IMP

Process View

Homo sapiens

22 genes annotated in human

positive regulation of epithelial to mesenchymal transition

Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in human Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of epithelial to mesenchymal transition"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of epithelial to mesenchymal transition" (in gray)

Name	Description	Probability	Func Analog Organism
SMAD3	SMAD family member 3	1.000
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	1.000
SMAD7	SMAD family member 7	0.991	Human
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.984
JAG1	jagged 1	0.957
COL1A1	collagen, type I, alpha 1	0.939
COL1A2	collagen, type I, alpha 2	0.897	Human
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.883
SMAD2	SMAD family member 2	0.881	Human Mouse
FSTL1	follistatin-like 1	0.873
SMAD1	SMAD family member 1	0.852	Human
NOTCH1	notch 1	0.849
SPARC	secreted protein, acidic, cysteine-rich (osteonectin)	0.773
COL4A1	collagen, type IV, alpha 1	0.743
BMPR1A	bone morphogenetic protein receptor, type IA	0.613
ZFYVE9	zinc finger, FYVE domain containing 9	0.586
SMAD4	SMAD family member 4	0.564	Human Mouse
COL3A1	collagen, type III, alpha 1	0.539	Human
TGFB1	transforming growth factor, beta 1	0.477
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.418
LATS2	LATS, large tumor suppressor, homolog 2 (Drosophila)	0.408
SETD8	SET domain containing (lysine methyltransferase) 8	0.343
SKIL	SKI-like oncogene	0.304
DDR2	discoidin domain receptor tyrosine kinase 2	0.267
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.264
SMAD6	SMAD family member 6	0.237	Human
FBLN1	fibulin 1	0.232
MAFA	v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)	0.223
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.209
AMMECR1	Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1	0.196
NOTCH3	notch 3	0.195	Human
COL5A1	collagen, type V, alpha 1	0.178	Human
COL6A1	collagen, type VI, alpha 1	0.173
CXXC5	CXXC finger protein 5	0.158
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.156
RUNX1	runt-related transcription factor 1	0.143
PARVA	parvin, alpha	0.142
TGFB3	transforming growth factor, beta 3	0.137
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.133
COL5A2	collagen, type V, alpha 2	0.132	Human
SMAD5	SMAD family member 5	0.125	Human
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.119
TGFBR1	transforming growth factor, beta receptor 1	0.117
LPXN	leupaxin	0.107	Human
MXRA5	matrix-remodelling associated 5	0.098
LOX	lysyl oxidase	0.096
POSTN	periostin, osteoblast specific factor	0.089
TCF4	transcription factor 4	0.080
YY1	YY1 transcription factor	0.078
GATA2	GATA binding protein 2	0.077
GSK3B	glycogen synthase kinase 3 beta	0.073
BGN	biglycan	0.070
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.069
BTRC	beta-transducin repeat containing	0.067
S100B	S100 calcium binding protein B	0.065
NCK2	NCK adaptor protein 2	0.063
TGFB1I1	transforming growth factor beta 1 induced transcript 1	0.060
AR	androgen receptor	0.058
HOXA1	homeobox A1	0.057
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.054
PSEN1	presenilin 1	0.053
WDYHV1	WDYHV motif containing 1	0.053
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.052
TLE1	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	0.052
FHL2	four and a half LIM domains 2	0.052
ADAM12	ADAM metallopeptidase domain 12	0.050
EGR1	early growth response 1	0.050
AXIN1	axin 1	0.048	Human
COL11A1	collagen, type XI, alpha 1	0.047	Human
DLL1	delta-like 1 (Drosophila)	0.045
LIMS1	LIM and senescent cell antigen-like domains 1	0.044	Human
GLIS2	GLIS family zinc finger 2	0.042
ID3	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	0.041
NRP1	neuropilin 1	0.039
PXDN	peroxidasin homolog (Drosophila)	0.037
JUB	jub, ajuba homolog (Xenopus laevis)	0.035
ENG	endoglin	0.034
PHF21A	PHD finger protein 21A	0.033
BBS10	Bardet-Biedl syndrome 10	0.031
TRIP6	thyroid hormone receptor interactor 6	0.030
CDH2	cadherin 2, type 1, N-cadherin (neuronal)	0.030
CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	0.029
AMOTL2	angiomotin like 2	0.027
CALD1	caldesmon 1	0.027
HIC1	hypermethylated in cancer 1	0.026
HEY1	hairy/enhancer-of-split related with YRPW motif 1	0.026
YAP1	Yes-associated protein 1	0.025	Human
TAL1	T-cell acute lymphocytic leukemia 1	0.025	Human
ZNF426	zinc finger protein 426	0.023
AMOTL1	angiomotin like 1	0.023
BMP4	bone morphogenetic protein 4	0.023	Human
ITGBL1	integrin, beta-like 1 (with EGF-like repeat domains)	0.023
CTGF	connective tissue growth factor	0.022
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.021
FBXL15	F-box and leucine-rich repeat protein 15	0.021
DSP	desmoplakin	0.021
JAG2	jagged 2	0.021
LEF1	lymphoid enhancer-binding factor 1	0.020
FN1	fibronectin 1	0.020
COL6A3	collagen, type VI, alpha 3	0.020
VCL	vinculin	0.019
COL2A1	collagen, type II, alpha 1	0.019	Human
MKL2	MKL/myocardin-like 2	0.019
LRRC17	leucine rich repeat containing 17	0.019
SOX7	SRY (sex determining region Y)-box 7	0.019
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.018
GSK3A	glycogen synthase kinase 3 alpha	0.018
PHC2	polyhomeotic homolog 2 (Drosophila)	0.017
ELN	elastin	0.017
EP300	E1A binding protein p300	0.017
PTPN14	protein tyrosine phosphatase, non-receptor type 14	0.017
NID2	nidogen 2 (osteonidogen)	0.017
DACT1	dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)	0.017
MCAM	melanoma cell adhesion molecule	0.017
FBN1	fibrillin 1	0.017
NOTCH2	notch 2	0.016	Human
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.016
FNDC1	fibronectin type III domain containing 1	0.016
HEYL	hairy/enhancer-of-split related with YRPW motif-like	0.016
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.016
LTBP2	latent transforming growth factor beta binding protein 2	0.016
MYOD1	myogenic differentiation 1	0.015
PAPPA	pregnancy-associated plasma protein A, pappalysin 1	0.015
PLXDC1	plexin domain containing 1	0.015
OLFML3	olfactomedin-like 3	0.015
LAMB1	laminin, beta 1	0.015
MAML1	mastermind-like 1 (Drosophila)	0.015
DNMT3B	DNA (cytosine-5-)-methyltransferase 3 beta	0.015
TRAF4	TNF receptor-associated factor 4	0.015
SDC2	syndecan 2	0.015
CNN1	calponin 1, basic, smooth muscle	0.015
CDC42EP1	CDC42 effector protein (Rho GTPase binding) 1	0.014
UNC5B	unc-5 homolog B (C. elegans)	0.014
GRB7	growth factor receptor-bound protein 7	0.014
FKBP10	FK506 binding protein 10, 65 kDa	0.013
BMP2	bone morphogenetic protein 2	0.013
THY1	Thy-1 cell surface antigen	0.013
THBS1	thrombospondin 1	0.013
EGFL7	EGF-like-domain, multiple 7	0.013
GLT8D2	glycosyltransferase 8 domain containing 2	0.013
FOXF2	forkhead box F2	0.013
SOX11	SRY (sex determining region Y)-box 11	0.013
APC	adenomatous polyposis coli	0.013
NOTCH2NL	notch 2 N-terminal like	0.012
CTNNBIP1	catenin, beta interacting protein 1	0.012
IGFBP3	insulin-like growth factor binding protein 3	0.012
ZEB2	zinc finger E-box binding homeobox 2	0.012
LAPTM5	lysosomal protein transmembrane 5	0.012
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.012
EVC2	Ellis van Creveld syndrome 2	0.011
LRRN2	leucine rich repeat neuronal 2	0.011
MDFI	MyoD family inhibitor	0.011
GIT2	G protein-coupled receptor kinase interacting ArfGAP 2	0.011
TEAD4	TEA domain family member 4	0.011
DIP2A	DIP2 disco-interacting protein 2 homolog A (Drosophila)	0.011
FZD1	frizzled homolog 1 (Drosophila)	0.011
CD248	CD248 molecule, endosialin	0.011
TNS3	tensin 3	0.011
CBFA2T3	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	0.011
CREBBP	CREB binding protein	0.011
CTHRC1	collagen triple helix repeat containing 1	0.011
ACVR2B	activin A receptor, type IIB	0.010
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.010
TNIK	TRAF2 and NCK interacting kinase	0.010
TBX2	T-box 2	0.010
NOG	noggin	0.010
EHD2	EH-domain containing 2	0.010
EDNRA	endothelin receptor type A	0.010
CSNK1D	casein kinase 1, delta	0.010