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Homo sapiens

21 genes annotated in human

positive regulation of fibroblast proliferation

Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of fibroblast proliferation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of fibroblast proliferation" (in gray)

Name	Description	Probability	Func Analog Organism
CDK2	cyclin-dependent kinase 2	1.000
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.997
VEGFA	vascular endothelial growth factor A	0.994	Human
E2F1	E2F transcription factor 1	0.968
RING1	ring finger protein 1	0.959
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.950	Human
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.948	Human Rat
RB1	retinoblastoma 1	0.941
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.881
CCNE1	cyclin E1	0.815
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.737
CCND1	cyclin D1	0.717
NRP1	neuropilin 1	0.686
RBL2	retinoblastoma-like 2 (p130)	0.681
CDK6	cyclin-dependent kinase 6	0.665
TFDP1	transcription factor Dp-1	0.625
RNF2	ring finger protein 2	0.591
SKP2	S-phase kinase-associated protein 2 (p45)	0.572
CBX8	chromobox homolog 8	0.554
CBX7	chromobox homolog 7	0.535
TFDP2	transcription factor Dp-2 (E2F dimerization partner 2)	0.528
AXL	AXL receptor tyrosine kinase	0.519
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.444	Human
APLF	aprataxin and PNKP like factor	0.443
RBL1	retinoblastoma-like 1 (p107)	0.394
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.353
PLAU	plasminogen activator, urokinase	0.327
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.324
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.296
CCNA2	cyclin A2	0.293
RBBP8	retinoblastoma binding protein 8	0.287
RYBP	RING1 and YY1 binding protein	0.247
PGF	placental growth factor	0.229	Human
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.211
PDGFC	platelet derived growth factor C	0.203
CCND2	cyclin D2	0.193
PDGFA	platelet-derived growth factor alpha polypeptide	0.189
CBX6	chromobox homolog 6	0.183
USP11	ubiquitin specific peptidase 11	0.155
CCND3	cyclin D3	0.127
CUX1	cut-like homeobox 1	0.117
E2F4	E2F transcription factor 4, p107/p130-binding	0.116	Human
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.112
PLCG1	phospholipase C, gamma 1	0.105
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.104
PLAUR	plasminogen activator, urokinase receptor	0.102
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.100
S100B	S100 calcium binding protein B	0.100
COL11A2	collagen, type XI, alpha 2	0.096
HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	0.085
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.074
PLAT	plasminogen activator, tissue	0.074
CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	0.072	Human
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.070
BCOR	BCL6 corepressor	0.062
STMN2	stathmin-like 2	0.060
EGFR	epidermal growth factor receptor	0.060
RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	0.056
CKS1B	CDC28 protein kinase regulatory subunit 1B	0.056
EFEMP2	EGF containing fibulin-like extracellular matrix protein 2	0.055
CXCR4	chemokine (C-X-C motif) receptor 4	0.052
FOSL1	FOS-like antigen 1	0.052
ITGB1BP3	integrin beta 1 binding protein 3	0.051
LGALS8	lectin, galactoside-binding, soluble, 8	0.046
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.044
SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	0.044	Rat
IGF2R	insulin-like growth factor 2 receptor	0.043
CDC27	cell division cycle 27 homolog (S. cerevisiae)	0.041
CAV1	caveolin 1, caveolae protein, 22kDa	0.041
HLA-DPA1	major histocompatibility complex, class II, DP alpha 1	0.041
TNFRSF12A	tumor necrosis factor receptor superfamily, member 12A	0.039
VEGFC	vascular endothelial growth factor C	0.038	Human
CTBP2	C-terminal binding protein 2	0.038
JUNB	jun B proto-oncogene	0.037
IGFBP5	insulin-like growth factor binding protein 5	0.036
ALK	anaplastic lymphoma receptor tyrosine kinase	0.035
AHR	aryl hydrocarbon receptor	0.035
LIN9	lin-9 homolog (C. elegans)	0.034
NTRK1	neurotrophic tyrosine kinase, receptor, type 1	0.033
RAD18	RAD18 homolog (S. cerevisiae)	0.033
BCL3	B-cell CLL/lymphoma 3	0.031
KITLG	KIT ligand	0.030
DCN	decorin	0.027
KLF6	Kruppel-like factor 6	0.027
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.027
FLT4	fms-related tyrosine kinase 4	0.027	Human
CDK1	cyclin-dependent kinase 1	0.026
MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	0.025
TIMP3	TIMP metallopeptidase inhibitor 3	0.025
CKS2	CDC28 protein kinase regulatory subunit 2	0.024
BHLHE40	basic helix-loop-helix family, member e40	0.024
FGFR1	fibroblast growth factor receptor 1	0.024
INSR	insulin receptor	0.022
NFIL3	nuclear factor, interleukin 3 regulated	0.022
E2F3	E2F transcription factor 3	0.021	Human
THBS1	thrombospondin 1	0.021
PURA	purine-rich element binding protein A	0.021
BRCA1	breast cancer 1, early onset	0.021
CCNB2	cyclin B2	0.020
FGF18	fibroblast growth factor 18	0.020
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.020
SALL2	sal-like 2 (Drosophila)	0.020
PPP1R15A	protein phosphatase 1, regulatory (inhibitor) subunit 15A	0.019
MAPK14	mitogen-activated protein kinase 14	0.019
MAX	MYC associated factor X	0.019
PCGF3	polycomb group ring finger 3	0.019	Human
HLA-DRA	major histocompatibility complex, class II, DR alpha	0.019
ORC1	origin recognition complex, subunit 1	0.018
KCTD17	potassium channel tetramerisation domain containing 17	0.018
NGF	nerve growth factor (beta polypeptide)	0.018
GAB2	GRB2-associated binding protein 2	0.018
COL6A1	collagen, type VI, alpha 1	0.018
CTBP1	C-terminal binding protein 1	0.018
CHEK1	CHK1 checkpoint homolog (S. pombe)	0.017
DYRK1A	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	0.017
E2F2	E2F transcription factor 2	0.017	Human
ADAMTSL4	ADAMTS-like 4	0.017
SOS1	son of sevenless homolog 1 (Drosophila)	0.017
SFRP1	secreted frizzled-related protein 1	0.016
CDT1	chromatin licensing and DNA replication factor 1	0.016
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.016
CDC6	cell division cycle 6 homolog (S. cerevisiae)	0.016
CCNE2	cyclin E2	0.015
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.014
NHEJ1	nonhomologous end-joining factor 1	0.014
ENG	endoglin	0.014
CBX4	chromobox homolog 4	0.014
BCAR1	breast cancer anti-estrogen resistance 1	0.014
PLOD2	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2	0.014
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.014
CTSB	cathepsin B	0.014
TTR	transthyretin	0.014
IER3	immediate early response 3	0.013
FNDC3A	fibronectin type III domain containing 3A	0.013
ACVR1	activin A receptor, type I	0.013
A2M	alpha-2-macroglobulin	0.013
SHC2	SHC (Src homology 2 domain containing) transforming protein 2	0.013
UQCRB	ubiquinol-cytochrome c reductase binding protein	0.013
INHBA	inhibin, beta A	0.013
GRB7	growth factor receptor-bound protein 7	0.012
FAF1	Fas (TNFRSF6) associated factor 1	0.012
CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	0.012
DDIT3	DNA-damage-inducible transcript 3	0.012
PTPRB	protein tyrosine phosphatase, receptor type, B	0.012
MYCN	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.012	Human
MGST3	microsomal glutathione S-transferase 3	0.012
TGFB3	transforming growth factor, beta 3	0.011
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.011
LTBP2	latent transforming growth factor beta binding protein 2	0.011
TAF1	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	0.011
SPSB1	splA/ryanodine receptor domain and SOCS box containing 1	0.011
TGFB2	transforming growth factor, beta 2	0.011
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.011
SHB	Src homology 2 domain containing adaptor protein B	0.011
STC1	stanniocalcin 1	0.011
CCNA1	cyclin A1	0.011
YAF2	YY1 associated factor 2	0.011
IGFBP3	insulin-like growth factor binding protein 3	0.010
CYR61	cysteine-rich, angiogenic inducer, 61	0.010
IL6ST	interleukin 6 signal transducer (gp130, oncostatin M receptor)	0.010
JAK2	Janus kinase 2	0.010