IMP

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Homo sapiens

3 genes annotated in human

canonical wnt signaling pathway involved in heart development

The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to the progression of the heart over time. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "canonical wnt signaling pathway involved in heart development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "canonical wnt signaling pathway involved in heart development" (in gray)

Name	Description	Probability	Func Analog Organism
DVL1	dishevelled, dsh homolog 1 (Drosophila)	0.999	Fly
DVL3	dishevelled, dsh homolog 3 (Drosophila)	0.999	Fly
LRRK2	leucine-rich repeat kinase 2	0.999
AXIN1	axin 1	0.997
APC	adenomatous polyposis coli	0.993
CSNK1E	casein kinase 1, epsilon	0.990
GSK3B	glycogen synthase kinase 3 beta	0.986
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.962
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.905	Mouse Fly
CTNND1	catenin (cadherin-associated protein), delta 1	0.898
CTNNBIP1	catenin, beta interacting protein 1	0.855
LRP6	low density lipoprotein receptor-related protein 6	0.831	Mouse
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.831
ATXN1L	ataxin 1-like	0.782
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.504
CEP164	centrosomal protein 164kDa	0.500
NOTCH1	notch 1	0.439
NCOA2	nuclear receptor coactivator 2	0.410
FZD1	frizzled homolog 1 (Drosophila)	0.410
WT1	Wilms tumor 1	0.374
GLIS2	GLIS family zinc finger 2	0.354
SPEN	spen homolog, transcriptional regulator (Drosophila)	0.353
ZNF512B	zinc finger protein 512B	0.324
TCF4	transcription factor 4	0.303
PSEN1	presenilin 1	0.205
MAML1	mastermind-like 1 (Drosophila)	0.161
PRPF3	PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae)	0.155
MYST2	MYST histone acetyltransferase 2	0.149
DSP	desmoplakin	0.136
FGF18	fibroblast growth factor 18	0.136
JAG1	jagged 1	0.131
CDH2	cadherin 2, type 1, N-cadherin (neuronal)	0.114
SNIP1	Smad nuclear interacting protein 1	0.112
BAHD1	bromo adjacent homology domain containing 1	0.104
WNT3A	wingless-type MMTV integration site family, member 3A	0.099
PARD3	par-3 partitioning defective 3 homolog (C. elegans)	0.098
PIK3CB	phosphoinositide-3-kinase, catalytic, beta polypeptide	0.094
MCC	mutated in colorectal cancers	0.080
U2AF2	U2 small nuclear RNA auxiliary factor 2	0.080
TAOK1	TAO kinase 1	0.079
FZD8	frizzled homolog 8 (Drosophila)	0.079
KLHL12	kelch-like 12 (Drosophila)	0.079
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.070
CSNK1D	casein kinase 1, delta	0.063
CCNK	cyclin K	0.056
FERMT2	fermitin family member 2	0.055
PITX1	paired-like homeodomain 1	0.052
FAM110C	family with sequence similarity 110, member C	0.046
FAM110A	family with sequence similarity 110, member A	0.046
JUP	junction plakoglobin	0.045	Fly
OCLN	occludin	0.045
WIF1	WNT inhibitory factor 1	0.044
WNT1	wingless-type MMTV integration site family, member 1	0.044	Human Fly
AMMECR1	Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1	0.040
WDYHV1	WDYHV motif containing 1	0.039
IHH	Indian hedgehog	0.038
DVL2	dishevelled, dsh homolog 2 (Drosophila)	0.037	Fly
MDFI	MyoD family inhibitor	0.036
CDH3	cadherin 3, type 1, P-cadherin (placental)	0.035
SFRP1	secreted frizzled-related protein 1	0.035
ATXN3	ataxin 3	0.035
MAP2K6	mitogen-activated protein kinase kinase 6	0.035
ZBTB48	zinc finger and BTB domain containing 48	0.034
ZMYND8	zinc finger, MYND-type containing 8	0.031
SORBS3	sorbin and SH3 domain containing 3	0.030
STRN3	striatin, calmodulin binding protein 3	0.030
HIC1	hypermethylated in cancer 1	0.029
AR	androgen receptor	0.028
RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2	0.028
HOXC8	homeobox C8	0.028
HES1	hairy and enhancer of split 1, (Drosophila)	0.028
PTK7	PTK7 protein tyrosine kinase 7	0.027
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.027
ZFPM1	zinc finger protein, multitype 1	0.027
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.026
C16orf48	chromosome 16 open reading frame 48	0.026
CCDC92	coiled-coil domain containing 92	0.026
CIR1	corepressor interacting with RBPJ, 1	0.025
FGF8	fibroblast growth factor 8 (androgen-induced)	0.025
CPSF7	cleavage and polyadenylation specific factor 7, 59kDa	0.025
WNT10A	wingless-type MMTV integration site family, member 10A	0.024	Human
RAB5B	RAB5B, member RAS oncogene family	0.024
ITGB4	integrin, beta 4	0.024
WNT3	wingless-type MMTV integration site family, member 3	0.024	Human
NCOR2	nuclear receptor corepressor 2	0.024
WNT4	wingless-type MMTV integration site family, member 4	0.023	Human
ARHGEF19	Rho guanine nucleotide exchange factor (GEF) 19	0.022
KIAA1191	KIAA1191	0.022
FGF3	fibroblast growth factor 3	0.022
PER1	period homolog 1 (Drosophila)	0.022
HSD17B14	hydroxysteroid (17-beta) dehydrogenase 14	0.021
BHLHE23	basic helix-loop-helix family, member e23	0.021
DST	dystonin	0.021
TNFAIP8L1	tumor necrosis factor, alpha-induced protein 8-like 1	0.021
NKD2	naked cuticle homolog 2 (Drosophila)	0.021
ZNF408	zinc finger protein 408	0.020
SHH	sonic hedgehog	0.020
CADM4	cell adhesion molecule 4	0.020
SNF8	SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)	0.019
RAC3	ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)	0.019
DPPA2	developmental pluripotency associated 2	0.019
MAPT	microtubule-associated protein tau	0.019
FOXF2	forkhead box F2	0.019
MMP11	matrix metallopeptidase 11 (stromelysin 3)	0.019
AXIN2	axin 2	0.019
LBX1	ladybird homeobox 1	0.018
FGF4	fibroblast growth factor 4	0.018
AQP5	aquaporin 5	0.018
GDNF	glial cell derived neurotrophic factor	0.018
SPECC1L	sperm antigen with calponin homology and coiled-coil domains 1-like	0.018
WNT7A	wingless-type MMTV integration site family, member 7A	0.018	Human
NIN	ninein (GSK3B interacting protein)	0.017
HS3ST6	heparan sulfate (glucosamine) 3-O-sulfotransferase 6	0.017
BMP4	bone morphogenetic protein 4	0.017
MAP1B	microtubule-associated protein 1B	0.017
PCBD1	pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha	0.017
DSG2	desmoglein 2	0.017
FZD2	frizzled homolog 2 (Drosophila)	0.017
LMO4	LIM domain only 4	0.017
XAB2	XPA binding protein 2	0.016
APH1A	anterior pharynx defective 1 homolog A (C. elegans)	0.016
TCF7	transcription factor 7 (T-cell specific, HMG-box)	0.016
DAAM1	dishevelled associated activator of morphogenesis 1	0.016
LEF1	lymphoid enhancer-binding factor 1	0.016
TIFA	TRAF-interacting protein with forkhead-associated domain	0.016
PKP1	plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)	0.016
HES2	hairy and enhancer of split 2 (Drosophila)	0.015
PKP4	plakophilin 4	0.015
ZNF746	zinc finger protein 746	0.015
NPAS1	neuronal PAS domain protein 1	0.015
SCRIB	scribbled homolog (Drosophila)	0.014
ST8SIA2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.014
WNT9B	wingless-type MMTV integration site family, member 9B	0.014	Human
ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7	0.014
COL13A1	collagen, type XIII, alpha 1	0.014
TRIM29	tripartite motif containing 29	0.014
KIAA1543	KIAA1543	0.014
TMEM44	transmembrane protein 44	0.014
FAM83H	family with sequence similarity 83, member H	0.014
FOXE1	forkhead box E1 (thyroid transcription factor 2)	0.014
HMX1	H6 family homeobox 1	0.013
FOXL1	forkhead box L1	0.013
DIDO1	death inducer-obliterator 1	0.013
CYP26A1	cytochrome P450, family 26, subfamily A, polypeptide 1	0.013
DKK1	dickkopf homolog 1 (Xenopus laevis)	0.013
JAG2	jagged 2	0.013
BICD1	bicaudal D homolog 1 (Drosophila)	0.013
FZD5	frizzled homolog 5 (Drosophila)	0.013
DLX4	distal-less homeobox 4	0.013
USP13	ubiquitin specific peptidase 13 (isopeptidase T-3)	0.013
EVPL	envoplakin	0.012
NEUROG2	neurogenin 2	0.012
CACNA1G	calcium channel, voltage-dependent, T type, alpha 1G subunit	0.012
FOXD3	forkhead box D3	0.012
CRLF1	cytokine receptor-like factor 1	0.012
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.012
FAM83D	family with sequence similarity 83, member D	0.012
KCNJ5	potassium inwardly-rectifying channel, subfamily J, member 5	0.012
FZD10	frizzled homolog 10 (Drosophila)	0.012
COL4A6	collagen, type IV, alpha 6	0.012
SMAD7	SMAD family member 7	0.012
TNIK	TRAF2 and NCK interacting kinase	0.012
GGN	gametogenetin	0.011
ENTPD2	ectonucleoside triphosphate diphosphohydrolase 2	0.011
TLX3	T-cell leukemia homeobox 3	0.011
PITX2	paired-like homeodomain 2	0.011
FKBP14	FK506 binding protein 14, 22 kDa	0.011
NOTCH2	notch 2	0.011
EXOC3L2	exocyst complex component 3-like 2	0.011
RGS9BP	regulator of G protein signaling 9 binding protein	0.011
SOX21	SRY (sex determining region Y)-box 21	0.011
CHAC1	ChaC, cation transport regulator homolog 1 (E. coli)	0.011
FGFR1	fibroblast growth factor receptor 1	0.011
NKD1	naked cuticle homolog 1 (Drosophila)	0.011
CHST3	carbohydrate (chondroitin 6) sulfotransferase 3	0.011
EPHB3	EPH receptor B3	0.011
CSF2	colony stimulating factor 2 (granulocyte-macrophage)	0.011
PAX8	paired box 8	0.011
VSTM2L	V-set and transmembrane domain containing 2 like	0.011
HOXA11	homeobox A11	0.011
FOXO1	forkhead box O1	0.011
ENTPD6	ectonucleoside triphosphate diphosphohydrolase 6 (putative)	0.011
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.011
KIAA0174	KIAA0174	0.011
FOXB1	forkhead box B1	0.011
FIBCD1	fibrinogen C domain containing 1	0.011
MRFAP1	Morf4 family associated protein 1	0.011
ZNF609	zinc finger protein 609	0.011
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.011
BBS10	Bardet-Biedl syndrome 10	0.011
HOXD13	homeobox D13	0.011
ABI2	abl-interactor 2	0.011
NKX3-2	NK3 homeobox 2	0.011
ZFP106	zinc finger protein 106 homolog (mouse)	0.011
FAM83B	family with sequence similarity 83, member B	0.011
OTP	orthopedia homeobox	0.010
MNX1	motor neuron and pancreas homeobox 1	0.010
LMX1A	LIM homeobox transcription factor 1, alpha	0.010
EPHB2	EPH receptor B2	0.010
HSD11B2	hydroxysteroid (11-beta) dehydrogenase 2	0.010
SIX2	SIX homeobox 2	0.010
SIX5	SIX homeobox 5	0.010
TBX5	T-box 5	0.010
FEZF2	FEZ family zinc finger 2	0.010
CTTNBP2NL	CTTNBP2 N-terminal like	0.010
FLNB	filamin B, beta	0.010
MMP13	matrix metallopeptidase 13 (collagenase 3)	0.010
SEMA3F	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	0.010
VEGFC	vascular endothelial growth factor C	0.010
COL2A1	collagen, type II, alpha 1	0.010
SOX1	SRY (sex determining region Y)-box 1	0.010
EZR	ezrin	0.010
RBM11	RNA binding motif protein 11	0.010
ZNF165	zinc finger protein 165	0.010