IMP

Process View

Homo sapiens

17 genes annotated in human

response to osmotic stress

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "response to osmotic stress"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "response to osmotic stress" (in gray)

Name	Description	Probability	Func Analog Organism
MAPK14	mitogen-activated protein kinase 14	0.989	Human Yeast Worm Fly
MAP2K4	mitogen-activated protein kinase kinase 4	0.792	Human
JUN	jun proto-oncogene	0.606	Human
DUSP1	dual specificity phosphatase 1	0.596
ATF2	activating transcription factor 2	0.492
MAPK1	mitogen-activated protein kinase 1	0.454
NCOA3	nuclear receptor coactivator 3	0.331
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.225
DNM2	dynamin 2	0.170
MAPK3	mitogen-activated protein kinase 3	0.156
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.150
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.147
SCNN1B	sodium channel, nonvoltage-gated 1, beta	0.132	Fly
CAB39	calcium binding protein 39	0.117
MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1	0.108
HDAC4	histone deacetylase 4	0.103
TAB1	TGF-beta activated kinase 1/MAP3K7 binding protein 1	0.097
GIT1	G protein-coupled receptor kinase interacting ArfGAP 1	0.064
ZFP36L1	zinc finger protein 36, C3H type-like 1	0.062
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.056	Rat
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.053
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.052
SOCS3	suppressor of cytokine signaling 3	0.052
LRRK2	leucine-rich repeat kinase 2	0.050
RB1	retinoblastoma 1	0.049
SNTA1	syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)	0.048
MAP2K6	mitogen-activated protein kinase kinase 6	0.047	Human
ATF3	activating transcription factor 3	0.046
ARRB1	arrestin, beta 1	0.041
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.040
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.038	Mouse
PKD1	polycystic kidney disease 1 (autosomal dominant)	0.037
JUNB	jun B proto-oncogene	0.035	Human
MED31	mediator complex subunit 31	0.034
ZFP36	zinc finger protein 36, C3H type, homolog (mouse)	0.032
MAPKAPK3	mitogen-activated protein kinase-activated protein kinase 3	0.028	Fly
PAX8	paired box 8	0.026
ALDH1A1	aldehyde dehydrogenase 1 family, member A1	0.026	Yeast
CCR5	chemokine (C-C motif) receptor 5	0.026
SH3RF1	SH3 domain containing ring finger 1	0.025
HTT	huntingtin	0.024
PAK2	p21 protein (Cdc42/Rac)-activated kinase 2	0.023	Yeast
MAPK11	mitogen-activated protein kinase 11	0.023	Human Yeast Worm Fly
FASLG	Fas ligand (TNF superfamily, member 6)	0.023
ALDH2	aldehyde dehydrogenase 2 family (mitochondrial)	0.023	Yeast
MAPK8	mitogen-activated protein kinase 8	0.023	Human Yeast Rat Worm
CUL2	cullin 2	0.022
IRF2	interferon regulatory factor 2	0.022
MAPK12	mitogen-activated protein kinase 12	0.022	Human Yeast Worm Fly
EIF4G1	eukaryotic translation initiation factor 4 gamma, 1	0.022
PAK1	p21 protein (Cdc42/Rac)-activated kinase 1	0.022	Yeast
PDK1	pyruvate dehydrogenase kinase, isozyme 1	0.021
IER2	immediate early response 2	0.021
ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7	0.021
MKNK1	MAP kinase interacting serine/threonine kinase 1	0.021	Mouse
EPOR	erythropoietin receptor	0.020
MAP2K3	mitogen-activated protein kinase kinase 3	0.020	Human
DUSP7	dual specificity phosphatase 7	0.019
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.019
CRH	corticotropin releasing hormone	0.019
ADAMTSL4	ADAMTS-like 4	0.019
PKN1	protein kinase N1	0.019	Mouse
MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	0.019	Fly
JUND	jun D proto-oncogene	0.018	Human
EGR1	early growth response 1	0.018
MKNK2	MAP kinase interacting serine/threonine kinase 2	0.018
BCL6	B-cell CLL/lymphoma 6	0.018
GADD45B	growth arrest and DNA-damage-inducible, beta	0.017
ARRB2	arrestin, beta 2	0.017
BAK1	BCL2-antagonist/killer 1	0.017
MAP3K4	mitogen-activated protein kinase kinase kinase 4	0.017	Fly
CTTN	cortactin	0.017
MEF2A	myocyte enhancer factor 2A	0.016	Yeast
EIF4A3	eukaryotic translation initiation factor 4A3	0.016
DUSP9	dual specificity phosphatase 9	0.016
CREB1	cAMP responsive element binding protein 1	0.016
PRKACB	protein kinase, cAMP-dependent, catalytic, beta	0.016
ZNF282	zinc finger protein 282	0.016
CPNE6	copine VI (neuronal)	0.016
PPP3R1	protein phosphatase 3, regulatory subunit B, alpha	0.015
FKBP8	FK506 binding protein 8, 38kDa	0.015
RNF144B	ring finger protein 144B	0.015
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.015
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.015
MAPK9	mitogen-activated protein kinase 9	0.015	Human Yeast Worm
IQGAP1	IQ motif containing GTPase activating protein 1	0.015
ATP6V1B2	ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2	0.014
ATXN3	ataxin 3	0.014
VIM	vimentin	0.014
ATP6V1D	ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D	0.014
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.013
MEF2C	myocyte enhancer factor 2C	0.013	Yeast
HSF1	heat shock transcription factor 1	0.013
HDAC9	histone deacetylase 9	0.012
ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	0.012
RNF11	ring finger protein 11	0.012
CUL1	cullin 1	0.012
FOSB	FBJ murine osteosarcoma viral oncogene homolog B	0.012
FLNB	filamin B, beta	0.012
USP10	ubiquitin specific peptidase 10	0.012
SPTBN1	spectrin, beta, non-erythrocytic 1	0.011
ZMYND10	zinc finger, MYND-type containing 10	0.011
PPP1R15A	protein phosphatase 1, regulatory (inhibitor) subunit 15A	0.011
XPO7	exportin 7	0.011
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.011
JDP2	Jun dimerization protein 2	0.011
LIMK1	LIM domain kinase 1	0.011
HNRNPU	heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)	0.011
RPS6KA4	ribosomal protein S6 kinase, 90kDa, polypeptide 4	0.011
PTPRR	protein tyrosine phosphatase, receptor type, R	0.011
SCNN1A	sodium channel, nonvoltage-gated 1 alpha	0.011	Fly
ARHGAP9	Rho GTPase activating protein 9	0.010
SH3KBP1	SH3-domain kinase binding protein 1	0.010
EIF4G3	eukaryotic translation initiation factor 4 gamma, 3	0.010
BRAF	v-raf murine sarcoma viral oncogene homolog B1	0.010
EGLN1	egl nine homolog 1 (C. elegans)	0.010