IMP

Process View

Homo sapiens

31 genes annotated in human

diabetes mellitus

DOID:9351

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Known genes in the process in human Include functional analogs

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Gene Predictions

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Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "diabetes mellitus" (in gray)

Name	Description	Probability	Func Analog Organism
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.997
INSR	insulin receptor	0.995
GRB10	growth factor receptor-bound protein 10	0.973
IGF1R	insulin-like growth factor 1 receptor	0.952
MAFA	v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)	0.924
IRS2	insulin receptor substrate 2	0.668
MAP2K7	mitogen-activated protein kinase kinase 7	0.634
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.580
HNF4A	hepatocyte nuclear factor 4, alpha	0.564
STAT5B	signal transducer and activator of transcription 5B	0.405
ESRRG	estrogen-related receptor gamma	0.333
PTPN11	protein tyrosine phosphatase, non-receptor type 11	0.308
IRS1	insulin receptor substrate 1	0.297
PROX1	prospero homeobox 1	0.281
SH2B1	SH2B adaptor protein 1	0.276
PTBP1	polypyrimidine tract binding protein 1	0.271
PSEN1	presenilin 1	0.251
HNF1A	HNF1 homeobox A	0.208
SREBF2	sterol regulatory element binding transcription factor 2	0.180
IL6R	interleukin 6 receptor	0.149
ENPP1	ectonucleotide pyrophosphatase/phosphodiesterase 1	0.143
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.091
SRCIN1	SRC kinase signaling inhibitor 1	0.083
ABCC8	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	0.078
VAV1	vav 1 guanine nucleotide exchange factor	0.077
HNRNPD	heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)	0.075
PDX1	pancreatic and duodenal homeobox 1	0.073
LAT	linker for activation of T cells	0.072
KCNJ11	potassium inwardly-rectifying channel, subfamily J, member 11	0.067
MAPK8	mitogen-activated protein kinase 8	0.066
CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	0.065
GCKR	glucokinase (hexokinase 4) regulator	0.056
OASL	2'-5'-oligoadenylate synthetase-like	0.054	Human
CD247	CD247 molecule	0.052
JUP	junction plakoglobin	0.052
PTPN2	protein tyrosine phosphatase, non-receptor type 2	0.046	Human
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.046
HNF1B	HNF1 homeobox B	0.045
NR0B2	nuclear receptor subfamily 0, group B, member 2	0.042
MAP3K10	mitogen-activated protein kinase kinase kinase 10	0.041
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.040
HTT	huntingtin	0.039
TNIK	TRAF2 and NCK interacting kinase	0.038
HIC1	hypermethylated in cancer 1	0.037
SH3RF1	SH3 domain containing ring finger 1	0.037
PTK2	PTK2 protein tyrosine kinase 2	0.035
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.034
HNRNPL	heterogeneous nuclear ribonucleoprotein L	0.034
PCBD2	pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2	0.033
STAT5A	signal transducer and activator of transcription 5A	0.033
RECQL5	RecQ protein-like 5	0.033
MASP2	mannan-binding lectin serine peptidase 2	0.031
PCBD1	pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha	0.030
BCR	breakpoint cluster region	0.029
HMGA2	high mobility group AT-hook 2	0.028	Human
BCAR1	breast cancer anti-estrogen resistance 1	0.027
USP18	ubiquitin specific peptidase 18	0.027
HDAC9	histone deacetylase 9	0.027
SPRR2A	small proline-rich protein 2A	0.026
SOCS3	suppressor of cytokine signaling 3	0.026
APOB	apolipoprotein B (including Ag(x) antigen)	0.026
GRB14	growth factor receptor-bound protein 14	0.025
CDX2	caudal type homeobox 2	0.025
CAV2	caveolin 2	0.024
POU2F1	POU class 2 homeobox 1	0.024
LTK	leukocyte receptor tyrosine kinase	0.023
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.022
HDAC7	histone deacetylase 7	0.022
PPARG	peroxisome proliferator-activated receptor gamma	0.022
APBB2	amyloid beta (A4) precursor protein-binding, family B, member 2	0.021
PFKFB1	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	0.021
MMP14	matrix metallopeptidase 14 (membrane-inserted)	0.021
NR1I2	nuclear receptor subfamily 1, group I, member 2	0.020	Human
HOXB7	homeobox B7	0.020
ONECUT1	one cut homeobox 1	0.020
BST2	bone marrow stromal cell antigen 2	0.020
ITGA2B	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	0.019
ISG15	ISG15 ubiquitin-like modifier	0.019
TRIM14	tripartite motif containing 14	0.019
ADAM15	ADAM metallopeptidase domain 15	0.019
MTNR1A	melatonin receptor 1A	0.019	Human
TNK2	tyrosine kinase, non-receptor, 2	0.019
PYY	peptide YY	0.018
NKX6-1	NK6 homeobox 1	0.018
GLIS2	GLIS family zinc finger 2	0.018
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.018
APBB1	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	0.018
FOXA2	forkhead box A2	0.018
EPOR	erythropoietin receptor	0.018
PAX6	paired box 6	0.018	Human
AGAP2	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	0.017
DYRK1B	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B	0.017
CCL14	chemokine (C-C motif) ligand 14	0.017
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.016
YBX1	Y box binding protein 1	0.016
JAK2	Janus kinase 2	0.016
SST	somatostatin	0.016
NKX2-2	NK2 homeobox 2	0.016
POU3F4	POU class 3 homeobox 4	0.015
POFUT1	protein O-fucosyltransferase 1	0.015
SNCG	synuclein, gamma (breast cancer-specific protein 1)	0.015
OAS3	2'-5'-oligoadenylate synthetase 3, 100kDa	0.015	Human
GCG	glucagon	0.015
GP2	glycoprotein 2 (zymogen granule membrane)	0.015
SMARCD3	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3	0.014
NR1I3	nuclear receptor subfamily 1, group I, member 3	0.014	Human
GJB1	gap junction protein, beta 1, 32kDa	0.014
CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.014
LBX1	ladybird homeobox 1	0.014
ESRRB	estrogen-related receptor beta	0.014
APP	amyloid beta (A4) precursor protein	0.014
TRPV6	transient receptor potential cation channel, subfamily V, member 6	0.014
TCF4	transcription factor 4	0.014
ZAP70	zeta-chain (TCR) associated protein kinase 70kDa	0.014
CHGA	chromogranin A (parathyroid secretory protein 1)	0.014
HP	haptoglobin	0.014
APBA1	amyloid beta (A4) precursor protein-binding, family A, member 1	0.014
SLC13A2	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2	0.014
PTGER1	prostaglandin E receptor 1 (subtype EP1), 42kDa	0.014
IKZF4	IKAROS family zinc finger 4 (Eos)	0.014
EMD	emerin	0.014
TRIB1	tribbles homolog 1 (Drosophila)	0.013
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.013
CARM1	coactivator-associated arginine methyltransferase 1	0.013
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.013
PLCG1	phospholipase C, gamma 1	0.013
PIK3AP1	phosphoinositide-3-kinase adaptor protein 1	0.013
PDK1	pyruvate dehydrogenase kinase, isozyme 1	0.013
SLC4A1	solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)	0.013
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.013
SCGN	secretagogin, EF-hand calcium binding protein	0.013
CXCL2	chemokine (C-X-C motif) ligand 2	0.013
SLC25A40	solute carrier family 25, member 40	0.013
NEUROG3	neurogenin 3	0.013	Human
FOXO1	forkhead box O1	0.013
RGS20	regulator of G-protein signaling 20	0.013
RHOB	ras homolog gene family, member B	0.012
RHPN2	rhophilin, Rho GTPase binding protein 2	0.012
SAMD9	sterile alpha motif domain containing 9	0.012
ABCG8	ATP-binding cassette, sub-family G (WHITE), member 8	0.012
SLC2A2	solute carrier family 2 (facilitated glucose transporter), member 2	0.012
ITIH2	inter-alpha (globulin) inhibitor H2	0.012
CDH2	cadherin 2, type 1, N-cadherin (neuronal)	0.012
GSTCD	glutathione S-transferase, C-terminal domain containing	0.012
VIL1	villin 1	0.012
TDRD7	tudor domain containing 7	0.012
IL8	interleukin 8	0.012
DTX3L	deltex 3-like (Drosophila)	0.012
HGFAC	HGF activator	0.012
PPY	pancreatic polypeptide	0.012
ACTL6B	actin-like 6B	0.012
HRH1	histamine receptor H1	0.012
INPPL1	inositol polyphosphate phosphatase-like 1	0.012
XPNPEP2	X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound	0.012
INSM1	insulinoma-associated 1	0.012
OAS2	2'-5'-oligoadenylate synthetase 2, 69/71kDa	0.012	Human
GUCA2B	guanylate cyclase activator 2B (uroguanylin)	0.011
NR5A2	nuclear receptor subfamily 5, group A, member 2	0.011
SAMD4B	sterile alpha motif domain containing 4B	0.011
HNRNPH3	heterogeneous nuclear ribonucleoprotein H3 (2H9)	0.011
AR	androgen receptor	0.011
TRANK1	tetratricopeptide repeat and ankyrin repeat containing 1	0.011
CMTM8	CKLF-like MARVEL transmembrane domain containing 8	0.011
GPT	glutamic-pyruvate transaminase (alanine aminotransferase)	0.011
CXCL3	chemokine (C-X-C motif) ligand 3	0.011
CBX6	chromobox homolog 6	0.011
TMSB4Y	thymosin beta 4, Y-linked	0.011
UBE2L6	ubiquitin-conjugating enzyme E2L 6	0.011
LY6G6F	lymphocyte antigen 6 complex, locus G6F	0.011
PRMT6	protein arginine methyltransferase 6	0.011
PNPLA3	patatin-like phospholipase domain containing 3	0.011
STC1	stanniocalcin 1	0.011
REPS2	RALBP1 associated Eps domain containing 2	0.011
CAPN1	calpain 1, (mu/I) large subunit	0.011
TLN1	talin 1	0.011
SPRY2	sprouty homolog 2 (Drosophila)	0.010
VAV3	vav 3 guanine nucleotide exchange factor	0.010
MYT1	myelin transcription factor 1	0.010
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.010
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.010
RAC3	ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)	0.010
TBCD	tubulin folding cofactor D	0.010
SERPINA10	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	0.010
FSCN2	fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)	0.010
RBP4	retinol binding protein 4, plasma	0.010
PAX2	paired box 2	0.010
SIAH2	seven in absentia homolog 2 (Drosophila)	0.010
RARA	retinoic acid receptor, alpha	0.010
NEUROD1	neurogenic differentiation 1	0.010
PAX4	paired box 4	0.008
GCGR	glucagon receptor	0.008
LIPC	lipase, hepatic	0.007
MTNR1B	melatonin receptor 1B	0.007
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.005
GPD2	glycerol-3-phosphate dehydrogenase 2 (mitochondrial)	0.005
IGF2BP2	insulin-like growth factor 2 mRNA binding protein 2	0.005
WFS1	Wolfram syndrome 1 (wolframin)	0.004
CDKAL1	CDK5 regulatory subunit associated protein 1-like 1	0.004
GCK	glucokinase (hexokinase 4)	0.004
SLC30A8	solute carrier family 30 (zinc transporter), member 8	0.004
HMGA1	high mobility group AT-hook 1	0.003
MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1	0.003
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.003
FOXP3	forkhead box P3	0.003
RETN	resistin	0.002
PTPN22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.002
OAS1	2',5'-oligoadenylate synthetase 1, 40/46kDa	0.001
IL6	interleukin 6 (interferon, beta 2)	0.001