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Homo sapiens

2 genes annotated in human

eosinophil degranulation

The regulated exocytosis of secretory granules containing preformed mediators such as major basic protein, eosinophil peroxidase, and eosinophil cationic protein by an eosinophil.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "eosinophil degranulation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "eosinophil degranulation" (in gray)

Name	Description	Probability	Func Analog Organism
CCR5	chemokine (C-C motif) receptor 5	1.000
CXCL9	chemokine (C-X-C motif) ligand 9	0.995
CCL4	chemokine (C-C motif) ligand 4	0.993	Human
CCL2	chemokine (C-C motif) ligand 2	0.983	Human
CCL5	chemokine (C-C motif) ligand 5	0.950	Human
CCL8	chemokine (C-C motif) ligand 8	0.946	Human
IL8	interleukin 8	0.932
CXCL10	chemokine (C-X-C motif) ligand 10	0.916
CCL13	chemokine (C-C motif) ligand 13	0.916	Human
DPP4	dipeptidyl-peptidase 4	0.902
ANKRD27	ankyrin repeat domain 27 (VPS9 domain)	0.898
IL1B	interleukin 1, beta	0.859
IDE	insulin-degrading enzyme	0.858
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.833	Human
CCL22	chemokine (C-C motif) ligand 22	0.822	Human
CXCL2	chemokine (C-X-C motif) ligand 2	0.803
CCR7	chemokine (C-C motif) receptor 7	0.778
CXCL11	chemokine (C-X-C motif) ligand 11	0.777
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.666
IL6	interleukin 6 (interferon, beta 2)	0.659
IFNG	interferon, gamma	0.607
CXCL13	chemokine (C-X-C motif) ligand 13	0.562
CXCL3	chemokine (C-X-C motif) ligand 3	0.561
CCR1	chemokine (C-C motif) receptor 1	0.545
CCL19	chemokine (C-C motif) ligand 19	0.538	Human
CCL7	chemokine (C-C motif) ligand 7	0.531	Human
TNF	tumor necrosis factor	0.505
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.495
CCL3	chemokine (C-C motif) ligand 3	0.483
CCR4	chemokine (C-C motif) receptor 4	0.408
IL2RB	interleukin 2 receptor, beta	0.387
ICAM1	intercellular adhesion molecule 1	0.386
CD83	CD83 molecule	0.314
CCL11	chemokine (C-C motif) ligand 11	0.308	Human
CXCR6	chemokine (C-X-C motif) receptor 6	0.303
UBD	ubiquitin D	0.296
VCAM1	vascular cell adhesion molecule 1	0.244
IL7R	interleukin 7 receptor	0.235
CXCL5	chemokine (C-X-C motif) ligand 5	0.221
IL10RA	interleukin 10 receptor, alpha	0.177
RGS1	regulator of G-protein signaling 1	0.176
FPR3	formyl peptide receptor 3	0.175
SELE	selectin E	0.170
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.169
SLAMF7	SLAM family member 7	0.152
IL1RN	interleukin 1 receptor antagonist	0.148
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.129
KLRB1	killer cell lectin-like receptor subfamily B, member 1	0.128
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.125
LAMP3	lysosomal-associated membrane protein 3	0.103
CH25H	cholesterol 25-hydroxylase	0.101
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.100
IL10	interleukin 10	0.098
CAV2	caveolin 2	0.095
IL18RAP	interleukin 18 receptor accessory protein	0.092
GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	0.086
KLRD1	killer cell lectin-like receptor subfamily D, member 1	0.080
ADAMDEC1	ADAM-like, decysin 1	0.077
IDO1	indoleamine 2,3-dioxygenase 1	0.075
LTA	lymphotoxin alpha (TNF superfamily, member 1)	0.074
CCR3	chemokine (C-C motif) receptor 3	0.073
CD69	CD69 molecule	0.070
BCL2A1	BCL2-related protein A1	0.067
IL2RG	interleukin 2 receptor, gamma	0.066
IRF4	interferon regulatory factor 4	0.065
CCL20	chemokine (C-C motif) ligand 20	0.063	Human
IL1R2	interleukin 1 receptor, type II	0.062
CD84	CD84 molecule	0.062
CD48	CD48 molecule	0.061
CXCR3	chemokine (C-X-C motif) receptor 3	0.060
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.058
CLEC10A	C-type lectin domain family 10, member A	0.058
IL1A	interleukin 1, alpha	0.057
SNAP23	synaptosomal-associated protein, 23kDa	0.057
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.056
INADL	InaD-like (Drosophila)	0.056
SLAMF1	signaling lymphocytic activation molecule family member 1	0.055
CD160	CD160 molecule	0.055
AGFG1	ArfGAP with FG repeats 1	0.055
SLAMF8	SLAM family member 8	0.054
PLA2G7	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	0.053
DARC	Duffy blood group, chemokine receptor	0.050
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.049
CCL21	chemokine (C-C motif) ligand 21	0.049
INHBA	inhibin, beta A	0.047
XCL1	chemokine (C motif) ligand 1	0.047	Human
CCL3L3	chemokine (C-C motif) ligand 3-like 3	0.046
GPR171	G protein-coupled receptor 171	0.046
CD86	CD86 molecule	0.045
CHMP2B	chromatin modifying protein 2B	0.043
STAT4	signal transducer and activator of transcription 4	0.040
CCL1	chemokine (C-C motif) ligand 1	0.040	Human
EBI3	Epstein-Barr virus induced 3	0.040
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.038
CCL23	chemokine (C-C motif) ligand 23	0.037	Human
RSAD2	radical S-adenosyl methionine domain containing 2	0.037
ICOS	inducible T-cell co-stimulator	0.036
HLA-DRB4	major histocompatibility complex, class II, DR beta 4	0.036
IL21R	interleukin 21 receptor	0.035
ARRB1	arrestin, beta 1	0.035
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.035
GZMK	granzyme K (granzyme 3; tryptase II)	0.035
MSC	musculin	0.034
CD80	CD80 molecule	0.034
CCL17	chemokine (C-C motif) ligand 17	0.033	Human
IRF8	interferon regulatory factor 8	0.033
MMP10	matrix metallopeptidase 10 (stromelysin 2)	0.032
IL2RA	interleukin 2 receptor, alpha	0.032
NKG7	natural killer cell group 7 sequence	0.030
CD209	CD209 molecule	0.030
XCL2	chemokine (C motif) ligand 2	0.030	Human
IL18R1	interleukin 18 receptor 1	0.030
TFEC	transcription factor EC	0.029
IL16	interleukin 16 (lymphocyte chemoattractant factor)	0.029
ZC3H12A	zinc finger CCCH-type containing 12A	0.028
KLRK1	killer cell lectin-like receptor subfamily K, member 1	0.026
IER3	immediate early response 3	0.024
CCRL2	chemokine (C-C motif) receptor-like 2	0.024
GPR109B	G protein-coupled receptor 109B	0.024
RGS16	regulator of G-protein signaling 16	0.024
LILRB5	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	0.024
CTSW	cathepsin W	0.023
CAV1	caveolin 1, caveolae protein, 22kDa	0.023
KLRF1	killer cell lectin-like receptor subfamily F, member 1	0.023
BATF	basic leucine zipper transcription factor, ATF-like	0.023
IL3	interleukin 3 (colony-stimulating factor, multiple)	0.023
RUNX3	runt-related transcription factor 3	0.023
CD1A	CD1a molecule	0.023
NLRP3	NLR family, pyrin domain containing 3	0.023
IL11	interleukin 11	0.023
CCR6	chemokine (C-C motif) receptor 6	0.023
CD2	CD2 molecule	0.023
GPR18	G protein-coupled receptor 18	0.022	Human
LAG3	lymphocyte-activation gene 3	0.022
PROCR	protein C receptor, endothelial	0.022
CXCR4	chemokine (C-X-C motif) receptor 4	0.022
OLR1	oxidized low density lipoprotein (lectin-like) receptor 1	0.022
SLCO2B1	solute carrier organic anion transporter family, member 2B1	0.022
MSR1	macrophage scavenger receptor 1	0.022
SNX3	sorting nexin 3	0.022
PRF1	perforin 1 (pore forming protein)	0.021
GPR84	G protein-coupled receptor 84	0.021
CLEC7A	C-type lectin domain family 7, member A	0.021
PI3	peptidase inhibitor 3, skin-derived	0.021
CD40	CD40 molecule, TNF receptor superfamily member 5	0.021
C2	complement component 2	0.020
CD1C	CD1c molecule	0.020
CST7	cystatin F (leukocystatin)	0.020
SELL	selectin L	0.020
CSF2	colony stimulating factor 2 (granulocyte-macrophage)	0.020
IL13	interleukin 13	0.020
PLEK	pleckstrin	0.020
HLA-DOA	major histocompatibility complex, class II, DO alpha	0.019
PDPN	podoplanin	0.019
CYTIP	cytohesin 1 interacting protein	0.019
DNASE1L3	deoxyribonuclease I-like 3	0.019
CCBP2	chemokine binding protein 2	0.019
AQP9	aquaporin 9	0.019
HSD11B1	hydroxysteroid (11-beta) dehydrogenase 1	0.019
CRMP1	collapsin response mediator protein 1	0.019
LRRC32	leucine rich repeat containing 32	0.019
P2RY6	pyrimidinergic receptor P2Y, G-protein coupled, 6	0.019	Human
ITK	IL2-inducible T-cell kinase	0.018
CMKLR1	chemokine-like receptor 1	0.018
CSF1	colony stimulating factor 1 (macrophage)	0.018
CD1B	CD1b molecule	0.018
OSMR	oncostatin M receptor	0.018
MMP1	matrix metallopeptidase 1 (interstitial collagenase)	0.018
TNFRSF4	tumor necrosis factor receptor superfamily, member 4	0.017
ATP6V1A	ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A	0.017
PLAU	plasminogen activator, urokinase	0.017
HLA-DRB5	major histocompatibility complex, class II, DR beta 5	0.017
NR4A3	nuclear receptor subfamily 4, group A, member 3	0.017
GNAQ	guanine nucleotide binding protein (G protein), q polypeptide	0.017
IL4I1	interleukin 4 induced 1	0.017
IL1F5	interleukin 1 family, member 5 (delta)	0.017
TM7SF4	transmembrane 7 superfamily member 4	0.017
TRAF3IP3	TRAF3 interacting protein 3	0.017
PTGES	prostaglandin E synthase	0.017
OASL	2'-5'-oligoadenylate synthetase-like	0.017
IL1F9	interleukin 1 family, member 9	0.017
C1QA	complement component 1, q subcomponent, A chain	0.016
SCP2	sterol carrier protein 2	0.016
IL32	interleukin 32	0.016
CXCR2	chemokine (C-X-C motif) receptor 2	0.016
IGJ	immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides	0.016
TLR2	toll-like receptor 2	0.016
TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	0.016
IL7	interleukin 7	0.016
SLC2A5	solute carrier family 2 (facilitated glucose/fructose transporter), member 5	0.015
PDCD1LG2	programmed cell death 1 ligand 2	0.015
KYNU	kynureninase	0.015
HLA-DQB2	major histocompatibility complex, class II, DQ beta 2	0.015
CD40LG	CD40 ligand	0.015
MMP7	matrix metallopeptidase 7 (matrilysin, uterine)	0.015
SERPINB2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	0.015
IFNB1	interferon, beta 1, fibroblast	0.015
CLEC5A	C-type lectin domain family 5, member A	0.014
AIM2	absent in melanoma 2	0.014
G0S2	G0/G1switch 2	0.014
APOC1	apolipoprotein C-I	0.014
TXNRD1	thioredoxin reductase 1	0.014
LIF	leukemia inhibitory factor (cholinergic differentiation factor)	0.014
MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	0.014
PVRIG	poliovirus receptor related immunoglobulin domain containing	0.013
SRGN	serglycin	0.013
ADORA3	adenosine A3 receptor	0.013
CCR2	chemokine (C-C motif) receptor 2	0.013	Mouse
BDKRB1	bradykinin receptor B1	0.013
CD163	CD163 molecule	0.013
CHIT1	chitinase 1 (chitotriosidase)	0.013
ICOSLG	inducible T-cell co-stimulator ligand	0.013
IL12RB1	interleukin 12 receptor, beta 1	0.013
IL15RA	interleukin 15 receptor, alpha	0.013
EREG	epiregulin	0.013
GNLY	granulysin	0.013
GZMA	granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)	0.013
NNMT	nicotinamide N-methyltransferase	0.013
CSF3	colony stimulating factor 3 (granulocyte)	0.013
TFPI2	tissue factor pathway inhibitor 2	0.013
TARP	TCR gamma alternate reading frame protein	0.013
GPR183	G protein-coupled receptor 183	0.012
TBX21	T-box 21	0.012
SDS	serine dehydratase	0.012
SIGLEC7	sialic acid binding Ig-like lectin 7	0.012
DYNLT3	dynein, light chain, Tctex-type 3	0.012
CLC	Charcot-Leyden crystal protein	0.012
PGRMC1	progesterone receptor membrane component 1	0.012
SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	0.012
CCNDBP1	cyclin D-type binding-protein 1	0.012
SERPINB9	serpin peptidase inhibitor, clade B (ovalbumin), member 9	0.012
TPSB2	tryptase beta 2 (gene/pseudogene)	0.012
ALPI	alkaline phosphatase, intestinal	0.012
CXCR5	chemokine (C-X-C motif) receptor 5	0.012
DUSP2	dual specificity phosphatase 2	0.012
IL6R	interleukin 6 receptor	0.012
IGL@	immunoglobulin lambda locus	0.012
SCARF1	scavenger receptor class F, member 1	0.012
GPR65	G protein-coupled receptor 65	0.012
STX11	syntaxin 11	0.012
XCR1	chemokine (C motif) receptor 1	0.012
MOSPD1	motile sperm domain containing 1	0.012
MS4A6A	membrane-spanning 4-domains, subfamily A, member 6A	0.012
IL18BP	interleukin 18 binding protein	0.011
TNIP3	TNFAIP3 interacting protein 3	0.011
RNASE6	ribonuclease, RNase A family, k6	0.011
SMAP1	small ArfGAP 1	0.011
CST1	cystatin SN	0.011
CCL24	chemokine (C-C motif) ligand 24	0.011	Human
CD226	CD226 molecule	0.011
CHI3L2	chitinase 3-like 2	0.011
GIMAP4	GTPase, IMAP family member 4	0.011
C14orf129	chromosome 14 open reading frame 129	0.011
P2RY10	purinergic receptor P2Y, G-protein coupled, 10	0.011
KIFC3	kinesin family member C3	0.011
EDN1	endothelin 1	0.011
CCR8	chemokine (C-C motif) receptor 8	0.011
CD28	CD28 molecule	0.011
SPRR2A	small proline-rich protein 2A	0.011
IL5	interleukin 5 (colony-stimulating factor, eosinophil)	0.011
CD38	CD38 molecule	0.011
IL4	interleukin 4	0.011
FCER2	Fc fragment of IgE, low affinity II, receptor for (CD23)	0.011
CSF2RA	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	0.011
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.011
HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	0.011
RNASE3	ribonuclease, RNase A family, 3	0.010
SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	0.010
CLEC4E	C-type lectin domain family 4, member E	0.010
HS3ST1	heparan sulfate (glucosamine) 3-O-sulfotransferase 1	0.010
PRG2	proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)	0.010
NFE2L3	nuclear factor (erythroid-derived 2)-like 3	0.010
PLA1A	phospholipase A1 member A	0.010
HK3	hexokinase 3 (white cell)	0.010
IL9	interleukin 9	0.010
PEX2	peroxisomal biogenesis factor 2	0.010
PTEN	phosphatase and tensin homolog	0.010