IMP

Process View

Homo sapiens

3 genes annotated in human

endosome transport via multivesicular body sorting pathway

The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in human Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "endosome transport via multivesicular body sorting pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "endosome transport via multivesicular body sorting pathway" (in gray)

Name	Description	Probability	Func Analog Organism
PDCD6IP	programmed cell death 6 interacting protein	0.996
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.979	Yeast
RNF11	ring finger protein 11	0.955
GGA1	golgi-associated, gamma adaptin ear containing, ARF binding protein 1	0.940
TSG101	tumor susceptibility gene 101	0.927	Worm
GGA2	golgi-associated, gamma adaptin ear containing, ARF binding protein 2	0.917
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.837	Yeast
ARCN1	archain 1	0.832
ROCK1	Rho-associated, coiled-coil containing protein kinase 1	0.729
CALCOCO2	calcium binding and coiled-coil domain 2	0.673
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.645	Yeast
CHMP4B	chromatin modifying protein 4B	0.610
SYNRG	synergin, gamma	0.554
SNF8	SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)	0.553
STAMBP	STAM binding protein	0.518
SMAD1	SMAD family member 1	0.515
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.479	Yeast
SMAD4	SMAD family member 4	0.477
CHMP1A	chromatin modifying protein 1A	0.466
ZFYVE9	zinc finger, FYVE domain containing 9	0.457
SH3GL2	SH3-domain GRB2-like 2	0.378
SMAD5	SMAD family member 5	0.355
SH3KBP1	SH3-domain kinase binding protein 1	0.345
FBXL15	F-box and leucine-rich repeat protein 15	0.294
SORT1	sortilin 1	0.292
COPB1	coatomer protein complex, subunit beta 1	0.291
ANKRD13A	ankyrin repeat domain 13A	0.277
CD2AP	CD2-associated protein	0.263
SORL1	sortilin-related receptor, L(DLR class) A repeats containing	0.263	Human
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.259	Yeast
RABEP1	rabaptin, RAB GTPase binding effector protein 1	0.255
TAX1BP1	Tax1 (human T-cell leukemia virus type I) binding protein 1	0.253
VPS28	vacuolar protein sorting 28 homolog (S. cerevisiae)	0.237
PDCD6	programmed cell death 6	0.230
RHOA	ras homolog gene family, member A	0.184
WWP1	WW domain containing E3 ubiquitin protein ligase 1	0.153	Yeast
LRSAM1	leucine rich repeat and sterile alpha motif containing 1	0.143
NBR1	neighbor of BRCA1 gene 1	0.134
EEA1	early endosome antigen 1	0.131
SNX9	sorting nexin 9	0.131
LRRK2	leucine-rich repeat kinase 2	0.127
STAM2	signal transducing adaptor molecule (SH3 domain and ITAM motif) 2	0.113
RAPGEF2	Rap guanine nucleotide exchange factor (GEF) 2	0.113
GGA3	golgi-associated, gamma adaptin ear containing, ARF binding protein 3	0.112
IGF2R	insulin-like growth factor 2 receptor	0.111
SCNN1B	sodium channel, nonvoltage-gated 1, beta	0.107
SPG20	spastic paraplegia 20 (Troyer syndrome)	0.093
SMAD7	SMAD family member 7	0.092
SPG21	spastic paraplegia 21 (autosomal recessive, Mast syndrome)	0.088
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.084
C1orf93	chromosome 1 open reading frame 93	0.080
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.078	Yeast
RAB6A	RAB6A, member RAS oncogene family	0.077
DNM2	dynamin 2	0.076
CXXC5	CXXC finger protein 5	0.074
HGS	hepatocyte growth factor-regulated tyrosine kinase substrate	0.070	Fly
PTPN23	protein tyrosine phosphatase, non-receptor type 23	0.068	Yeast
ELL	elongation factor RNA polymerase II	0.067
DAZAP2	DAZ associated protein 2	0.058
ING2	inhibitor of growth family, member 2	0.057
EPS15	epidermal growth factor receptor pathway substrate 15	0.056
RAB22A	RAB22A, member RAS oncogene family	0.055
OCRL	oculocerebrorenal syndrome of Lowe	0.050
SGK3	serum/glucocorticoid regulated kinase family, member 3	0.048
TOM1L1	target of myb1 (chicken)-like 1	0.045
APIP	APAF1 interacting protein	0.044
RAB5A	RAB5A, member RAS oncogene family	0.044	Yeast
PPFIBP2	PTPRF interacting protein, binding protein 2 (liprin beta 2)	0.042
PLEKHO1	pleckstrin homology domain containing, family O member 1	0.041
CARD11	caspase recruitment domain family, member 11	0.041
POU5F1	POU class 5 homeobox 1	0.038
TRAF4	TNF receptor-associated factor 4	0.038
VPS24	vacuolar protein sorting 24 homolog (S. cerevisiae)	0.037
CHMP6	chromatin modifying protein 6	0.037	Fly
MED15	mediator complex subunit 15	0.036
SCNN1A	sodium channel, nonvoltage-gated 1 alpha	0.035
DTX1	deltex homolog 1 (Drosophila)	0.034
COPA	coatomer protein complex, subunit alpha	0.033
ZRANB1	zinc finger, RAN-binding domain containing 1	0.033
SMAD6	SMAD family member 6	0.031
GOLGA5	golgin A5	0.031
NDFIP2	Nedd4 family interacting protein 2	0.031
ADRBK1	adrenergic, beta, receptor kinase 1	0.031
KRT15	keratin 15	0.030
KLF5	Kruppel-like factor 5 (intestinal)	0.029
UBQLN2	ubiquilin 2	0.029
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.029
YAP1	Yes-associated protein 1	0.029
EIF1B	eukaryotic translation initiation factor 1B	0.028
CCDC127	coiled-coil domain containing 127	0.028
EXOC7	exocyst complex component 7	0.027
WNK1	WNK lysine deficient protein kinase 1	0.027
ZFAND5	zinc finger, AN1-type domain 5	0.027
CLTC	clathrin, heavy chain (Hc)	0.026
ARRDC3	arrestin domain containing 3	0.026
APPL1	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1	0.026
SBF1	SET binding factor 1	0.025
ATP6V1E1	ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1	0.025
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.025
CBLC	Cas-Br-M (murine) ecotropic retroviral transforming sequence c	0.025
COPG2	coatomer protein complex, subunit gamma 2	0.024
TMED10	transmembrane emp24-like trafficking protein 10 (yeast)	0.024
GRAP2	GRB2-related adaptor protein 2	0.024
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.023
MYO6	myosin VI	0.023
SOX7	SRY (sex determining region Y)-box 7	0.022
OPTN	optineurin	0.022
VPS37C	vacuolar protein sorting 37 homolog C (S. cerevisiae)	0.022
MAP1LC3B	microtubule-associated protein 1 light chain 3 beta	0.022
RNF168	ring finger protein 168	0.022
DCUN1D1	DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)	0.021
POLDIP2	polymerase (DNA-directed), delta interacting protein 2	0.021
TGFBR1	transforming growth factor, beta receptor 1	0.021
USP54	ubiquitin specific peptidase 54	0.020
GABARAPL2	GABA(A) receptor-associated protein-like 2	0.020
TAB1	TGF-beta activated kinase 1/MAP3K7 binding protein 1	0.020
SPAG9	sperm associated antigen 9	0.020
C20orf43	chromosome 20 open reading frame 43	0.019
CHMP4A	chromatin modifying protein 4A	0.019
ASAP2	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	0.019
CALCOCO1	calcium binding and coiled-coil domain 1	0.019
COPG	coatomer protein complex, subunit gamma	0.019
STAM	signal transducing adaptor molecule (SH3 domain and ITAM motif) 1	0.018
LRP3	low density lipoprotein receptor-related protein 3	0.018
RHOXF2	Rhox homeobox family, member 2	0.018
NPLOC4	nuclear protein localization 4 homolog (S. cerevisiae)	0.018
ZFYVE16	zinc finger, FYVE domain containing 16	0.018
CLIP1	CAP-GLY domain containing linker protein 1	0.018
TCAP	titin-cap (telethonin)	0.017
DAPK1	death-associated protein kinase 1	0.017
MKL2	MKL/myocardin-like 2	0.017
MON2	MON2 homolog (S. cerevisiae)	0.017
SMAD2	SMAD family member 2	0.017
PTEN	phosphatase and tensin homolog	0.016
FTL	ferritin, light polypeptide	0.016
PTK2	PTK2 protein tyrosine kinase 2	0.016
UBE2Z	ubiquitin-conjugating enzyme E2Z	0.015
RNF41	ring finger protein 41	0.015
ACTN4	actinin, alpha 4	0.015
RIOK3	RIO kinase 3 (yeast)	0.015
ACAP2	ArfGAP with coiled-coil, ankyrin repeat and PH domains 2	0.014
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.014
TOM1	target of myb1 (chicken)	0.014
C17orf37	chromosome 17 open reading frame 37	0.014
RANBP9	RAN binding protein 9	0.014
SUN2	Sad1 and UNC84 domain containing 2	0.014
ZFYVE20	zinc finger, FYVE domain containing 20	0.014
DOCK9	dedicator of cytokinesis 9	0.014
TOLLIP	toll interacting protein	0.014
UBAP1	ubiquitin associated protein 1	0.014
SNX18	sorting nexin 18	0.014
ADRB2	adrenergic, beta-2-, receptor, surface	0.013
IQGAP1	IQ motif containing GTPase activating protein 1	0.013
EFEMP2	EGF containing fibulin-like extracellular matrix protein 2	0.013
SEC22B	SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)	0.013
ADARB1	adenosine deaminase, RNA-specific, B1	0.013
VPS25	vacuolar protein sorting 25 homolog (S. cerevisiae)	0.013	Fly
VPS36	vacuolar protein sorting 36 homolog (S. cerevisiae)	0.013
ARRB2	arrestin, beta 2	0.013
UBB	ubiquitin B	0.013
WBP2	WW domain binding protein 2	0.013
ACVR1B	activin A receptor, type IB	0.013
DEDD	death effector domain containing	0.013
RYBP	RING1 and YY1 binding protein	0.013
LEMD3	LEM domain containing 3	0.013
SQSTM1	sequestosome 1	0.012
POLH	polymerase (DNA directed), eta	0.012
MUL1	mitochondrial E3 ubiquitin protein ligase 1	0.012
ARRDC1	arrestin domain containing 1	0.012
SCNN1G	sodium channel, nonvoltage-gated 1, gamma	0.012
RAP1B	RAP1B, member of RAS oncogene family	0.012
SOCS6	suppressor of cytokine signaling 6	0.012
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.012
ING1	inhibitor of growth family, member 1	0.012
RABGEF1	RAB guanine nucleotide exchange factor (GEF) 1	0.012
USP2	ubiquitin specific peptidase 2	0.012
ETFB	electron-transfer-flavoprotein, beta polypeptide	0.011
SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	0.011
UQCR11	ubiquinol-cytochrome c reductase, complex III subunit XI	0.011
PDK1	pyruvate dehydrogenase kinase, isozyme 1	0.011
EIF1	eukaryotic translation initiation factor 1	0.011
RNF115	ring finger protein 115	0.011
EHMT2	euchromatic histone-lysine N-methyltransferase 2	0.011
ECH1	enoyl CoA hydratase 1, peroxisomal	0.011
ERCC6	excision repair cross-complementing rodent repair deficiency, complementation group 6	0.011
TRIP12	thyroid hormone receptor interactor 12	0.011
PPIL4	peptidylprolyl isomerase (cyclophilin)-like 4	0.011
HERC3	hect domain and RLD 3	0.010
PACSIN2	protein kinase C and casein kinase substrate in neurons 2	0.010
MTMR4	myotubularin related protein 4	0.010
DNM1	dynamin 1	0.010
ATP6V1D	ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D	0.010
HMGCL	3-hydroxymethyl-3-methylglutaryl-CoA lyase	0.010
HECW2	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	0.010
R3HCC1	R3H domain and coiled-coil containing 1	0.010