3	0.021	Human
ZBTB8A	zinc finger and BTB domain containing 8A	0.021
C16orf48	chromosome 16 open reading frame 48	0.020
PARD3	par-3 partitioning defective 3 homolog (C. elegans)	0.020
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.020
ZMYND8	zinc finger, MYND-type containing 8	0.020
SRRM2	serine/arginine repetitive matrix 2	0.019
DDI1	DNA-damage inducible 1 homolog 1 (S. cerevisiae)	0.019
PDX1	pancreatic and duodenal homeobox 1	0.019
OCLN	occludin	0.018
POU3F1	POU class 3 homeobox 1	0.018	Human
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.018
FAM110C	family with sequence similarity 110, member C	0.018
PTK7	PTK7 protein tyrosine kinase 7	0.018
POU4F1	POU class 4 homeobox 1	0.018	Human
BMP2	bone morphogenetic protein 2	0.017
FAM83D	family with sequence similarity 83, member D	0.017
LBX1	ladybird homeobox 1	0.017
NEUROG3	neurogenin 3	0.017
RAC3	ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)	0.017
TLX2	T-cell leukemia homeobox 2	0.016
UTF1	undifferentiated embryonic cell transcription factor 1	0.016
TNFAIP8L1	tumor necrosis factor, alpha-induced protein 8-like 1	0.016
AP2B1	adaptor-related protein complex 2, beta 1 subunit	0.016
LHX1	LIM homeobox 1	0.015
CLDN7	claudin 7	0.015
HES1	hairy and enhancer of split 1, (Drosophila)	0.015
HOXC8	homeobox C8	0.015
FGF8	fibroblast growth factor 8 (androgen-induced)	0.015
ARHGEF1	Rho guanine nucleotide exchange factor (GEF) 1	0.015
PKP4	plakophilin 4	0.015
SMAD2	SMAD family member 2	0.015
STRN3	striatin, calmodulin binding protein 3	0.015
NKX2-8	NK2 homeobox 8	0.015
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.015
TIFA	TRAF-interacting protein with forkhead-associated domain	0.014
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.014
FZD2	frizzled homolog 2 (Drosophila)	0.014
BMPR1B	bone morphogenetic protein receptor, type IB	0.014
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.014
BMP4	bone morphogenetic protein 4	0.014
MUC1	mucin 1, cell surface associated	0.014
DSG2	desmoglein 2	0.014
EZR	ezrin	0.014
TGFB2	transforming growth factor, beta 2	0.014
DAAM1	dishevelled associated activator of morphogenesis 1	0.013
DPPA2	developmental pluripotency associated 2	0.013
NKX2-1	NK2 homeobox 1	0.013
DIP2A	DIP2 disco-interacting protein 2 homolog A (Drosophila)	0.013
PYY	peptide YY	0.013
ATN1	atrophin 1	0.013
OLIG2	oligodendrocyte lineage transcription factor 2	0.013
RAX	retina and anterior neural fold homeobox	0.013
JRK	jerky homolog (mouse)	0.013
WNT10A	wingless-type MMTV integration site family, member 10A	0.013
FST	follistatin	0.013
ST8SIA2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.012
ATF7IP	activating transcription factor 7 interacting protein	0.012
WNT3	wingless-type MMTV integration site family, member 3	0.012
DRD4	dopamine receptor D4	0.012
HOXB13	homeobox B13	0.012
PSMF1	proteasome (prosome, macropain) inhibitor subunit 1 (PI31)	0.012
PITX2	paired-like homeodomain 2	0.012
NPAS1	neuronal PAS domain protein 1	0.012
ALX3	ALX homeobox 3	0.012
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.012
SLC30A3	solute carrier family 30 (zinc transporter), member 3	0.012
DLX4	distal-less homeobox 4	0.012
PAX6	paired box 6	0.012
C10orf46	chromosome 10 open reading frame 46	0.012
NCOA1	nuclear receptor coactivator 1	0.011
LHX5	LIM homeobox 5	0.011
CDH3	cadherin 3, type 1, P-cadherin (placental)	0.011
LEF1	lymphoid enhancer-binding factor 1	0.011
WWTR1	WW domain containing transcription regulator 1	0.011
ARHGEF19	Rho guanine nucleotide exchange factor (GEF) 19	0.011
HRK	harakiri, BCL2 interacting protein (contains only BH3 domain)	0.011
CALCA	calcitonin-related polypeptide alpha	0.011
FOXL1	forkhead box L1	0.011
GATA5	GATA binding protein 5	0.011
NFYA	nuclear transcription factor Y, alpha	0.011
FOXA2	forkhead box A2	0.011
TFAP2B	transcription factor AP-2 beta (activating enhancer binding protein 2 beta)	0.011
MTA2	metastasis associated 1 family, member 2	0.011
NEUROG1	neurogenin 1	0.011
EGR1	early growth response 1	0.011
SIX6	SIX homeobox 6	0.011
CHERP	calcium homeostasis endoplasmic reticulum protein	0.011
F3	coagulation factor III (thromboplastin, tissue factor)	0.011
PAX7	paired box 7	0.011
HTR2C	5-hydroxytryptamine (serotonin) receptor 2C	0.010
SNF8	SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)	0.010
GSC2	goosecoid homeobox 2	0.010
MAPT	microtubule-associated protein tau	0.010
ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	0.010
GRIP1	glutamate receptor interacting protein 1	0.010
PNOC	prepronociceptin	0.010
ZNF408	zinc finger protein 408	0.010
CCDC92	coiled-coil domain containing 92	0.010
TBX5	T-box 5	0.010
HES2	hairy and enhancer of split 2 (Drosophila)	0.010
SETD1A	SET domain containing 1A	0.010
CHAC1	ChaC, cation transport regulator homolog 1 (E. coli)	0.010
SORBS3	sorbin and SH3 domain containing 3	0.010
FGF4	fibroblast growth factor 4	0.010
KLHL12	kelch-like 12 (Drosophila)	0.010
KLF5	Kruppel-like factor 5 (intestinal)	0.010
SIX2	SIX homeobox 2	0.010
PRDM13	PR domain containing 13	0.010