IMP

Process View

Homo sapiens

4 genes annotated in human

neurotrophin trk receptor signaling pathway

A series of molecular signals initiated by the binding of a neurotrophin to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "neurotrophin trk receptor signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "neurotrophin trk receptor signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.996
GRB2	growth factor receptor-bound protein 2	0.988
EGFR	epidermal growth factor receptor	0.895
CAV1	caveolin 1, caveolae protein, 22kDa	0.817
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.775
BCAR1	breast cancer anti-estrogen resistance 1	0.692	Rat
GGA2	golgi-associated, gamma adaptin ear containing, ARF binding protein 2	0.647
GGA1	golgi-associated, gamma adaptin ear containing, ARF binding protein 1	0.454
FYN	FYN oncogene related to SRC, FGR, YES	0.397
ATG13	ATG13 autophagy related 13 homolog (S. cerevisiae)	0.313
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.295
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.289
SESN2	sestrin 2	0.269
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.265
SRCIN1	SRC kinase signaling inhibitor 1	0.258
IRS1	insulin receptor substrate 1	0.257
IER3	immediate early response 3	0.234
PTK2	PTK2 protein tyrosine kinase 2	0.232
IGF2R	insulin-like growth factor 2 receptor	0.223
LAT	linker for activation of T cells	0.215
SORT1	sortilin 1	0.189
SORL1	sortilin-related receptor, L(DLR class) A repeats containing	0.170	Human
SYNRG	synergin, gamma	0.161
NGF	nerve growth factor (beta polypeptide)	0.159
SOS1	son of sevenless homolog 1 (Drosophila)	0.154
TNK2	tyrosine kinase, non-receptor, 2	0.151
RLN3	relaxin 3	0.141
MMP14	matrix metallopeptidase 14 (membrane-inserted)	0.092
MUC1	mucin 1, cell surface associated	0.076
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.067	Rat
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.066
NTF4	neurotrophin 4	0.066
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.065
STAT5A	signal transducer and activator of transcription 5A	0.062
SPRY4	sprouty homolog 4 (Drosophila)	0.057
RABEP1	rabaptin, RAB GTPase binding effector protein 1	0.051
INSR	insulin receptor	0.048
RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	0.048
PTPN12	protein tyrosine phosphatase, non-receptor type 12	0.044
SPRY2	sprouty homolog 2 (Drosophila)	0.044	Mouse
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.042
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.041
GHR	growth hormone receptor	0.034
EFS	embryonal Fyn-associated substrate	0.034
ZNF512B	zinc finger protein 512B	0.033
INPPL1	inositol polyphosphate phosphatase-like 1	0.032
PXN	paxillin	0.032
ATG9A	ATG9 autophagy related 9 homolog A (S. cerevisiae)	0.032
RET	ret proto-oncogene	0.031
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.031
MAPT	microtubule-associated protein tau	0.029
PLCG1	phospholipase C, gamma 1	0.029
SPG21	spastic paraplegia 21 (autosomal recessive, Mast syndrome)	0.028
SPRY1	sprouty homolog 1, antagonist of FGF signaling (Drosophila)	0.028	Mouse
PTPRA	protein tyrosine phosphatase, receptor type, A	0.028
DNAJC1	DnaJ (Hsp40) homolog, subfamily C, member 1	0.027
SHC3	SHC (Src homology 2 domain containing) transforming protein 3	0.027
BCR	breakpoint cluster region	0.026
BAG1	BCL2-associated athanogene	0.026
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.025
TIMP3	TIMP metallopeptidase inhibitor 3	0.024
FRS2	fibroblast growth factor receptor substrate 2	0.023
C9orf25	chromosome 9 open reading frame 25	0.023
LTK	leukocyte receptor tyrosine kinase	0.023
IGF1R	insulin-like growth factor 1 receptor	0.023
NTRK3	neurotrophic tyrosine kinase, receptor, type 3	0.023	Human
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.023
PTPN21	protein tyrosine phosphatase, non-receptor type 21	0.022
SSR1	signal sequence receptor, alpha	0.022
EPOR	erythropoietin receptor	0.022
PDCD6IP	programmed cell death 6 interacting protein	0.022
MMGT1	membrane magnesium transporter 1	0.021
PAK3	p21 protein (Cdc42/Rac)-activated kinase 3	0.021
PTPN23	protein tyrosine phosphatase, non-receptor type 23	0.021
ARHGAP32	Rho GTPase activating protein 32	0.020
SH2B2	SH2B adaptor protein 2	0.020
HDAC5	histone deacetylase 5	0.020
ATG16L1	ATG16 autophagy related 16-like 1 (S. cerevisiae)	0.020
NTF3	neurotrophin 3	0.019
LRP3	low density lipoprotein receptor-related protein 3	0.019
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.018
JAK2	Janus kinase 2	0.018
ABL2	v-abl Abelson murine leukemia viral oncogene homolog 2	0.018
GRB10	growth factor receptor-bound protein 10	0.018
BDKRB1	bradykinin receptor B1	0.018	Human
CRMP1	collapsin response mediator protein 1	0.018
NTRK1	neurotrophic tyrosine kinase, receptor, type 1	0.018
ADH1B	alcohol dehydrogenase 1B (class I), beta polypeptide	0.017
MAP2K1	mitogen-activated protein kinase kinase 1	0.017
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.017
CTTN	cortactin	0.017
SERPINA5	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5	0.017
PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha	0.016
ELANE	elastase, neutrophil expressed	0.016
BRAF	v-raf murine sarcoma viral oncogene homolog B1	0.015
PPP2R1B	protein phosphatase 2, regulatory subunit A, beta	0.015
PEBP1	phosphatidylethanolamine binding protein 1	0.015
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.015
TRPV6	transient receptor potential cation channel, subfamily V, member 6	0.014
KIF5B	kinesin family member 5B	0.014
MAPK1	mitogen-activated protein kinase 1	0.014
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.014
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.014
BDKRB2	bradykinin receptor B2	0.014	Human
SLC4A1	solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)	0.013
PTPLB	protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b	0.013
MAP2	microtubule-associated protein 2	0.013
DAG1	dystroglycan 1 (dystrophin-associated glycoprotein 1)	0.013
DMD	dystrophin	0.013
NPTN	neuroplastin	0.013
STAT5B	signal transducer and activator of transcription 5B	0.013
CELSR2	cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)	0.013
GABARAPL2	GABA(A) receptor-associated protein-like 2	0.012
GABARAP	GABA(A) receptor-associated protein	0.012
BEX4	brain expressed, X-linked 4	0.012
PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	0.012
MATK	megakaryocyte-associated tyrosine kinase	0.012
TYK2	tyrosine kinase 2	0.012
SH3KBP1	SH3-domain kinase binding protein 1	0.012
LAMC3	laminin, gamma 3	0.012
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.012
SCRG1	stimulator of chondrogenesis 1	0.012
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.012
PRKCG	protein kinase C, gamma	0.012
ARRB1	arrestin, beta 1	0.011
GAP43	growth associated protein 43	0.011
PTPRD	protein tyrosine phosphatase, receptor type, D	0.011
EDNRB	endothelin receptor type B	0.011
CANX	calnexin	0.011
AMBRA1	autophagy/beclin-1 regulator 1	0.011
MPZL1	myelin protein zero-like 1	0.011
RHOU	ras homolog gene family, member U	0.011
ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	0.011
OCLN	occludin	0.011
HTATSF1	HIV-1 Tat specific factor 1	0.011
SYN2	synapsin II	0.011
EPHB2	EPH receptor B2	0.011
ADRB2	adrenergic, beta-2-, receptor, surface	0.011
SPRR2A	small proline-rich protein 2A	0.011
ASPA	aspartoacylase	0.011
SH3GL2	SH3-domain GRB2-like 2	0.011
CAPN1	calpain 1, (mu/I) large subunit	0.011
AMPH	amphiphysin	0.011
TBC1D4	TBC1 domain family, member 4	0.011
SORBS1	sorbin and SH3 domain containing 1	0.011
ZBTB16	zinc finger and BTB domain containing 16	0.010
CAMKV	CaM kinase-like vesicle-associated	0.010
RIN1	Ras and Rab interactor 1	0.010
GRIA2	glutamate receptor, ionotropic, AMPA 2	0.010
E2F2	E2F transcription factor 2	0.010