IMP

Process View

Homo sapiens

4 genes annotated in human

distal tubule development

GO:0072017

The process whose specific outcome is the progression of the distal tubule over time, from its formation to the mature structure. In mammals, the distal tubule is a nephron tubule that begins at the macula densa and extends to the connecting tubule.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "distal tubule development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "distal tubule development" (in gray)

Name	Description	Probability	Func Analog Organism
NOTCH3	notch 3	0.999
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.990
JAG1	jagged 1	0.988	Mouse
CUL3	cullin 3	0.982
NOTCH1	notch 1	0.967	Mouse
TSC22D4	TSC22 domain family, member 4	0.941
KLHL3	kelch-like 3 (Drosophila)	0.884
PKD2	polycystic kidney disease 2 (autosomal dominant)	0.859
KLHL2	kelch-like 2, Mayven (Drosophila)	0.852	Human
WNK4	WNK lysine deficient protein kinase 4	0.811
PKD1	polycystic kidney disease 1 (autosomal dominant)	0.765
KLHL12	kelch-like 12 (Drosophila)	0.717	Human
XIAP	X-linked inhibitor of apoptosis	0.458
NOTCH2	notch 2	0.418
MED28	mediator complex subunit 28	0.414
MAML1	mastermind-like 1 (Drosophila)	0.412
DAPK1	death-associated protein kinase 1	0.383
NKX2-1	NK2 homeobox 1	0.275
TRPV5	transient receptor potential cation channel, subfamily V, member 5	0.237
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.213
DPP3	dipeptidyl-peptidase 3	0.206
NFE2L2	nuclear factor (erythroid-derived 2)-like 2	0.204
TRPC1	transient receptor potential cation channel, subfamily C, member 1	0.171
JAG2	jagged 2	0.134
OXSR1	oxidative-stress responsive 1	0.129
DLL1	delta-like 1 (Drosophila)	0.112
BTBD10	BTB (POZ) domain containing 10	0.089
GLIS2	GLIS family zinc finger 2	0.086
CDC37	cell division cycle 37 homolog (S. cerevisiae)	0.081
LNX1	ligand of numb-protein X 1	0.081
SPOP	speckle-type POZ protein	0.072
ZMYND10	zinc finger, MYND-type containing 10	0.070
GADD45A	growth arrest and DNA-damage-inducible, alpha	0.067
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.067
ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	0.059
ATXN1	ataxin 1	0.055
KBTBD7	kelch repeat and BTB (POZ) domain containing 7	0.055
GET4	golgi to ER traffic protein 4 homolog (S. cerevisiae)	0.054
NFE2L1	nuclear factor (erythroid-derived 2)-like 1	0.054
DGCR14	DiGeorge syndrome critical region gene 14	0.051
ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	0.047
NPHP1	nephronophthisis 1 (juvenile)	0.044
KLHDC5	kelch domain containing 5	0.041
DVL3	dishevelled, dsh homolog 3 (Drosophila)	0.040
BBS4	Bardet-Biedl syndrome 4	0.039
UBA1	ubiquitin-like modifier activating enzyme 1	0.038
EFNB2	ephrin-B2	0.038
NCOR2	nuclear receptor corepressor 2	0.038
VTA1	Vps20-associated 1 homolog (S. cerevisiae)	0.037
RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2	0.034
CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	0.033
BBS1	Bardet-Biedl syndrome 1	0.032
PRMT6	protein arginine methyltransferase 6	0.031
PRR13	proline rich 13	0.031
KDM5A	lysine (K)-specific demethylase 5A	0.030
SNX20	sorting nexin 20	0.027
SPEN	spen homolog, transcriptional regulator (Drosophila)	0.026
ATXN1L	ataxin 1-like	0.025
DCUN1D1	DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)	0.024
TULP3	tubby like protein 3	0.024
WNK1	WNK lysine deficient protein kinase 1	0.021	Human
WDFY3	WD repeat and FYVE domain containing 3	0.021
ACVR1	activin A receptor, type I	0.021
SESN2	sestrin 2	0.021
DIAPH1	diaphanous homolog 1 (Drosophila)	0.020
ADAM17	ADAM metallopeptidase domain 17	0.020
C3orf64	chromosome 3 open reading frame 64	0.019
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.019
PFN2	profilin 2	0.018
DMPK	dystrophia myotonica-protein kinase	0.018
TRPV6	transient receptor potential cation channel, subfamily V, member 6	0.017
MAP1LC3B	microtubule-associated protein 1 light chain 3 beta	0.017
PAM	peptidylglycine alpha-amidating monooxygenase	0.017
MACF1	microtubule-actin crosslinking factor 1	0.017
KIAA0174	KIAA0174	0.017
MAPK8IP3	mitogen-activated protein kinase 8 interacting protein 3	0.016
MBIP	MAP3K12 binding inhibitory protein 1	0.016
RGS7	regulator of G-protein signaling 7	0.015
BAG3	BCL2-associated athanogene 3	0.015
MCMBP	minichromosome maintenance complex binding protein	0.015
CPSF6	cleavage and polyadenylation specific factor 6, 68kDa	0.015
WNK2	WNK lysine deficient protein kinase 2	0.015	Human
LAMC1	laminin, gamma 1 (formerly LAMB2)	0.014
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.014
KLHL20	kelch-like 20 (Drosophila)	0.014	Human
KBTBD6	kelch repeat and BTB (POZ) domain containing 6	0.014
FAM46A	family with sequence similarity 46, member A	0.014
ATP10D	ATPase, class V, type 10D	0.014
DCUN1D5	DCN1, defective in cullin neddylation 1, domain containing 5 (S. cerevisiae)	0.014
CASP3	caspase 3, apoptosis-related cysteine peptidase	0.013
FHOD3	formin homology 2 domain containing 3	0.013
FAM21C	family with sequence similarity 21, member C	0.013
DOCK7	dedicator of cytokinesis 7	0.013
ATXN2	ataxin 2	0.013
WNT7A	wingless-type MMTV integration site family, member 7A	0.013
DHX38	DEAH (Asp-Glu-Ala-His) box polypeptide 38	0.013
MEX3C	mex-3 homolog C (C. elegans)	0.013
PLK2	polo-like kinase 2	0.012
OTX2	orthodenticle homeobox 2	0.012
LHX1	LIM homeobox 1	0.012
HOXB7	homeobox B7	0.012
EGFL7	EGF-like-domain, multiple 7	0.012
ZNF431	zinc finger protein 431	0.012
BBS7	Bardet-Biedl syndrome 7	0.012
HMGA2	high mobility group AT-hook 2	0.012
ASAP2	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	0.012
MAP1LC3A	microtubule-associated protein 1 light chain 3 alpha	0.012
CSDE1	cold shock domain containing E1, RNA-binding	0.012
ZHX2	zinc fingers and homeoboxes 2	0.012
CDH16	cadherin 16, KSP-cadherin	0.012
ID2	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein	0.012
NUDCD3	NudC domain containing 3	0.012
CCNK	cyclin K	0.012
ZXDC	ZXD family zinc finger C	0.012
NBR1	neighbor of BRCA1 gene 1	0.011
F3	coagulation factor III (thromboplastin, tissue factor)	0.011
MAZ	MYC-associated zinc finger protein (purine-binding transcription factor)	0.011
PLXNA3	plexin A3	0.011
EPHA4	EPH receptor A4	0.011
PPP4C	protein phosphatase 4, catalytic subunit	0.011
ITGA6	integrin, alpha 6	0.011
ADAMTS10	ADAM metallopeptidase with thrombospondin type 1 motif, 10	0.011
BCL6	B-cell CLL/lymphoma 6	0.011
WSB1	WD repeat and SOCS box containing 1	0.011
KIAA2026	KIAA2026	0.011
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.011
MAFG	v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)	0.011
COL2A1	collagen, type II, alpha 1	0.010
USP9X	ubiquitin specific peptidase 9, X-linked	0.010
USP22	ubiquitin specific peptidase 22	0.010
ZNF264	zinc finger protein 264	0.010
EXT2	exostosin 2	0.010
FEM1A	fem-1 homolog a (C. elegans)	0.010
PMEPA1	prostate transmembrane protein, androgen induced 1	0.010
NOVA2	neuro-oncological ventral antigen 2	0.010
SGMS1	sphingomyelin synthase 1	0.010
RBM45	RNA binding motif protein 45	0.010
CIC	capicua homolog (Drosophila)	0.010