IMP

Process View

Homo sapiens

12 genes annotated in human

spindle assembly involved in mitosis

The aggregation, arrangement and bonding together of a set of components to form the spindle that contributes to the process of mitosis.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "spindle assembly involved in mitosis"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "spindle assembly involved in mitosis" (in gray)

Name	Description	Probability	Func Analog Organism
TCP1	t-complex 1	0.996	Fly
CCT8	chaperonin containing TCP1, subunit 8 (theta)	0.989
AURKA	aurora kinase A	0.982	Yeast Worm
LIN9	lin-9 homolog (C. elegans)	0.976	Fly
CCT2	chaperonin containing TCP1, subunit 2 (beta)	0.976	Fly
AURKB	aurora kinase B	0.951
CCT4	chaperonin containing TCP1, subunit 4 (delta)	0.924	Fly
CCNB1	cyclin B1	0.913
CDC20	cell division cycle 20 homolog (S. cerevisiae)	0.908
CCT5	chaperonin containing TCP1, subunit 5 (epsilon)	0.796	Fly
PTTG1	pituitary tumor-transforming 1	0.788
PRC1	protein regulator of cytokinesis 1	0.742
TPX2	TPX2, microtubule-associated, homolog (Xenopus laevis)	0.694
CENPE	centromere protein E, 312kDa	0.673
CCT3	chaperonin containing TCP1, subunit 3 (gamma)	0.651	Fly
DLGAP5	discs, large (Drosophila) homolog-associated protein 5	0.611
NCAPG	non-SMC condensin I complex, subunit G	0.594
CCT6A	chaperonin containing TCP1, subunit 6A (zeta 1)	0.587
CDK1	cyclin-dependent kinase 1	0.568
KIF20A	kinesin family member 20A	0.562	Human Worm
TTK	TTK protein kinase	0.511
HMMR	hyaluronan-mediated motility receptor (RHAMM)	0.510
KIF18A	kinesin family member 18A	0.470	Fly
BIRC5	baculoviral IAP repeat containing 5	0.462
CENPF	centromere protein F, 350/400kDa (mitosin)	0.438
FLNA	filamin A, alpha	0.431
VIPAR	VPS33B interacting protein, apical-basolateral polarity regulator	0.423
CCNB2	cyclin B2	0.393
NEK2	NIMA (never in mitosis gene a)-related kinase 2	0.331	Mouse
NDC80	NDC80 homolog, kinetochore complex component (S. cerevisiae)	0.330
DEPDC1	DEP domain containing 1	0.327
KIF15	kinesin family member 15	0.321
KIF23	kinesin family member 23	0.310
CDCA8	cell division cycle associated 8	0.302	Fly
SGCD	sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)	0.302
KIF11	kinesin family member 11	0.291
ASPM	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	0.290
RACGAP1	Rac GTPase activating protein 1	0.263
ARHGAP1	Rho GTPase activating protein 1	0.260
INCENP	inner centromere protein antigens 135/155kDa	0.235
TOP2A	topoisomerase (DNA) II alpha 170kDa	0.231
NCAPH	non-SMC condensin I complex, subunit H	0.214
SMC4	structural maintenance of chromosomes 4	0.193
GAS2L3	growth arrest-specific 2 like 3	0.181
TNFAIP1	tumor necrosis factor, alpha-induced protein 1 (endothelial)	0.158
GPSM2	G-protein signaling modulator 2	0.152
PSMA6	proteasome (prosome, macropain) subunit, alpha type, 6	0.144
LIN54	lin-54 homolog (C. elegans)	0.142
NCAPD2	non-SMC condensin I complex, subunit D2	0.141
KIF4A	kinesin family member 4A	0.136	Fly
PSMA3	proteasome (prosome, macropain) subunit, alpha type, 3	0.133
KIF14	kinesin family member 14	0.124
CEP55	centrosomal protein 55kDa	0.124
CKAP5	cytoskeleton associated protein 5	0.122
PSMA4	proteasome (prosome, macropain) subunit, alpha type, 4	0.116
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.107
PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	0.104
MKI67	antigen identified by monoclonal antibody Ki-67	0.102
BUB1B	budding uninhibited by benzimidazoles 1 homolog beta (yeast)	0.100	Fly
PPP2R2C	protein phosphatase 2, regulatory subunit B, gamma	0.095
HJURP	Holliday junction recognition protein	0.090
SMC2	structural maintenance of chromosomes 2	0.081
CDC27	cell division cycle 27 homolog (S. cerevisiae)	0.081
CCNF	cyclin F	0.075
RAN	RAN, member RAS oncogene family	0.072
CBX5	chromobox homolog 5	0.069
BUB1	budding uninhibited by benzimidazoles 1 homolog (yeast)	0.065
PSMD14	proteasome (prosome, macropain) 26S subunit, non-ATPase, 14	0.064
SGOL2	shugoshin-like 2 (S. pombe)	0.064
ECT2	epithelial cell transforming sequence 2 oncogene	0.062
PSMB7	proteasome (prosome, macropain) subunit, beta type, 7	0.059
PPP4C	protein phosphatase 4, catalytic subunit	0.059
CDKN3	cyclin-dependent kinase inhibitor 3	0.058
PLK1	polo-like kinase 1	0.057
CCT7	chaperonin containing TCP1, subunit 7 (eta)	0.055	Fly
FOXM1	forkhead box M1	0.052
KPNA2	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	0.052
NPM1	nucleophosmin (nucleolar phosphoprotein B23, numatrin)	0.051
CCNA2	cyclin A2	0.050
KIF2C	kinesin family member 2C	0.043	Fly
TUBA1C	tubulin, alpha 1c	0.043
RAD21	RAD21 homolog (S. pombe)	0.043
HSPD1	heat shock 60kDa protein 1 (chaperonin)	0.043
PSMD6	proteasome (prosome, macropain) 26S subunit, non-ATPase, 6	0.041
E2F4	E2F transcription factor 4, p107/p130-binding	0.041
NUSAP1	nucleolar and spindle associated protein 1	0.041
DDX1	DEAD (Asp-Glu-Ala-Asp) box polypeptide 1	0.039
UBE2C	ubiquitin-conjugating enzyme E2C	0.038
PSMB5	proteasome (prosome, macropain) subunit, beta type, 5	0.038
C13orf34	chromosome 13 open reading frame 34	0.037
DDX47	DEAD (Asp-Glu-Ala-Asp) box polypeptide 47	0.037
MAD2L1	MAD2 mitotic arrest deficient-like 1 (yeast)	0.034
PSRC1	proline/serine-rich coiled-coil 1	0.032
ARHGDIA	Rho GDP dissociation inhibitor (GDI) alpha	0.032
GTSE1	G-2 and S-phase expressed 1	0.031
RHOA	ras homolog gene family, member A	0.029
FLNB	filamin B, beta	0.029	Human
NLK	nemo-like kinase	0.027
PSMC5	proteasome (prosome, macropain) 26S subunit, ATPase, 5	0.027
TACC3	transforming, acidic coiled-coil containing protein 3	0.027
SKA1	spindle and kinetochore associated complex subunit 1	0.026
IPO5	importin 5	0.026
NUF2	NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.026
PSMA1	proteasome (prosome, macropain) subunit, alpha type, 1	0.025
CKS2	CDC28 protein kinase regulatory subunit 2	0.025
LBR	lamin B receptor	0.023
SPAG5	sperm associated antigen 5	0.023
PSMA5	proteasome (prosome, macropain) subunit, alpha type, 5	0.021
ANLN	anillin, actin binding protein	0.021
TUBB	tubulin, beta	0.020
PPA1	pyrophosphatase (inorganic) 1	0.019
CDK2	cyclin-dependent kinase 2	0.019
SGCG	sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)	0.019
NEK1	NIMA (never in mitosis gene a)-related kinase 1	0.019
POMP	proteasome maturation protein	0.019
ERCC6L	excision repair cross-complementing rodent repair deficiency, complementation group 6-like	0.018
PSEN1	presenilin 1	0.018
BCCIP	BRCA2 and CDKN1A interacting protein	0.017
KIF18B	kinesin family member 18B	0.017	Yeast Fly
STIL	SCL/TAL1 interrupting locus	0.017
HMGB2	high mobility group box 2	0.017
E2F3	E2F transcription factor 3	0.015
HIPK2	homeodomain interacting protein kinase 2	0.015
XIRP1	xin actin-binding repeat containing 1	0.015
FAM64A	family with sequence similarity 64, member A	0.014
PPP2R2D	protein phosphatase 2, regulatory subunit B, delta	0.014
MKI67IP	MKI67 (FHA domain) interacting nucleolar phosphoprotein	0.014
KIFC1	kinesin family member C1	0.014
MYH9	myosin, heavy chain 9, non-muscle	0.013
MELK	maternal embryonic leucine zipper kinase	0.013
XPO1	exportin 1 (CRM1 homolog, yeast)	0.013
CIT	citron (rho-interacting, serine/threonine kinase 21)	0.013
PKP4	plakophilin 4	0.013
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.013
TROAP	trophinin associated protein (tastin)	0.013
TFDP1	transcription factor Dp-1	0.013
KIFAP3	kinesin-associated protein 3	0.013
RB1	retinoblastoma 1	0.012
APOBEC3B	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B	0.012
KPNB1	karyopherin (importin) beta 1	0.012
PSMD4	proteasome (prosome, macropain) 26S subunit, non-ATPase, 4	0.012
TRIM63	tripartite motif containing 63	0.011
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.011
PLK4	polo-like kinase 4	0.011
CLTC	clathrin, heavy chain (Hc)	0.011
PSEN2	presenilin 2 (Alzheimer disease 4)	0.010
MYBL2	v-myb myeloblastosis viral oncogene homolog (avian)-like 2	0.010	Mouse Fly
MIS18BP1	MIS18 binding protein 1	0.010