IMP

Process View

Homo sapiens

3 genes annotated in human

Multi-species View

mitral valve development

GO:0003174

The progression of the mitral valve over time, from its formation to the mature structure.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in human Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "mitral valve development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "mitral valve development" (in gray)

Name	Description	Probability	Func Analog Organism
JAG1	jagged 1	1.000
TGFB1	transforming growth factor, beta 1	0.996
FKBP1A	FK506 binding protein 1A, 12kDa	0.995
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.993
FSTL1	follistatin-like 1	0.967
TGFB3	transforming growth factor, beta 3	0.950
BMP2	bone morphogenetic protein 2	0.932
GDF5	growth differentiation factor 5	0.888
SMAD7	SMAD family member 7	0.856
ENG	endoglin	0.837
SETD8	SET domain containing (lysine methyltransferase) 8	0.722
MAML1	mastermind-like 1 (Drosophila)	0.702
PRKG1	protein kinase, cGMP-dependent, type I	0.674
NRP1	neuropilin 1	0.660
DLL1	delta-like 1 (Drosophila)	0.646
ZMYND11	zinc finger, MYND-type containing 11	0.638
NOTCH1	notch 1	0.462
NOTCH2	notch 2	0.393	Human
XIAP	X-linked inhibitor of apoptosis	0.334
JAG2	jagged 2	0.320
PDGFC	platelet derived growth factor C	0.275
MAPK8	mitogen-activated protein kinase 8	0.258
GSK3B	glycogen synthase kinase 3 beta	0.202
SMAD2	SMAD family member 2	0.193
MARCKSL1	MARCKS-like 1	0.183
REL	v-rel reticuloendotheliosis viral oncogene homolog (avian)	0.173
RBBP4	retinoblastoma binding protein 4	0.169
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.163
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.143
RXRA	retinoid X receptor, alpha	0.102
GFI1B	growth factor independent 1B transcription repressor	0.100
IQGAP1	IQ motif containing GTPase activating protein 1	0.096
NOTCH3	notch 3	0.089	Human
EGFL7	EGF-like-domain, multiple 7	0.084
NOTCH2NL	notch 2 N-terminal like	0.082
TGFBR1	transforming growth factor, beta receptor 1	0.081	Human
BMP4	bone morphogenetic protein 4	0.076
NPR1	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	0.073
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	0.071
CTBP2	C-terminal binding protein 2	0.065
APP	amyloid beta (A4) precursor protein	0.064
SPEN	spen homolog, transcriptional regulator (Drosophila)	0.061
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.056
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.050
VEGFA	vascular endothelial growth factor A	0.048
TGFBR3	transforming growth factor, beta receptor III	0.047
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.047
FNDC3B	fibronectin type III domain containing 3B	0.045
ACVR1	activin A receptor, type I	0.044
ATXN1L	ataxin 1-like	0.044
TACC1	transforming, acidic coiled-coil containing protein 1	0.042
ACVR1B	activin A receptor, type IB	0.039	Human
EFNB2	ephrin-B2	0.038
LRP6	low density lipoprotein receptor-related protein 6	0.037
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.032
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.031
KLK10	kallikrein-related peptidase 10	0.031
RAMP2	receptor (G protein-coupled) activity modifying protein 2	0.030
ATP2B4	ATPase, Ca++ transporting, plasma membrane 4	0.030
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.030	Human
ANTXR2	anthrax toxin receptor 2	0.029
ICAM2	intercellular adhesion molecule 2	0.029
HIC1	hypermethylated in cancer 1	0.029
TIE1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.028
BICD1	bicaudal D homolog 1 (Drosophila)	0.028
C20orf4	chromosome 20 open reading frame 4	0.027
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.027
CDH5	cadherin 5, type 2 (vascular endothelium)	0.027
SOX13	SRY (sex determining region Y)-box 13	0.027
VWF	von Willebrand factor	0.027
DOCK8	dedicator of cytokinesis 8	0.026
GJB5	gap junction protein, beta 5, 31.1kDa	0.026	Human
CD34	CD34 molecule	0.026
GATA2	GATA binding protein 2	0.026
ACVRL1	activin A receptor type II-like 1	0.026	Human
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.025
HIPK2	homeodomain interacting protein kinase 2	0.024
ACVR2A	activin A receptor, type IIA	0.023
FOXF2	forkhead box F2	0.022
FGFBP1	fibroblast growth factor binding protein 1	0.022
SOX7	SRY (sex determining region Y)-box 7	0.022
AQP5	aquaporin 5	0.021
NBPF10	neuroblastoma breakpoint family, member 10	0.021
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.020
AXIN1	axin 1	0.020
RBMS1	RNA binding motif, single stranded interacting protein 1	0.020
TMEM44	transmembrane protein 44	0.020
PCDH12	protocadherin 12	0.019
PDGFA	platelet-derived growth factor alpha polypeptide	0.019
MED25	mediator complex subunit 25	0.019
CD248	CD248 molecule, endosialin	0.019
ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	0.018
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.018
ACVR2B	activin A receptor, type IIB	0.018
INHBB	inhibin, beta B	0.018
GJB3	gap junction protein, beta 3, 31kDa	0.018	Human
GATA1	GATA binding protein 1 (globin transcription factor 1)	0.018
USP15	ubiquitin specific peptidase 15	0.018
CLU	clusterin	0.017
FZD7	frizzled homolog 7 (Drosophila)	0.017
SOX17	SRY (sex determining region Y)-box 17	0.017
HOXA5	homeobox A5	0.017
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.017
FGF18	fibroblast growth factor 18	0.016
MYL2	myosin, light chain 2, regulatory, cardiac, slow	0.016
GATAD2B	GATA zinc finger domain containing 2B	0.016
PLVAP	plasmalemma vesicle associated protein	0.016
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.015
POU4F3	POU class 4 homeobox 3	0.015
KCNK7	potassium channel, subfamily K, member 7	0.015
KAT2B	K(lysine) acetyltransferase 2B	0.015
PHACTR2	phosphatase and actin regulator 2	0.015
TRIM29	tripartite motif containing 29	0.015
SMAD1	SMAD family member 1	0.015
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.015
APLNR	apelin receptor	0.015
DLL4	delta-like 4 (Drosophila)	0.015
KANK3	KN motif and ankyrin repeat domains 3	0.015
RARA	retinoic acid receptor, alpha	0.015
THBS1	thrombospondin 1	0.014
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.014
SLCO2A1	solute carrier organic anion transporter family, member 2A1	0.014
PMEPA1	prostate transmembrane protein, androgen induced 1	0.014
ERN2	endoplasmic reticulum to nucleus signaling 2	0.014
NRP2	neuropilin 2	0.014
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.014
SPRED1	sprouty-related, EVH1 domain containing 1	0.014
IL6ST	interleukin 6 signal transducer (gp130, oncostatin M receptor)	0.014
SCEL	sciellin	0.014
SPIN1	spindlin 1	0.014
NIN	ninein (GSK3B interacting protein)	0.014
HIGD1B	HIG1 hypoxia inducible domain family, member 1B	0.013
HOXB7	homeobox B7	0.013
PRRX2	paired related homeobox 2	0.013
BRD3	bromodomain containing 3	0.013
KIAA1191	KIAA1191	0.013
BMP6	bone morphogenetic protein 6	0.013
CHRM5	cholinergic receptor, muscarinic 5	0.013
BCAM	basal cell adhesion molecule (Lutheran blood group)	0.013
GPR116	G protein-coupled receptor 116	0.013
GATA4	GATA binding protein 4	0.013
EP300	E1A binding protein p300	0.013
SCARB2	scavenger receptor class B, member 2	0.013
COL5A3	collagen, type V, alpha 3	0.013
GPR4	G protein-coupled receptor 4	0.013
CLDN5	claudin 5	0.013
BTNL3	butyrophilin-like 3	0.013
RAMP3	receptor (G protein-coupled) activity modifying protein 3	0.013
IHH	Indian hedgehog	0.013
NOG	noggin	0.013
EMCN	endomucin	0.013
SERPINB5	serpin peptidase inhibitor, clade B (ovalbumin), member 5	0.013
ZFYVE9	zinc finger, FYVE domain containing 9	0.013
CRHR2	corticotropin releasing hormone receptor 2	0.013
KDM5B	lysine (K)-specific demethylase 5B	0.013
HRC	histidine rich calcium binding protein	0.012
SMAD6	SMAD family member 6	0.012
MAP2K7	mitogen-activated protein kinase kinase 7	0.012
SNAI1	snail homolog 1 (Drosophila)	0.012
LAD1	ladinin 1	0.012
TGIF1	TGFB-induced factor homeobox 1	0.012
PWWP2B	PWWP domain containing 2B	0.012
NPPB	natriuretic peptide B	0.012
FOXN1	forkhead box N1	0.012
TRAK2	trafficking protein, kinesin binding 2	0.012
HES6	hairy and enhancer of split 6 (Drosophila)	0.012
CXXC5	CXXC finger protein 5	0.012
BAMBI	BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)	0.012
MYBPC2	myosin binding protein C, fast type	0.012
PKP3	plakophilin 3	0.012
NOS3	nitric oxide synthase 3 (endothelial cell)	0.012
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.012
LIMK1	LIM domain kinase 1	0.012
PKD2	polycystic kidney disease 2 (autosomal dominant)	0.012
MYO6	myosin VI	0.012
PKP1	plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)	0.012
IGSF1	immunoglobulin superfamily, member 1	0.012
GPX2	glutathione peroxidase 2 (gastrointestinal)	0.012
KRT6B	keratin 6B	0.012
LRP12	low density lipoprotein receptor-related protein 12	0.012
AZGP1	alpha-2-glycoprotein 1, zinc-binding	0.012
PSG9	pregnancy specific beta-1-glycoprotein 9	0.012
TINAGL1	tubulointerstitial nephritis antigen-like 1	0.012
PLEKHG3	pleckstrin homology domain containing, family G (with RhoGef domain) member 3	0.012
HOXB13	homeobox B13	0.012
ABTB1	ankyrin repeat and BTB (POZ) domain containing 1	0.012
ANKIB1	ankyrin repeat and IBR domain containing 1	0.012
VGLL1	vestigial like 1 (Drosophila)	0.011
ARHGEF15	Rho guanine nucleotide exchange factor (GEF) 15	0.011
GBX2	gastrulation brain homeobox 2	0.011
MBNL2	muscleblind-like 2 (Drosophila)	0.011
NDUFA4L2	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2	0.011
PTPRB	protein tyrosine phosphatase, receptor type, B	0.011
ARRDC3	arrestin domain containing 3	0.011
PTCRA	pre T-cell antigen receptor alpha	0.011
ENDOU	endonuclease, polyU-specific	0.011
WDFY1	WD repeat and FYVE domain containing 1	0.011
ELK1	ELK1, member of ETS oncogene family	0.011
HYAL1	hyaluronoglucosaminidase 1	0.011
UTRN	utrophin	0.011
FKBP14	FK506 binding protein 14, 22 kDa	0.011
GDF6	growth differentiation factor 6	0.011
LEF1	lymphoid enhancer-binding factor 1	0.011
HES1	hairy and enhancer of split 1, (Drosophila)	0.011
TBX2	T-box 2	0.011
LAMA5	laminin, alpha 5	0.011
HEG1	HEG homolog 1 (zebrafish)	0.011
TGFB2	transforming growth factor, beta 2	0.011
ZNF608	zinc finger protein 608	0.011
YY1	YY1 transcription factor	0.011
ERG	v-ets erythroblastosis virus E26 oncogene homolog (avian)	0.011
GRASP	GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein	0.011
SLCO2B1	solute carrier organic anion transporter family, member 2B1	0.011
RPS6KA6	ribosomal protein S6 kinase, 90kDa, polypeptide 6	0.011
MMRN2	multimerin 2	0.011
ANKRD50	ankyrin repeat domain 50	0.011
APC	adenomatous polyposis coli	0.011
ROBO4	roundabout homolog 4, magic roundabout (Drosophila)	0.011
CACNA1F	calcium channel, voltage-dependent, L type, alpha 1F subunit	0.011
NKX6-1	NK6 homeobox 1	0.011
EFNA1	ephrin-A1	0.011
FUT1	fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)	0.011
PEG10	paternally expressed 10	0.011
HYAL2	hyaluronoglucosaminidase 2	0.011
ZBTB38	zinc finger and BTB domain containing 38	0.011
MDK	midkine (neurite growth-promoting factor 2)	0.011
TGIF2	TGFB-induced factor homeobox 2	0.011
SCNN1B	sodium channel, nonvoltage-gated 1, beta	0.011
SOX10	SRY (sex determining region Y)-box 10	0.011
FGF3	fibroblast growth factor 3	0.011
PDE2A	phosphodiesterase 2A, cGMP-stimulated	0.010
GABRR2	gamma-aminobutyric acid (GABA) receptor, rho 2	0.010
HR	hairless homolog (mouse)	0.010
SOX18	SRY (sex determining region Y)-box 18	0.010
HOXA2	homeobox A2	0.010
GJA3	gap junction protein, alpha 3, 46kDa	0.010	Human
ID3	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	0.010
WFIKKN1	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1	0.010
CXorf36	chromosome X open reading frame 36	0.010
ENPP3	ectonucleotide pyrophosphatase/phosphodiesterase 3	0.010
RASSF9	Ras association (RalGDS/AF-6) domain family (N-terminal) member 9	0.010
KCTD20	potassium channel tetramerisation domain containing 20	0.010
RAB3IL1	RAB3A interacting protein (rabin3)-like 1	0.010
MYOF	myoferlin	0.010
ALS2CL	ALS2 C-terminal like	0.010
ATP10D	ATPase, class V, type 10D	0.010
PAX4	paired box 4	0.010
MAML2	mastermind-like 2 (Drosophila)	0.010
SOX15	SRY (sex determining region Y)-box 15	0.010
CNTN1	contactin 1	0.010
AHR	aryl hydrocarbon receptor	0.010
KRT75	keratin 75	0.010
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.010
TBC1D1	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1	0.010
ADAM17	ADAM metallopeptidase domain 17	0.010
SLC6A13	solute carrier family 6 (neurotransmitter transporter, GABA), member 13	0.010
SHOX2	short stature homeobox 2	0.010
GPR182	G protein-coupled receptor 182	0.010
OS9	osteosarcoma amplified 9, endoplasmic reticulum lectin	0.010